iiinova — where your digital self keeps evolving

Reposted by Young-Pearse Lab

Garrett Fogo @garrettfogo.bsky.social · 29/09/2026

Excited to share our new paper from the @typlab.bsky.social describing interesting new connections between BAG3 and the retromer complex, as well as proteostatic machinery as it relates to Alzheimer’s disease. www.pnas.org/doi/10.1073/...

pnas.org

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

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Young-Pearse Lab @typlab.bsky.social · 21/09/2026

New TYP lab publication is out today! A phenomenal review by @heuerwego.bsky.social, Fasih Ahsan and Tracy providing a thorough overview of human cellular models to study AD lipid biology!

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Young-Pearse Lab @typlab.bsky.social · 19/09/2026

Congratulations to TYP lab postdoc @heuerwego.bsky.social on being awarded a F32 NRSA Postdoctoral Fellowship through the NIA, titled "Identifying the cellular consequences of ABCA7 genetic risk in Alzheimer's disease." Looking forward to more amazing findings from Dr. Heuer's work!

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Young-Pearse Lab @typlab.bsky.social · 29/08/2026

Congratulations to the Young-Pearse lab's newest doctor @gizemterzioglu.bsky.social on her successful PhD defense!!! We are so proud of her!!

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Young-Pearse Lab @typlab.bsky.social · 23/06/2026

We are excited to welcome Nalini Oliver to the lab! We are thrilled that she chose to join our lab for her thesis through Harvard's BBS program and look forward to working with her!

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Young-Pearse Lab @typlab.bsky.social · 20/06/2026

We are happy to welcome Julia Choi to the lab as our newest undergrad! We are also excited to have Arnab Misra and Cecilia Riordan-Bourges continuing their studies in our lab this summer as well!

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Young-Pearse Lab @typlab.bsky.social · 13/05/2026

TYP lab takes Chicago! Grateful for the organizers putting together another great ROSMAP meeting and for the opportunity to share our work! Tracy, our amazing postdoc @garrettfogo.bsky.social and PhD student Olivia Pembridge all gave great talks! #RUSH #ROSMAP

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Young-Pearse Lab @typlab.bsky.social · 13/05/2026

Shoutout graduate student Olivia Pembridge who gave a fantastic talk on her work studying the role of VGF in excitatory neurons at the Annual ROSMAP conference and won the Martha Ondrey Jr. Investigator Award 🏆

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Young-Pearse Lab @typlab.bsky.social · 02/05/2026

Tracy and our fabulous postdoc @kelliannealexa1.bsky.social both gave fantastic talks on their work using IPSC models to study vascular dysfunction in AD at the @jax.org Vascular Contributions to Cognitive Impairment workshop! Thank you to the organizers for such an amazing meeting!

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Young-Pearse Lab @typlab.bsky.social · 01/05/2026

Shout out to our fabulous postdoc @heuerwego.bsky.social who gave a great talk on her work leveraging iPSC models to uncover how genetic risk factors influence dysfunction in microglia in AD at the ACT Research Symposium hosted by the Kaiser Permanente Washington Health Research Institute! #ACT2026

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Young-Pearse Lab @typlab.bsky.social · 18/04/2026

Exciting science from our own Dr. Benoit at the Harvard Bipolar Symposium! Her poster on a population-scale single-cell atlas of peripheral immune cells in bipolar disorder highlights the growing importance of immune mechanisms in psychiatric disease. 🔬

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Reposted by Young-Pearse Lab

Sarah Heuer @heuerwego.bsky.social · 13/04/2026

Very cool to have ABCA7-centric presentations from AD/PD featured by Alzforum, including the work presented by @typlab.bsky.social that I've been working on over the past few years! www.alzforum.org/news/confere...

alzforum.org

Lipids, Lysosomes, and Plaques: How ABCA7 Nudges Up Alzheimer’s Risk | ALZFORUM

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Young-Pearse Lab @typlab.bsky.social · 13/03/2026

Great to attend the BD² Funded Investigators Meeting in Fort Lauderdale with colleagues. We had inspiring discussions, established new collaborations, and the had the opportunity to share our work. We are grateful to be part of a community working to help individuals with bipolar disorder thrive.

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Young-Pearse Lab @typlab.bsky.social · 20/02/2026

Excited to share our labs latest review “Decoding Alzheimer's genetic risk through intercellular communication in the human brain: Lessons from Clusterin” Check it out here: authors.elsevier.com/sd/article/S...

authors.elsevier.com

ScienceDirect.com | Science, health and medical journals, full text articles and books.

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Young-Pearse Lab @typlab.bsky.social · 14/01/2026

We really enjoyed being guests on this episode. Huge thanks to the hosts for a great conversation and for highlighting our work exploring the role of POU3F2 in neurodevelopment!!

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Young-Pearse Lab @typlab.bsky.social · 14/11/2025

Thank you to Jason Meyer and the team at Indiana University for including us in their 2nd Annual Indiana Stem Cell Research Symposium this week!

