iiinova — where your digital self keeps evolving

Thomas Gorochowski @chofski.bsky.social · 01/10/2026

A great CYBER visit to the Algal Innovation Centre at University of Cambridge to see how some of the approaches and challenges to taking research with photosynthetic organisms out of the lab and towards scale-up and deployment. Excited to see what emerges from the visit! #synbio #engbio @ukri.org

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Thomas Gorochowski @chofski.bsky.social · 22/09/2026

My favourite bit is observing the temporal dynamics of a recombinase cascade split across two plasmids, nicely matching up with a simple dynamic model. Quantitative biology for the win!

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Thomas Gorochowski @chofski.bsky.social · 22/09/2026

Work led by the unstoppable Veronica Greco (now COO at CDotBio) with help from @sarah-kay3.bsky.social on the automation side, Shivang Joshi on the cloning, and @sarah-guiziou.bsky.social, @jennbrophy.bsky.social and Claire Grierson on expanding the work from bacteria into plants!

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Thomas Gorochowski @chofski.bsky.social · 22/09/2026

Using recombinases to build robust cross-kingdom genetic circuits? 🧬 Need to know what they are *actually* doing? We got you covered! In the latest from the lab, we show the power of nanopore sequencing for unraveling the inner workings of these circuits. doi.org/10.1038/s414...

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Olivier Borkowski @oborkowski.bsky.social · 21/09/2026

Characterization of recombinase-based genetic parts and circuits using nanopore sequencing doi.org/10.1038/s414...

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Sebastian S. Cocioba @atinygreencell.bsky.social · 05/05/2026

Hey, if anyone wants to support my SpliceCraft project, where proceeds go to paying for Claude Code Max, I set up a Ko-Fi account. No pressure, of course. This project is born free and will remain free forever. TYIA! 💚 ko-fi.com/atinygreencell

ko-fi.com

Buy Sebastian S. Cocioba a Coffee

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Thomas Gorochowski @chofski.bsky.social · 05/05/2026

🤖📚🧪#AI is having such a big impact on #synbio and science more broadly. Check out our latest perspective "Knowledge preservation in the era of big science and AI" on this topic that emerged from a workshop led by Penn Rainford a year or so ago! doi.org/10.1038/s414...

doi.org

Knowledge preservation in the era of big science and AI: strategies for sustainable scientific research - Nature Communications

Science routinely discards valuable knowledge, from unpublished negative results to the tacit expertise lost when researchers move on. Here, the authors propose a roadmap for preserving this hidden kn...

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European Synthetic Cell Initiative @syncelleu.bsky.social · 13/04/2026

New scientific publication by the group of Thomas Gorochowski on DNA synthesis

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Thomas Gorochowski @chofski.bsky.social · 09/04/2026

Work emerged from discussions with the wonderfully creative @adrianwoolfson.bsky.social and Andrew Hessel, with Sim and Thea doing the heavy lifting in the lab. Would love to build a team to take this towards programmable DNA printers and I'm sure doodling plays an interesting role in evolution!

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Thomas Gorochowski @chofski.bsky.social · 09/04/2026

🧬Want to synthesise kilobase-scale DNA? We got you covered!🥳 In latest from the lab we explore the "doodling" capabilities of DNA polymerases and ways to guide the sequences produced. Loads of data + beautiful AFM of the molecules themselves. #synbio ... doi.org/10.1038/s414...

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Olivier Borkowski @oborkowski.bsky.social · 10/03/2026

Analysis and control of untemplated DNA polymerase activity for guided synthesis of kilobase-scale DNA sequences doi.org/10.1038/s414...

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Olivier Borkowski @oborkowski.bsky.social · 05/06/2025

New on @biorxiv!!!!!! We’re excited to share our latest paper on combining cell-free systems and machine learning to express full genome in vitro. Check it out now! 👉 www.biorxiv.org/content/10.1... Catch us at SEED in Houston this June to discuss this work. #CellFree

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Ákos T Kovács @evolvedbiofilm.bsky.social · 25/02/2026

Faculty position in Plant Molecular Biology (Associate Professor or Tenure-Track Assistant Professor) at Aarhus University, Denmark mbg.au.dk/aktuelt/ledi...

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Thomas Gorochowski @chofski.bsky.social · 17/02/2026

A fun (and mostly coherent!) discussion with Ezra Chapman on the intersection of AI and engineering biology. We live in such exciting times and I hope some of that excitement came across. Thanks Ezra for the invite. #engbio #synbio #ai www.youtube.com/watch?v=SC4X...

youtube.com

The Immense Power Of Combining AI With Engineered Biology | Thomas Gorochowski #0037

YouTube video by Curious with Ezra Chapman

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Royal Society Publishing @royalsocietypublishing.org · 05/02/2026

Many microorganisms modify their movement in response to light. This new #JRSocInterface paper has developed an integrated pipeline capable of acquiring temporal imaging data and extracting kinematics to create digital twins: doi.org/10.1098/rsif... @chofski.bsky.social

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Thomas Gorochowski @chofski.bsky.social · 28/01/2026

