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Edoardo Melilli

@edoardomelilli.bsky.social
514 followers 445 following 43 posts

no man is an island.. an italian nephrologist living and working in barcelona. Medicine, food, and sports are my interests

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Reposted by Edoardo Melilli
Sarah Melville @sarahkmels.medsky.network · 23/11/2025
Most #AI right now be like:
Cartoon of AI
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Nephrology Journal Club @nephjc.bsky.social · 20/11/2025
5/10 A figure paints🖼️ a 1000 words! Emerging evidence from APRIL/BAFF–axis trials underscores how central this pathway is to IgAN biology. Let’s put ORIGIN side by side with the others and see what we learn!
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ISNkidneycare @theisn.org · 21/11/2025
📖 This weekend don't miss our @kireports.bsky.social #ISNFridaySelection: The Impact of Donor and Recipient Diabetes on Patient and Graft Survival in Kidney Transplant Recipients www.kireports.org/ar...
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Science News @scinews.bsky.social · 16/11/2025
Maintaining a moderate level of physical activity approximately 17 MET-hours/week (ie, 5 hours of brisk walking or 2 hours of running each week) over 3 decades was sufficient to achieve optimal benefit in reducing Digestive System Cancer risk. jamanetwork.com/journals/jam...
jamanetwork.com
Consistent Adherence to Physical Activity Guidelines and Digestive System Cancer Risk and Mortality
This cohort study using data from 3 large US prospective cohorts assesses whether adherence to the recommended physical activity level measured in metabolic equivalent task over time is associated wit...
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American Journal of Kidney Diseases @ajkd.bsky.social · 16/11/2025
2025 AJKD Editors' Choice Award winning article: Genetic Characterization of Kidney Failure of Unknown Etiology in Spain: Findings From the GENSEN Study bit.ly/3WeEZ72 #VisualAbstract
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NEJM.org @nejm.org · 10/11/2025
A follow-up report showed that the overall benefit of machine perfusion over cold storage in kidney graft survival remained present 10 years after transplantation. Read the full report: nej.md/4hDQNK4 #MedSky #Nephrology #Surgery
A figure showing graft survival in 818 patients who received kidney transplants and were included in the combined data for all kidneys obtained from donors after brain death and after circulatory death.
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Wisit Cheungpasitporn, MD, FACP, FASN, FAST @wisit661.bsky.social · 11/11/2025
📘 “Responsible Use of Artificial Intelligence to Improve Kidney Care” 🧩 Journal of the American Society of Nephrology (JASN) – Published online November 7, 2025 @asnkidney.bsky.social @asnpublications.bsky.social journals.lww.com/jasn/fulltex...
journals.lww.com
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Fernando de Frutos Seminario @fdefrutossemi.bsky.social · 11/11/2025
🚨🧬 Registrations for the IV Bootcamp are now open! Limited to 30 spots—first come, first served. Acces the link in this thread.
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Eric Topol @erictopol.bsky.social · 11/11/2025
The APOE4 allele, present in >20% of the population, is a significant risk marker for #Alzheimers. What if we could flip it to the protective APOE2 allele? Encouraging results in the experimental model www.nature.com/articles/s41... www.nature.com/articles/s41...
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Journal of Clinical Investigation @jci.org · 11/11/2025
Chronic kidney disease currently affects 850 million people @mariejeansson.bsky.social discover antibody-mediated TIE2 activation prevents vascular injury and ensuing tubular injury and tubulointerstitial fibrosis in experimental chronic kidney disease: www.jci.org/articles/vie...
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Michelle Rheault, MD @rheaultm.bsky.social · 08/11/2025
Late breakers that included children: ✅Setanaxib in Alport (12+) Late breakers that did NOT include children: 🚫Atacicept in IgAN 🚫CONFIDENCE 🚫PISCES: Fish oil in Dialysis 🚫LIBERATE-D 🚫balcinrenone + dapa 🚫Obintuzumab in lupus nephritis 🚫Sibeprenlimab in IgA 🚫MIL62 in membranous +more #KidneyWk
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Eric Topol @erictopol.bsky.social · 09/11/2025
Get this: Coffee suppressed atrial fibrillation! Unexpected results for recurrence from a randomized trial in participants after cardioversion from AF #AHA25 @jama.com jamanetwork.com/journals/jam...
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JAMA Internal Medicine @jamainternalmed.com · 08/11/2025
💬 @jama.com Editorial: The LIBERATE-D trial shows conservative dialysis—guided by A-E-I-O-U indications and asking "Why"—promotes earlier kidney recovery and fewer dialysis sessions in AKI. #KidneyWK @asnkidney.bsky.social ja.ma/4hOkM1W
JAMA journal cover, published November 7, 2025. Editorial titled "A-E-I-O-U and Sometimes Why—Dialysis in Acute Kidney Injury" by Sushrut S. Waikar, MD, MPH. Article discusses dialysis indications for acute kidney injury.
