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Simon McArthur

@drsimonmcarthur.bsky.social
1.5K followers 351 following 48 posts

Neuropharmacologist at Queen Mary, University of London, studying how diet, the gut/oral #microbiota and their products affect the #brain & #Alzheimer's disease (he/him) 🏳️‍🌈🇪🇺

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Simon McArthur @drsimonmcarthur.bsky.social · 28/08/2026
Happy to share our latest publication! 🧪🧠 doi.org/10.1111/ejn.... We found that brief, repeated isoflurane anaesthesia, a common feature of many longitudinal preclinical studies, can induce significant behavioural, vascular and neuroimmune effects in adult mice...
doi.org
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Queen Mary University of London @qmul.bsky.social · 03/08/2026
Queen Mary has received a £1.3m Wolfson Foundation grant to establish a Health and Pollution Research Hub. Led by Dr Vahitha Abdul Salam and Dr Abish Stephen, the Hub will explore how pollution impacts health. Read more: www.qmul.ac.uk/news/latest-...
qmul.ac.uk
Queen Mary awarded prestigious grant to better understand links between pollution and health
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Chemistry World @chemistryworld.com · 16/07/2026
Science sleuths say the doctored Western blots uncovered so far are likely the ‘tip of the iceberg’ and greater transparency & accountability is needed moving forward. @elisabethbik.bsky.social @reeserichardson.bsky.social @sholtodavid.bsky.social www.chemistryworld.com/news/thermo-...
chemistryworld.com
Thermo Fisher antibody data manipulation is a breach of trust, say researchers
Science sleuths say the problem is impacting research progress and Thermo's response falls short
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Cristina Legido-Quigley @legidoquigley.bsky.social · 15/07/2026
Our latest paper is out, looks at hormones in Alzheimer's Disease please see as open access publication link.springer.com/article/10.1...
link.springer.com
Steroid hormones in Alzheimer’s disease: a molecular analysis of blood and cerebrospinal fluid - Alzheimer's Research & Therapy
Background Alzheimer's disease (AD) disproportionately affects women, yet existing studies have been limited to single biofluids, individual hormones, or single dementia subtypes, leaving sex-stratifi...
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medRxivpreprint @medrxivpreprint.bsky.social · 06/07/2026
Integrated epidemiology and toxicology reveals the protective effects of TMAO against chemical neurotoxicity in children www.medrxiv.org/content/10.64898/20…
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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 06/07/2026
TMAO is a major component of fish. It protected against effects of mercury (a common environmental contaminant of fish) in our in vitro model. /5
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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 06/07/2026
In a 3D in vitro human cell model, TMAO activated synaptogenesis-related gene expression. /4
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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 06/07/2026
Cohort study of childhood mental health (N=1,203) - TMAO was associated with fewer internalising problems. Its precursor microbial metabolite trimethylamine was associated with more behavioural problems in the cohort and an independent longitudinal study from 1-15 years of age (N=630-820). /3
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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 06/07/2026
Our previous work showed that TMAO supplementation protects the blood-brain barrier in vitro (human cells) and barrier function and cognition in vivo (mice). Here we show the positive neural effects of TMAO extend to humans. /2
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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 06/07/2026
First of our (@drsimonmcarthur.bsky.social) papers from the ATHLETE exposome study. Integrated epidemiology and toxicology reveals the protective effects of TMAO against chemical neurotoxicity in children /1
medrxiv.org
Integrated epidemiology and toxicology reveals the protective effects of TMAO against chemical neurotoxicity in children
Interest in microbiota-host co-metabolism and the effects of its derived co-metabolites on biological processes is increasing rapidly. In addition to their demonstrated associations with mammalian met...
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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 06/07/2026
Our new findings emphasise the importance of interdisciplinary approaches to evaluate associations and potential pathways of microbiota-host co-metabolites (endogenous) and environmental (exogenous) metabolites on neurodevelopment in #exposome studies. #microbiome #gutbrainaxis
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Caroline Menard @caromenard666.bsky.social · 17/04/2026
Excited to share the latest one from the lab led by José Solano @jolusolo.bsky.social who explored how early life #stress impacts the mouse 🐭 brain 🧠 vasculature Science 🧪🔬 can be surprising & 2x stress can induce beneficial adaptations leading to resilience, phew! www.biorxiv.org/content/10.6...
biorxiv.org
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Science X / Phys.org @sciencex.bsky.social · 01/04/2026
New findings indicate that blood markers linked to gut bacteria may help identify early cognitive decline, potentially enabling earlier detection of dementia before symptoms appear. doi.org/hbvkm7
medicalxpress.com
Simple blood test could spot dementia years earlier, research shows
A blood test could help identify people at higher risk of cognitive decline years before a traditional diagnosis is possible—according to University of East Anglia research published in the journal Gut Microbes.
