Sign in

Francesca Ceroni

@ceronifranci.bsky.social
664 followers 120 following 24 posts

Senior Lecturer @ Chemical Engineering Department, Imperial College London (views are my own)

PostsRepliesMedia
Reposted by Francesca Ceroni
LondonSynbioNetwork @londonsynbio.bsky.social · 10/04/2026
Join us Apr. 16 UCL! Removing Host-Induced Bias in Directed Evolution with Cell-Free Ultra-High Throughput Screening Platform Lise Boursinhac (Cambridge) Deciphering Human Gene Biochemistry at Scale Using Synthetic, Homology-Free DNA Josh Mayne (UCL, Imperial) events.humanitix.com/copy-of-lond...
events.humanitix.com
London SynBio Network 15
London SynBio afterwork talks and networking event on Thursday 16th of April
122
Francesca Ceroni @ceronifranci.bsky.social · 17/12/2025
So you think your mammalian plasmids have nothing to fear from cloning and propagation in E.coli? Quantitative profiling of millions of nucleotides by Tom Copeman will prove you wrong! Supervised with the amazing @proftomellis.bsky.social and AZ, now on BioRxiv: doi.org/10.64898/202...
doi.org
Quantitative profiling of millions of nucleotides reveals sequence-encoded interactions that govern plasmid propagation
Plasmids are central to modern biotechnology, especially therapeutic development, yet their propagation in Escherichia coli remains difficult to predict. Although expression-induced burden is well und...
1118
Francesca Ceroni @ceronifranci.bsky.social · 21/11/2025
Do you want to engineer mammalian protein secretion? We present STAMPS: signal-peptide transformer for tuning mammalian protein secretion! Led by Jacopo in the lab, in collaboration with Cleo Kontoravdi and colleagues at Astra Zeneca, STAMPS is now on Bioarxiv! www.biorxiv.org/content/10.1...
biorxiv.org
STAMPS: Signal-peptide Transformer for Augmenting Mammalian Protein Secretion
While secretion plays a key role in the diverse applications of cell engineering, to date only a handful of mammalian signal peptides have been characterised in depth and systematic efforts to build n...
043
Francesca Ceroni @ceronifranci.bsky.social · 27/10/2025
'Transgene integration in mammalian cells' led by John Fong from the group, is out now! Check it at www.sciencedirect.com/science/arti... Thanks @cp-cellsystems.bsky.social for the opportunity!
sciencedirect.com
Transgene integration in mammalian cells: The tools, the challenges, and the future
Robust and stable expression of genes of interest is crucial for studying and engineering biology. While expressing desired gene products in some micr…
030
Francesca Ceroni @ceronifranci.bsky.social · 06/10/2025
PhD positions available in our group! Please share! www.findaphd.com/phds/project...
findaphd.com
PhD Scholarship project: Engineering biology approaches to mammalian cells at Imperial College London on FindAPhD.com
PhD Project - PhD Scholarship project: Engineering biology approaches to mammalian cells at Imperial College London, listed on FindAPhD.com
023
Francesca Ceroni @ceronifranci.bsky.social · 02/07/2025
Just out: 'Aptamer-based burden biosensors' led by Alice in the lab. Funded by NSF-BBSRC in collaboration with @francolab.bsky.social, we show aptamers cause burden in E.coli. We then develop a burden biosensor for identification of low-burden genetic variants: www.sciencedirect.com/science/arti...
sciencedirect.com
Design of an intracellular aptamer-based fluorescent biosensor to track burden in Escherichia coli
Cell burden impacts the performance of engineered genetic constructs with great interest towards the development of tools to track it and improve biot…
042
Reposted by Francesca Ceroni
Tom Ellis @proftomellis.bsky.social · 30/06/2025
We're hiring for 2 postdocs to work in our lab in London on the newly announced Wellcome Trust SynHG project. If you know people looking to work on big-scale ambitious science like this, please RT and share this with them. Apply by 7/20, interviews in Aug. imperial.ac.uk/jobs/search-...
11934
Francesca Ceroni @ceronifranci.bsky.social · 19/06/2025
