CHAPEL HILL, NC—Praising it as the definitive treatment of the source material, literary scholars confirmed Monday that Prof.

Bioisosteric replacement is a powerful strategy for optimizing physicochemical, pharmacological, and safety properties of drug candidates. In this article, we provide a bioisosteres cheat sheet comple...

Abstract. The resurgence of targeted covalent inhibitors (TCIs) has expanded the diversity of electrophilic warheads used in drug discovery. TCIs must bala

CHICAGO, IL—Sitting in increasingly tense silence as the third act of “Batman Begins” unfolded on the television screen, Abbvie scientist Dr.

BETHESDA, MD—In an effort to maximize flexibility and ensure taxpayer dollars are allocated responsibly, the National Institutes of Health announced Tuesday that it would transition all research…

An explosion that caused extensive damage to a 20-L rotary evaporator and nearby equipment in a kilo laboratory was determined to have been caused by diazidomethane accumulated in the condenser. Facto...

ALT: Canadian Flag Waving Proudly

By Dr. Rachel Simmons, Postdoctoral Fellow, Stanford University

The Postmedia-Leger survey also found that Canadians think Alberta’s separation would have a greater economic impact than Quebec's.

Recent advances have made possible the replacement of individual atoms within a molecular skeleton while preserving the integrity of the surrounding framework. These skeletal editing reactions are emerging as powerful tools for molecular optimization, as they directly mirror tactics central to structure–activity-relationship studies and therefore have the potential to accelerate progress in discovery chemistry settings. This review introduces a comprehensive framework for categorizing atom replacement reactions in aromatic systems, while also delineating strategies that enable these transformations. Important heuristics related to shape-conservation are discussed, including notions of skeletal rotation, introduction of vestigial substituents, and retrosynthetic simplicity. Examples of reactions which obey these principles are analyzed, focusing first on C-to-N replacement in aromatic systems (“benzene to pyridine” and related reactions) before moving to other classes of aromatic and aliphatic replacement reactions.

Move comes after Roger Innes complained about the government’s prosecution of Chinese postdocs

The first general three-component intermolecular Pd-catalyzed carboamination of conjugated enynes enables the coupling of anilines and aryl triflates to produce functionalized allenic amines, utilizi...

Indole is widely present in pharmaceuticals and natural products. In this work, we report an intramolecular skeletal editing reaction of tryptamine derivatives enabled by photoreaction of a pendant am...

Given the prevalence of nitrogen heterocycles in pharmaceuticals, divergent skeletal editing techniques that enable rapid access to a diverse library of azacycles from a single substrate are highly de...

Medicinal chemistry campaigns routinely require access to series of saturated nitrogen heterocycle (SNH)–based analogs that place nitrogen at different positions to probe structure-activity relationsh...

Radio-Canada’s Enquête program has uncovered fake maple syrup being sold on store shelves in Quebec. The lab responsible for testing maple syrup in Quebec says it’s a first. The producer in question i...

HEIDELBERG, GERMANY — Dr.

Proteolysis-targeting chimeras (PROTACs) represent a transformative strategy in drug discovery, enabling the selective degradation of target proteins …