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bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 09/07/2026

Reposted by Florey Lab

SOLAR Mediates Lysosomal Membrane Repair and Redox Defense www.biorxiv.org/content/10.64898/20…

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Reposted by Florey Lab

bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 08/07/2026

CASM regulates p62/KEAP1/NRF2 antioxidant responses to lysosome damage www.biorxiv.org/content/10.64898/20…

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Florey Lab @floreylab.bsky.social · 10/07/2026

Thank you to everyone involved @babrahaminst.bsky.social and our partners at Stemnovate. Also, check out the accompanying preprint from the Tan lab. Always great science when 2 separate labs converge on the same results! www.biorxiv.org/content/10.6... 2/2

biorxiv.org

SOLAR Mediates Lysosomal Membrane Repair and Redox Defense

Lysosomal damage is increasingly recognized as a hallmark of aging. Understanding lysosomal quality control may open new therapeutic strategies to enhance lysosomal resilience. Here, we identify SOLAR...

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Florey Lab @floreylab.bsky.social · 10/07/2026

Please check out our new preprint! We find an unexpected role for #CASM in regulating p62 mediated activation of the KEAP1/NRF2 pathway to initiate a cytoprotective antioxidant transcriptional response. More functions for #CASM in responding to lysosome stress. www.biorxiv.org/content/10.6... 1/2

biorxiv.org

CASM regulates p62/KEAP1/NRF2 antioxidant responses to lysosome damage

Effective lysosome function is essential for health, and declines with ageing and disease. Upon lysosome damage, cells mount a complex stress response to restore homeostasis. Membrane ATG8ylation play...

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Florey Lab @floreylab.bsky.social · 25/06/2026

Communication is so important. Congratulations to the 1%, on its own, can feel like Commiserations to the 99%. The phrase 1% carries so much baggage. Anyway, aren't we scientists, shouldn't it be 5% p<0.05 to be significant.

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Reposted by Florey Lab

Journal of Cell Science @jcellsci.bsky.social · 26/03/2026

Our Cell Scientist to Watch is Helene Knævelsrud @helene-knavelsrud.bsky.social. We spoke to Helene about her career, her research and her advice on mentorship. journals.biologists.com/jcs/article/... #autophagy #kidneycancer #mentorship #conferences #procrastination #advocacy #beer

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Florey Lab @floreylab.bsky.social · 14/03/2026

Excited to be on my way to #GRCautophagy2026 to co-chair with @rushika-perera.bsky.social . But first the GRS! See you there

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Reposted by Florey Lab

Journal of Cell Biology @jcb.org · 11/03/2026

Are you headed to #GRC #Autophagy in Stress, Development and Disease next week, and interested in speaking with a JCB editor about publishing? Get in touch with our Executive Editor Tim Spencer, who will be there! ✉️ Email Tim: rupress.org/jcb/pages/ed...

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Reposted by Florey Lab

satooze.bsky.social @satooze.bsky.social · 26/03/2025

I am looking for a post/doc! Are you motivated to study the fundamental questions in autophagy? Have a look!

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Reposted by Florey Lab

Babraham Institute @babrahaminst.bsky.social · 26/01/2026

We are pleased to welcome Prof Sir Jim Smith as the Institute's Interim Director. Read more 👇

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Florey Lab @floreylab.bsky.social · 10/12/2025

Don't miss out on attending the Mar 15-20th 2026 GRC on #Autophagy in Ventura, California! All the latest findings from the field - check out the program and come tell us about your amazing science. www.grc.org/autophagy-in...

2026 Autophagy in Stress, Development and Disease Conference GRC

The 2026 Gordon Research Conference on Autophagy in Stress, Development and Disease will be held in Ventura, California. Apply today to reserve your spot.

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Florey Lab @floreylab.bsky.social · 06/11/2025

Don't miss out on hearing all the latest #autophagy discoveries at the 2026 GRC meeting in Ventura, US. We and the amazing line up of speakers look forward to meeting YOU 🫵. Follow link to register!!! www.grc.org/autophagy-in...

2026 Autophagy in Stress, Development and Disease Conference GRC

The 2026 Gordon Research Conference on Autophagy in Stress, Development and Disease will be held in Ventura, California. Apply today to reserve your spot.

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Florey Lab @floreylab.bsky.social · 21/10/2025

Check out the line up of amazing speakers at the 2026 GRC Autophagy meeting in Ventura, California, 15-20 March. Register now and share your latest findings. www.grc.org/autophagy-in...

2026 Autophagy in Stress, Development and Disease Conference GRC

The 2026 Gordon Research Conference on Autophagy in Stress, Development and Disease will be held in Ventura, California. Apply today to reserve your spot.

