Sequence-specific RNA-binding proteins (RBPs) must efficiently locate their targets among a multitude of cellular RNAs. Cas13, an RNA-guided CRISPR protein, represents an ideal model system in which t...

Highly pathogenic avian influenza viruses (HPAIVs) derive from H5 and H7 low pathogenic avian influenza viruses (LPAIVs). Although insertion of a furin-cleavable multibasic cleavage site (MBCS) in the...

Fever promotes aberrant influenza A virus RNA synthesis and innate immune activation.

An effective CRISPR RNA occlusion strategy enhances mismatch detection when using Cas13.

A three-year-old girl who became Mexico’s first confirmed human case of H5N1 avian influenza has died, the country’s Health Ministry announced. It marks Mexico’s first fatality linked to the bird flu ...

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Research pitting people against AI systems gives AI an edge by asking us to perform in machine-like ways

The eight genomics segments of Influenza A virus exhibit different replication dynamics during infection. Here, the authors show through a range of mutant libraries of HA and PB1 segments that Influen...

Influenza A virus (IAV) non-canonical replication products can be bound by various host pathogen sensors, including retinoic acid-inducible gene I (RIG-I). However, it is not clear why non-canonical I...

A person in Louisiana has the first severe illness caused by bird flu in the U.S., health officials said Wednesday.

Transcription of interferons upon viral infection is critical for cell-intrinsic innate immunity. This process is influenced by many host and viral factors. To identify host factors that modulate inte...

During influenza A virus (IAV) infection, host pathogen receptor retinoic acid-inducible gene I (RIG-I) detects the partially complementary, 5’-triphosphorylated ends of the viral genome segments and ...

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution

New mask studies relying on a medical paradigm do not erase decades of engineering and occupational science that show they work