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J. Andrew N. Alexander

@j-a-n-alexander.bsky.social
143 followers 327 following 13 posts

Postdoctoral researcher at @ethz.ch in the Locher lab🇨🇭 PhD alumnus of the Strynadka lab at the University of British Columbia 🇨🇦 Interested in Glycobiology, Structural biology, Cryo-EM, Membrane proteins and signalling! orcid.org/0000-0002-8759-1389

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J. Andrew N. Alexander @j-a-n-alexander.bsky.social · 21/09/2026
Me too @lornamilne.bsky.social! Very excited to read everyone's abstracts! This is an amazing opportunity for early career researchers to expand their networks, gain exposure to different areas of research and get experience communicating their work.
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Elisa Fadda @elisafadda.bsky.social · 16/09/2026
Fantastic opportunity to talk, listen and discuss the future of #glycotime 🧪 with ECRs and PhD students at the upcoming GRS Glycobiology 2027 organised by the über talented @j-a-n-alexander.bsky.social and @lornamilne.bsky.social who put together a sensational programme. Register asap!! ⬇️
GRS flyer with a view of the town of Ventura (CA) from the hills, tree on the right hand side, sea in the distance. Flyer has a blue background
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Elisa Fadda @elisafadda.bsky.social · 14/09/2026
🚨 Want to be part of top #glycotime on the seaside in the California sunshine? Register to the 2027 GRC Glycobiology ⬇️ Stacy and Lance put togteher up one of the most exciting programmes I have ever seen with phenomenal keynotes! We have 32 abstracts to select, so the next speaker could be YOU! 😎
Announcement of the GRC Glycobiology 2027 to be held in Ventura CA on March 14 to 19, 2027. Blue background with an photo of Ventura from the visitventuraca.com
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Bergeron lab @bergeronlab.bsky.social · 23/04/2026
Latest paper from the lab - particularly glad that we managed to get this one out, after getting scooped several times over… more spectacular work from PhD students extraordinaire, Kailin and Rosa, in close collaboration with Marc Erhardt’s group.
nature.com
The structure of the Vibrio alginolyticus flagellar filament suggests molecular mechanism for the rotation of sheathed flagella - Nature Communications
Most bacteria use a flagellum, to swim and disseminate in their environment, and it is essential for virulence. In Vibrio, the flagellum is surrounded by a sheath, a membrane-like shield that protects...
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Neil Gow @neil-gow.bsky.social · 17/04/2026
50 medical mycologists put their shoulder behind an action plan to mitigate the rising threat of antifungal drug resistance. Check out in Nature Medicine. @youngecmm.bsky.social @ecmmcandidaiv.bsky.social @ishamycology.bsky.social @bsmm-meeting.bsky.social @mrccmm.bsky.social
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Elisa Fadda @elisafadda.bsky.social · 17/04/2026
We have some fresh and cool #glycotime 🧪 on the impact of including glycosylation explicitly in de novo binder design. Filtering the results of a recent open competition for novel binders to the Nipah Virus Glycoptrotein (NiV-G) with ReGlyco improves the pipeline efficiency significantly ⬇️
a. Structure of the Nipah Virus Glycoprotein (NiV-G) homotetramer (aa 92-602) reconstructed from cryo-EM structures (PDB 7TXZ and 7TY0) bound to broadly neutralising antibody nAH1.3 Fabs30 (not shown). Static (single) glycans 3D structures (shown with sticks in blue) were reconstructed with GlycoShape ReGlyco17, where the choice of the glycan type was guided by glycoproteomics analysis36. The visible six glycan sites on chains A, B and D are mapped onto the structure, while glycans on chain C are not labelled for clarity. b. Structure of the glycosylated NiV-G recostructured with GlycoShape ReGlyco Ensemble29 using 150 frames from the MD trajectories of each selected glycan. Rendering effect is obtained with a “long exposure” filter to reflect the glycan dynamics. Sterically constrained glycans and rigid regions of the saccharides can be identified by the darker blue colour. c. Structure of the glycosylated NiV-G as in panel b. but with each one of the 150 glycan frames shown in dark blue, to illustrate the potentially occluded volume of the NiV-G protein surface
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Juliet Turner @juliet-turner.bsky.social · 17/03/2026
I always say that it’s good to be in nature (surrounded by flowers and insects)… but to be in Nature (the scientific journal) is not bad either 😊
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Gene Chong @chongg.bsky.social · 17/03/2026
FYI, the first transparent peer review file @natchembio.nature.com has been published with this paper 👀 Yes, we publish them now if the authors elect to!
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Sjors Scheres @sjorsscheres.bsky.social · 18/03/2026
We're excited to announce the beta-release of #RELION-5.1! 🥳 This release has important updates on our #amyloid processing pipeline, as described in this preprint: doi.org/10.64898/202... There are also some tweaks for #teamtomo. #OpenSoftwareAcceleratesScience
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Nature Chemical Biology @natchembio.nature.com · 10/03/2026
The three enzymes ALG3, ALG9, and ALG12 catalyze the synthesis of the branched mannose core in N-glycans in four distinct steps. Now, their structures reveal the molecular logic of oligomannose core assembly #glycotime www.nature.com/articles/s41...
nature.com
Structures of ALG3/9/12 reveal the assembly logic of the N-glycan oligomannose core - Nature Chemical Biology
Three endoplasmic reticulum luminal mannosyltransferases ALG3, ALG9 and ALG12 catalyze the synthesis of the branched mannose core in N-glycans in four distinct steps. Now, cryo-electron microscopy str...
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IUCr2026 @iucr2026.bsky.social · 12/03/2026
IUCr highlighted Crystallography in Canada with a historic collection of portraits #tbt #IUCr2026 www.iucr.org/gallery...
Collage of images from the IUCr

