iiinova — where your digital self keeps evolving

Reposted by Hannah Kiely-Collins

Jordan Meier @doc-jlmeier.bsky.social · 05/04/2025

Crazy new pre-print from TSRI: fix whole mice, clear them transparent, click on fluorophores, & use light sheet microscopy to visualize where drugs bind throughout the body. Find ibrutinib-yne in low BTK heart & blood vessels, correlates with cardiac side effects. www.biorxiv.org/content/10.1...

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Hannah Kiely-Collins @hannahkielycollins.bsky.social · 30/03/2025

The sun is shining in London for the first day of #ABPP2025 ! Really excited to welcome everyone to the Crick later with an incredible lineup for the first session @abpp2025.bsky.social

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Reposted by Hannah Kiely-Collins

Ryan Potts - real @pottslab.bsky.social · 21/03/2025

🚨 Rational discovery of VHL molecular glues. New Preprint from @amgen.bsky.social Induced Proximity group led by postdoc Jonathan Bushman reports the discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq. Read on for details. 🧵1/8 www.biorxiv.org/content/10.1...

biorxiv.org

Discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq

Targeted protein degradation (TPD) is an emerging therapeutic modality in which small molecules are used to recruit targets to the natural protein degradation machinery of the cell. Molecular glue deg...

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Reposted by Hannah Kiely-Collins

Canadian History Ehx @cdnhistoryehx.bsky.social · 20/03/2025

On this day in 1879, Maud Menten was born in Port Lambton, Ontario. In her work as a medical researcher, she became a leading expert in histochemistry and enzyme kinetics while fighting against sexism in her field. Let's learn more about her life! 🧵1/10

A black-and-white photo shows a woman in a patterned dress with a lace collar and pearl necklace, sitting in a chair. The background features shelves with bottles and a wire basket, suggesting an early 20th-century setting, possibly a pharmacy or study.

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Reposted by Hannah Kiely-Collins

Cheryl Arrowsmith @carrowsm.bsky.social · 02/03/2025

This excellent commentary is a must-read for cancer biologists (and all biologists, really). Probing cancer with small-molecule tools—Progress and challenges: Cancer Cell www.cell.com/cancer-cell/...

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Reposted by Hannah Kiely-Collins

Derek Lowe @dereklowe.bsky.social · 12/03/2025

The first bifunctional protein degrader to deliver Phase III data! It seems to work, but people were definitely expecting more:

science.org

A Bifunctional Degrader Reads Out in Phase 3

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Reposted by Hannah Kiely-Collins

Crick Chemical Biology @crickchembio.bsky.social · 07/03/2025

This week we hosted the inaugural Chemistry at the @crick.ac.uk symposium. Nearly 200 attendees enjoyed great talks from a range of group leaders across chemistry, biology, and translation. Huge thanks to our sponsors Cresset, IDT, Buchi, Merck, Dotmatics, WuXi, MedChem Express, and Enamine

An auditorium full of people looking at a stage with a presenter and a slide saying "Enabling Discovery: Chemistry at the Crick" along with the event sponsors

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Reposted by Hannah Kiely-Collins

Ryan Potts - real @pottslab.bsky.social · 18/02/2025

Happy to share a @nature.com News and Views on the amazing discoveries by @brianliau.bsky.social & Ning Zheng labs on how a molecular glue unexpectedly mimics the effect of cancer mutations. Such cool science and with implications to drug discovery. Check it out. www.nature.com/articles/d41...

nature.com

Molecular glue unexpectedly mimics the effect of cancer mutations

Protein structures could guide the design of molecular glue degraders.

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Reposted by Hannah Kiely-Collins

Sri Kosuri @srikosuri.bsky.social · 08/02/2025

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

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Reposted by Hannah Kiely-Collins

Chris Parker @chrisgparker.bsky.social · 05/02/2025

Check out our recent efforts in chemrxiv to expand the chemical tractability of the proteome through NP-inspired photoaffinity probes chemrxiv.org/engage/chemr...

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