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Lori O'Brien @llobrienlab.bsky.social · 07/11/2025
Flashback #FluorescenceFriday to some of the first light-sheet imaging we were doing. Video shows the collecting duct system of the developing kidney labeled with a pan-cytokeratin antibody. Courtesy of former talented technician Deanna Hardesty.
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Sarah Sanghavi @sarahsanghavi.bsky.social · 08/11/2025
After empa-kidney, it still wasn’t clear what to do for patients with CKD without diabetes or albuminuria. This meta-analysis suggests you use flozins. #kidneywk jamanetwork.com/journals/jam...
jamanetwork.com
SGLT2 Inhibitors and Kidney Outcomes by Glomerular Filtration Rate and Albuminuria
This meta-analysis examines whether estimated glomerular filtration rate or degree of albuminuria, as measured by urinary albumin to creatinine ratio, modifies the effects of sodium-glucose cotranspor...
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ASN Publications @asnpublications.bsky.social · 07/11/2025
Now live in #ASNJASN, simultaneously published with #KidneyWk: "Immunosuppression in Older Kidney Transplant Recipients: A Randomized Controlled Trial" Read more: kidney.pub/JASN0924
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Green Nephrology - Italian Society of Nephrology @greennephrologysin.bsky.social · 27/10/2025
Air pollution doesn’t just harm the lungs and heart — it also accelerates kidney disease. A new @ClinKidneyJ review links exposure to fine particulate matter (PM2.5) and black carbon with faster progression of glomerular diseases. 🔗 academic.oup.com/ckj/article/...
academic.oup.com
Elevated exposure to air pollutants accelerates primary glomerular disease progression
ABSTRACT. Air pollution is a global problem and a major contributor to adverse health outcomes in patients of all ages. Most research has focused on the ad
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NEJM.org @nejm.org · 27/10/2025
In patients with chronic coronary syndrome taking oral anticoagulants, adding aspirin led to higher risks of cardiovascular events, major bleeding, and death from any cause than anticoagulation alone. Full AQUATIC trial results and Research Summary: nej.md/45AU4Wp #MedSky #CardioSky
The New England Journal of Medicine                   
Aspirin and Anticoagulation in Chronic Coronary Syndrome 
A Research Summary based on Lemesle G et al. | 10.1056/NEJMoa2507532 | Published on August 31, 2025 

Visual representations of the patients in the trial and the treatments they were assigned.    

Read the full Research Summary at NEJM.org.
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Eric Topol @erictopol.bsky.social · 22/10/2025
How do mRNA vaccines help fight cancer? A @nature.com paper today tells the story, one with big implications, as reviewed here erictopol.substack.com/p/how-mrna-v...
erictopol.substack.com
How mRNA Vaccines Can Help Fight Cancer
Turning "cold" tumors "hot"
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Eric Topol @erictopol.bsky.social · 22/10/2025
A meta-analysis of 13 studies comparing health care professionals vs generative A.I. showed the latter was more likely to be perceived as more empathetic in all but 1 study academic.oup.com/bmb/article/...
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F. Perry Wilson, MD @fperrywilson.bsky.social · 22/10/2025
A new Nature study found that people with cancer who received an mRNA COVID vaccine while on immunotherapy lived nearly twice as long. Median survival jumped from 20.6 to 37.3 months. That’s not a typo. Let’s talk about how, and why, that might be. 🧵
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transplantation.bsky.social @transplantation.bsky.social · 20/10/2025
Frailty and sarcopenia double mortality in liver transplant candidates and impair recovery. Early detection, nutritional optimization, and personalized (p)rehabilitation are essential to improve outcomes. @BirminghamBRC #TXPforAll #LiverTransplantation tinyurl.com/4u4rr689
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Eric Topol @erictopol.bsky.social · 13/10/2025
What does the naked mole rat’s extreme healthspan have to do with ongoing clinical trials? open.substack.com/pub/erictopo...
open.substack.com
A Long-Awaited Longevity Mystery Solved
Spotlighting an essential human biologic pathway targeted by drugs in clinical trials
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kidneynerd.bsky.social @kidneynerd.bsky.social · 07/10/2025
Really interesting study. I would be curious to know what the average travel distance is for in centre hemodialysis given the 36% estimated contribution from travel to the overall carbon footprint www.ajkd.org/article/S027...
ajkd.org
Carbon Emissions From Different Dialysis Modalities: A Life Cycle Assessment
As the health impacts of climate change intensify, the health care sector faces growing pressure to minimize its carbon footprint. Achieving this goal requires understanding of the carbon impact of wi...
