Reposted by Edoardo MelilliSarah Melville @sarahkmels.medsky.network · 23/11/2025Most #AI right now be like: 2113
Reposted by Edoardo MelilliNephrology Journal Club @nephjc.bsky.social · 20/11/20255/10 A figure paints🖼️ a 1000 words! Emerging evidence from APRIL/BAFF–axis trials underscores how central this pathway is to IgAN biology. Let’s put ORIGIN side by side with the others and see what we learn! 162
Reposted by Edoardo MelilliISNkidneycare @theisn.org · 21/11/2025📖 This weekend don't miss our @kireports.bsky.social #ISNFridaySelection: The Impact of Donor and Recipient Diabetes on Patient and Graft Survival in Kidney Transplant Recipients www.kireports.org/ar... 032
Reposted by Edoardo MelilliScience News @scinews.bsky.social · 16/11/2025Maintaining a moderate level of physical activity approximately 17 MET-hours/week (ie, 5 hours of brisk walking or 2 hours of running each week) over 3 decades was sufficient to achieve optimal benefit in reducing Digestive System Cancer risk. jamanetwork.com/journals/jam...jamanetwork.comConsistent Adherence to Physical Activity Guidelines and Digestive System Cancer Risk and MortalityThis cohort study using data from 3 large US prospective cohorts assesses whether adherence to the recommended physical activity level measured in metabolic equivalent task over time is associated wit... 0182
Reposted by Edoardo MelilliAmerican Journal of Kidney Diseases @ajkd.bsky.social · 16/11/20252025 AJKD Editors' Choice Award winning article: Genetic Characterization of Kidney Failure of Unknown Etiology in Spain: Findings From the GENSEN Study bit.ly/3WeEZ72 #VisualAbstract 054
Reposted by Edoardo MelilliNEJM.org @nejm.org · 10/11/2025A follow-up report showed that the overall benefit of machine perfusion over cold storage in kidney graft survival remained present 10 years after transplantation. Read the full report: nej.md/4hDQNK4 #MedSky #Nephrology #Surgery 0135
Reposted by Edoardo MelilliWisit Cheungpasitporn, MD, FACP, FASN, FAST @wisit661.bsky.social · 11/11/2025📘 “Responsible Use of Artificial Intelligence to Improve Kidney Care” 🧩 Journal of the American Society of Nephrology (JASN) – Published online November 7, 2025 @asnkidney.bsky.social @asnpublications.bsky.social journals.lww.com/jasn/fulltex...journals.lww.com 044
Reposted by Edoardo MelilliFernando de Frutos Seminario @fdefrutossemi.bsky.social · 11/11/2025🚨🧬 Registrations for the IV Bootcamp are now open! Limited to 30 spots—first come, first served. Acces the link in this thread. 122
Reposted by Edoardo MelilliEric Topol @erictopol.bsky.social · 11/11/2025The APOE4 allele, present in >20% of the population, is a significant risk marker for #Alzheimers. What if we could flip it to the protective APOE2 allele? Encouraging results in the experimental model www.nature.com/articles/s41... www.nature.com/articles/s41... 110720
Reposted by Edoardo MelilliJournal of Clinical Investigation @jci.org · 11/11/2025Chronic kidney disease currently affects 850 million people @mariejeansson.bsky.social discover antibody-mediated TIE2 activation prevents vascular injury and ensuing tubular injury and tubulointerstitial fibrosis in experimental chronic kidney disease: www.jci.org/articles/vie... 141
Reposted by Edoardo MelilliMichelle Rheault, MD @rheaultm.bsky.social · 08/11/2025Late breakers that included children: ✅Setanaxib in Alport (12+) Late breakers that did NOT include children: 🚫Atacicept in IgAN 🚫CONFIDENCE 🚫PISCES: Fish oil in Dialysis 🚫LIBERATE-D 🚫balcinrenone + dapa 🚫Obintuzumab in lupus nephritis 🚫Sibeprenlimab in IgA 🚫MIL62 in membranous +more #KidneyWk 12012
Reposted by Edoardo MelilliEric Topol @erictopol.bsky.social · 09/11/2025Get this: Coffee suppressed atrial fibrillation! Unexpected results for recurrence from a randomized trial in participants after cardioversion from AF #AHA25 @jama.com jamanetwork.com/journals/jam... 2133976
Reposted by Edoardo MelilliJAMA Internal Medicine @jamainternalmed.com · 08/11/2025💬 @jama.com Editorial: The LIBERATE-D trial shows conservative dialysis—guided by A-E-I-O-U indications and asking "Why"—promotes earlier kidney recovery and fewer dialysis sessions in AKI. #KidneyWK @asnkidney.bsky.social ja.ma/4hOkM1W 022