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Simon McArthur @drsimonmcarthur.bsky.social · 30/03/2026
Excited to present our latest paper, led by @dvauzour.bsky.social and Dr Emily Connell. We have promising data showing that a pattern of microbe-derived metabolites can distinguish early stage cognitive impairment in humans. doi.org/10.1080/19490976.2026.2649487 🧪🧠🦠 #microbiome #gutbrainaxis
doi.org
Circulatory dietary and gut-derived metabolites predict early cognitive decline
A key component of disease prevention is the identification of at-risk individuals. Microbial dysbiosis in the early stages of cognitive decline and Alzheimer's disease (AD) and can modulate the le...
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Dr David Vauzour @dvauzour.bsky.social · 30/03/2026
Key takeaway: 🧠 Shifts in “good” vs “toxic” metabolites may signal early disease risk 🧪 Machine learning identified a 6-metabolite signature 🔬 Potential pathway toward non-invasive screening tools @ueamedical.bsky.social @uniofeastanglia.bsky.social @ukgibanetwork.bsky.social
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Dr David Vauzour @dvauzour.bsky.social · 30/03/2026
What if a simple blood test could help detect early cognitive decline? Our latest study shows that microbe-derived metabolites shaped by the gut microbiome can distinguish early-stage cognitive impairment with promising accuracy.
tandfonline.com
Circulatory dietary and gut-derived metabolites predict early cognitive decline
A key component of disease prevention is the identification of at-risk individuals. Microbial dysbiosis in the early stages of cognitive decline and Alzheimer's disease (AD) and can modulate the le...
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QMUL Centre for Psychiatry & Mental Health @qmulpsychiatry.bsky.social · 24/02/2026
@qmul.bsky.social @bartscharity.bsky.social Doctoral Training Programme - five fully funded 4 year PhD Studentships in Biomedical Research. Closing date for applications: Monday March 16th 2026 Please share - more info here: www.findaphd.com/phds/program...
findaphd.com
FindAPhD : Queen Mary University of London: Barts Charity Doctoral Training Programme at Queen Mary University of London
Apply for a PhD: Queen Mary University of London: Barts Charity Doctoral Training Programme at Queen Mary University of London
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Simon McArthur @drsimonmcarthur.bsky.social · 24/02/2026
Fully Funded PhD Studentship Opportunity (4 years) at Queen Mary, University of London Why is gum disease a risk factor for dementia? Come and help us find out! 🗓 Application deadline: 15th May 2026 Apply here: tinyurl.com/4xvdzpjs Please share! #Microbiome #Dementia #neuroskyence 🧪 1/3
tinyurl.com
Oral–systemic links: periodontal microbes and the blood-brain barrier at Queen Mary University of London on FindAPhD.com
PhD Project - Oral–systemic links: periodontal microbes and the blood-brain barrier at Queen Mary University of London, listed on FindAPhD.com
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Simon McArthur @drsimonmcarthur.bsky.social · 13/01/2026
Very pleased this is now published - led by Dr Emily Connell & @dvauzour.bsky.social, we show that a Mediterranean diet-inspired supplement can improve disease signs in an Alzheimer's mouse model, acting via the gut microbiota www.tandfonline.com/doi/full/10.... 🧪🧠 #gutbrainaxis #meddiet
tandfonline.com
A novel Mediterranean diet-inspired supplement reduces hippocampal amyloid deposits and microglial activation through the modulation of the microbiota gut-brain axis in 5xFAD mice
Alzheimer's disease (AD) is projected to increase in prevalence, heightening the need for strategies to alleviate its neuropathological burden. The bioactive constituents of a Mediterranean-style d...