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Florey Lab @floreylab.bsky.social · 18/10/2025

Want to hear about the latest #autophagy discoveries? Join us in Ventura California for the 2026 GRC Autophagy meeting 15-20 March. Keynote speakers Sharon Tooze, Eileen White and Ivan Dikic. Registration open now⬇️ Bring your science! www.grc.org/autophagy-in...

a man in a tuxedo and suspenders is holding a baton and says science

ALT: a man in a tuxedo and suspenders is holding a baton and says science

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Reposted by Florey Lab

Rushika M. Perera @rushika-perera.bsky.social · 17/10/2025

Join us in sunny California for the 2026 GRC Autophagy meeting! Excited to co-chair with Oliver Florey and vice chairs Helene Knaevelsrud and @robzonculab.bsky.social Keynote speakers incl. Eileen White, @idikic.bsky.social and Sharon Tooze- Registration is open: link⬇️ www.grc.org/autophagy-in...

2026 Autophagy in Stress, Development and Disease Conference GRC

The 2026 Gordon Research Conference on Autophagy in Stress, Development and Disease will be held in Ventura, California. Apply today to reserve your spot.

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Florey Lab @floreylab.bsky.social · 30/09/2025

Last day in the lab for student Jake @jakecross96.bsky.social. So we had a naming ceremony for a freezer in his honor. Good luck at the @cellbiol-mrclmb.bsky.social

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Florey Lab @floreylab.bsky.social · 22/09/2025

This will end up being another attack on research institutions in the US. I worked in New York on an H1 visa for many years. It benefited me and the lab I was in. Would it have happened if I cost an additional $100,000 per year? www.whitehouse.gov/presidential...

whitehouse.gov

Restriction on Entry of Certain Nonimmigrant Workers

BY THE PRESIDENT OF THE UNITED STATES OF AMERICA A PROCLAMATION The H-1B nonimmigrant visa program was created to bring temporary workers into the United

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Florey Lab @floreylab.bsky.social · 22/09/2025

So, Farage wants to kick out my mum, a French citizen who has lived, worked, paid taxes and raised 2 kids in the UK for over 50 years. I'll make sure to yell at her to "go back to where you came from".

a man in a suit and tie is saying `` i have no words '' .

ALT: a man in a suit and tie is saying `` i have no words '' .

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Florey Lab @floreylab.bsky.social · 07/08/2025

It is disappointing. Some real results are sunk by lazy and deceitful decisions on others. How many research hours/$$££ are wasted following some of those observations?

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ALT: a screenshot of a video game with the words we must be better

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Florey Lab @floreylab.bsky.social · 21/07/2025

Another excellent study showing #CASM at play in plant stress responses!

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Florey Lab @floreylab.bsky.social · 23/06/2025

My guess... the LC3B structures are not all autophagosomes #CASM

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Florey Lab @floreylab.bsky.social · 02/06/2025

Neighbors may not like our overgrown lawn. But if it lets wild flowers like this grow, who cares! Bee Orchid #biodiversity

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Florey Lab @floreylab.bsky.social · 07/05/2025

Thanks, and the same to you too.

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Florey Lab @floreylab.bsky.social · 07/04/2025

Say Hi to Mike Overholtzer if you see him!

Yamuna Krishnan @krishnanyamuna.bsky.social · 02/04/2025

Reposted by Florey Lab

Unbelievable. Richard Youle, winner of the Breakthrough Prize for Life Sciences, just got fired from the NIH. If you want to know what madness looks like, here it is, my friend.

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Florey Lab @floreylab.bsky.social · 29/03/2025

It was wonderful to be part of this story. Well done everyone. We enjoyed hosting you and look forward to your return this summer!!

a black and white photo of a woman holding a trophy

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lmachesky.bsky.social @lmachesky.bsky.social · 27/03/2025

Reposted by Florey Lab

Congrats to Ian Ganley of Dundee University on winning the #BSCB Hooke Medal 🥇for his outstanding work on mitophagy 🎉🎉🌟

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Reposted by Florey Lab

Max Gutierrez @maxgg.bsky.social · 27/03/2025

Happy to share the latest work from the lab @crick.ac.uk. Outstanding work from Di Chen and Tony Fearns showing the link between Mtb membrane damage, calcium leakage and ATG8/LC3 lipidation in macrophages. Congratulations Di and Tony! www.science.org/doi/10.1126/...

science.org

Mycobacterium tuberculosis phagosome Ca2+ leakage triggers multimembrane ATG8/LC3 lipidation to restrict damage in human macrophages

Ca2+ leakage triggers LC3 lipidation on multimembrane as Mtb phagosome damage response, independent of autophagy.

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Florey Lab @floreylab.bsky.social · 27/03/2025

Really cool story. Congrats all ! (although, I would still call this process CASM 😉, multimembrane compartment probably started out as a single membrane one)