Reposted by Eleanor
by destroying our infrastructure.
This is just such a low and cruel betrayal that it's hard to wrap my head around...
Eleanor
@eleanoralbaugh.bsky.social
989 followers 1.1K following 5.4K posts
Crafter by necessity to stay occupied whilst dealing with health issues. MCAS PoTS Hypothyroidism (need T3 for life) ME. Please entertain me and let’s connect. In a previous life xcountry skier, hen and beekeeper, keen gardener and HCW. Alt text required.
![10. Measures.
10.1 Primary outcome measures.
10.1.1 Primary efficacy measures.
Since we are interested in changes in both symptoms and disability we have chosen to designate both the symptoms of fatigue and physical function as primary outcomes. This is because it is possible that a specific treatment may relieve symptoms without reducing disability, or vice versa. Both these measures will be self-rated.
The 11 item Chalder Fatigue Questionnaire measures the severity of symptomatic fatigue, [27] and has been the most frequently used measure of fatigue in most previous trials of these interventions. We will use the 0,0,1,1 item scores to allow a possible score of between 0 and 11. A positive outcome will be a 50% reduction in fatigue score, or a score of 3 or less, this threshold having been previously shown to indicate normal fatigue. [27]
The SF-36 physical function sub-scale [28] measures physical function, and has often been used as a primary outcome measure in trials of CBT and GET. We will count a score of 75 (out of a maximum of 100) or more, or a 50% increase from baseline in SF-36 sub-scale
score as a positive outcome. A score of 70 is about one standard deviation below the mean score (about 85, depending on the study) for the UK adult population. [50, 51]
Those participants who improve in both outcome measures will be regarded as overall improvers.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:idf6m3amxguxiftesf7y24hd/bafkreiaufjildxhjsihuevml6z5d453dxk6txatnjmlgdaccimqlhmxa6m)
