iiinova — where your digital self keeps evolving

Reposted by Chris Ashwood

Phenomenal #glycotime by Meg Lunn-Halbert, Joel Allen and colleagues demonstrates through de novo protein design how steric hindrance controls N-glycan maturation ⬇️ doi.org/10.64898/202... Protein design with RFdiffusionAA coupled with glycosylation with GlycoShape 🧪

screenshot of Fig. 2 in the paper, titled "Systematically altering steric restriction controls glycan processing" the following corresponds to the figure caption in the paper.
Panel a, AF3-predicted protein with GlycoShape-modeled Man9 glycan (green) for glycoproteins THRgly1-4. b-d, Deconvoluted intact
mass spectra for analyzing native glycosylation with 1–3 major peaks corresponding to glycosylation shifts labeled. Glycans
matching in theoretical molecular weight to the corresponding shift are schematically annotated as follows: mannose residues as
green circles, N-acetyl glucosamine residues as blue squares, galactose as yellow circles, sialic acid as pink diamonds, and glucose
as blue circles. Unglycosylated sizes are estimated based on predicted MW and labeled, when present. b: Native glycosylation. c:
Native protein digested with Endo H. d: Overlaid protein from kifunensine-treated cells (color, solid line) and digested with Endo H
(gray, dotted line). Estimated predominant glycans present are shown in MW (Da) differences from predicted unglycosylated size.
For peak table see Supplementary Data S3; amino acid sequences provided in Supplementary Data S1.

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Reposted by Chris Ashwood

Australian Glycoscience Society @ozglyco.bsky.social · 17h

🔬⭐ Thank you to our outgoing leaders ⭐🔬 Following our AGM on 5 October, we thank outgoing AGS President Morten Thaysen-Andersen, Secretary Nick Scott, and Kevin Chau for their dedication, leadership and service to AGS. We are deeply grateful for your contributions to AGS and its members.

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Chris Ashwood @cashwood.proteaglyco.com · 20h

The weak argument presented in the report is that it could be used for development of viral weapons. A high res mass spec is capable of characterising viral particles. They can’t assist with preparation. Single cell-oriented MS were recently export controlled by the Biden admin.

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Chris Ashwood @cashwood.proteaglyco.com · 20h

It sounds like more of a war on science than a war on bioterrorism. What’s next, pipettes?

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Chris Ashwood @cashwood.proteaglyco.com · 21h

“2022 through 2025, HHS and USDA sold 1,316 pieces of lab equipment, including nine freeze dryers and mass spectrometers on the Commerce Control List, or subject to export controls.” Surprised MS systems are on the commerce control list, and that they’re implied to be a severe bioterrorism threat

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Chris Ashwood @cashwood.proteaglyco.com · 21h

I remember when they were just little propreteins.

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Reposted by Chris Ashwood

GlycoNet @glyconet.bsky.social · 08/10/2026

🧬 How can we expand access to complex carbohydrates for glycan research? Join Dr. Jenifer Hendel, Trent University, for a webinar on N-glycan isolation and synthetic approaches to glycomimetics. 📅 Oct. 27 | 🕚 11 a.m. MT #GlycoNet #Glycomics #Glycobiology #Glycomimetics

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Research – Toronto Metropolitan University (TMU) @researchtmu.bsky.social · 07/10/2026

Join @torontomet.bsky.social & @gairdnerawards.bsky.social on Tuesday, Oct. 20 for Adventures in Protein Chemistry using Mass Spectrometers, a free lecture from 2026 Canada Gairdner International Award Laureate professor John R. Yates. Register here before Friday, Oct. 16: tinyurl.com/yje52b3t

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MOBILion Systems, Inc. @mobilionsystems.bsky.social · 06/10/2026

Join Lauren Royer Dissinger at Skyline Online on Oct. 14, 5:30–6:30 PM EDT, for fast, flexible SLIM data analysis using CCS. Explore a related LCGC article including Skyline’s role in PFAS screening: www.chromatographyonline.com/view/address... #IonMobility #Skyline