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American Journal of Hypertension @amjhypertension.bsky.social · 05/10/2025
#weekendReads from the #EditorsChoice Does Reserpine deserve a Relook for Resistant Hypertension? academic.oup.com/ajh/article/... #Free
academic.oup.com
Reserpine Substantially Lowers Blood Pressure in Patients With Refractory Hypertension: A Proof-of-Concept Study
AbstractBACKGROUND. Refractory hypertension (RfHTN), a phenotype of antihypertensive treatment failure, is defined as uncontrolled automated office blood p
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Science News @scinews.bsky.social · 05/10/2025
Trends in the incidence of lung cancer in never smokers in Eastern China "There is a significant increasing trend in LCNS incidence from 2009 through 2020, especially in women and the young population." bmjopen.bmj.com/content/15/9...
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Johns Hopkins Berman Institute of Bioethics @bermaninstitute.bsky.social · 03/10/2025
First human transplant of kidney modified to have ‘universal’ blood type: Recipient diagnosed with brain death received a type-O organ, which is compatible with all blood types. www.nature.com/articles/d41...
nature.com
First human transplant of kidney modified to have ‘universal’ blood type
Recipient diagnosed with brain death received a type-O organ, which is compatible with all blood types.
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amturiel.bsky.social @amturiel.bsky.social · 01/10/2025
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Atroz Con Leche @atrozconleche.bsky.social · 24/09/2025
Ten esta respuesta preparada para los próximos meses. La vas a necesitar...
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Sociedad Española de Nefrología @senefrologia.bsky.social · 24/09/2025
Gracias al equipo docente, + 100 Residentes de Centros españoles y portugueses y CSL VIFOR por hacer posible la edición 18 del #EncuentroMirNefro25 en Cocentaina (Alicante) 👏 Formación práctica a través de casos clínicos de todas las áreas de la nefrología... ¡Seguimos! #FormaciónSenefro
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ASN Publications @asnpublications.bsky.social · 19/09/2025
Can genetic factors act as determinants of salt sensitivity and modify the effect of salt intake on CKD? This #ASNCJASN study of the UK Biobank investigates: kidney.pub/CJASN0793
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todossomosSEN @todossomossen.bsky.social · 02/09/2025
Nos presentamos con mucha ilusión y responsabilidad a la Junta Directiva de la S.E.N. 2026-2029. Una candidatura para TODOS! Conócela y súmate si lo deseas! ⬇️⬇️⬇️ sites.google.com/view/todosso...
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Eric Topol @erictopol.bsky.social · 31/08/2025
How much protein should you consume? erictopol.substack.com/p/our-preocc...
erictopol.substack.com
Our Preoccupation With Protein Intake
The data on high protein diets, bars, supplements, and powders will surprise you
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John Penniman @historiographos.bsky.social · 27/11/2023
I will never recover from this student email.
Image of an email from a student asking if sources "from the late 1900s" are acceptable.
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American Journal of Transplantation @amjtransplant.bsky.social · 28/08/2025
Check out a new article by Holle et al, "Gut microbiome alterations precede graft rejection in kidney transplantation patients" from the August issue of AJT! #kidneytransplant #graftrejection 10.1016/j.ajt.2025.02.010
Figure 2 Microbiome alteration precedes kidney transplant rejection. Patients with available fecal samples prior to kidney rejection (rejection group) for propensity score matched (1:2) to patients without kidney rejection (nonrejection group). (A) Plasma creatinine levels are depicted over time. The shaded area represents the 95% CI. Red bars indicate individual rejection events over time. (B) Analysis of minimum creatinine levels before and after sampling, along with the time taken to reach the first. (C) Principal coordinates analysis (PCoA) based on Bray-Curtis dissimilarity; the squares mark the centroids of each group. P value and F value from statistical comparison by PERMANOVA. (D) Number of detected operational taxonomic units (OTUs), Shannon diversity, and Simpson evenness for the propensity score–matched cohort. (E) Differential abundance analysis for bacterial taxa...
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Michelle Rheault, MD @rheaultm.bsky.social · 28/08/2025
The US sparsentan REMS requirements have been updated and now require Q3 month liver labs instead of monthly. ir.travere.com/press-releas...
ir.travere.com
Travere Therapeutics Announces U.S. FDA Approves REMS Modification for FILSPARI® (sparsentan) in IgA Nephropathy
FDA simplifies liver monitoring schedule from monthly to every three months for the duration of treatment and removes embryo-fetal toxicity REMS monitoring Travere Therapeutics, Inc., (Nasdaq: TVTX) t...