🫣 Now for something a little different from the lab: a data-centric approach to building digital twins as a route to control of emergent population level behaviours in microbial swarms 🤔 If that means nothing to you, then just check out the video! doi.org/10.1098/rsif... #engbio #control

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Angel Goñi-Moreno @angelgm.eurosky.social · 15/01/2026

Next in Lab's conference agenda: AI, Engineering Biology and beyond. It starts today in Bristol hosted by @chofski.bsky.social. Looks great: aiebab.github.io. From our side, @lewisgrozinger.bsky.social will be talking about our approach to the use of evolutionary algorithms for biocomputation.

aiebab.github.io

AIEBaB-2026

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Elias Najarro @najarro.science · 14/01/2026

In Bristol for the week for the AI, Engineering Biology and Beyond conference hosted by @chofski.bsky.social. Very excited to meet the UK synthbio community. First day hackathon event was a blast!

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Thomas Gorochowski @chofski.bsky.social · 14/01/2026

It's so cute! All credit to Shiv the lead author for devising the name.

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Thomas Gorochowski @chofski.bsky.social · 14/01/2026

Cold and "nippy" 🥶 start to the #AIEBaB26 Hack-a-thon 💻. The students helping with the organisation have done an amazing job in pulling this all together. A big thank you to the @jgibristol.bsky.social and @aibio-uk.bsky.social for the support!

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Thomas Gorochowski @chofski.bsky.social · 14/01/2026

If you work with R6K plasmids for transient DNA delivery, our latest SHARK strains might be of use! Work out at ACS Synthetic Biology led by Shivang Joshi and strains plus plasmids for their assembly will be available @addgene.bsky.social very soon! doi.org/10.1021/acss...

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Thomas Gorochowski @chofski.bsky.social · 06/01/2026

If you are looking to integrate your latest genetic creation into the genome of your favourite bug, you might find our latest review now out in OUP Synthetic Biology useful. 🧬⚒️ Work led by Riesa Rohmat with input from Thea Irvine and Shivang Joshi. #genome #synbio doi.org/10.1093/synb...

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Francesca Ceroni @ceronifranci.bsky.social · 17/12/2025

So you think your mammalian plasmids have nothing to fear from cloning and propagation in E.coli? Quantitative profiling of millions of nucleotides by Tom Copeman will prove you wrong! Supervised with the amazing @proftomellis.bsky.social and AZ, now on BioRxiv: doi.org/10.64898/202...

doi.org

Quantitative profiling of millions of nucleotides reveals sequence-encoded interactions that govern plasmid propagation

Plasmids are central to modern biotechnology, especially therapeutic development, yet their propagation in Escherichia coli remains difficult to predict. Although expression-induced burden is well und...

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Thomas Gorochowski @chofski.bsky.social · 10/12/2025

🚨 Last call for the 'AI, Engineering Biology and Beyond' conference taking place in Bristol on the 15-16 January 2026. There is a limited capacity and some places are still left, but worth signing up soon before the 19th December deadline! Register at: aiebab.github.io

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Thomas Gorochowski @chofski.bsky.social · 10/12/2025

📕My review for Jane Calvert's latest book, 'A Place for Science and Technology Studies' is out in Interdisciplinary Science Reviews! I really enjoyed the stories and learnt so mcuh. Well worth a read if you are interested in the ways that that study of science works: doi.org/10.1177/0308...

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Thomas Gorochowski @chofski.bsky.social · 09/12/2025

End of year Science Bonanza is always something I look forward to, not only for hearing about what the team has been up to all year, but also for the amazing food everyone brings. Christmas has started proper now 🎅

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Thomas Gorochowski @chofski.bsky.social · 02/12/2025

Only available to UK applicants, and did I mention these studentships are part of the TechExpert pilot providing an enhanced annual (tax-free) stipend of £31,000. Do something amazing, and get paid for it!

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Thomas Gorochowski @chofski.bsky.social · 02/12/2025

(PhD 2) Join Heather Whitney, me and others to take plant RNA synthetic biology to a new level. Create new biofacbrication processes to enable the robust and effective RNA delivery to turbo-charge agriculture. 3/4 www.findaphd.com/phds/project...

findaphd.com

Optimising a platform for RNA delivery in plants (Plant BioDesign Bristol project) at University of York on FindAPhD.com

PhD Project - Optimising a platform for RNA delivery in plants (Plant BioDesign Bristol project) at University of York, listed on FindAPhD.com

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Thomas Gorochowski @chofski.bsky.social · 02/12/2025

(PhD 1) Join @PierreBuscaill and me to create SynProm, a modular synthetic biology toolkit for rapid, spatio-temporal monitoring of plant gene activity. Design, test & model synthetic promoters in Nicotiana benthamiana with a focus on plant immunity. 2/4 www.findaphd.com/phds/project...

findaphd.com

SynProm: Fast, Modular Spatio-Temporal Transcriptional Reporters for Plants (Plant BioDesign Bristol project) at University of York on FindAPhD.com

PhD Project - SynProm: Fast, Modular Spatio-Temporal Transcriptional Reporters for Plants (Plant BioDesign Bristol project) at University of York, listed on FindAPhD.com

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Thomas Gorochowski @chofski.bsky.social · 02/12/2025

A couple new #PhD opportunities to join my lab at the intersection of #synbio, #plantsci and #biotech as part of the Plant BioDesign doctoral programme spanning the University of York, University of Cambridge, University of Bristol and John Innes Centre. 1/4

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Thomas Gorochowski @chofski.bsky.social · 02/12/2025

Very excited for this project with @pierrebuscaill.bsky.social! Will bring together a lot of exciting tools we have up and running in the lab for working with diverse biology and put them to use in building new technologies to trace gene expression across plants. 🧬 🔍 Applications open!