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Reposted by Chris Ashwood

Mahshid @mahshidmoballegh.bsky.social · 07/10/2026

Another successful #HUPO 2026 congress in the books! I am thrilled to have participated in this event once again, this time in beautiful #Singapore! Looking forward to translating these new insights into our ongoing research and upcoming collaborations! #AcademicNetworking #ScientificConference

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Lukas Käll @lukaskall.bsky.social · 07/10/2026

Self-supervised pretraining can improve de novo peptide sequencing. To our knowledge, our new model dIon is the first to show it. Preprint with Alfred Nilsson, Joel Lapin, Samuel Payne and Mathias Wilhelm. doi.org/10.48550/arX... 1/9

doi.org

dIon: Fragmentation-Based Invariance for Self-Supervised Learning of Tandem Mass Spectra

We introduce a novel invariance for peptide tandem mass spectrometry data, unlocking self-supervised representation learning that improves de novo sequencing of peptides. This invariance exploits the ...

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GlyCosmos @glycosmos.bsky.social · 07/10/2026

Want to learn how to deposit glycan-related MS data? Join us for an introduction to GlycoPOST and its latest updates! ✨ #GlyCosmos #GlycoPOST #glycotime 📅 Date: Oct 20 (Tue), 16:00 JST (Free; English) 👤 Speaker: Yushi Takahashi 👇 Register: us02web.zoom.us/meeting/regi...

us02web.zoom.us

Welcome! You are invited to join a meeting: GlySpace Webinar. After registering, you will receive a confirmation email about joining the meeting.

Webinar on GlycoPOST sponsored by GlyCosmos

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Chris Ashwood @cashwood.proteaglyco.com · 07/10/2026

They just posted their “722 math preprints” on GitHub. It’s like if someone dropped 700 proteomics preprints, each preprint a different sample. I think concentrated efforts iteratively improving is much more valuable than the scattershot approach they’re showing, and that’s why people are important

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Ben Neely @benneely.com · 06/10/2026

Do you know someone who knows lotsa cool stuff (macro to molecular) about sweat, ear wax, stomach/bowels, or the placenta? Cause we need them for #THEProteomicsShow. I am striking out too hard on these. Person just needs to be excited to chat, expertise is optional. DM or email me.

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Will Fondrie @willfondrie.com · 06/10/2026

We released Ptarmigan-1 last week, our structure-free AI model for proteome-wide drug discovery. The model reaches all proteins, including the 40% that have no fixed structure, and can run 3.4 billion compounds against every human protein in a day. 🐦 Try Ptarmigan-1 for free: ptarmigan.app 🧵 (1/8)

ptarmigan.app

Ptarmigan-1 — Protein–compound predictions by Talus Bio

Prioritize compounds for experimental testing with Ptarmigan-1. Screen protein targets against compound libraries without requiring a protein structure.

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Reposted by Chris Ashwood

SCIEX @sciex.bsky.social · 06/10/2026

⏰ 30 minutes to go! Day 1 of #SCIEXSummit2026 starts soon 🚀 Join us today as we explore the future of mass spectrometry and analytical innovation. 🔬 There's still time to register and join us live at 10 AM ET 👀 🔗 sciex.li/t9lx1al8 #SCIEX #MassSpectrometry #AnalyticalScience

sciex.li

SCIEX Summit

Step into the frontier of innovation at the upcoming SCIEX summit 2026, where the brightest minds in analytical science will converge to ignite conversation, challenge ...

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Reposted by Chris Ashwood

Nature Plants @natplants.nature.com · 05/10/2026

New Article: "N-glycosylation code diversifies paralogous chitinases to balance plant immunity and growth" rdcu.be/FYUFGfiTi8Xa Two chitinases that produce or degrade immunogenic chitin oligomers => plants that gain chitin-triggered fungal resistance without a growth penalty. #PlantScience

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Reposted by Chris Ashwood

Matt Padula @mattpadula.bsky.social · 05/10/2026

Seen by an APAF colleague at Summer Hill rail station in Sydney. Any Sydney-sider want to claim responsibility? 🤣

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Chris Ashwood @cashwood.proteaglyco.com · 03/10/2026

I've been caught out by that twice. The first was when they wanted a 2 week turnaround time on the review, and the second was the exact same situation, told 1-2 days before deadline that it wasn't needed. I get the need to get a single round of review to pass, but it's wasted time for the reviewer.

