iiinova — where your digital self keeps evolving

Nicolas Chiaruttini @nkiaru.bsky.social · 28/09/2026

So, will intellectual work be done purely for sport in the future, human vs human? Here's 3b1b's quick take: youtu.be/9HlIuxnuTKQ?...

youtu.be

What now for Mathematics (with 3Blue1Brown) - Numberphile

YouTube video by Numberphile

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Science Étonnante @scienceetonnante.com · 16/09/2026

Le 02 octobre à l'occasion de la Fête de la Science, j'interviendrai à l'Isart Digital pour parler de "sciences & jeux vidéo" ! Ca aura lieu à 18h. J'espère vous y voir nombreuses et nombreux ! Il faut s'inscrire par ici: www.eventbrite.fr/e/isart-digi...

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John C. Baez @johncarlosbaez.bsky.social · 12/09/2026

AI alignment.

A Nancy comic strip:

https://mathstodon.xyz/@nancycomics@mastodon.social/117258763311864862

P1- FRITZI HEARS A SQUEEK COMING FROM THE KITCHEN

P2- FRITZI CATCHES NANCY GETTING COOKIES FROM A CABINET IN THE KITCHEN

FRITZI: IN THE COOKIE CLOSET AGAIN--GO STAND IN THE CORNER FOR AN HOUR

P3- NANCY IS STANDING IN THE CORNER

FRITZI: I DON'T WANT THAT EVER TO HAPPEN AGAIN

NANCY: IT WON’T

P4- LATER WE SEE NANCY OILING THE HINGES ON THE KITCHEN CABINETS

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Terence Tao @teorth.bsky.social · 11/09/2026

A group of 25 Fields Medalists, including myself, have made a joint declaration on Math and AI: mathandai.org . We welcome additional signatories. See also this article in the Economist announcing the declaration: www.economist.com/science-and-...

mathandai.org

Declaration — Math and AI

Read the declaration and add your name.

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Baukje Hoogenberg @baukjeje.bsky.social · 11/09/2026

Do you want to label the nuclear envelope? Do you work on a non-model species? Try Concanavalin A! We tested ConA on various species across the eukaryotic tree and find it is a very useful ExM-compatible marker for the NE and ER. Read all about it in our preprint: www.biorxiv.org/content/10.6...

biorxiv.org

Concanavalin A as a pan-eukaryotic nuclear envelope marker for expansion microscopy

Across eukaryotes, the nuclear envelope exhibits distinct remodelling strategies during mitosis: complete breakdown (open mitosis), partial disruption (intermediate), or full retention (closed). Howev...

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Felix Mikus @fmikus.bsky.social · 11/09/2026

Are you interested in the nuclear envelope and are still lacking a dye for it? Try the lectin concanavalin A in #U-ExM! Together with @baukjeje.bsky.social, @gautamdey.bsky.social and @dudinlab.bsky.social and many collaborators sharing species with us we explored the versatility of this dye

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Nicolas Chiaruttini @nkiaru.bsky.social · 08/09/2026

Love Claude's roast: "That's a sharper question than it looks"

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Nicolas Chiaruttini @nkiaru.bsky.social · 30/08/2026

Found on reddit - pretty good read: www.math.brown.edu/reschwar/Sto...

math.brown.edu

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Nicolas Chiaruttini @nkiaru.bsky.social · 23/08/2026

Anybody has any good resources to suggest about teaching and AI ? Conferences, books ? I really enjoyed this: www.youtube.com/watch?v=0xS6..., but maybe it's because it says there's not much to change.

youtube.com

Veritasium: What Everyone Gets Wrong About AI and Learning – Derek Muller Explains

YouTube video by Perimeter Institute for Theoretical Physics

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Nicolas Chiaruttini @nkiaru.bsky.social · 21/08/2026

I wanted to believe a bit, but it's over. Mistral is not fighting to make frontiers models anymore. (in French) www.journaldunet.com/intelligence...

