Obesity is a global public health concern closely linked to cardiometabolic complications. This Comment provides our views on recent breakthroughs, emerging innovations and future needs of therapeutic interventions to counteract obesity and its associated health risks.

Cai et al. revealed that transplanting gut microbiota from women with fibromyalgia—a chronic widespread pain condition of unknown etiology—into mice induces pain. It also induces phenotypes commonly o...

The colonic mucus barrier and sentinel goblet cells protect the distal gut from microbial challenges. This study demonstrates that microbial colonization d

Nature Reviews Gastroenterology & Hepatology, Published online: 14 May 2025; doi:10.1038/s41575-025-01072-wCurrent treatments for Crohn’s disease prioritize early intervention with biological therapies, with several landmark trials demonstrating that starting biologic agents within the first years of diagnosis leads to superior patient outcomes. Although challenges remain, early use of biological treatments is increasingly supported in managing moderate to severe Crohn’s disease.

Nature Reviews Gastroenterology & Hepatology, Published online: 13 May 2025; doi:10.1038/s41575-025-01080-wInflammatory bowel disease: classifying global regions by epidemiological stage

Author summary This study explores the interplay between biology and mechanics in tissue architecture, particularly the 3D organization of human colonic epithelial organoid. The experimental approach ...

This review addresses the dimensions and mechanisms of food and nutrition insecurity, as well as assessment, populations at highest risk, and health consequences across diverse contexts.

Serotonergic enterochromaffin cells of the intestine exhibit distinct sensory, secretory and physiological properties depending on their location within the complex crypt–villus architecture of the gut.

Modelling the tumour immune microenvironment in vitro is a valuable tool to test immunotherapy efficiency but capturing its complexity is challenging. Here authors present a fully humanised in vitro p...

Nature Reviews Gastroenterology & Hepatology, Published online: 31 January 2025; doi:10.1038/s41575-024-01035-7The management of inflammatory bowel disease (IBD) continues to evolve. This Review is a practical guide on the therapeutic toolkit for IBD,…

Using ethnically and geographically diverse metagenomic data, the authors identify microbiota alterations associated with inflammatory bowel disease (IBD). They discover universal IBD-associated bacte...

Antagonism shapes microbiomes. Lim et al. identify a mechanism used by human gut commensals to antagonize related bacteria. The secreted effector Bte1 alters the protein-folding machinery of targeted ...

NAC regulates the ribosome localization, metabolic profile, and fate of intestinal stem cells.

Author summary This study explores the interplay between biology and mechanics in tissue architecture, particularly the 3D organization of human colonic epithelial organoid. The experimental approach ...