Reposted by Jenn Brophy
Turns out the way DNA is packed inside the nucleus can tune the mechanics of the entire cell!
Super excited that our first paper is out in Nature Communications! www.nature.com/articles/s41... !
nature.com
Chromatin decompaction within the nucleus increases plasma membrane tension promoting NETosis execution, independently of transcription - Nature Communications
Chromatin organizes nuclear DNA, but whether it actively regulates whole-cell mechanics remains unknown. Here, we used NETosis to show that chromatin decompaction within the nucleus increases plasma membrane tension and cell volume, establishing chromatin as a regulator of cell mechanics.