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Young-Pearse Lab @typlab.bsky.social · 12/11/2025

Thank you to Paul Tesar and Raeka Aiyar for including us in the inaugural Translational Glial Sciences Conference in the Institute for Glial Sciences at Case Western Reserve University School of Medicine. It was a great event!

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Young-Pearse Lab @typlab.bsky.social · 04/11/2025

We're excited to share our new pre-print, where @gizemterzioglu.bsky.social et al. identify SHIP1, the protein encoded by the Alzheimer's disease risk gene INPP5D, as a regulator of endo-lysosome function and selective phagocytosis in human iPSC-derived microglia! www.biorxiv.org/content/10.1...

biorxiv.org

INPP5D/SHIP1 is a dual regulator of endo-lysosome function and selective phagocytosis in human microglia

INPP5D, the gene encoding SHIP1, is genetically associated with Alzheimer’s disease (AD) risk and plays a central role in regulating immune function. Here, we aimed to elucidate the mechanism by which...

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Young-Pearse Lab @typlab.bsky.social · 18/10/2025

Congratulations to Dr. Zach Augur, who successfully defended his PhD thesis on Friday!! Zach had an amazing defense which highlighted his incredible productivity in the lab, culminating in 3 first-author publications throughout his thesis work!

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Young-Pearse Lab @typlab.bsky.social · 15/10/2025

Our study “Genetic and proteomic analysis identifies BAG3 as an amyloid‑responsive regulator of neuronal proteostasis" was published in Acta Neuropathologica this week! Congratulations to lead author Zach Augur, who will be defending his thesis later this week!! link.springer.com/epdf/10.1007...

link.springer.com

Genetic and proteomic analysis identifies BAG3 as an amyloid-responsive regulator of neuronal proteostasis

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Young-Pearse Lab @typlab.bsky.social · 25/08/2025

Best of luck today to @alexlish.bsky.social on her first day at Novartis! We will miss her greatly but look forward to seeing all of the fabulous things she accomplishes in her new scientific endeavors!

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Young-Pearse Lab @typlab.bsky.social · 31/07/2025

Honored to have our work featured!Huge thanks for highlighting our triculture Alzheimer’s model!

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Young-Pearse Lab @typlab.bsky.social · 10/07/2025

Huge congrats to @zacharyrmurphy.bsky.social selected as a 2025 Fujifilm Fellow at @harvard.edu 🎉 The Fujifilm Fellowship Program fully funds PhD students doing groundbreaking work in the life sciences!!

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Young-Pearse Lab @typlab.bsky.social · 13/06/2025

Huge shoutout to our brilliant graduate student @gizemterzioglu.bsky.social for delivering a fantastic talk at the HMS Neurobiology Pizza Talk series! 🍕🧠 She highlighted exciting insights into how SHIP1 shapes microglial function at the intersection of intracellular trafficking and immune response.

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Young-Pearse Lab @typlab.bsky.social · 13/06/2025

🧠 New study led by our talented graduate student Courtney Benoit, uncovers how the autism-linked gene POU3F2 supports brain development by promoting neural stem cell growth via Wnt signaling and key targets like ADNP and SOX13. Check it out here in Brain: academic.oup.com/brain/articl...

academic.oup.com

Validate User

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Young-Pearse Lab @typlab.bsky.social · 12/06/2025

Highlights from our lab at the @keystonesymposia.bsky.social Neurodegeneration meeting! @heuerwego.bsky.social delivered an excellent talk on ABCA7 loss and microglial dysfunction in Alzheimer’s @alexlish.bsky.social presented a great poster on CLU and intercellular communication in Alzheimer’s

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Young-Pearse Lab @typlab.bsky.social · 04/06/2025

Proud of our amazing postdoc @heuerwego.bsky.social 👏 who gave a fantastic talk today on her work leveraging stem cell models 🧫to examine the molecular and functional consequences of Alzheimer's disease genetic risk in microglia today as part of the BWH Neuroscience Seminar Series!

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Young-Pearse Lab @typlab.bsky.social · 04/06/2025

We are proud to celebrate Tracy as the recipient of the Harvard Medical School Clifford Barger Excellence in Mentoring Award! 🎉 Her guidance, encouragement, and dedication mean so much to all of us. Congratulations on this well-deserved honor!

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Young-Pearse Lab @typlab.bsky.social · 03/06/2025

Thrilled to celebrate our incredible undergrad Ellie Grogan, who was awarded the Harvard Hoopes Prize for her exceptional senior thesis! 🏆📖 We’re so proud of her hard work and insight, and a great time taking her out to dinner to celebrate! 🎉🍽️

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Young-Pearse Lab @typlab.bsky.social · 31/05/2025

🎓Congratulations to our incredible grads! 🎉 Dr. Lish and outstanding undergrads Seohyun Kim & Ellie Grogan are officially Harvard alumni! 🥂 We’re so proud of all you’ve accomplished—and can’t wait to see what you do next! 💫 @alexlish.bsky.social

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Young-Pearse Lab @typlab.bsky.social · 30/05/2025

Huge congrats to our Master’s student Emma Karp for receiving the GBM Master Prize from the Society for Biochemistry and Molecular Biology! 🏆🧬 Emma earned it for her work in Biomedical Neurosciences at TUM! 🎓🧠 🔗 gbm-online.de/de/studium-k...

gbm-online.de

GBM-Masterpreis - Homepage der Gesellschaft für Biochemie und Molekularbiologie e.V.

