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CBCB Newcastle

@cbcb-newcastle.bsky.social
368 followers 481 following 34 posts

Centre for Bacterial Cell Biology at Newcastle University. Understanding fundamental bacterial processes to aid medical and industrial applications. www.ncl.ac.uk/cbcb

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Reposted by CBCB Newcastle
LEGEND: Leukaemia EpiGenomic & ENhancer Dysregulation group @ljrusselllab.bsky.social · 06/10/2026
🧬 Research Technician Opportunity 🧬 ​ ​ Looking to contribute to cutting-edge paediatric leukaemia research funded by @cancerresearchuk.org using advanced epigenomics and CRISPR methods?​ ​ The LEGEND group is hiring, join the team! 🔬​ Full details in the link 👇​ bit.ly/3VOQipJ%E2%8... ​
The LEGEND group in the lab, at the Wolfson Childhood Cancer Research Centre, Newcastle University.
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CBCB Newcastle @cbcb-newcastle.bsky.social · 29/09/2026
A great day for CBCB! Big congratulations guys!
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Reposted by CBCB Newcastle
Rachel Darnell @rachel-darnell19.bsky.social · 10/09/2026
A new preprint out doi.org/10.64898/202... exploring the bioenergetics and metabolism of the bacterial pathogen Enterococcus faecalis with some very interesting results! Fantastic work from @olivia-paxie.bsky.social during her PhD!
doi.org
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Prof Paula Salgado @pssalgado.bsky.social · 24/06/2026
Great treat to hear about @cbcb-newcastle.bsky.social history and great science from Jeff Errington #microsky
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Prof Paula Salgado @pssalgado.bsky.social · 08/06/2026
Great to have @carokobras.bsky.social presenting her work on #bacterial strategies against #beta-lactams part of @cbcb-newcastle.bsky.social celebration day!
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Reposted by CBCB Newcastle
Dr Katherine Duncan @kateduncan.bsky.social · 01/05/2026
Please share - full funded (UK students only) PhD studentship in the Duncan lab ‘intergrated ‘omics for accelerated antibtioic dicovery from abyssal actinomycetes’. Co-supervisors @thecopperdoctor.bsky.social, Marcel Jaspars, @zmaw.bsky.social- deadline 20th May www.findaphd.com/phds/project...
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Kevin Whitley @kevindwhitley.bsky.social · 30/04/2026
**PhD opportunity** Join me, @henrikstrahl.bsky.social, and Alistair Brown at @newcastleuni.bsky.social to uncover how Mycobacterium tuberculosis survives antibiotics, one molecule at a time! 🔬🦠 #PhD #microbiology #biophysics #microscopy 📅 Deadline 20 May 2026 (UK home only) RT = 🙏
findaphd.com
Resolving the mechanism of Mycobacterium tuberculosis antibiotic tolerance through single-molecule microscopy at Newcastle University on FindAPhD.com
PhD Project - Resolving the mechanism of Mycobacterium tuberculosis antibiotic tolerance through single-molecule microscopy at Newcastle University, listed on FindAPhD.com
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Reposted by CBCB Newcastle
Lis Lowe @lislowe.bsky.social · 29/04/2026
We have a PhD studentship open! (UK only sadly) but if you are or know a student keen to work on some *really* weird mycobacterial enzymes then get in touch! #glycotime Advert below www.findaphd.com/phds/project...