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UK GIBA Network+ @ukgibanetwork.bsky.social · 19/12/2025
🚨 GIBA Network+ Fellowships now open! We are funding early-career awards, up to £500k each, for ambitious, interdisciplinary research on gut-immune-brain axis (GIBA) mechanisms across the life-course. 🗓️ Apply by 15 April 2026 👉 www.giba-uk.org/funding-oppo...
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UK GIBA Network+ @ukgibanetwork.bsky.social · 24/11/2025
How does your Christmas Dinner shape your gut, brain and immunity? 🎄🍽️ Join us for Feast for Thought – a festive deep dive for all with short talks and questions on food & health! 📅 11th Dec, 7pm-8pm 🎟️ Book now: feast-for-thought.eventbrite.com #GutHealth #BrainFood #ChristmasDinner
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Ran Blekhman @blekhman.bsky.social · 19/11/2025
I wrote about the recent autism-microbiome paper, why I think it's the most important microbiome paper this year, and what it says about the field open.substack.com/pub/blekhman...
open.substack.com
The Autism-Microbiome Hypothesis Is Falling Apart
Why this new review paper should be required reading for every microbiome researcher
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Mindy Weisberger @laminda.bsky.social · 17/11/2025
You're a parasitic ant queen eyeing the colony of another species. You have a simple plan: 1. Hide your scent by rubbing workers on your body 2. Infiltrate the nest 3. Spray the queen with chemicals that goad her daughters into tearing her to bits 4. All hail the usurper! (my latest for CNN) 🧪
cnn.com
Parasitic ant queen chemically manipulates workers into killing their mother | CNN
Scientists newly described how a parasitic ant queen infiltrates another ant species’ colony and tricks the workers into killing their mother.
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Willem van Schaik @wvschaik.bsky.social · 16/11/2025
Wow 'MHRA-led study reveals major inconsistencies in global microbiome research' www.gov.uk/government/n... 'Species identification varied from 63% to 100% accuracy across different methods, meaning that some laboratories failed to detect a third of the bacterial species present in the sample'
gov.uk
MHRA-led study reveals major inconsistencies in global microbiome research
International collaboration establishes new quality standards to improve reliability of gut health studies – improving accuracy to provide better diagnosis and treatment.
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Dr Farbod @emergencybod.medsky.social · 15/11/2025
I came to this country as a child refugee. No English, no certainty, no idea what my life could become. Britain gave me refuge. Not on a timer, not with conditions attached, but with a chance to grow roots. A thread 🧵 1/8 www.bbc.co.uk/news/article...
bbc.co.uk
UK set to limit refugees to temporary stays
Shabana Mahmood is expected to say the era of permanent protection for refugees is over, in major changes to the UK's asylum and immigration system.
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The i Paper @theipaper.com · 14/11/2025
Claims that autism could be caused by problems with the gut microbiome have caught media attention but some microbiologists are sceptical trib.al/fgv5oLv
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Cell Press @cellpress.bsky.social · 13/11/2025
The link between the gut #microbiome and autism is not backed by science, researchers say. Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA @wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social
First page of Opinion piece: "Conceptual and methodological flaws undermine claims of a link between the gut microbiome and autism"
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Aimee Parker @parker-aim.bsky.social · 14/11/2025
Two postdoc positions open now: let's work together to understand microbial regulation of the gut-brain axis in ageing: buff.ly/UuJciHZ buff.ly/vjp98fx
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Kevin Mitchell @wiringthebrain.bsky.social · 13/11/2025
New paper with @statsepi.bsky.social and @deevybee.bsky.social in which we show there's really no evidence for a link between the gut microbiome and autism www.cell.com/neuron/fullt...
cell.com
Conceptual and methodological flaws undermine claims of a link between the gut microbiome and autism
Claims that the gut microbiome causally contributes to autism regularly appear in the scientific literature and popular press. Mitchell et al. critically examine influential studies underpinning these...
