PI: Edward S.X. Moh (ARC Centre of Excellence in Synthetic Biology, Macquarie University, Sydney, Australia) Keywords: Glycoengineering, Glycosylation, Mass spectrometry, Glycomics, Immobilised enzyme reactors, glycosyltransferases Controlling protein glycosylation as a critical quality attribute of biopharmaceuticals remains challenging when glycosylation is coupled to cellular production systems. Here, we present a proof-of-co...

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PI: Shunji Natsuka (Niigata University) Keywords: brain, Xenopus, N-glycans, pyridylamination N-glycans derived from Xenopus laevis brain were separated by reverse-phase LC and subsequently analyzed by ESI-MS/MS....

Colorectal adenomas represent precursor lesions in the adenoma–carcinoma sequence and are characterized by chronic low-grade inflammation. Chemokine

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PI: Douglas Dyer and David Knight (The University of Manchester) Keywords: GAG disaccharide analysis, heparan sulphate, chondroitin sulphate, dermatan sulphate, hyaluronan Proteoglycans, and their glycosaminoglycan (GAG) side chains, are critical components of the ECM and the glycocalyx. GAGs can bind to many different proteins, such as chemokines, and form hydrated bar...

GlycoRNAs are a newly identified class of post‑transcriptionally modified small non‑coding RNAs that carry covalently attached N‑ and O&#

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PI: Prof. Dr. Véronique Blanchard (Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Laboratory Medicine, Clinical Chemistry and Pathobiochemistry, Augustenburger Platz 1, 13353 Berlin, Germany) Keywords: mesenchymal stem cells, N-glycans, glycomics, MALDI-TOF, permethylation, chondrogenic differentiation, dedifferentiation, aging Mesenchymal stem cells (MSCs) are adult stem cells able to self-renewal or to differentiation into a variety of cell types including chondrocytes. N-Glycans are post-translational modifications of gly...

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PI: Abhay Pandit (Research Ireland Research Centre for Biomedical Devices) Keywords: intervertebral disc; N-glycan; degeneration This study characterizes glycan alterations in human healthy and degenerated IVDs using UPLC-MS...

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PI: Daneil Bajar (Department of Chemistry and Molecular Biology, University of Gothenburg, 41390 Gothenburg, Sweden) Keywords: Glycobiology, nucleus, systems biology, bioinformatics, RNA-binding protein, O-linked glycans O-glycomics of cell lysates and nuclei of mammalian cell lines...

PI: Volkan Seyrantepe (İzmir Institute of Technology, Department of Molecular Biology and Genetics, İzmir, Turkey) Keywords: N-glycan, O-glycan, autophagy, ER stress, Tay-Sachs disease, lithium Tay-Sachs disease is a rare neurodegenerative disorder caused by mutations in the HEXA gene. HEXA gene encodes the α-subunit of the enzyme β-hexosaminidase A, which degrades GM2 ganglioside. Previousl...

PI: Shu Zhang (Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China) Keywords: SLC35A3; hepatocellular carcinoma; N-glycosylation; glycoproteomics; LC-MS/MS; UDP-GlcNAc This project investigates the role of the Golgi-resident UDP-GlcNAc transporter SLC35A3 in hepatocellular carcinoma (HCC) using quantitative proteomics and intact N-glycoproteomics. LC-MS/MS analysis ...

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