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Chris Ashwood @cashwood.proteaglyco.com · 03/10/2026

“any model that depends on a human reading every submission was going to break” I think relying on automated processes as the sole gatekeeping method to judge preprint submissions is a dangerous precedent. Efforts are better spent working out how human reviewers can be assisted or supported better.

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Chris Ashwood @cashwood.proteaglyco.com · 02/10/2026

2027 is Milan, 2028 is Rio de Janeiro.

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Chris Ashwood @cashwood.proteaglyco.com · 01/10/2026

Milk was chosen as the proof of concept because it has the strongest matrix effects (significant milk sugars) but, combined with the dried blood spot approach, we think this platform is PERFECT for clinical biofluid sampling (urine, saliva, blood, and more). Always happy to discuss collaborations.

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Chris Ashwood @cashwood.proteaglyco.com · 01/10/2026

We were hesitant about such an approach, due to the potential loss of glycome specificity resulting from the mixed glycomes, but surprisingly, we see higher glycan intensities AND the same structures are specifically attributed to the correct glycome.

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Chris Ashwood @cashwood.proteaglyco.com · 01/10/2026

It was great to attend #HUPO2026 and catch up with new friends and old. Here's our (@maiakelly.bsky.social) main poster for the conference, achieving the most comprehensive representation of the glycome to date with N-, O-, GSL-, and free- glycans acquired in a single LC-MS run. #glycotime

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Reposted by Chris Ashwood

BioF:GREAT @biof-great.bsky.social · 29/09/2026

🧪 Need specialized sugar donors for your research? BioF offers NDP sugars, sugar analogs & derivatives for glycoscience research—with custom synthesis and bulk quantities available. 🍬 Democratizing Glycoscience. biofgreat.org/donors/ #biofgreat #nsf #teledyne #glycotime

biofgreat.org

NDP sugars and derivatives

NDP sugars and derivatives — Glycoscience Research, Education and Training — democratizing glycoscience by increasing accessibility to research, education and training

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Reposted by Chris Ashwood

Rita Strack @ritastrack.bsky.social · 29/09/2026

We've had a wave of source data corrections lately across the Nature Portfolio. We wrote an editorial about the importance of bookkeeping and QC when preparing manuscripts. www.nature.com/articles/s41...

nature.com

Source data under scrutiny - Nature Biomedical Engineering

The source data underlying results and figures in our manuscripts can be critical for assessing the rigour of our studies and for reproducibility. Ensuring the quality and provenance of these data dur...

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Chris Ashwood @cashwood.proteaglyco.com · 28/09/2026

I’d love to see them pivot to a really niche application like glyco. I use it for non-sensitive data that will be preprinted, but curious how they pick which data to steal.

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Chris Ashwood @cashwood.proteaglyco.com · 27/09/2026

One thing I don’t see enough of, on social media, for these conferences is SWAG. Please find below what I’ve found so far at #HUPO2026

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The NCFG @thencfg.bsky.social · 24/09/2026

Did you know carbohydrates can modify 10 of the 20 amino acids, from GlcNAc-Tyr in tumor cells to Glc-Arg in bacterial signaling? Find out about more: research.bidmc.org/ncfg/blog/30... #glycobiology #biochemistry #proteomics #posttranslationalmodification #cellbiology #glycotime

research.bidmc.org

30] Unusual Modification of Peptides/Proteins with Sugars

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Reposted by Chris Ashwood

Paul Daly @paulsh02.bsky.social · 24/09/2026

Please see our latest Biotechnology Advances review on cell wall degrading CAZymes in biocontrol of fungal- and oomycete-caused crop diseases. With Irina Druzhinina @rbgkew.bsky.social and colleagues from Cranfield Uni. (This share link works until Nov 11th) authors.elsevier.com/a/1nqM22d7Ir...