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Sean Gibbons 🦠💩 @gibbological.bsky.social · 13/11/2025
📣 Join us for the 2025 @isbscience.org Virtual Microbiome Symposium, focused on "Gut Microbial Metabolites and Their Impact on Host Systems". co-director - @flash-point.bsky.social 🦠💥 It's free, & we have an amazing line-up of speakers! Dec. 12th. Please share! isbscience.org/2025-isb-vir...
isbscience.org
2025 ISB Virtual Microbiome Symposium - Institute for Systems Biology (ISB)
Symposium Schedule All presentation times are shown in Pacific Daylight Time (GMT -07:00 / UTC -07:00) Time Talk / Session 9:00 Welcoming remarks by Sid Venkatesh Session One: Neural Effects
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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 16/10/2025
I enjoyed contributing to the @ilsieurope.bsky.social Healthy Ageing Task Force. Leonie and Thomas have done a great job summarising workshop findings on what's needed to develop nutritional interventions that support healthy ageing. @dvauzour.bsky.social @drsimonmcarthur.bsky.social
sciencedirect.com
Building a roadmap to nutrition for Healthy Ageing: a brief report on the ILSI Europe Healthy Ageing Task Force
At the end of October 2024, ILSI Europe brought together industry and academic experts from different fields to identify research gaps and challenges …
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BK. Titanji @boghuma.bsky.social · 22/07/2025
Y’all. They used dental floss on mice.... for vaccine delivery!!! Not kidding. This is the type of research that keeps me so excited about science and innovation and why we should not be defunding science. www.science.org/content/arti...
science.org
Engineers transform dental floss into needle-free vaccine
New method places inactivated viruses directly into mice’s gums
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Nathan Davies @profnathandavies.bsky.social · 18/07/2025
A great night Wednesday - our first Hub for Dementia in East London (HuDEL) get together. From basic science to psycho-social intervention research our team @qmul.bsky.social cover it all. Hopefully get the whole team together next time too. @qmulpsychiatry.bsky.social @qmul-wiph.bsky.social
linkedin.com
Last night, we convened the first meeting of the Hub for Dementia in East London (HuDEL). | Claudia Cooper
Last night, we convened the first meeting of the Hub for Dementia in East London (HuDEL). HuDEL brings together researchers and clinicians working on dementia across departments and institutions, in...
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John F. Cryan @jfcryan.bsky.social · 07/07/2025
Exciting Senior Scientist 👩‍🔬 👨‍🔬 role available in my research group 🧠 🦠 - Closing date Tuesday 5th August 2025. Please Share @apcmicrobiomeirel.bsky.social @anatneuroucc.bsky.social Full details here my.corehr.com/pls/uccrecru...
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Microbiology Society @microbiologysociety.org · 01/07/2025
Today, Professor Donal Wall, @uofglasgow.bsky.social attended a pitch session as part of the Science, Innovation and Technology Committee's 'Under the Microscope' inquiry to explain why they should be interested in microbiomes.
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Phillip Ayoub @payoub.bsky.social · 28/06/2025
Absolutely incredible turnout for Budapest Pride! So proud of all the organizers, including some old friends, who estimate hundreds of thousands— major embarrassment to Orban
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Nature Microbiology @natmicrobiol.nature.com · 27/06/2025
It's #WorldMicrobiomeDay! 🦠 We are proud to be a part of this exciting research area through contributions by our amazing authors. To celebrate this occasion, here are some of our favourite microbiome papers. Do you have a favourite of yours? let us know in the replies. #MicroSky #MicrobiomeSky
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Microbiota and Host @microbiotaandhost.bsky.social · 04/06/2025
This new review by Anne L McCartney and Lesley Hoyles examines the often overlooked role of Klebsiella bioactives in host-microbiota dynamics. 🔗 Access the full article here: doi.org/10.1530/MAH-24-0011
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Atin Sharma @atinsharma.bsky.social · 13/06/2025
Nature awards and Yakult have announced another round of 'Global Grants for Gut Health'. An excellent opportunity for gut microbiota researchers, at any career stage, to win $100,000 for a year to cover their interesting research! #MicrobiomeSky #MicroSky www.nature.com/immersive/gu...
nature.com
Nature Awards Global Grants for Gut Health
Grants for researchers investigating the gut microbiota and its role in human health.
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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 04/06/2025
Great to see this review out on dietary glucuronides with @drsimonmcarthur.bsky.social, and our lovely colleagues in chemistry at the University of Liverpool. Often thought of as inert chemicals, these glucuronides have wide-ranging biological activity. #microbiomesky
pubs.rsc.org
Dietary substances and their glucuronides: structures, occurrence and biological activity
Covering up to 2025.Plant-derived polyphenols of various chemical classes are widely distributed in dietary substances, e.g. fruits, nuts, vegetables and teas. Such phenolic derivatives are natural an...
