Antigenic variation is a very widespread process for pathogen evasion of mammalian adaptive immunity, involving the continuous change of exposed antigens. In many single-celled pathogens, antigen expr...

Trypanosoma brucei exploits an extreme form of antigenic variation to escape the mammalian immune response. This involves the progressive expression of antigenically distinct variant surface glycoprot...

The Matthews Lab

This project will seek to understand the basis of increased virulence after long term coinfection by a combination of genomic, transcriptomic and laboratory manipulation of the selected parasite lines...

Kinetoplastids, such as Trypansoma brucei, are eukaryotes that likely separated from the main lineage at an exceptionally early point in evolution. Consequently, many aspects of kinetoplastid biology ...

Tsetse-transmitted Trypanosoma parasites infect a wide host range and cause Human African Trypanosomiasis and Animal African Trypanosomosis in sub-Saharan Africa. The primary hosts of Trypanosoma bruc...

R.J. Beynon; CABIOS EDITORIAL, Bioinformatics, Volume 1, Issue 1, 1 January 1985, Pages 1, https://doi.org/10.1093/bioinformatics/1.1.1

A powerful exhibition to mark World Neglected Tropical Disease Day.

Decoding the role of inter-chromosomal DNA-DNA interactions remains challenging. Here, the authors use Micro-C to study the T. brucei genome architecture at high resolution and reveal an intricate net...

African trypanosomes can reduce their requirement for tsetse fly transmission, allowing an expanded geographical range. Here, molecular analyses of field and laboratory selected lines has identified a...

Nature Communications - African trypanosomes can reduce their requirement for tsetse fly transmission, allowing an expanded geographical range. Here, molecular analyses of field and laboratory...