Reposted by Edoardo MelilliLori O'Brien @llobrienlab.bsky.social · 07/11/2025Flashback #FluorescenceFriday to some of the first light-sheet imaging we were doing. Video shows the collecting duct system of the developing kidney labeled with a pan-cytokeratin antibody. Courtesy of former talented technician Deanna Hardesty. 17822
Reposted by Edoardo MelilliSarah Sanghavi @sarahsanghavi.bsky.social · 08/11/2025After empa-kidney, it still wasn’t clear what to do for patients with CKD without diabetes or albuminuria. This meta-analysis suggests you use flozins. #kidneywk jamanetwork.com/journals/jam...jamanetwork.comSGLT2 Inhibitors and Kidney Outcomes by Glomerular Filtration Rate and AlbuminuriaThis meta-analysis examines whether estimated glomerular filtration rate or degree of albuminuria, as measured by urinary albumin to creatinine ratio, modifies the effects of sodium-glucose cotranspor... 1114
Reposted by Edoardo MelilliASN Publications @asnpublications.bsky.social · 07/11/2025Now live in #ASNJASN, simultaneously published with #KidneyWk: "Immunosuppression in Older Kidney Transplant Recipients: A Randomized Controlled Trial" Read more: kidney.pub/JASN0924 176
Reposted by Edoardo MelilliGreen Nephrology - Italian Society of Nephrology @greennephrologysin.bsky.social · 27/10/2025Air pollution doesn’t just harm the lungs and heart — it also accelerates kidney disease. A new @ClinKidneyJ review links exposure to fine particulate matter (PM2.5) and black carbon with faster progression of glomerular diseases. 🔗 academic.oup.com/ckj/article/...academic.oup.comElevated exposure to air pollutants accelerates primary glomerular disease progressionABSTRACT. Air pollution is a global problem and a major contributor to adverse health outcomes in patients of all ages. Most research has focused on the ad 122
Reposted by Edoardo MelilliNEJM.org @nejm.org · 27/10/2025In patients with chronic coronary syndrome taking oral anticoagulants, adding aspirin led to higher risks of cardiovascular events, major bleeding, and death from any cause than anticoagulation alone. Full AQUATIC trial results and Research Summary: nej.md/45AU4Wp #MedSky #CardioSky 0126
Reposted by Edoardo MelilliEric Topol @erictopol.bsky.social · 22/10/2025How do mRNA vaccines help fight cancer? A @nature.com paper today tells the story, one with big implications, as reviewed here erictopol.substack.com/p/how-mrna-v...erictopol.substack.comHow mRNA Vaccines Can Help Fight CancerTurning "cold" tumors "hot" 13604223
Reposted by Edoardo MelilliEric Topol @erictopol.bsky.social · 22/10/2025A meta-analysis of 13 studies comparing health care professionals vs generative A.I. showed the latter was more likely to be perceived as more empathetic in all but 1 study academic.oup.com/bmb/article/... 126014
Reposted by Edoardo MelilliF. Perry Wilson, MD @fperrywilson.bsky.social · 22/10/2025A new Nature study found that people with cancer who received an mRNA COVID vaccine while on immunotherapy lived nearly twice as long. Median survival jumped from 20.6 to 37.3 months. That’s not a typo. Let’s talk about how, and why, that might be. 🧵 151
Reposted by Edoardo Melillitransplantation.bsky.social @transplantation.bsky.social · 20/10/2025Frailty and sarcopenia double mortality in liver transplant candidates and impair recovery. Early detection, nutritional optimization, and personalized (p)rehabilitation are essential to improve outcomes. @BirminghamBRC #TXPforAll #LiverTransplantation tinyurl.com/4u4rr689 011
Reposted by Edoardo MelilliEric Topol @erictopol.bsky.social · 13/10/2025What does the naked mole rat’s extreme healthspan have to do with ongoing clinical trials? open.substack.com/pub/erictopo...open.substack.comA Long-Awaited Longevity Mystery SolvedSpotlighting an essential human biologic pathway targeted by drugs in clinical trials 210830
Reposted by Edoardo Melillikidneynerd.bsky.social @kidneynerd.bsky.social · 07/10/2025Really interesting study. I would be curious to know what the average travel distance is for in centre hemodialysis given the 36% estimated contribution from travel to the overall carbon footprint www.ajkd.org/article/S027...ajkd.orgCarbon Emissions From Different Dialysis Modalities: A Life Cycle AssessmentAs the health impacts of climate change intensify, the health care sector faces growing pressure to minimize its carbon footprint. Achieving this goal requires understanding of the carbon impact of wi... 042
