High-resolution spatial transcriptome analysis of a human embryo at Carnegie stage 6 reveals three distinct developmental trajectories from the epiblast towards amnion, primitive streak and axial meso...

Van Nerum et al. show that dimethyl α-ketoglutarate enhances the production and functional maturation of human trophectoderm-like cells from embryonic stem cells by regulating histone acetyltransferas...

The APC/C ubiquitylates histones to regulate gene expression in pluripotent cells. Here, the authors pair cryo-EM and biochemical and biophysical assays to show that instead of modifying nucleosome-in...

Here, the authors identify that reduced DNA methylation in developing germ cells alters nucleosome retention in sperm and allows H3K4me3 establishment on paternal DNA in early embryos, highlighting a ...

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A cache of precious metal regalia recently discovered in a Lithuanian cathedral sheds light on medieval royalty.

Using epigenome-wide mediation analyses to investigate DNA methylation as a path between adversity and depression, the authors found 31 cytosine–guanine dinucleotides (CpGs) associated with risk and 3...

The paternal preconception environment has been implicated as a modulator of phenotypic traits and disease risk in F1 offspring. However, the prevalence and mechanisms of such intergenerational epigen...

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