Nature, Published online: 06 October 2025; doi:10.1038/d41586-025-03193-3 Mary Brunkow, Fred Ramsdell and Shimon Sakaguchi discovered cells that protect the body from autoimmune diseases.

Hyslop et al. identify CD7 as a tissue-specific receptor essential for maintaining terminally exhausted CD8+ T cells during chronic infection. CD7 is highly expressed on a CD101+Tim3low liver-resident...

Fibroblastic reticular cells of the spleen coordinate inflammation for optimal antiviral T cell responses and protective memory.

B cells that give rise to neutralizing antibody responses can be extremely rare in the naive B cell repertoire. Madden et al. show that delivery strategy and adjuvant selection affect the recruitment ...

Circulating memory CD8+ T cells are thought to be highly dependent on interleukin (IL)-7 signaling. Using inducible Il7ra deletion in circulating and tissue-resident memory CD8+ T cell subsets, Jarjour et al. reveal resilience to loss of IL-7 signaling…

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Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)

ID3 defines stem-like T cells with high developmental potential that sustain T cell responses to chronic infection and cancer.

Nature - Precursors of exhausted T cells are preemptively formed in acute infection