This Viewpoint argues that understanding how the brain controls behavior requires an explicitly evolutionary framework. The mammalian brain did not emerge through the replacement of earlier circuits w...

Position DescriptionThe School of Natural Sciences and Mathematics at The University of Texas at Dallas (UT Dallas) seeks to fill multiple open-rank (Full, Associate, or Assistant Professor) tenured/t...

Neuroscience researchers often surgically implant hardware into model organisms to measure and manipulate neural activity. Designing and optimizing th…

Neural mechanisms underlying flexible learning and decision-making are not fully understood. Using single-cell calcium imaging, authors here found that neurons in orbitofrontal and secondary motor cortex exhibit complementary roles in reward learning, with neurons in the former exerting a sustained role in conditions of uncertainty.

Skilled movement often requires flexibly combining multiple subskills, each requiring dedicated control strategies and underlying computations. How the motor system achieves such versatility remains u...

Human exploration is driven by two distinct neural mechanisms, a valence-independent rate signal and a valence-dependent global noise signal.

Extensive measurements of visual selectivity in the fly optic lobe enable a broad assessment of connectome-based functional predictions. Strong connections possess an outsized share of the connectome’...

When choosing between options with multiple attributes, the orbitofrontal cortex (OFC) is thought to integrate across those attributes, aiding in value comparisons. This study shows in monkeys that OF...

The last twenty years have seen multiple methodological revolutions in the philosophy of science: There has been increased diversity concerning the questions...

Following up on yesterday’s whinesplaining about the relative difficulty of getting a NIH grant across pertinent career eras, I had some more thoughts on generational expectations and gasligh…

Single-cell transcriptomic analysis of mouse hypothalamus and behavioural experiments show that specific hypothalamic networks regulate conflicting feeding versus parenting behaviours of female mice.

Recent advances in neuroscience have revealed how neural population activity underlying behavior can be well described by topological objects called neural manifolds. Understanding how nature, nurture...

Characterising the mechanisms underlying naturalistic defensive behavior remains a significant challenge. While substantial progress has been made in …

Adaptive decision-making often requires an understanding of our agency in a situation; however, chronic stress can disrupt agency and promote inflexible, habitual behaviour by turning off a brain path...

Voltage-gated ion channels (VGICs) are pivotal in regulating electrical activity in excitable cells and are critical pharmaceutical targets for treating many diseases including cardiac arrhythmia and ...