Host body temperature can define a virus’s replicative profile—influenza A viruses (IAVs) adapted to 40° to 42°C in birds are less temperature sensitive in vitro compared with human isolates adapted t...

Court documents and internal correspondence show the cost-cutting force has broad control over the world’s largest public biomedical funder.

Viral polymerases rely on cellular cofactors to support efficient transcription of viral genes and replication of the viral genome. The RNA-dependent RNA polymerase of influenza virus, an orthomyxovir...

Jeffery Taubenberger becomes acting director of NIH’s second largest institute

Policy follows firings of tenure-track scientists and suspension of training programs

The USDA said four Nevada dairy herds were infected with an H5N1 bird flu strain that has circulated in wild birds, making prospects for containment in cows appear dim.

Researchers facing

In early 2024, an unprecedented outbreak of H5N1 high pathogenicity avian influenza was detected in dairy cattle in the USA. The epidemic remains uncontrolled, with spillbacks into poultry, wild birds...

Past influenza pandemics contained polymerase genes from avian influenza viruses, affecting viral replication and pathogenicity.