Here, we report the validation and expansion of small-molecule inhibitors targeting the HDAC6 ZnF-UBD pocket. Following molecular modeling, hits were synthesized, and candidate compounds were tested ...

Protein editing, as mediated by protein trans-splicing, offers the ability to manipulate, label, and modify proteins in vitro and in live mammalian cells. This ability to observe and control proteins...

AbstractAssigning causal function to post-translational modifications (PTMs) remains a central challenge in molecular biology, as most modification events

Lysine acylation is emerging as a fundamental mechanism linking cellular metabolism to protein regulation. Hintzen and Burslem synthesize the chemical biology, mechanistic principles, and unresolved questions that are redefining lysine acylation from an expanding catalog of modifications into a unifying framework for understanding metabolic regulation while outlining challenges.

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.

Metabolism and post-translational modifications (PTMs) are intrinsically linked and the number of identified metabolites that can covalently modify proteins continues to increase. This metabolism/PTM ...

Caspases are a family of cysteine proteases that act as molecular scissors to cleave substrates and regulate biological processes, such as programmed cell death and inflammation. Extensive efforts hav...

Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...

Influenza viruses replicate and transcribe their genome in the context of a conserved ribonucleoprotein (RNP) complex. By integrating cryo–electron microscopy single-particle analysis and cryo–electro...

Scientists deploy self-splicing protein subunits to insert strange new additions into target proteins.

Pairs of split protein segments can modify a variety of target proteins in a living cell

The ability to study proteins in their native cellular context is crucial to our understanding of biology. In this work, we report a technology for intracellular protein editing, drawing from split in...

Two families who had lived in the United States for years, including a child with cancer and a pregnant mother, were deported by ICE on Friday.

Sansbury and Serebrenik et al. use pooled gene tagging with in situ sequencing and high-throughput image analysis to generate a cell pool with endogenous HaloTag fusions. Hydrophobic targeting is then...

Primary Work Address: 19700 Helix Drive, Ashburn, VA, 20147 Current HHMI Employees, click here to apply via your Workday account. Summary: Open Chemistry is a collaborative research group whose missio...

Tsusaka et al. discover that histone deacetylases, which are well known to remove protein modifications, such as lysine acetylation and β-hydroxybutyrylation, can also reverse their chemical activity ...

Acetylation is an increasing area of focus for cancer research as it is closely related to a variety of cellular processes through modulation of histo…

Metabolism and post-translational modifications (PTMs) are intrinsically linked and the number of identified metabolites that can covalently modify proteins continues to increase. This metabolism/PTM ...

Metabolism and post-translational modifications (PTMs) are intrinsically linked and the number of identified metabolites that can covalently modify proteins continues to increase. This metabolism/PTM ...