Reposted by Edoardo MelilliAmerican Journal of Hypertension @amjhypertension.bsky.social · 05/10/2025#weekendReads from the #EditorsChoice Does Reserpine deserve a Relook for Resistant Hypertension? academic.oup.com/ajh/article/... #Freeacademic.oup.comReserpine Substantially Lowers Blood Pressure in Patients With Refractory Hypertension: A Proof-of-Concept StudyAbstractBACKGROUND. Refractory hypertension (RfHTN), a phenotype of antihypertensive treatment failure, is defined as uncontrolled automated office blood p 054
Reposted by Edoardo MelilliScience News @scinews.bsky.social · 05/10/2025Trends in the incidence of lung cancer in never smokers in Eastern China "There is a significant increasing trend in LCNS incidence from 2009 through 2020, especially in women and the young population." bmjopen.bmj.com/content/15/9... 091
Reposted by Edoardo MelilliJohns Hopkins Berman Institute of Bioethics @bermaninstitute.bsky.social · 03/10/2025First human transplant of kidney modified to have ‘universal’ blood type: Recipient diagnosed with brain death received a type-O organ, which is compatible with all blood types. www.nature.com/articles/d41...nature.comFirst human transplant of kidney modified to have ‘universal’ blood typeRecipient diagnosed with brain death received a type-O organ, which is compatible with all blood types. 3218
Reposted by Edoardo MelilliAtroz Con Leche @atrozconleche.bsky.social · 24/09/2025Ten esta respuesta preparada para los próximos meses. La vas a necesitar... 03418
Reposted by Edoardo MelilliSociedad Española de Nefrología @senefrologia.bsky.social · 24/09/2025Gracias al equipo docente, + 100 Residentes de Centros españoles y portugueses y CSL VIFOR por hacer posible la edición 18 del #EncuentroMirNefro25 en Cocentaina (Alicante) 👏 Formación práctica a través de casos clínicos de todas las áreas de la nefrología... ¡Seguimos! #FormaciónSenefro 021
Reposted by Edoardo MelilliASN Publications @asnpublications.bsky.social · 19/09/2025Can genetic factors act as determinants of salt sensitivity and modify the effect of salt intake on CKD? This #ASNCJASN study of the UK Biobank investigates: kidney.pub/CJASN0793 031
Reposted by Edoardo MelillitodossomosSEN @todossomossen.bsky.social · 02/09/2025Nos presentamos con mucha ilusión y responsabilidad a la Junta Directiva de la S.E.N. 2026-2029. Una candidatura para TODOS! Conócela y súmate si lo deseas! ⬇️⬇️⬇️ sites.google.com/view/todosso... 064
Reposted by Edoardo MelilliEric Topol @erictopol.bsky.social · 31/08/2025How much protein should you consume? erictopol.substack.com/p/our-preocc...erictopol.substack.comOur Preoccupation With Protein IntakeThe data on high protein diets, bars, supplements, and powders will surprise you 2427377
Reposted by Edoardo MelilliJohn Penniman @historiographos.bsky.social · 27/11/2023I will never recover from this student email. 37993822331
Reposted by Edoardo MelilliAmerican Journal of Transplantation @amjtransplant.bsky.social · 28/08/2025Check out a new article by Holle et al, "Gut microbiome alterations precede graft rejection in kidney transplantation patients" from the August issue of AJT! #kidneytransplant #graftrejection 10.1016/j.ajt.2025.02.010 021
Reposted by Edoardo MelilliMichelle Rheault, MD @rheaultm.bsky.social · 28/08/2025The US sparsentan REMS requirements have been updated and now require Q3 month liver labs instead of monthly. ir.travere.com/press-releas...ir.travere.comTravere Therapeutics Announces U.S. FDA Approves REMS Modification for FILSPARI® (sparsentan) in IgA NephropathyFDA simplifies liver monitoring schedule from monthly to every three months for the duration of treatment and removes embryo-fetal toxicity REMS monitoring Travere Therapeutics, Inc., (Nasdaq: TVTX) t... 153
Reposted by Edoardo MelilliBoback Ziaeian @boback.bsky.social · 26/08/2025Going to add this to my lecture slides. 02915
Reposted by Edoardo MelilliEric Topol @erictopol.bsky.social · 25/08/2025Exposure to heat waves and accelerated biological aging www.nature.com/articles/s41...nature.comLong-term impacts of heatwaves on accelerated ageing - Nature Climate ChangeAgeing is linked to environmental factors. This study shows that although participants gradually adapted to heat over time, cumulative exposure to heatwaves had stable and adverse impacts on ageing, e... 614245