Maria Przybylska (1923-2008). May 1953.

[Contributed by Steven Przybylski on 10 Nov 2009] 

Ian Swainson at the DUALSPEC C5 spectrometer and C2 neutron powder diffractometer, Chalk River Laboratories, Ontario, Canada. circa 1993.

[Contributed by L. M. D. Cranswick on 24 Dec 2009] 



I-Nan Hsu, Louis Delbaere and Michael James examining the newly constructed model of Penicillopepsin (University of Alberta circa 1977). Photo courtesy Graheme Williams and Gary Brayer; figure caption Gary Brayer.

[Contributed by L. M. D. Cranswick on 21 Dec 2009] 


Louis Delbaere presenting the ACA Etter Early Career Award to Jennifer Swift (ACA 2005).

[Contributed by ACA Newsletter on 02 Dec 2009] 



Michael James. Photo courtesy Graheme Williams and Gary Brayer.

[Contributed by L. M. D. Cranswick on 21 Dec 2009]
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J. Andrew N. Alexander @j-a-n-alexander.bsky.social · 10/03/2026
I’m very excited to share some newly published work that uncovers the molecular basis for oligomannose synthesis! www.nature.com/articles/s41...
Images of molecular models of ALG3 and ALG9 proteins with substates bound.
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Sjors Scheres @sjorsscheres.bsky.social · 16/10/2025
I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗 beta.ideas.lego.com/product-idea...
beta.ideas.lego.com
Biological Laboratory | LEGO® Ideas
This is a two-floor realistic Biological Laboratory building. In this design, I try to tell stories about biologists, introduce biology concepts to general publ…
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J. Andrew N. Alexander @j-a-n-alexander.bsky.social · 16/01/2026
Thanks @glycoshape.org ! It's very nice to have this finally out!
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J. Andrew N. Alexander @j-a-n-alexander.bsky.social · 15/12/2025
Very happy to have had the opportunity to present some unpublished research at the Biological Structures Group winter meeting in Oxford this past week. It’s always so inspiring to see and discuss cutting-edge science! And, Oxford, you really are a stunning town!
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J. Andrew N. Alexander @j-a-n-alexander.bsky.social · 15/12/2025
OK, I’m a little late to the Bluesky switch, but finally I’m here. Looking forward to seeing all the cool science everyone is doing!
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