findaphd.com
Uncovering a new class of toxins in pathogenic mycobacteria at Newcastle University on FindAPhD.com
PhD Project - Uncovering a new class of toxins in pathogenic mycobacteria at Newcastle University, listed on FindAPhD.com
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James Connolly @ruamicro.bsky.social · 29/04/2026
Want to research the basis of how drug resistant bacteria interact with human immune cells? Fully funded 4-year PhD position available (UK home students). Come and join our amazing interdisciplinary team at the intersection of microbiology, immunity, metabolism and the clinic! Please spread the word
findaphd.com
Hiding in plain sight: How a multi-drug resistant pathogen evades detection and killing by human neutrophils at Newcastle University on FindAPhD.com
PhD Project - Hiding in plain sight: How a multi-drug resistant pathogen evades detection and killing by human neutrophils at Newcastle University, listed on FindAPhD.com
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Reposted by CBCB Newcastle
Prof Paula Salgado @pssalgado.bsky.social · 29/04/2026
🧫 #AMR #PhD open @newcastleuni.bsky.social! How does #Cdifficile protein "armour" help it resist antimicrobials? Join me and @henrikstrahl.bsky.social to find out using: 🔬 #Structuralbiology, #microbiology #microscopy #genetics 📅 Deadline 20 May 2026 #PhD #PhDLife Pls share! (UK home only)
findaphd.com
C. difficile S-layer’s role in antimicrobial resistance at Newcastle University on FindAPhD.com
PhD Project - C. difficile S-layer’s role in antimicrobial resistance at Newcastle University, listed on FindAPhD.com
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Reposted by CBCB Newcastle
Charles Winterhalter @winterhalterlab.bsky.social · 29/04/2026
What are the genetic and molecular determinants underpinning the repair of bidirectional replication fork collapse in bacteria? PhD position open in my lab in collaboration with the brilliant @heathmurraylab.bsky.social. Please share and contact me if interested: www.findaphd.com/phds/project...
findaphd.com
Identifying bacterial DNA repair requirements enabling stable genetic inheritance during bidirectional replication fork collapse at Newcastle University on FindAPhD.com
PhD Project - Identifying bacterial DNA repair requirements enabling stable genetic inheritance during bidirectional replication fork collapse at Newcastle University, listed on FindAPhD.com
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CBCB Newcastle @cbcb-newcastle.bsky.social · 30/03/2026
Big congratulations, Marwa Sayed Ahmed (Richard Daniel's lab), for a successful PhD defence! Also, thanks to @gingermicrobe.bsky.social and David Bolam for the examination.
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Reposted by CBCB Newcastle
Henrik Strahl @henrikstrahl.bsky.social · 23/03/2026
Check out our new preprint providing direct in vivo evidence for transertion in Bacillus subtilis (also arguing for coupled transcription-translation). Excellent work by Jonathan Norris, co-supervised by Nikolay Zenkin and me during his PhD. www.biorxiv.org/content/10.6... #microsky
biorxiv.org
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CBCB Newcastle @cbcb-newcastle.bsky.social · 16/03/2026
It's been our great pleasure to host @lalouxlab.bsky.social for a seminar today, and we thoroughly enjoyed learning about Bdellovibrio polarity and polar protein targeting. Such an odd little bacterium!
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CBCB Newcastle @cbcb-newcastle.bsky.social · 23/02/2026
Very happy to host Fred Antson (University of York) today for a seminar! Stunning structures and functional insights into phage/virus capsids and DNA loading.
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Reposted by CBCB Newcastle
heathmurraylab.bsky.social @heathmurraylab.bsky.social · 16/02/2026
www.nature.com/articles/s41...
nature.com
Mechanism and reconstitution of circadian transcription in cyanobacteria - Nature Structural & Molecular Biology
Fang et al. reveal how a bacterial circadian clock turns genes on and off at the right times of day and use the purified proteins to drive circadian gene transcription in a test tube for days.
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Reposted by CBCB Newcastle
Henrik Strahl @henrikstrahl.bsky.social · 14/01/2026
Fabian was quicker :) But yes, we have an open postdoc position in bacterial bioenergetics and membrane biology, using on B. subtilis as the model. Come join us! @cbcb-newcastle.bsky.social is a great place to work, and we are a friendly, international lab. Visa+IHS fees covered. #microsky
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CBCB Newcastle @cbcb-newcastle.bsky.social · 22/12/2025
Happy holidays everyone from a not very wintry Newcastle!
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CBCB Newcastle @cbcb-newcastle.bsky.social · 03/12/2025
Congratulations Laura, the latest CBCB PhD graduate heading for a science career!
