Disorders of arousal (DOA), including sleepwalking, sleep terrors, and confusional arousals, are characterized by complex behaviors emerging from non-…

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

In this study the authors develop a computational pipeline to infer the molecular properties of c-FOS-labelled active neurons and analyze the networks they form. They use this pipeline to characterize...

Using simultaneous EEG-PET-MRI, this study reveals tightly coupled physiological dynamics during the descent from wakefulness into NREM sleep and identifies network-specific activity underlying sensor...

Slow waves mediate restorative functions of non-rapid eye movement (NREM) sleep. To enhance slow wave activity (SWA, 0.5-4 Hz) non-invasively, we employed a novel neuromodulatory tool, Transcranial El...

Research on Drosophila neurons shows links between the need to sleep and aerobic metabolism, indicating that the pressure to sleep may have a mitochondrial origin.

The increase in growth hormone release during sleep is driven by sleep-wake-dependent activity of stimulatory GHRH neurons and inhibitory SST neurons in the hypothalamus. The released growth hormone e...

Sleep is crucial for memory formation. Deng et al. find that cAMP levels in mice oscillate with a 1-min cycle during slow-wave sleep, and hippocampal activity at the peak of these oscillations is nece...

The outflow pathway of cerebrospinal fluid into lymph nodes in the neck and how non-invasive mechanical stimulation can enhance drainage and restore impaired outflow in aged mice are explored.

An established theory for how good sleep reduces a person’s risk of neurodegenerative disease has been called into question. The ensuing argument could have enormous consequences for the treatment of ...

Synchrony between neuronal activity and the respiratory cycle has been observed in numerous brain regions and across many species. Tort et al. discuss the mechanisms by which brain activity is modulat...

Neural mechanisms underlying memory acquisition and encoding are not fully understood. Here authors show that during sleep, besides the replay of past memory, coactivity of a new set of cells arises (...

Metabolism plays a key role in the maintenance of sleep/wake states. Brain lactate fluctuations are a biomarker of sleep/wake transitions, where in...

Using magnetic resonance imaging on marathon runners, Ramos-Cabrer, Cabrera-Zubizarreta et al. report that the signal detected as a surrogate of myelin content is significantly reduced after exercise,...

Sleep is known to support memory. In this study, the authors identify an instance where memory hyperfunction may actually provoke sleep deficits. They find that the short-sleep Drosophila mutants, ins...

Sleep-inducing neurons in Drosophila rely on Hyperkinetic, the β-subunit of the KV1 channel Shaker, to monitor sleep need by translating lipid peroxidation events into changes in the oxidation state o...

Integrated information theory (IIT) starts from consciousness, which is subjective, and accounts for its presence and quality in objective, testable terms. Attempts to label as ‘pseudoscientific’ a th...

Arousal levels regulate sleep, but accurate noninvasive measures are lacking. Here, a novel method is introduced to track pupil-indexed arousal levels during human sleep, revealing pupil size changes ...

In wearable smart systems, continuous monitoring and accurate classification of different sleep-related conditions are critical for enhancing sleep...

Metabolism plays a key role in the maintenance of sleep/wake states. Brain lactate fluctuations are a biomarker of sleep/wake transitions, where in...

How does emotion prioritize associated memory? Saito et al. show that emotional association enhances perceptual memory retention and amygdalo-cortical coordination during learning and early-NREM sleep...

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by cognitive decline, beta-amyloid plaques, and tau tangles. Growing evidence suggests a strong link between sleep disturbances a...

Scott, Tan et al. characterize the neural circuits that link mechanic stimuli in the heart and gut with whole-body energy homeostasis and vigilance.

As the brain transitions from wakefulness to sleep, processing of external information diminishes while restorative processes, such as glymphatic remo…

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

Sleep disturbances are associated with intrusive memories, but the neurocognitive mechanisms underpinning this relationship are poorly understood. ...

The temporal microstructure of the brain can multiplex distinct cognitive processes during sleep to support continuous learning.

The open-access title’s bold publishing model has bought long-bubbling conflicts to the fore.

Zheng and Meister write about the paradoxical slowness of human behavior. Although our senses gather data at 109 bits/s, our overall information throughput is only 10 bits/s. This stark contrast touches on many fundamental aspects of brain function.

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

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Whether and how slow wave activity (SWA) and the underlying membrane potential UP and DOWN states initiate mechanisms that augment memory functions in humans are not fully understood. Here authors use...

How microglia sculpt brain circuits is not clear. Here, the authors propose that their contribution to synapse removal may occur by severing synapses (culling) or collecting synapses shed off by neuro...

Recycling of cholesterol-rich myelin debris by macrophages leads to the emergence of lipid-laden macrophages (LLMs) in glioblastoma. LLMs support glioblastoma malignancy through transfer of myelin-derived lipids to tumor cells, fueling cancer cell proliferation and recurrence.

Sleep is both a state of disconnection from the environment and a critical period for restoration. But how does sleep balance responsiveness with the protection of key functions? The infraslow fluctua...