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Mitochondria are dynamic organelles that remodel their shape to regulate cell fate. Mitochondrial division involves interactions with the endoplasmic reticulum (ER), lysosomes, and trans-Golgi network...

Dominguez-Martin et al. reveal a link between mitochondria and STING degradation. Fis1 recruits the Rab-GAP TBC1D15 to the mitochondria increasing its affinity for Rab7A. Upon STING activation, TBC1D15 translocates to the Golgi. The absence of the Fis1-TBC1D15 axis hampers STING late-stage trafficking and degradation.

Good Sunday, all! A wonderful summary of papers in #cancermetabolism and #mitochondrialbiology is out. Don't miss it! https://lnkd.in/e__jSvjE Biomed News mitoworld.org #keepreading "How often in li...

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Most of our cells contain mitochondria and rely on them for signaling, information processing, energy transformation, and other essential functions. So when a genetic mutation affects mitochondria, ...

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Cells face a continual metabolic decision: should fatty acids be stored for later, or mobilized and burned for energy? Mitochondria sit at the heart of both processes. Although they are best known for...

Cell-mediated immunity requires cytotoxic CD8+ T cells that adopt and maintain an effector phenotype. Here, D-α-hydroxybutyrate (DAHB) is shown to act as a metabolic adjuvant, driving the conversion of proliferating CD8+ T cells into cytotoxic effector cells by linking mitochondrial ATP production to chromatin remodeling and gene expression.

Das et al. show that succinate regulates mitochondrial protein import through an interaction between Sfc1 (succinate-fumarate carrier) and the Tim23 translocase subunit. In the absence of succinate, Sfc1 associates with Tim23 and reduces protein import. Succinate promotes dissociation of the Sfc1-Tim23 complex, thereby enhancing TIM23 mediated protein translocation into mitochondria.

In their work, Windisch et al. demonstrate the successful adaptation of volumetric 3D printing to photosynthetically active green microalgae-based engineered living materials (ELMs), addressing key fa...

The role of mtDNA integrity in muscle progenitor function remains poorly understood. Sen et al. show that mtDNA alterations in myoblasts impair myogenic differentiation and reshape the mitochondrial p...