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Dr Katherine Duncan @kateduncan.bsky.social · 01/12/2025
Today, we are lucky to have Imane El Meouche from IAME, France to give a MCM seminar @medicalsciencesncl.bsky.social (chaired by @henrikstrahl.bsky.social) on antibiotics tolerance in E. Coli
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CBCB Newcastle @cbcb-newcastle.bsky.social · 28/11/2025
Big congratulations Neha!
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Reposted by CBCB Newcastle
Henrik Strahl @henrikstrahl.bsky.social · 24/11/2025
Now properly published at @natcomms.nature.com with few additional experiments incl. demonstration of Daptomycin's ability to depolarise non-growing cells. See the original preprint-thread for a summary of our findings. www.nature.com/articles/s41... #microsky
nature.com
The last resort antibiotic daptomycin exhibits two independent antibacterial mechanisms of action - Nature Communications
The precise mechanism of action of the antibiotic daptomycin is controversial. Here, Buttress et al. provide evidence for two independent antibacterial mechanisms: membrane depolarisation and inhibiti...
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CBCB Newcastle @cbcb-newcastle.bsky.social · 04/11/2025
Transcription in malaria Plasmodium organelles: Mechanisms and drug targets. Supervised by Yulia Yuzenkova and @nishaphilip.bsky.social. www.findaphd.com/phds/project...
findaphd.com
MRC DiMeN Doctoral Training Partnership: Transcription in malaria Plasmodium organelles: Mechanisms and Drug Targets at Newcastle University on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Transcription in malaria Plasmodium organelles: Mechanisms and Drug Targets at Newcastle University, listed on FindAPhD.com
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CBCB Newcastle @cbcb-newcastle.bsky.social · 04/11/2025
Global pathogen, local impact: Genomic and functional dissection of S. infantis in Peru. Supervised by Matt Bawn and @jomcinerney.bsky.social. www.findaphd.com/phds/project...
findaphd.com
MRC DiMeN Doctoral Training Partnership: Global Pathogen, Local Impact: Genomic and Functional Dissection of S. Infantis in Peru at Newcastle University on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Global Pathogen, Local Impact: Genomic and Functional Dissection of S. Infantis in Peru at Newcastle University, listed on FindAPhD.com
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CBCB Newcastle @cbcb-newcastle.bsky.social · 04/11/2025
Structural and functional analysis of drug resistance in tuberculosis via a novel MmpL3 binding site. Supervised by @mycobacterium-ncl.bsky.social and @kshbeckham.bsky.social. www.findaphd.com/phds/project...
findaphd.com
MRC DiMeN Doctoral Training Partnership: Structural and Functional Analysis of Drug Resistance in Tuberculosis via a Novel MmpL3 Binding Site at Newcastle University on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Structural and Functional Analysis of Drug Resistance in Tuberculosis via a Novel MmpL3 Binding Site at Newcastle University, listed on FindAPhD....
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CBCB Newcastle @cbcb-newcastle.bsky.social · 04/11/2025
Molecular mechanism of slow growth and antibiotic tolerance in Mycobacterium tuberculosis using single-molecule microscopy. Supervised by @kevindwhitley.bsky.social and @mycobacterium-ncl.bsky.social. www.findaphd.com/phds/project...
findaphd.com
MRC DiMeN Doctoral Training Partnership: Molecular mechanism of slow growth and antibiotic tolerance in Mycobacterium tuberculosis using single-molecule microscopy at Newcastle University on FindAPhD....
PhD Project - MRC DiMeN Doctoral Training Partnership: Molecular mechanism of slow growth and antibiotic tolerance in Mycobacterium tuberculosis using single-molecule microscopy at Newcastle Universit...