Thanks @manishmicrobe.bsky.social and @oborkowski.bsky.social for two wonderful days!
030
Reposted by Francesca Ceroni
Tom Ellis @proftomellis.bsky.social · 10/06/2025
Annalise Zouein's main PhD research paper is published today in Trends in Biotech. Building and using repetitive transcription factor-binding arrays to modulate gene regulation in mammalian cells. No RNA, no protein - just DNA doing the work! www.sciencedirect.com/science/arti...
1238
Francesca Ceroni @ceronifranci.bsky.social · 12/05/2025
Thrilled I am going to be speaking at the Royal Society Theo Murphy Workshop on Generative Biology next October! royalsociety.org/science-even...
royalsociety.org
Generative biology: new approaches to study developmental design principles | Royal Society
Theo Murphy meeting organised by Mr Jake Cornwall-Scoones, Dr Dirk Benzinger, and Professor Sally Lowell.
050
Reposted by Francesca Ceroni
Taylor priest @taylorpriest.bsky.social · 22/04/2025
A huge, new resource for plasmid research - PlasmidScope is a database of 852,000 #plasmid sequences with a rich set of annotations, automated online analysis and interactive visualisation academic.oup.com/nar/article/...
academic.oup.com
PlasmidScope: a comprehensive plasmid database with rich annotations and online analytical tools
Abstract. Plasmids are extrachromosomal genetic molecules that replicate independent of chromosomes in bacteria, archaea, and eukaryotic organisms. They co
312155
Reposted by Francesca Ceroni
Thomas Gorochowski @chofski.bsky.social · 04/02/2025
www.nature.com/articles/s41...
nature.com
Degradation bottlenecks and resource competition in transiently and stably engineered mammalian cells - Nature Communications
Resource competition leads to coupling of co-expressed heterologous genes in mammalian cell lines. Here, the authors highlight the effect of competition for protein degradation on gene expression of t...
101
Reposted by Francesca Ceroni
Nature Biotechnology @natbiotech.nature.com · 31/01/2025
Rearranging mammalian genomes with recombinases to study structural variants at scale provides insights into genome organization and dispensability #NBTHighlight www.science.org/doi/10.1126/... and www.science.org/doi/10.1126/...
science.org
Randomizing the human genome by engineering recombination between repeat elements
We lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to insert recombination handles into re...
0182
Francesca Ceroni @ceronifranci.bsky.social · 03/01/2025
Our work on 'Degradation bottlenecks in mammalian cells' is now out @NatureComms: www.nature.com/articles/s41... Well done to the whole team! You can read this at rdcu.be/d5o2h Happy 2025 everyone!
nature.com
131
Reposted by Francesca Ceroni
Geert De Jaeger’s lab @dejaegerlab.bsky.social · 19/12/2024
Check out our latest pre-print where we used our ASP-#SPARK #sensor to unveil #SnRK1's multifaceted role during #plant growth and #development! bit.ly/49JVZrY Including real-time #spatiotemporal visualization of SnRK1 activity in a growing #Arabidopsis root! 😀
23517
Reposted by Francesca Ceroni
Tom Ellis @proftomellis.bsky.social · 08/12/2024
Latest preprint from Jane (Xinyu Lu) in our group explores what happens when we build a synthetic genome cluster in yeast for Histidine biosynthesis and SCRaMbLE it to see whether selected-for gene rearrangements can guide better design.
0157
Francesca Ceroni @ceronifranci.bsky.social · 05/12/2024
Still time to apply, please share and spread the opportunity!
024
Francesca Ceroni @ceronifranci.bsky.social · 20/11/2024
Great to have @ciaranlkelly.bsky.social presenting the exciting work his group is doing here at Imperial!
130
Francesca Ceroni @ceronifranci.bsky.social · 20/11/2024
NAPIC website is now live!: www.napic.ac.uk
022
Francesca Ceroni @ceronifranci.bsky.social · 13/11/2024
Exciting post doc opportunity: we are seeking a post doc to work with us and @ProfTomEllis on large DNA engineering in mammalian cells funded by @ChanZuckerberg. Come and join us at @ImperialChemEng! Apply at the link below: www.imperial.ac.uk/jobs/search-...
1914