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Simon McArthur @drsimonmcarthur.bsky.social · 04/06/2025
Very happy to see this published, with @bugsinyourguts.bsky.social and our colleagues at the University of Liverpool Looking at the biological roles of what are often dismissed as waste - glucuronide conjugates of dietary and gut microbe-derived phenolic compounds pubs.rsc.org/en/content/a...
pubs.rsc.org
Dietary substances and their glucuronides: structures, occurrence and biological activity
Covering up to 2025.Plant-derived polyphenols of various chemical classes are widely distributed in dietary substances, e.g. fruits, nuts, vegetables and teas. Such phenolic derivatives are natural an...
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John Lukens @lukensjohnr.bsky.social · 15/05/2025
JCI - The gut microbiome controls reactive astrocytosis during Aβ amyloidosis via propionate-mediated regulation of IL-17 www.jci.org/articles/vie...
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European Commission @ec.europa.eu · 08/05/2025
Choose Science. Choose Europe. A new Marie Skłodowska-Curie Actions Postdoctoral Fellowships 2025 call is now open. With a budget of €404.3 million, it will support around 1,650 researchers from Europe and beyond. Apply by 10 September → europa.eu/!fBTMgF
A graphic for the Marie Skłodowska-Curie Actions (MSCA), showing a historical portrait of Marie Skłodowska-Curie overlaid with an image of four young researchers walking down a hallway. The European Commission logo is in the top left. Text reads: "Marie Skłodowska-Curie Actions – €404.3 million to support postdoctoral researchers”
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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 24/04/2025
Very pleased to see this review out on host interactions of bioactive molecules produced by Klebsiella spp. #MicroSky
mah.bioscientifica.com
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Politics.co.uk @politics.co.uk · 09/04/2025
“Behind every statistic is a real child, and a real family doing their best to heal wounds that others inflicted”, writes Lib Dem MP @tomgordonld.bsky.social 🗣️ Adoption breakdown in the UK is a silent crisis demanding urgent reform www.politics.co.uk/mp-comment/2...
politics.co.uk
Adoption breakdown in the UK is a silent crisis demanding urgent reform
Adoption is often viewed as the happy ending in a child’s journey through trauma and instability, but for many families across the UK, it marks the beginning of a far more complex and challenging chap...
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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 29/03/2025
This has made @drsimonmcarthur.bsky.social and I laugh this morning (but in a good - and very middle class - way). #gutbrainaxis #IShopAtWaitroseBecause
Waitrose magazine discussing the effects of SCFAs on the gut-brain axis, specifically their protective effects on the blood-brain barrier.
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J. David Jentsch 🏳️‍🌈 @jdavidjentsch.bsky.social · 21/03/2025
Bravo, Society for Behavioral Neuroendocrinology! Thank you to the members who crafted this important statement. @drglitterbear.bsky.social sbn.org/news/news/wh...
sbn.org
What Are Transgender Animal Experiments and Why Should We Do Them? | Society for Behavioral Neuroendocrinology (SBN)
The Society for Behavioral Neuroendocrinology (SBN) is an interdisciplinary scientific organization dedicated to the study of hormonal processes and neuroendocrine systems that regulate behavior.
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Simon McArthur @drsimonmcarthur.bsky.social · 07/03/2025
From big data and experimental models to clinical trials: Iterative strategies in microbiome research: Cell www.cell.com/cell/fulltex...
cell.com
From big data and experimental models to clinical trials: Iterative strategies in microbiome research
For microbiome research to be translated into clinical applications, the field needs to move beyond correlational studies; we suggest adopting a multi-phase iterative approach that leverages in vivo a...
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Caroline Menard @caromenard666.bsky.social · 27/02/2025
So excited to share the work of the fantastic Katarzyna, 1st 🧪PhD student of my lab 🧠, out in @natureneuro.bsky.social 🥂🥳 Cheers to the team, thanks to our precious collaborators and support from @braincanada.bsky.social #CIHR @fondsrechercheqc.bsky.social #newPI www.nature.com/articles/s41...
nature.com
Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood–brain barrier alterations - Nature Neuroscience
The mechanisms of neurovascular adaptations underlying stress resilience remain unclear. Here the authors show that the astrocytic endocannabinoid system modulates the blood–brain barrier changes duri...
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