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Reposted by Chris Ashwood

Noelle Held @proteocean.bsky.social · 23/09/2026

We are still looking for a postdoc to work on molecular underpinnings of nitrogen fixation in the South Pacific, with potential to inform approaches to mCDR. Please share! proteoceanlab.github.io/assets/img/2...

proteoceanlab.github.io

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Chris Ashwood @cashwood.proteaglyco.com · 22/09/2026

The pricing is one of my biggest concerns. These companies are largely unprofitable at their current price. Will they all end up like MoviePass, where the sudden price increase to be profitable results in the product being economically unreasonable? Then what happens to reliant users?

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ASMS @asms.org · 21/09/2026

The September 30 deadline to submit to the @jasms.bsky.social Carbohydrates Special Issue is approaching. Working in glycomics, glycobioinformatics, or other areas of carbohydrate-focused mass spectrometry? We want to see your research! Submit by September 30, 2026! bit.ly/4gvFzbI

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Reposted by Chris Ashwood

Joost Snijder @joostsnijder.bsky.social · 21/09/2026

Time for our Advanced BioMS course this week! Here’s Kelly kicking things off.

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Marcin Czerwinski @czerwinsmarcin.bsky.social · 21/09/2026

How to study glycosylation using bioorthogonal glycan-based tools: now in one comprehensive review. Highly recommended! tinyurl.com/27z2rhvv #glycotime

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Joe Bak-Coleman @jbakcoleman.bsky.social · 20/09/2026

To the original argument, Solving complex problems does not require thinking or understanding. It’s not a dichotomy whereby either humans have souls or whatever. It’s entirely possible that, say, thought as we experience it is a spandrel. en.wikipedia.org/wiki/Spandre...

en.wikipedia.org

Spandrel (biology) - Wikipedia

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Chris Ashwood @cashwood.proteaglyco.com · 18/09/2026

How many 2D gels do you think you run at Proteome Systems? I'd guess 100+

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Chris Ashwood @cashwood.proteaglyco.com · 17/09/2026

We even have a course (functional proteomics) at Macquarie University where everyone runs their own 2D gel

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Ben Schumann @drglycoben.bsky.social · 17/09/2026

⚠️ 🥳 check out our new pre-print led by the fantastic @sophiedschmidt.bsky.social: An in vivo chemical genetic approach for targeted glycoproteome analysis in Drosophila melanogaster: www.biorxiv.org/content/10.6... We present FlyMOE, a strategy for targeted glycoprotein profiling in vivo.

biorxiv.org

An in vivo chemical genetic approach for targeted glycoproteome analysis in Drosophila melanogaster

Glycans impact every aspect of physiology. Despite the rapid increase in relevance and translational potential, there remains a lack of tools for studying glycosylation in vivo. Here, we present FlyMO...

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Lorna Milne @lornamilne.bsky.social · 17/09/2026

SO excited to be teaming up with @j-a-n-alexander.bsky.social to chair next years Glycobiology GRS! 🍬 Welcoming abstracts from all areas of #glycotime - we can't wait to see you all in Ventura! 🌞

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Chris Ashwood @cashwood.proteaglyco.com · 16/09/2026

Please introduce a new nomenclature where the internal gradient direction indicates linkage

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Prof. Gavin Reid @gurugav69.bsky.social · 16/09/2026

For academics in Australia who are eager to know more about the new Australian Research Council National Competitive Grants Program schemes, the Grant Guidelines for the new Explore scheme were presented to the Senate as a disallowable instrument on Sept. 14. www.legislation.gov.au/F2026L01187/...

legislation.gov.au

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Elisa Fadda @elisafadda.bsky.social · 14/09/2026

🚨 Want to be part of top #glycotime on the seaside in the California sunshine? Register to the 2027 GRC Glycobiology ⬇️ Stacy and Lance put togteher up one of the most exciting programmes I have ever seen with phenomenal keynotes! We have 32 abstracts to select, so the next speaker could be YOU! 😎

Announcement of the GRC Glycobiology 2027 to be held in Ventura CA on March 14 to 19, 2027. Blue background with an photo of Ventura from the visitventuraca.com

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