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Nicolas Chiaruttini @nkiaru.bsky.social · 05/08/2026

Just saw Claude applying some affine transforms and using the good old trick of testing all composition order + inverse until it falls right. Human after all.

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Nicolas Chiaruttini @nkiaru.bsky.social · 30/06/2026

Anybody with some old Leica DM-IL filter cubes (GFP + mCherry) lost in a drawer willing to sell them or exchange against a good bottle ?

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Nicolas Chiaruttini @nkiaru.bsky.social · 23/06/2026

Took me 3 weeks to realise there's no curly brackets on my keyboard. Ok. Indeed AI writes it all. Scary.

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Nicolas Chiaruttini @nkiaru.bsky.social · 01/06/2026

New chapter: I've joined @sciencesunige.bsky.social as an image analyst, supporting six labs across cell biology and biophysics. Bring on the microscopy and the challenging datasets!

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Andrew G. York @andrewgyork.bsky.social · 29/04/2026

Meet MagLuc: a magnetically-controlled luminescent protein. This is a foundational tool for remote control of biological processes, also known as "magnetogenetics". Can you tell when the magnetic field turns on and off? From @mariaingaramo.bsky.social and the team at @nonfictionlabs.bsky.social

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Nicolas Chiaruttini @nkiaru.bsky.social · 03/05/2026

Unhinged Claude: "That reframes your installer question. You're not packaging an app for grandmothers." Well, I like well-packaged app. I guess I'm a grandfather now.

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Dani Beck, PhD @danibeck.bsky.social · 17/04/2026

Absolutely butchering my manuscript in order to appease my reviewers. It's like playing jenga, but in addition to removing vital structural integrity, you add completely random shit like a cactus here, a dildo there, some hippo turd on the side, and sprinkle it all with dead bees. ta-da, science.

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Eugene Katrukha 🇺🇦 @ekatrukha.bsky.social · 31/03/2026

The new release of #BigVolumeBrowser (0.1.0) finally adds animation render functionality to it, plus some other navigation improvements and bug fixes. Here is a movie I've made for the microtubule network (via ExM) in different cell types. Contact me if you want it for educational/research purposes.

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Nicolas Chiaruttini @nkiaru.bsky.social · 20/03/2026

Converted my old elastix + transformix Java wrapper to use the appose.org approach with Opus. Total cost? $12. Worth it.

appose.org

APPOSE | Homepage

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Nicolas Chiaruttini @nkiaru.bsky.social · 15/03/2026

I retried this given the claimed new capabilities of Claude for (interactive) sketches. Better, but we're not there yet (look at the v0 tangent:

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Nicolas Chiaruttini @nkiaru.bsky.social · 10/03/2026

👏 and so happy to see the task progress bar being used!

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Nicolas Chiaruttini @nkiaru.bsky.social · 02/03/2026

Appose processing hackathon with @jytinevez.bsky.social, @ctrue.bsky.social, @gaellel.bsky.social, @strigaud.bsky.social, Carlos and Thomas . Simple POC with Java calling python through Appose to flip blocks. Promising!

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Nicolas Chiaruttini @nkiaru.bsky.social · 22/02/2026

YouTube's real genius: get companies to pay for ads so annoying that users end up paying Google directly to remove them. Brands fund their own irrelevance.

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Nicolas Chiaruttini @nkiaru.bsky.social · 02/02/2026

Smashing console logs (which are not errors) -> very dumb bottleneck 😅.

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Nicolas Chiaruttini @nkiaru.bsky.social · 30/01/2026

Claude code flexing: ---- For your case with uniform TIFFs on network storage, lazy validation would transform a multi-hour init into seconds. The validation cost is amortized across actual reads. ---- Let's see if that's true!

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Nicolas Chiaruttini @nkiaru.bsky.social · 24/01/2026

Is there a way to sync claude code with git: if I switch branch or checkout an older commit then the discussions revert to their states at these previous points / branch ?