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Reposted by Young-Pearse Lab

Rush Alzheimer's Disease Center @rushalzheimers.bsky.social · 21/05/2025

With the support of Dr. Frank Ondrey, the RADC is pleased to present the Martha Ondrey Postdoctoral Prize to Sarah Heuer, PhD. Dr. Heuer presented on leveraging human stem cells to elucidate how polygenic risk affects cellular state transitions & communication networks in AD.

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Young-Pearse Lab @typlab.bsky.social · 21/05/2025

Big shoutout to our lab at the annual ROSMAP meeting in Chicago! 🎉 @heuerwego.bsky.social gave a great talk & won the Martha Ondrey Jr. Investigator Award 🏆 🧠 @gizemterzioglu.bsky.social crushed it with her presentation on SHIP1 & the inflammasome in microglia!

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Young-Pearse Lab @typlab.bsky.social · 15/05/2025

Excited to see our recent study featured on Alzforum! Thank you for highlighting our new study on how AD risk variants at the CLU locus lower astrocytic clusterin, disrupt neuroimmune crosstalk, and drive synapse loss. Read the full story here!

nam04.safelinks.protection.outlook.com

Alzheimer’s Risk Variants Leave Astrocytes CLUless | ALZFORUM

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Young-Pearse Lab @typlab.bsky.social · 15/05/2025

A big day for the TYP lab! Master's student Emma successfully defended her incredible thesis work today where she's been working with @gizemterzioglu.bsky.social on studying how SHIP1 regulates lysosomal function in microglia. She will be missed!

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Young-Pearse Lab @typlab.bsky.social · 14/05/2025

Some TYP members attended the BIGG meeting at UMass on Monday, and had a great time presenting talks and posters! PhD student @gizemterzioglu.bsky.social & postdoc @kelliannealexa1.bsky.social gave amazing short talks, Master's student Emma & postdoc @heuerwego.bsky.social got great poster traffic!

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Young-Pearse Lab @typlab.bsky.social · 10/05/2025

Tracy gave a great presentation at the 3rd Targeting Therapy of Alzheimer’s and Related Neurodegenerative Disease Conference in Chania, Crete! Huge thanks to Peter St. George-Hyslop, Li-Huei Tsai & Riqiang Yan for an incredible meeting. So many inspiring talks! #TargetAD25

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Reposted by Young-Pearse Lab

alexlish.bsky.social @alexlish.bsky.social · 30/04/2025

Thrilled to share my first first-author paper is out @cp-neuron.bsky.social! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes. Read here www.sciencedirect.com/science/arti...

sciencedirect.com

CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density

Genetic studies implicate clusterin (CLU) in the pathogenesis of Alzheimer’s disease (AD), yet its precise molecular impact remains unclear. Through u…

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Young-Pearse Lab @typlab.bsky.social · 12/04/2025

Congratulations our newly-minted PhD candidate Olivia Pembridge on passing her PQE with flying colors today! Olivia will be using a wide array of iPSC and organoid models to study mechanisms of neurodevelopment!

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Young-Pearse Lab @typlab.bsky.social · 10/04/2025

Congratulations to TYP lab postdoc @kelliannealexa1.bsky.social on an amazing talk at the Cold Spring Harbor Barriers meeting!! Keep a lookout for all the cool work Kellie is doing with iPSC models of the BBB!

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Young-Pearse Lab @typlab.bsky.social · 10/04/2025

Congratulations to TYP lab Postdoctoral Research Fellow @heuerwego.bsky.social on being awarded a @brightfocus.bsky.social Alzheimer's Disease Research Fellowship! Sarah is using iPSCs to determine the cellular impacts of ABCA7 mutations in Alzheimer's disease!

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Young-Pearse Lab @typlab.bsky.social · 10/04/2025

Some members of the TYP lab had a great (and only mildly frigid) outing to Fenway to see the Red Sox play this week!

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Young-Pearse Lab @typlab.bsky.social · 28/03/2025

If you're headed to #ADPD next week, be sure to stop by the TYP lab presentations by @gizemterzioglu.bsky.social and Zach Augur to learn about some of the amazing work the lab is doing!

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Young-Pearse Lab @typlab.bsky.social · 06/03/2025

Proud of our amazing postdoc @kelliannealexa1.bsky.social who gave a fantastic talk today on her work with neuronal hyperexcitability and modeling blood-brain-barrier dysfunction in Alzheimer's disease today as part of the BWH Neuroscience Seminar Series!

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Young-Pearse Lab @typlab.bsky.social · 28/02/2025

Congratulations to the newly minted PhD @alexlish.bsky.social on successfully defending her thesis today! Be on the lookout for all the amazing things to come from Dr. Lish!

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