iiinova — where your digital self keeps evolving

Reposted by Hannah Ledvina Ph.D.

Leading Edge Fellows Program @leadingedgeprogram.bsky.social · 05/11/2025

The Leading Edge Fellows gathered this week to celebrate Zara Weinberg, a beloved member of our community. Our 7th cohort of Leading Edge Fellows (2026) will be named in her honor. The Zara Weinberg Leading Edge Cohort application is now open! Due Feb 2. www.leadingedgesymposium.org/apply/

Candid photo of Zara Weinberg. She has short red hair, bangs and glasses. She is laughing.

214985

Hannah Ledvina Ph.D. @hannahledvina.bsky.social · 02/07/2025

Words cannot describe how excited I am to share the findings from the second half of my postdoc in @aaronwhiteley.bsky.social's lab where we discover that bacteria use functional amyloids to defend themselves from predatory bacteria. rdcu.be/euu5Y. See thread for details on this epic adventure 1/.

rdcu.be

Functional amyloid proteins confer defence against predatory bacteria

Nature - Escherichia coli uses curli fibres, oligomers of the functional amyloid CsgA, as a barrier to protect against the predatory bacteria Bdellovibrio bacteriovorus and Myxococcus xanthus in a...

616653

Hannah Ledvina Ph.D. @hannahledvina.bsky.social · 25/06/2025

Extremely excited to share I have accepted an offer to be an Assistant Professor in the MCDB department at the University of Michigan! Go Blue! The Ledvina lab will investigate the molecular interworking of the bacterial immune systems including defense against both viral and bacterial pathogens.

99212

Reposted by Hannah Ledvina Ph.D.

Sternberg Lab @sternberglab.bsky.social · 11/06/2025

1/10 New pre-print(s) from the Sternberg Lab in collaboration with Leifu Chang's Lab! We uncover the unprecedented molecular mechanism of CRISPR-Cas12f-like proteins, which drive RNA-guided transcription independently of canonical promoter motifs. Full story here: www.biorxiv.org/content/10.1...

39240

Reposted by Hannah Ledvina Ph.D.

Aaron Whiteley @aaronwhiteley.bsky.social · 08/04/2025

Check out our new story led by @aesully98.bsky.social describing how bacteria turn immune evasion against phage! In collaboration with @benmorehouse.bsky.social lab, we discover that bacteria guard their nucleotide second messenger pool using a nucleotidyltransferase related to Cas10/CRISPR enzymes

12811

Hannah Ledvina Ph.D. @hannahledvina.bsky.social · 08/04/2025

Stop your scrolling and read this AMAZING story from my coworker @aesully98.bsky.social in @aaronwhiteley.bsky.social's lab in collaboration with @benmorehouse.bsky.social ! An immune system which detects anti-immune mechanisms, incredible!!

061

Reposted by Hannah Ledvina Ph.D.

Sorek Lab @soreklab.bsky.social · 23/01/2025

Our paper out @CellCellPress: Structure guided discovery of viral proteins that inhibit host immunity Congrats Erez Yirmiya, Azita Leavitt, Gil Amitai, our collaborators at the Kranzusch lab, and coauthors A 🧵 1/10 www.cell.com/cell/abstrac...

cell.com

Structure-guided discovery of viral proteins that inhibit host immunity

Large-scale, structure-guided computational pipeline sifts through millions of phage proteins to identify those that bind and antagonize host immune proteins. Detected proteins are shown to inhibit no...

120174

Hannah Ledvina Ph.D. @hannahledvina.bsky.social · 19/12/2024

Check out this incredible preprint from my coworker @emilykibby.bsky.social! Emily developed a computational pipeline to identify activators of phage defense pathways. Incredibly she found that a bacterial NLR-related protein senses multiple phage proteins 🤯 bacteria never stop surprising me!

030

Hannah Ledvina Ph.D. @hannahledvina.bsky.social · 06/12/2024

The @jcchildsfund.bsky.social has been career changing for me! Such a fantastic organization. Check out their first ever Impact Report showing just how amazing they are 🤩

121

Reposted by Hannah Ledvina Ph.D.

Melanie Blokesch @mblokesch.bsky.social · 25/11/2024

Exciting times! Our latest preprint is now live 🤩! After nearly 16 yrs of running my lab, I truly believe this is one of the most significant contributions we've made. It offers fresh hypotheses about how pandemic Vibrio cholerae spreads globally. Let’s dive in!🧵..1/n www.biorxiv.org/content/10.1...

biorxiv.org

Diverse phage defence systems define West African South American pandemic Vibrio cholerae

Our understanding of the factors underlying the evolutionary success of different lineages of pandemic Vibrio cholerae remains incomplete. Interestingly, two unique genetic signatures define the West ...

4236112

Reposted by Hannah Ledvina Ph.D.

Leading Edge Fellows Program @leadingedgeprogram.bsky.social · 10/11/2024

If you want to follow awesome women and non-binary early career scientists, the starter pack of Leading Edge Fellows is here! go.bsky.app/He3EAcq

59869

Hannah Ledvina Ph.D. @hannahledvina.bsky.social · 01/03/2024

It’s here! Thrilled to be sharing a review article I wrote with @aaronwhiteley.bsky.social exploring the similarities and conservation of immune systems across life rdcu.be/dzSa3

1134