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Edismauro Freitas-Filho, Ph.D.

@efreitasfilho.bsky.social
79 followers 179 following 16 posts

Postdoc at the Department of Cell and Molecular Biology, USP/Brazil. Exploring how vesicular traffic regulates immune cell function.

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Edismauro Freitas-Filho, Ph.D. @efreitasfilho.bsky.social · 20/05/2026
How does the V-ATPase transmembrane core reach the phagosome during LAP (LC3 associated phagocytosis)? Live imaging shows V0 transfer occurs via contact between V0+ organelles and the phagosome membrane, a step controlled by RAB5c+ early endosomes. *STELLARIS Confocal Microscope #LeicaMicrosystems
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Edismauro Freitas-Filho, Ph.D. @efreitasfilho.bsky.social · 19/05/2026
A follow-up on one of the more unexpected findings from our recent @ScienceAdvances paper: RAB5c-dependent trafficking of the V-ATPase V0 sector to phagosomes. 🧵
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Reposted by Edismauro Freitas-Filho, Ph.D.
Korolchuk Lab @korolchuklab.bsky.social · 17/05/2026
There’s been lots of great science published in the past two weeks on #autophagy and #mTOR topics. Anyone with an interest in this area should look at these 👇🏼👇🏼👇🏼 biomed.news/bims-auttor/... biomed.news/bims-auttor/...
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Blue Power Ranger Billy: Okay, Now That's Cool!
ALT: Blue Power Ranger Billy: Okay, Now That's Cool!
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Edismauro Freitas-Filho, Ph.D. @efreitasfilho.bsky.social · 12/05/2026
RAB5c coordinates early endosome-to-phagosome trafficking to drive LC3-associated phagocytosis in macrophages — and without it, fungal killing fails even when ROS production goes up. New paper out in #ScienceAdvances. Thread below 🧵
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Reposted by Edismauro Freitas-Filho, Ph.D.
The EMBO Journal @embojournal.org · 12/06/2025
Autophagy-lysosome pathways are known targets of intracellular bacteria – Ivan Đikić @idikic.bsky.social et al find Legionella uses phosphoribosyl-ubiquitination via SidE to alter autophagic SNAREs & create a bacteria-containing vacuole unable to fuse with lysosomes www.embopress.org/doi/full/10....
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Reposted by Edismauro Freitas-Filho, Ph.D.
bioRxiv Cell Biology @biorxiv-cellbio.bsky.social · 20/05/2025
Phosphoribosyl ubiquitination of SNARE proteins regulate autophagy in Legionella infection www.biorxiv.org/content/10.1101/202…
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Reposted by Edismauro Freitas-Filho, Ph.D.
Joseph Gordon @josephwgordon.bsky.social · 17/05/2025
journals.biologists.com/jcs/article/...
journals.biologists.com
Mitochondria–membranous organelle contacts at a glance
Summary: We provide an overview of contacts between mitochondria and other membranous organelles, describing the interorganelle tethers involved and the factors that regulate the composition and funct...
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Reposted by Edismauro Freitas-Filho, Ph.D.
Korolchuk Lab @korolchuklab.bsky.social · 13/04/2025
#Autophagy and #mTOR papers and preprints from last week. As always a great selection, enjoy! 👌 biomed.news/bims-auttor/...
media.tenor.com
a man in a suit and tie is sitting at a table with his eyes closed and a pile of food ..
ALT: a man in a suit and tie is sitting at a table with his eyes closed and a pile of food ..
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Reposted by Edismauro Freitas-Filho, Ph.D.
David Pla Martin @dplamartin.bsky.social · 04/04/2025
Excited to share our latest paper in Science Advances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵 www.science.org/doi/10.1126/...
science.org
Retromer promotes the lysosomal turnover of mtDNA
Lysosomal uptake of mtDNA controls mitochondrial quality.
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Reposted by Edismauro Freitas-Filho, Ph.D.
Korolchuk Lab @korolchuklab.bsky.social · 30/03/2025
#Autophagy and #mTOR papers from last week, lots of relevant stuff as always, enjoy! biomed.news/bims-auttor/...
media.tenor.com
a man in a suit and tie is asking if he read it
ALT: a man in a suit and tie is asking if he read it
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Reposted by Edismauro Freitas-Filho, Ph.D.
bioRxiv Immunology @biorxiv-immuno.bsky.social · 29/03/2025
RAB5c controls the assembly of non-canonical autophagy machinery to promote phagosome maturation and microbicidal function of macrophages www.biorxiv.org/content/10.1101/202…
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Reposted by Edismauro Freitas-Filho, Ph.D.
Max Gutierrez @maxgg.bsky.social · 27/03/2025
Happy to share the latest work from the lab @crick.ac.uk. Outstanding work from Di Chen and Tony Fearns showing the link between Mtb membrane damage, calcium leakage and ATG8/LC3 lipidation in macrophages. Congratulations Di and Tony! www.science.org/doi/10.1126/...
science.org
Mycobacterium tuberculosis phagosome Ca2+ leakage triggers multimembrane ATG8/LC3 lipidation to restrict damage in human macrophages
Ca2+ leakage triggers LC3 lipidation on multimembrane as Mtb phagosome damage response, independent of autophagy.
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Reposted by Edismauro Freitas-Filho, Ph.D.
Komander Lab @komanderlab.bsky.social · 13/03/2025
Exciting news from the lab out today in Science - the structure of human PINK1 on a TOM-VDAC complex! @wehi-research.bsky.social
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Edismauro Freitas-Filho, Ph.D. @efreitasfilho.bsky.social · 29/03/2025
🚀Our latest work reveals how RAB5c orchestrates LC3-associated phagocytosis (LAP) to boost macrophage defense against A. fumigatus! 🦠🔬 🧵 Dive into the mechanisms linking endosomal traffic to innate immunity! #Immunology #Autophagy #Phagocytosis #Macrophage #Preprint doi.org/10.1101/2025...
doi.org
RAB5c controls the assembly of non-canonical autophagy machinery to promote phagosome maturation and microbicidal function of macrophages
Non-canonical conjugation of ATG8 proteins, including LC3, to single membranes implicates the autophagy machinery in cell functions unrelated to metabolic stress. One such pathway is LC3-associated ph...
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