When forming a cognitive map, a trade-off exists between facilitating novel inferences and storing veridical copies of past experience. Here the authors show that the neuromodulator noradrenaline sets...

Attention-Deficit/Hyperactivity Disorder (ADHD) is characterised by behavioural variability and heightened inattention associated with increased mind wandering (MW) and mind blanking (MB). Individuals...

AI-curated Bluesky feed for neuroscience and cognitive science. Real-time firehose filtering with keyword prefilter + local LLM classifier + engagement ranking. - micahgallen/bsky_neurobrain

Sleep is thought to globally downregulate neuronal network activity and synaptic connections enhanced during prior wakefulness and, in parallel, to up…

Administration of 5-MeO-DMT produces a dissociated brain state in mice, characterized by global slow-wave activity alongside behavioral wakefulness and marked pupil dilation.

Activity of VTA dopaminergic neurons during NREM sleep facilitates motor memory consolidation and is coordinated with spindles.

npj Biological Timing and Sleep - Adaptive introgression in modern human circadian rhythm genes

Li et al. propose a conceptual framework to study the phenomenon of falling asleep based on electroencephalogram data. They show that a tipping point marks the brain’s nonlinear wake-to-sleep transiti...

Yang et al. show that moments of failed attention we experience after sleep deprivation reflect brief ‘sleep-like’ episodes in the brain, corresponding to a brain- and body-wide event with altered bra...

Using simultaneous EEG-PET-MRI, this study reveals tightly coupled physiological dynamics during the descent from wakefulness into NREM sleep and identifies network-specific activity underlying sensor...

Statement of Significance This study introduces a systematic approach to assessing dream incorporation by linking presleep experiences to dream content usi

Can animals obtain core benefits of sleep while remaining awake? In mammals, slow-wave sleep is characterized by synchronized neuronal activity alternating between ON and OFF periods. Slow-wave activi...

Activating the <i>adra2a</i> receptors of the brain's norepinephrine (NE) system produces NREM-like sleep and hypothermia. Dexmedetomidine (DEX), a selective α2 receptor (<i>adra2a</i>) agonist, is an...

Cannabis use for sleep is increasingly prevalent, yet its effects on sleep architecture remain unclear. This systematic review and meta-analysis exami…

The drive to sleep is inescapable but its biological substrate remains largely elusive. Until recently, the search for sleep centres in the mammalian brain focussed on subcortical neurons that promote...

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Nature - Human exploration is driven by two distinct neural mechanisms, a valence-independent rate signal and a valence-dependent global noise signal.

Vigilance is increasingly conceived as a continuum, ranging from full alertness to deep sleep. Despite its fundamental role in cognition, behaviour, and health, reliable physiological markers of vigil...

Slow waves during sleep are fundamental for neural homeostasis, metabolic regulation, and waste clearance, and are known to be altered in neurodegenerative diseases. Sleep-like slow waves (SLSW) have ...

Rapid Eye Movement (REM) sleep degrades with age, and more severely in Alzheimer's disease (AD). REM sleep comprises about twenty percent of adult sleep, alternates between phasic and tonic periods, a...

The extinction of conditioned fear responses is crucial for adaptive behavior, and its impairment is a hallmark of anxiety disorders such as posttr...

Chouvaeff et al. show that social defeat stress recruits prefrontal projections to the VLPO to selectively shorten REM sleep bouts, even after overall REM amounts return to baseline. This pathway prom...

The extent to which the sleeping brain can discern safety from danger is poorly understood. In mice, the authors show that centro-medial thalamic neurons detect threat-related sounds and selectively t...

Training the mind to enter this rare state of conscious sleep may bring surprising benefits.

This study shows that emotionally charged sounds modulate the occurrence, shape, and downstream impact of K-complexes, revealing a flexible, multi-phase brain response during NREM sleep that may suppo...

In people with severe brain injuries, stimulation restored consciousness by engaging a deep brain circuit for wakefulness—revealing a target that may also guide treatment in stroke and epilepsy.

Sleep supports memory consolidation, but can it also facilitate memory reorganization? This study reveals that N2 sleep, but not N1 sleep during a nap, increases the likelihood of having an 'aha' mome...

Nature Communications - The neural processes involved in memory formation for realistic experiences remain poorly understood. Here, the authors found that ripple-like activity in the human...

High-frequency brain oscillations in humans are currently categorized into beta (13–30 Hz) and gamma (>30 Hz). Here, I introduce a new class of oscillations between 25 and 35 Hz, which I propose to ca...