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CBCB Newcastle @cbcb-newcastle.bsky.social · 04/11/2025
Unexpected role of RNA polymerase in development of Methicillin-Resistance in S. aureus (MRSA). Supervised by Nikolay Zenkin and Simon Foster. www.findaphd.com/phds/project...
findaphd.com
MRC DiMeN Doctoral Training Partnership: Unexpected role of RNA polymerase in development of Methicillin-Resistance in S. aureus (MRSA) at Newcastle University on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Unexpected role of RNA polymerase in development of Methicillin-Resistance in S. aureus (MRSA) at Newcastle University, listed on FindAPhD.com
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CBCB Newcastle @cbcb-newcastle.bsky.social · 04/11/2025
Resensitisation of antibiotic-tolerant Staphylococcus aureus small colony variants. Supervised by @henrikstrahl.bsky.social, @kateduncan.bsky.social, and @mycobacterium-ncl.bsky.social. www.findaphd.com/phds/project...
findaphd.com
MRC DiMeN Doctoral Training Partnership: Resensitisation of antibiotic-tolerant Staphylococcus aureus small colony variants at Newcastle University on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Resensitisation of antibiotic-tolerant Staphylococcus aureus small colony variants at Newcastle University, listed on FindAPhD.com
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CBCB Newcastle @cbcb-newcastle.bsky.social · 04/11/2025
Targeting thioredoxin reductase to combat antifungal resistance in Candida spp. Supervised by @alesdantas.bsky.social, Janet Quinn, and Francesco Del Carratore. @nclfungalgroup.bsky.social www.findaphd.com/phds/project...
findaphd.com
MRC DiMeN Doctoral Training Partnership: Targeting thioredoxin reductase to combat antifungal resistance in Candida spp. at Newcastle University on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Targeting thioredoxin reductase to combat antifungal resistance in Candida spp. at Newcastle University, listed on FindAPhD.com
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CBCB Newcastle @cbcb-newcastle.bsky.social · 04/11/2025
Hiding in plain sight: How multi-drug resistant pathogens evade detection and killing by human neutrophils. Supervised by @ruamicro.bsky.social, Marie Phelan, and @jleslie1.bsky.social. www.findaphd.com/phds/project...
findaphd.com
MRC DiMeN Doctoral Training Partnership: Hiding in plain sight: How multi-drug resistant pathogens evade detection and killing by human neutrophils at Newcastle University on FindAPhD.com
PhD Project - MRC DiMeN Doctoral Training Partnership: Hiding in plain sight: How multi-drug resistant pathogens evade detection and killing by human neutrophils at Newcastle University, listed on Fin...
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CBCB Newcastle @cbcb-newcastle.bsky.social · 04/11/2025
Looking for a PhD opportunity in Microbiology? Consider joining one of the UK's leading microbiology research clusters at Newcastle University. See the thread for MRC DTP studentships currently advertised. @medicalsciencesncl.bsky.social @sagencl.bsky.social @cbcb-newcastle.bsky.social #microsky
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CBCB Newcastle @cbcb-newcastle.bsky.social · 22/10/2025
You were already one of us. Now just under the same roof!
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Reposted by CBCB Newcastle
Stephan Gruber @gruberlab.bsky.social · 09/10/2025
How do SMC complexes load onto DNA to get ready for loop extrusion? @roisnehamelinf.bsky.social & co discovered that Wadjet, an SMC complex involved in bacterial DNA immunity, performs some impressive molecular gymnastics 🤸‍♂️🤸‍♂️🤸‍♂️. Check out the new paper: www.cell.com/molecular-ce...
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CBCB Newcastle @cbcb-newcastle.bsky.social · 07/10/2025
It was great to have Mark visit us today. Many great science discussions and hopefully new collaborations to start!
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Henrik Strahl @henrikstrahl.bsky.social · 22/08/2025
A new methods paper from us, this time with a focus on reliable monitoring membrane potential and cell lysis at different growth stages and cell densities. Also, note the surprisingly high level of background lysis in seemingly healthy B. subtilis cultures. www.biorxiv.org/content/10.1...
biorxiv.org
Monitoring single cell bioenergetic status and cell lysis in dense and differentiating Bacillus subtilis cultures
Bacillus subtilis is a major model organism for studying population heterogeneity in clonal bacterial cultures due to its high genetic tractability and ability to differentiate into subpopulations wit...
