Pathogens are becoming resistant to antibiotics. Scientists are working to slow the process and replenish the medicinal armoury.

We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog

Researchers have pinpointed genotypic and phenotypic changes that take place when colonising bacteria in a patient's gut invade and infect the bloodstream. The team aimed to determine what changes occ...

Author summary Noma is a rapidly progressing necrotic disease that destroys the tissues of the mouth and face, mainly affecting children living in abject poverty. Although antibiotic treatment can be ...

npj Antimicrobials and Resistance - Mechanistic insights into plasmid transfer inhibition in Enterobacterales by nucleoside analogues

Author summary Noma is a rapidly progressing necrotic disease that destroys the tissues of the mouth and face, mainly affecting children living in abject poverty. Although antibiotic treatment can be ...

Author summary Noma is a rapidly progressing necrotic disease that destroys the tissues of the mouth and face, mainly affecting children living in abject poverty. Although antibiotic treatment can be ...

Author summary Noma is a rapidly progressing necrotic disease that destroys the tissues of the mouth and face, mainly affecting children living in abject poverty. Although antibiotic treatment can be ...

Technical Project ManagerLocation: LiverpoolContract: Fixed-term contract until March 2028Salary: £47,389 - £59,967The Parish Lab at the Liverpool School of Tropical Medicine focuses on antimicrobial ...

We wish to appoint a PostDoctoral Research Associate to an exciting project exploring the assembly, stability and function of microbial decomposer communities.

We grant 30 fellowships for researchers of any nationality who wish to pursue a doctorate in a STEM discipline at research centres of excellence in Spain or Portugal.

Genomic comparison of E. coli and K. pneumoniae isolated from faeces and blood of the same neonatal patients revealed highly related pairs, suggesting translocation between the gastrointestinal tract ...

Franklin was no victim in how the DNA double helix was solved. An overlooked letter and an unpublished news article, both written in 1953, reveal that she was an equal player.

Author summary Why was this study done? Infections caused by bacteria that are resistant to antibiotics are a major and growing threat to public health. Older adults and men are at higher risk of...

Objectives Studies from Tanzania show rising prevalence of extended-spectrum β-lactamase (ESBL) amongst key bacterial pathogens. We aimed to look at the clinical impact of bloodstream infections (BSI)...

Sabnis et al. explain why non-conjugative plasmids move at a low rate in nature. While increased mobility can easily evolve by incorporating phage DNA into plasmids, this is disadvantageous because it...

Healthcare-associated infections (HAIs) result in prolonged hospital stays and an increased incidence of infections caused by antimicrobial-resistant bacteria. Small and Medium Enterprises (SMEs) play...

npj Antimicrobials and Resistance - Environmental hazards from pollution of antibiotics and resistance-driving chemicals in an urban river network from Malawi

​Freshwater snails across Africa and the UK carry bacteria containing a wide range of antimicrobial resistance (AMR) genes, including those predicted to confer resistance against last-resort antibioti...

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Experts describe findings as deeply concerning and predict 70% increase in related deaths by 2050 Hospitals across the world have recorded an alarming rise in common infections that are resistant to antibiotics, with doctors saying the number of deaths driven by drug resistance will increase sharply in the years ahead. One in six laboratory-confirmed bacterial infections were resistant to antibiotic treatments in 2023, with more than 40% of antibiotics losing potency against common blood, gut, urinary tract and sexually-transmitted infections between 2018 and 2023, records show. Continue reading...

Phages are typically viewed as very rapidly evolving biological entities. Little is known, however, about whether and how phages can establish long-term genetic stability. We addressed this eco-evolut...

Bacterial genomes often contain extrachromosomal replicons (ERs), ranging from small, mobile plasmids to large, stably inherited elements, such as meg…

Nature Communications - This study investigates the effects of the carbapenem resistance plasmid pOXA-48 in clinical enterobacteria. Using CRISPRi screens, the authors revealed that the...

Here, the authors show that giving probiotics to very low birth weight preterm babies can help reduce harmful antibiotic-resistant bacteria in the gut and support the development of a healthier microb...

We previously identified a morpholinobenzamide series with potent activity against Mycobacterium tuberculosis. We conducted structure–activity relationship studies focusing on removing the metabolical...

Klebsiella pneumoniae is a frequent cause of antimicrobial resistant healthcare associated infections in neonates across sub-Saharan Africa, with multiple lineages associated with neonatal sepsis. How...

Virologist Amadou Sall is the driving force behind a world-class manufacturing hub in Senegal.

npj Antimicrobials and Resistance - Planetary boundaries range from climate change to biosphere integrity. They define the safe space for humanity. Ecosystem impacts on microbes are missing from a...

AbstractBackground. Multidrug-resistant organisms (MDROs) are important in clinical practice worldwide. As whole genome sequencing (WGS) technologies are a

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Antimicrobial resistance (AMR) is one of the most pressing global health problems, with plasmids playing a central role in its evolution and dissemination. Over the past decades, many studies have inv...

Blood stream infections (BSIs) are a major cause of hospitalisation and death for children under the age of five in sub-Saharan Africa with members of the Gram-negative bacteria Enterobacterales such ...

African communities have a high prevalence of antimicrobial-resistant bacterial carriage, alongside high levels of antibiotic usage and environmental pollution. Limited access to water, sanitation and...