Luck et al. identify the bacterial protein ZmpB as a key factor in heart damage during severe Streptococcus pneumoniae infections. Variants of ZmpB with FIVAR domains enable cardiac cell invasion, whi...

The gut’s microbial ecosystem produces diverse metabolites that actively shape neural, immune, and endocrine function. Join leading researchers on December 12 as they share new discoveries into these ...

Symposium Schedule All presentation times are shown in Pacific Daylight Time (GMT -07:00 / UTC -07:00) Time Talk / Session 9:00 Welcoming remarks by Sid Venkatesh Session One: Neural Effects

Decoding Lyme Disease: Big Data Meets the Immune System Every year nearly half a million Americans are diagnosed with Lyme disease, yet the biology of this…

The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

The Nobel Prize rewards science, humanism and peace efforts. This is one of the central concepts in the will of Alfred Nobel, and it also permeates the outreach activities that have been developed for...

The rapid identification of protein–protein interactions has been significantly enabled by mass spectrometry (MS) proteomics-based methods, including affinity purification-MS, crosslinking-MS, and pr...

Short linear peptide motifs play important roles in cell signaling. They can act as modification sites for enzymes and as recognition sites for peptide binding domains. SH2 domains bind specifically t...

We demonstrate that phages have co-opted cas genes from CRISPR defence systems, which subsequently evolved anti-defence functions.

ISB was selected as a winner of the 2024 Amazon Web Services (AWS) IMAGINE Grant, which will support continued development of My Digital Gut.

Nature Communications - The immunologic differences induced by bactericidal versus bacteriostatic antibiotics remain unclear. Gross et al. show that, in contrast to static antibiotics, cidal...

ISB's MetaboCore is a diagnostic tool that can help physicians quickly select the most effective systemic therapy for each cancer patient.

A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms

Coffee consumption is associated with the presence and abundance of a specific member of the human gut microbiome, Lawsonibacter asaccharolyticus, and changes to the plasma metabolome.

Multi-domain signaling enzymes are often regulated through extensive inter-domain interactions, and disruption of inter-domain interfaces by mutations can lead to aberrant signaling and diseases. For ...

Dr. Sid Venkatesh, who joined ISB's faculty in 2023, is the co-first author of a paper in the journal Science.

imageimageIL-2 stimulation post-transcriptionally enhances splicing of IFNG mRNA in NK cells. Further, NF-κB signaling downstream of the IL-2 receptor is required for IFNG mRNA processing. IL-12 and ...

Gut microbes are known to modulate stress responsivity and behavior. Tofani et al. demonstrate that such modulations occur via the circadian system. The oscillations in gut microbiota composition regu...

Dr. Siddarth Venkatesh, now at the Institute for Systems Biology in Seattle, previously studied the gut microbiome's impact on childhood undernutrition and the therapeutic potential of microbiota-dire...

Undernutrition in Bangladeshi children is associated with disruption of postnatal gut microbiota assembly; compared with standard therapy, a microbiota-directed complementary food (MDCF) substantially...