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Reposted by CBCB Newcastle
Dr Katherine Duncan @kateduncan.bsky.social · 07/07/2025
Fascinating seminar by Prof @gebhardlab.bsky.social on ‘Building bacterial bridges – How an ancient bacterial trait can help us build the infrastructure of the future’ and visit at @cbcb-newcastle.bsky.social (hosted by @henrikstrahl.bsky.social) #bacillus #spores
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Letizia Marchetti @letimarchetti.bsky.social · 15/04/2025
Don’t miss your chance #Newcastle, tickets for #PINT25 are out! @pintofscience.uk @pintsworld.bsky.social More info for venues and tickets here pintofscience.co.uk/events/newca... Repost appreciated :)
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CBCB Newcastle @cbcb-newcastle.bsky.social · 20/03/2025
The role of membrane perturbations in antibiotic resistant Gram-negative bacteria. Supervised by @davychang.bsky.social, ‬Margarita Staykova, Mark Geoghegan and @adwol.bsky.social. www.findaphd.com/phds/project...
findaphd.com
The role of membrane perturbations in antibiotic resistant Gram-negative bacteria at Newcastle University on FindAPhD.com
PhD Project - The role of membrane perturbations in antibiotic resistant Gram-negative bacteria at Newcastle University, listed on FindAPhD.com
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CBCB Newcastle @cbcb-newcastle.bsky.social · 20/03/2025
New lysins for medically and environmentally important Mycobacteriales. Supervised by @lislowe.bsky.social and Paul James. www.findaphd.com/phds/project...
findaphd.com
New lysins for medically and environmentally important Mycobacteriales at Newcastle University on FindAPhD.com
PhD Project - New lysins for medically and environmentally important Mycobacteriales at Newcastle University, listed on FindAPhD.com
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CBCB Newcastle @cbcb-newcastle.bsky.social · 20/03/2025
Dissecting Gram-negative envelope biogenesis to understand drug delivery in Gram-negative pathogens. Supervised by Manuel Banzhaf, @thecopperdoctor.bsky.social and @henrikstrahl.bsky.social. www.findaphd.com/phds/project...
findaphd.com
Dissecting Gram-negative envelope biogenesis to understand drug delivery in Gram-negative pathogens at Newcastle University on FindAPhD.com
PhD Project - Dissecting Gram-negative envelope biogenesis to understand drug delivery in Gram-negative pathogens at Newcastle University, listed on FindAPhD.com
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CBCB Newcastle @cbcb-newcastle.bsky.social · 20/03/2025
Microbial metal-head: the integrated roles of metal homeostasis in host-pathogen interaction. Supervised by @ruamicro.bsky.social, @thecopperdoctor.bsky.social and Manuel Banzhaf. www.findaphd.com/phds/project...
findaphd.com
Microbial metal-head: the integrated roles of metal homeostasis in host-pathogen interaction at Newcastle University on FindAPhD.com
PhD Project - Microbial metal-head: the integrated roles of metal homeostasis in host-pathogen interaction at Newcastle University, listed on FindAPhD.com
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CBCB Newcastle @cbcb-newcastle.bsky.social · 20/03/2025
Adding functionality to C. difficile's armour; integrative structural biology studies of SlpA and CWPs. Supervised by @pssalgado.bsky.social, Peter Chivers, and Agnieszka Bronowska. www.findaphd.com/phds/project...
findaphd.com
Adding functionality to C. difficile’s armour – integrative structural biology studies of SlpA and CWPs at Newcastle University on FindAPhD.com
PhD Project - Adding functionality to C. difficile’s armour – integrative structural biology studies of SlpA and CWPs at Newcastle University, listed on FindAPhD.com
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CBCB Newcastle @cbcb-newcastle.bsky.social · 20/03/2025
Structure and functions of the novel type of RNA polymerases and their application in synthetic biology and biotechnology. Supervised by Nikolay Zenkin and Ehmke Pohl. www.findaphd.com/phds/project...
