Today, I’m proud to announce Homebrew 7.0.0. The most significant changes since 6.0.0 are faster installations and upgrades, stronger sandboxing, a native macOS app, built-in vulnerability checks and an advisory database, the end of macOS 10.15 support and Intel Macs moving to Tier 3.

The genomic regions regulating gene expression are often themselves transcribed into a variety of noncoding RNAs (ncRNAs). However, the regulatory roles of this noncoding transcription remain largely ...

Researchers may be wasting resources following false trails due to variations in interpretative methods.

Meanwhile, even with fewer staff, the agency just completed the largest expansion of hunting and fishing access in its entire history

House Appropriations Committee Ranking Member Rosa DeLauro (D-CT-03) has learned that officials at the Department of Defense (DoD) are working to divert billions of dollars from the National Institute...

RNA design has been hindered by the limited accuracy of three-dimensional (3D) structure prediction. In this study, we show that intricate RNA structures can be generated with current deep learning to...

The country singer was an advocate for vaccines, public health, literacy and marginalized communities.

The long-delayed 12 solicitations only cover some disciplines—and promise to give them much less money

Metastasis causes most cancer deaths, yet no recurrent mutation specifically drives it, raising the possibility that metastatic potential is a non-genetic yet heritable cell state. Classic experiments...

Language is part of bill to fund government until mid-December

Housekeeping genes maintain robust expression across cell types despite dynamic transcription factor fluctuations, yet their haploinsufficiency is associated with many tissue-specific developmental di...

High-spatial-resolution observations of the solar photosphere reveal a far more complex and dynamic solar scene than previously observed and show that ubiquitous Kelvin–Helmholtz instabilities drive plasma mixing on the Sun.

Using a combination of microglia-specific conditional mouse knockout and knockin approaches and xenotransplantation of human iPSC-derived microglia, Diaz-Salazar et al. demonstrate that the human-spec...

Rebuilding DivRef so CRISPR off-target searches can account for human variation

This study introduces iChIP2, a low-input chromatin immunoprecipitation followed by sequencing method that profiles histone post-translational modifications (hPTMs) simultaneously across diverse eukar...

Admixture between modern humans and extinct hominins has shaped the genomes of present-day individuals, but reconstructing this history has been constrained by the scarcity of archaic samples and unad...

Knowledge of the spatial location of a gene is necessary to understand its epigenomic regulation.

Wendy Valencia-Montoya, a Junior Fellow in the Harvard Society of Fellows affiliated with the lab of MCB Professor Nick Bellono, has been awarded two of the most coveted […]

Abstract. Multiple Sequence Alignment (MSA) is a key step in phylogenetic analysis and is prone to error. Unfortunately, algorithms that remove likely alig

Federal agencies that terminated more than a thousand research grants at the University of California last year admitted that they used keywords related to diversity, gender, vaccine hesitancy and COV...

Certain shallow-water species carry a mutation that reduces translation errors and prevents toxic protein buildup

Publisher denies a bot was to blame for withdrawing famed physicist’s work

Deep-learning models typically require large parameter spaces and extensive training data. Here the authors demonstrate that learning the fundamental biological rules of RNA base pairing can be achiev...

IU Biology news: The IU Stock Center maintains thousands of documented, living genetic strains of Drosophila melanogaster, a small fruit fly that has served as one of science’s most powerful tools for...

Imagine an American organization that convenes scientific experts not to advance any ideology or interest but to provide the nation with a clear understanding of complex problems. Imagine this body wo...

Miller, a saxophonist, discusses how he bridges math and music and his upcoming performance at the Brooklyn Public Library’s Night in the Library: The Philosophy of Mathematics.

This link will take you to a page that’s not on LinkedIn

Author summary Proteins fold into three-dimensional structures that are essential for their function. Because these structures depend on interactions among amino acids, the fitness effect of a mutatio...

Abstract. Many long-standing questions in population genomics can now be addressed through comparative analyses and by leveraging the vast amount of genomi

Nature - SIRT7 safeguards X-chromosome integrity and dosage balance with autosomes.

Although research has bipartisan support in the US Congress, and trust in science is above 75% across the country, the Trump administration seems as determined as ever to mortally wound the nation’s s...