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Boback Ziaeian @boback.bsky.social · 26/08/2025
Going to add this to my lecture slides.
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Eric Topol @erictopol.bsky.social · 25/08/2025
Exposure to heat waves and accelerated biological aging www.nature.com/articles/s41...
nature.com
Long-term impacts of heatwaves on accelerated ageing - Nature Climate Change
Ageing is linked to environmental factors. This study shows that although participants gradually adapted to heat over time, cumulative exposure to heatwaves had stable and adverse impacts on ageing, e...
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 19/08/2025
Anrikefon (previously known as HSK21542) aka difelikefalin cousin, and itching @kidneyboy.bsky.social choice of #KidneyWk draft now in the @bmj.com www.bmj.com/content/390/... #NephSky #Pruritis
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Mean change from baseline in 24 hour WI-NRS score over 12 weeks in anrikefon and placebo groups. Whiskers represent 95% confidence intervals. WI-NRS=worst itching intensity numerical rating scale
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Skyler Lentz @skylerlentz.bsky.social · 10/08/2025
Answer: #2 normotensive cardiogenic shock It’s sneaky, easy to miss but important to identify, diagnose cause, manage and admit to ICU—not the floor tele unit Occurs in about 12% of CS patients Mortality 17% www.jacc.org/doi/10.1016/...
jacc.org
Continuum of Preshock to Classic Cardiogenic Shock in the Critical Care Cardiology Trials Network Registry:
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Aimen Liaqat @aimenliaqat.bsky.social · 11/08/2025
Recently @nytimes.com created some uproar with misreporting about the noble gift of life. I am an organ donor and a proud caregiver to transplant recipients. 91,869 patients are waiting for a kidney transplant & 50% would die before transplant due to organ shortage.Learn about it: #donationsaveslife
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American Journal of Transplantation @amjtransplant.bsky.social · 10/08/2025
#OpenAccess in this month's issue! "Alloreactive adaptive Natural Killer cells in renal transplantation: potential contribution to allograft microvascular inflammation" by Alari-Pahissa et al. doi.org/10.1016/j.aj...
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alexgutierrezd.bsky.social @alexgutierrezd.bsky.social · 07/08/2025
An impressive leap forward in the field of transplantation. I'm eagerly awaiting a whole organ modification. @senefrologia.bsky.social @edoardomelilli.bsky.social Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | New England Journal of Medicine www.nejm.org/doi/full/10....
nejm.org
Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | NEJM
The need to suppress a patient’s immune system after the transplantation of allogeneic cells is associated with wide-ranging side effects. We report the outcomes of transplantation of genetically m...
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NEJM.org @nejm.org · 04/08/2025
Today at #WTC2025: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression. The results of this study support the concept of immune evasion by these modified cells. Read the Brief Report: nej.md/3TXVgwp @ttsorg.bsky.social
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Joel Topf @kidneyboy.bsky.social · 01/08/2025
I think I'm in love youtube.com/shorts/OJy1Q...
youtube.com
Fanconi Syndrome
YouTube video by Dr. Glaucomflecken
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alexgutierrezd.bsky.social @alexgutierrezd.bsky.social · 01/08/2025
Clear, direct, understandable, i love it www.youtube.com/watch?v=NukU...
youtube.com
Human Papillomavirus and Cancer | NEJM
YouTube video by NEJM Group
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Nephrology Times @nephtimes.bsky.social · 30/07/2025
⚠️ The FDA has approved pegcetacoplan (Empaveli) for treating C3G and IC-MPGN. #kidneydisease #nephrology #nephsky #c3g www.docwirenews.com/post/fda-app...
docwirenews.com
FDA Approves Pegcetacoplan for C3G and IC-MPGN | Docwire News
The FDA approved pegcetacoplan for treating C3 glomerulopathy (C3G) and primary immune complex membranoproliferative glomerulonephritis (IC-MPGN in patients age 12 and older.
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Eric Topol @erictopol.bsky.social · 28/07/2025
A Swedish cohort with long term follow-up once again highlights the link between diet and chronic diseases in older adults www.nature.com/articles/s43...
nature.com
Dietary patterns and accelerated multimorbidity in older adults - Nature Aging
In a Swedish cohort, Abbad-Gomez et al. report that diet quality is inversely associated with the rate of accumulation of total, cardiovascular and neuropsychiatric chronic diseases in older adults, s...
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Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 27/07/2025
Local study from Ottawa colleagues Reduced dose steroids in ANCA vasculitis is safe, in @kireports.bsky.social www.kireports.org/article/S246... #NephSky #Vasculitis
VA by Priya John
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