findaphd.com
Structure and functions of the novel type of RNA polymerases and their application in synthetic biology and biotechnology at Newcastle University on FindAPhD.com
PhD Project - Structure and functions of the novel type of RNA polymerases and their application in synthetic biology and biotechnology at Newcastle University, listed on FindAPhD.com
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CBCB Newcastle @cbcb-newcastle.bsky.social · 20/03/2025
Single-molecule analysis of the bacterial chromosome origin Basal Unwinding System (BUS). Supervised by @heathmurraylab.bsky.social and Aakash Basu. www.findaphd.com/phds/project...
findaphd.com
Single-molecule analysis of the bacterial chromosome origin Basal Unwinding System (BUS) at Newcastle University on FindAPhD.com
PhD Project - Single-molecule analysis of the bacterial chromosome origin Basal Unwinding System (BUS) at Newcastle University, listed on FindAPhD.com
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CBCB Newcastle @cbcb-newcastle.bsky.social · 20/03/2025
Antibiotics from the abyss; assessing the impact of deep-sea mining on biodiscovery. Supervised by @kateduncan.bsky.social, @thecopperdoctor.bsky.social and @ruamicro.bsky.social. www.findaphd.com/phds/project...
findaphd.com
Antibiotics from the abyss – assessing the impact of deep-sea mining on biodiscovery at Newcastle University on FindAPhD.com
PhD Project - Antibiotics from the abyss – assessing the impact of deep-sea mining on biodiscovery at Newcastle University, listed on FindAPhD.com
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CBCB Newcastle @cbcb-newcastle.bsky.social · 20/03/2025
Uncovering the hidden laws of grit: novel mechanisms of drug-resistance via ribosome hibernation. Supervised by @sergeymelnikov.bsky.social and @jamiebojko.bsky.social. www.findaphd.com/phds/project...
findaphd.com
Uncovering the hidden laws of grit: novel mechanisms of drug-resistance via ribosome hibernation at Newcastle University on FindAPhD.com
PhD Project - Uncovering the hidden laws of grit: novel mechanisms of drug-resistance via ribosome hibernation at Newcastle University, listed on FindAPhD.com
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CBCB Newcastle @cbcb-newcastle.bsky.social · 20/03/2025
Engineering anti-CRISPR/Cas systems to control the DNA damage response in live bacterial cells. Supervised by @winterhalterlab.bsky.social, @acdarby.bsky.social, and Katarzyna Mickiewicz. www.findaphd.com/phds/project...
findaphd.com
Engineering anti-CRISPR/Cas systems to control the DNA damage response in live bacterial cells at Newcastle University on FindAPhD.com
PhD Project - Engineering anti-CRISPR/Cas systems to control the DNA damage response in live bacterial cells at Newcastle University, listed on FindAPhD.com
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CBCB Newcastle @cbcb-newcastle.bsky.social · 20/03/2025
Looking for a PhD opportunity in Microbiology? Consider joining one of the strongest clusters of microbiology research in UK at @newcastleuni.bsky.social, Biosciences Institute, and @cbcb-newcastle.bsky.social. See thread for BBSRC DTP PhD studentships currently advertised.
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CBCB Newcastle @cbcb-newcastle.bsky.social · 11/03/2025
Congratulations Charles! It's a great paper!
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Reposted by CBCB Newcastle
Charles Winterhalter @winterhalterlab.bsky.social · 11/03/2025
Excited to share with you the story that enabled me to start my own lab: what happens when the bacterial DNA replication machinery encounters single-strand discontinuities on template DNA? What is required for break repair and replication restart? www.biorxiv.org/content/10.1...
biorxiv.org
Rescuing bacterial genome replication: essential functions to repair a double-strand break and restart DNA synthesis
Many antibiotics indirectly generate reactive oxygen species (ROS) that can damage bacterial genomes. Oxidised nucleobases become genotoxic when they are targeted for repair through excision, generati...
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