Nature - AI model AlphaGenome forecasts the consequences of altering every single DNA letter in the human genome.

Tracking influenza virus populations over 72 passages, the authors show that hundreds of defective viral genomes compete for dominance, ultimately resolving into a single variant carrying an adaptive ...

Laboratory Manager/Senior Scientist position in the Molecular Mucosal Immunology group at Oxford

Helicase-driven copy-back RNA synthesis in coronaviruses reveals how antivirals trap replication intermediates.

Highly pathogenic avian influenza viruses (HPAIVs) derive from H5 and H7 low pathogenic avian influenza viruses (LPAIVs). Although insertion of a furin-cleavable multibasic cleavage site (MBCS) in the...

Mycolic acids (MAs) are the major component of the mycobacterial outer membrane, a key contributor to the intrinsic resistance of mycobacteria to e...

Giant DNA viruses encode a cap-binding complex homologous to eIF4F, the defining translation-initiation complex of eukaryotes. The viral cap-binding complex is required for viral protein synthesis and enables an unusual degree of replication plasticity under altered host conditions.

The emergence of a chemical system capable of self-replication and evolution is a critical event in the origin of life. RNA polymerase ribozymes can replicate RNA, but their large size and structural ...

Biological function is fundamentally determined by nucleic acid and protein sequence. Beyond encoding genetic information, nucleic acids also display complex physicochemical parameters that shape stru...

Structural studies reveal how influenza virus switches between making new RNA genomes and exporting them from the host nucleus.

Using the visually accessible zebrafish-mycobacterium infection model, Wee et al demonstrate the caseous necrotic core of mycobacterial granulomas provides a safe-haven for opportunistic pathogens to ...

Abstract. Influenza A, a negative-sense RNA virus, has a genome that consists of eight single-stranded RNA segments. Influenza co-infections can result in

Abstract. Most bacterial sigma factors (σ) contain a highly conserved structural module, the ‘σ-finger’, which forms a loop that protrudes towards the RNA

Post-transcriptional gene regulation through m6A deposition is dysregulated in many diseases and is catalyzed by a multi-protein writer complex. This Unsolved Mystery investigates why the writer compl...

Introduction We live in a world split between mosquito magnets and those lucky enough to remain (nearly) untouched. The reasons why some people attract more mosquito bites than others remain largely m...