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Richard Goodman

@richard-goodman.bsky.social
184 followers 207 following 11 posts

| 📍Postdoctoral researcher at LSTM | 🧬 Researching the evolution of antimicrobial resistance | 🦠 Microbiology, Genomics, Bioinformatics

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Richard Goodman @richard-goodman.bsky.social · 31/03/2026
I’m pleased to share our latest paper which presents the first shotgun metagenomics of the oral microbiomes of children with noma. We found a distinct microbial composition associated with the disease, which has led to further funding to identify the organisms behind this devastating disease.
doi.org
Shotgun metagenomic analysis of the oral microbiomes of children with noma
Author summary Noma is a rapidly progressing necrotic disease that destroys the tissues of the mouth and face, mainly affecting children living in abject poverty. Although antibiotic treatment can be ...
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Reposted by Richard Goodman
Torsten Seemann @torstenseemann.bsky.social · 15/12/2025
💾 Prokka 1.15.6 is released! This is the last major release of Prokka. But don't be sad, because @oschwengers.bsky.social already has an excellent replacement called Bakta you can migrate to. #bioinformatics #microbiology #genomics github.com/tseemann/pro...
github.com
Release Heading into the sunset · tseemann/prokka
The future This is probably the last release of Prokka. I won't be making any code changes except bug fixes. I will update the databases occasionally. I strongly recommend you use Bakta by @oschwen...
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Richard Goodman @richard-goodman.bsky.social · 19/11/2025
I'm pleased to share our latest paper out in Communications Biology. We used comparative genomics to determine the relatedness of E. coli and K. pneumoniae isolates from faeces and blood of the same neonates with bloodstream infections. doi.org/10.1038/s420...
doi.org
Comparative genomics of blood and faecal E. coli and K. pneumoniae isolates from neonates with bloodstream infections in Tanzania - Communications Biology
Genomic comparison of E. coli and K. pneumoniae isolated from faeces and blood of the same neonatal patients revealed highly related pairs, suggesting translocation between the gastrointestinal tract ...
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Reposted by Richard Goodman
Adam P. Roberts @gcagatgcaatg.bsky.social · 18/11/2025
Really happy to see this published, fab international collabotation and excellent analysis led by Richard Goodman www.nature.com/articles/s42...
nature.com
Comparative genomics of blood and faecal E. coli and K. pneumoniae isolates from neonates with bloodstream infections in Tanzania - Communications Biology
Genomic comparison of E. coli and K. pneumoniae isolated from faeces and blood of the same neonatal patients revealed highly related pairs, suggesting translocation between the gastrointestinal tract ...
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Richard Goodman @richard-goodman.bsky.social · 30/04/2025
Pleased to share our new preprint! We used comparative genomics to determine the relatedness of E. coli and K. pneumoniae isolates from faeces and blood of the same children. We wanted to know if the bloodstream infection started in the gut; are the strains the same?
biorxiv.org
Genomic comparison of highly related pairs of E. coli and K. pneumoniae isolated from faeces and blood of the same neonatal patients hospitalized with fever in Dar es Salaam, Tanzania
Blood stream infections (BSIs) are a major cause of hospitalisation and death for children under the age of five in sub-Saharan Africa with members of the Gram-negative bacteria Enterobacterales such ...
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Reposted by Richard Goodman
Centre for Genomic Pathogen Surveillance @thecgps.bsky.social · 22/04/2025
Our latest preprint is out describing amr.watch - a platform for monitoring AMR trends from global genomics data: www.biorxiv.org/content/10.1... (1/6)
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Angus O’Ferrall @angusoferrall.bsky.social · 27/02/2025
Pleased to share our new preprint... We took a look into freshwater snail faecal metagenomes in four countries and found environmental #AMR reservoirs @lstmnews.bsky.social @gcagatgcaatg.bsky.social @russstothard.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
Freshwater snail faecal metagenomes reveal environmental reservoirs of antimicrobial resistance genes across two continents
The transfer of antimicrobial resistance genes (ARGs) from environmental microbes to pathogens is a critical but underexplored One Health driver of antimicrobial resistance (AMR). Here, we evaluate fr...
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Anita Williams @catanita.bsky.social · 02/12/2024
Volume 2 of the #AMR Starter Pack is here! go.bsky.app/EUY2FUJ Follow these amazing people along with those in Vol. 1 go.bsky.app/KkZfvrh And don't forget to pin the Antimicrobial Resistance feed to get all the AMR posts in one place bsky.app/profile/did:...
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Ryan Wick @rrwick.bsky.social · 31/12/2024
New year, new assemblies! I'm excited to announce Autocycler, my new tool for consensus assembly of long-read bacterial genomes! It's the successor to Trycycler, designed to be faster and less reliant on user intervention. Check it out: github.com/rrwick/Autoc... (1/5)
github.com
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A tool for generating consensus long-read assemblies for bacterial genomes - rrwick/Autocycler
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Ricardo León-Sampedro @rleonsampedro.bsky.social · 11/12/2024
🚨 New preprint!! How can antibiotic-resistant bacteria increase in abundance in the human gut microbiome, even without antibiotics? 🧐 We show that strain-specific ecological interactions are key to understanding resistance dynamics in microbial communities. 🧵👇 1/5 www.biorxiv.org/content/10.1...
biorxiv.org
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Richard Goodman @richard-goodman.bsky.social · 06/12/2024
As my first post on bsky post, I thought I'd share a recent paper of ours published in @naturecomms.bsky.social . Here we use various techniques to determine the molecular mechanisms for an observed rise in chloramphenicol susceptibility at the same time as an increase in ESBL resistance.
nature.com
Molecular mechanisms of re-emerging chloramphenicol susceptibility in extended-spectrum beta-lactamase-producing Enterobacterales - Nature Communications
In this work, authors probe the molecular mechanism of re-emerging CHL susceptibility in Malawian Enterobacterales isolates, where they identify a stable truncation of resistance genes by insertion se...
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