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Thomas Gorochowski @chofski.bsky.social · 20/11/2025

The initial lineup of keynotes and spotlight talks is finalised, with 10 contributed talks still up for grabs! Come join us in Bristol on 15-16 Jan 2026 for AI, Engineering Biology and Beyond to shape the future of these fields🤖🧬🦠Register now at: aiebab.github.io

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Thomas Gorochowski @chofski.bsky.social · 22/10/2025

🚨Interested in the intersection of AI and Engineering Biology? 🤖🧬 If so, come join us in Bristol, UK from 15-16 Jan 2026 for the latest instalment of the "AI, Engineering Biology and Beyond" conference! It's going to be a "banger" and registration is open NOW! #synbio #ai aiebab.github.io

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Victor de Lorenzo (CNB, Madrid) @vdlorenzo.bsky.social · 07/10/2025

Université Grenoble Alpes opens a full professorship in microbiology in 2026. The selected candidate will develop their research program on quantitative approaches in microbiology in the Laboratoire Interdisciplinaire de Physique. More info: liphy.univ-grenoble-alpes.fr/en/join-us/r...

liphy.univ-grenoble-alpes.fr

Professorship (tenure) in 'Quantitative approaches in microbiology' (CNU Sections 64/65) | LIPhy - Université Grenoble Alpes

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bioRxivpreprint @biorxivpreprint.bsky.social · 07/10/2025

SHARK: a specialized host for assembling R6K plasmids www.biorxiv.org/content/10.1101/202…

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Olivier Borkowski @oborkowski.bsky.social · 07/10/2025

SHARK: a specialized host for assembling R6K plasmids doi.org/10.1101/2025...

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Thomas Gorochowski @chofski.bsky.social · 07/10/2025

We've been using these strains in the lab for the past couple years and they are super solid. I should also point out this package will include a nice inducible λ-Red system called pREMORA! Big thank you to the supporters of the work including Dstl, BBSRC and @royalsociety.org.

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Thomas Gorochowski @chofski.bsky.social · 07/10/2025

🛠️New tool from the lab! #SHARK🦈: a new strain to support complex cloning of transient R6K expression plasmids – perfect for genome engineering. Work led by the talented Shivang Joshi and all strains and strain assembly tools enroute to Addgene. #synbio doi.org/10.1101/2025...

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Thomas Gorochowski @chofski.bsky.social · 24/09/2025

🥳Excited to share our latest collaborative work using whole-cell models and #AI to design genomes!🦠🧬 What a time to be alive! Project led by Ioana Gherman, with Kieren Sharma, Joshua Rees-Garbutt, Claire Grierson, Lucia Marucci, Wei Pang & Zahraa Abdallah #synbio authors.elsevier.com/sd/article/S...

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Thomas Gorochowski @chofski.bsky.social · 16/09/2025

Very excited to attend and speak at this years #UKOMAIN Multimodal AI workshop at the Barbican. Already learning a lot about emulators and generative models for novel materials.

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Thomas Gorochowski @chofski.bsky.social · 03/09/2025

Email me for further details or apply directly at: www.bristol.ac.uk/study/postgr... but be sure to mention Thomas Gorochowski as supervisor and funding from EPSRC IDLA.

bristol.ac.uk

Start your application

Search for your programme and select it from the dropdown list to see the available start dates. Select apply for your chosen start date to begin your application.

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Thomas Gorochowski @chofski.bsky.social · 03/09/2025

🚨I have a fully funded 4-year #PhD opportunity in my lab on 'Tuneable multi-input genetic logic circuits for designer probiotics'.🦠 We'll be throwing all the tech we have at this one to make reliable engineering of diverse microbes a reality. Applicants must be UK national...

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Thomas Gorochowski @chofski.bsky.social · 01/09/2025

Come and join us at a free complementary Japan-UK Engineering Biology meeting after the main ESSL conference (essl2025.org/). A few spaces left to some see some of the up and coming superstars of #synbio in the UK!

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Thomas Gorochowski @chofski.bsky.social · 12/08/2025

Standard day in Bristol... balloons!

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Thomas Gorochowski @chofski.bsky.social · 12/08/2025

Congrats! I look forward to reading :)

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Thomas Gorochowski @chofski.bsky.social · 07/08/2025

Reading some wonderful old Russian mathematics on automata theory and love this comment that just popped up! Coming from the rural countryside of Somerset, I'm not sure the people quite match this analysis! 🤠

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