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Reposted by Nicolas Chiaruttini

Omaya Dudin 𓂆 ¦🍉¦🦠¦🔬¦ @dudinlab.bsky.social · 16/01/2026

📢 Open faculty position – Origins of Life We have an opening in our section at the University of Geneva! 🧬🚀 SPREAD THE WORD Apply here: jobs.unige.ch/www/wd_porta...

media.tenor.com

a woman says " would you like to join us " with her eyes closed

ALT: a woman says " would you like to join us " with her eyes closed

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Nicolas Chiaruttini @nkiaru.bsky.social · 13/01/2026

"Resist the empire building" Too late! Here's the dependency graph of packages developed at the BIOP for ABBA (go.epfl.ch/abba) (except clij and labkit)

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Nicolas Chiaruttini @nkiaru.bsky.social · 08/01/2026

A bit late to the party but 🤯 by Claude code.

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Nicolas Chiaruttini @nkiaru.bsky.social · 06/01/2026

Are there any rankings of LLM capabilities by language? My intuition is: more verbose and grammatically strict languages would perform better.

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Yongdeng Zhang @yongdengzhang.bsky.social · 21/11/2025

We are happy to share our latest work, 4Pi-SIMFLUX, which combines structured illumination with interferometric detection to achieve near-isotropic 3D localization precision of 2–3 nm and resolve sub-10 nm structural features across whole mammalian cells. www.nature.com/articles/s41... rdcu.be/eQVxt

nature.com

4Pi-SIMFLUX: 4Pi single-molecule localization microscopy with structured illumination - Nature Methods

4Pi-SIMFLUX is a single-molecule localization microscopy approach that achieves a near-isotropic resolution below 10 nm in whole mammalian cells.

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Nicolas Chiaruttini @nkiaru.bsky.social · 19/11/2025

Diving into video editing to update ABBA's tutorial. CapCut's free version is pretty great! (Now I will need to make peace with the sound of my own voice). Here's a preview:

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Will Scott @wsctt.bsky.social · 17/11/2025

Our new paper is published in the Journal of Chemical Biology! 🏮 We share StayRose, a red version of StayGold 🏮 StayRose has an unnatural amino acid-based chromophore, and has the same immense photobleach-resistance as StayGold 💡

jbc.org

StayRose: A photostable StayGold derivative redshifted by genetic code expansion

Photobleaching of fluorescent proteins often limits the acquisition of high-quality images in microscopy. StayGold, a novel dimeric GFP recently monomerized through sequence engineering, addresses thi...

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Eugene Katrukha 🇺🇦 @ekatrukha.bsky.social · 10/10/2025

LUT color mapping for spots/particles rendering in #bigvolumeviewer is almost finished. The speed is mapped by color (middle) and color + spot size (right).

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Nicolas Chiaruttini @nkiaru.bsky.social · 07/10/2025

#QuPath + Imglib2 and #BDV ❤️ Promising start! (Mainly Léo and Pete's work github.com/qupath/qupat... + a small addition)

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Nicolas Chiaruttini @nkiaru.bsky.social · 07/10/2025

I managed to make #ABBA work with a white background and dark mode! #FijiSc #BDV. Useless for the moment, but I like it.

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Nicolas Chiaruttini @nkiaru.bsky.social · 01/10/2025

Pythonists & bio-image analysts: Any recommendations for a library to add simple metadata (axes names, dimensions, physical units) to a NumPy array? Bonus if it handles slicing gracefully. For instance img[::2, :] updates the output pixel size automatically.

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Journal of Cell Biology @jcb.org · 17/09/2025

Delage, Guilbert, and @frankyates.bsky.social provide a primer on light sheet fluorescence #microscopy to guide biologists through the specific challenges of this 3D imaging technique. rupress.org/jcb/article/... 📕 In #Reproducibility and Best Practices in Cell Biology: rupress.org/jcb/collecti...

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