Reposted by Edoardo MelilliSwapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 19/08/2025Anrikefon (previously known as HSK21542) aka difelikefalin cousin, and itching @kidneyboy.bsky.social choice of #KidneyWk draft now in the @bmj.com www.bmj.com/content/390/... #NephSky #Pruritis 094
Reposted by Edoardo MelilliSkyler Lentz @skylerlentz.bsky.social · 10/08/2025Answer: #2 normotensive cardiogenic shock It’s sneaky, easy to miss but important to identify, diagnose cause, manage and admit to ICU—not the floor tele unit Occurs in about 12% of CS patients Mortality 17% www.jacc.org/doi/10.1016/...jacc.orgContinuum of Preshock to Classic Cardiogenic Shock in the Critical Care Cardiology Trials Network Registry: 022
Reposted by Edoardo MelilliAimen Liaqat @aimenliaqat.bsky.social · 11/08/2025Recently @nytimes.com created some uproar with misreporting about the noble gift of life. I am an organ donor and a proud caregiver to transplant recipients. 91,869 patients are waiting for a kidney transplant & 50% would die before transplant due to organ shortage.Learn about it: #donationsaveslife 1126
Reposted by Edoardo MelilliAmerican Journal of Transplantation @amjtransplant.bsky.social · 10/08/2025#OpenAccess in this month's issue! "Alloreactive adaptive Natural Killer cells in renal transplantation: potential contribution to allograft microvascular inflammation" by Alari-Pahissa et al. doi.org/10.1016/j.aj... 011
Reposted by Edoardo Melillialexgutierrezd.bsky.social @alexgutierrezd.bsky.social · 07/08/2025An impressive leap forward in the field of transplantation. I'm eagerly awaiting a whole organ modification. @senefrologia.bsky.social @edoardomelilli.bsky.social Survival of Transplanted Allogeneic Beta Cells with No Immunosuppression | New England Journal of Medicine www.nejm.org/doi/full/10....nejm.orgSurvival of Transplanted Allogeneic Beta Cells with No Immunosuppression | NEJMThe need to suppress a patient’s immune system after the transplantation of allogeneic cells is associated with wide-ranging side effects. We report the outcomes of transplantation of genetically m... 021
Reposted by Edoardo MelilliNEJM.org @nejm.org · 04/08/2025Today at #WTC2025: A patient with type 1 diabetes underwent transplantation of genetically modified allogeneic islet cells with no immunosuppression. The results of this study support the concept of immune evasion by these modified cells. Read the Brief Report: nej.md/3TXVgwp @ttsorg.bsky.social 02311
Reposted by Edoardo MelilliJoel Topf @kidneyboy.bsky.social · 01/08/2025I think I'm in love youtube.com/shorts/OJy1Q...youtube.comFanconi SyndromeYouTube video by Dr. Glaucomflecken 55915
Reposted by Edoardo Melillialexgutierrezd.bsky.social @alexgutierrezd.bsky.social · 01/08/2025Clear, direct, understandable, i love it www.youtube.com/watch?v=NukU...youtube.comHuman Papillomavirus and Cancer | NEJMYouTube video by NEJM Group 011
Reposted by Edoardo MelilliNephrology Times @nephtimes.bsky.social · 30/07/2025⚠️ The FDA has approved pegcetacoplan (Empaveli) for treating C3G and IC-MPGN. #kidneydisease #nephrology #nephsky #c3g www.docwirenews.com/post/fda-app...docwirenews.comFDA Approves Pegcetacoplan for C3G and IC-MPGN | Docwire NewsThe FDA approved pegcetacoplan for treating C3 glomerulopathy (C3G) and primary immune complex membranoproliferative glomerulonephritis (IC-MPGN in patients age 12 and older. 096
Reposted by Edoardo MelilliEric Topol @erictopol.bsky.social · 28/07/2025A Swedish cohort with long term follow-up once again highlights the link between diet and chronic diseases in older adults www.nature.com/articles/s43...nature.comDietary patterns and accelerated multimorbidity in older adults - Nature AgingIn a Swedish cohort, Abbad-Gomez et al. report that diet quality is inversely associated with the rate of accumulation of total, cardiovascular and neuropsychiatric chronic diseases in older adults, s... 211421
Reposted by Edoardo MelilliSwapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 27/07/2025Local study from Ottawa colleagues Reduced dose steroids in ANCA vasculitis is safe, in @kireports.bsky.social www.kireports.org/article/S246... #NephSky #Vasculitis 032