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Warmflash lab

@warmflashlab.bsky.social
133 followers 61 following 13 posts

Quantitative development with pluripotent stem cells

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Reposted by Warmflash lab
Journal of Cell Science @jcellsci.bsky.social · 17/09/2026
We're now accepting submissions for our next special issue, which will focus on 'Proteostasis' and will be coordinated by two of our Academic Editors, Pedro Carvalho and Tamotsu Yoshimori. Submission deadline: 2 November Find out more: journals.biologists.com/jcs/pages/pr... #proteostasis
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Warmflash lab @warmflashlab.bsky.social · 08/07/2026
Reach out if you have questions about JCS! The journal has a long history of publishing outstanding science and supporting the research community.
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Reposted by Warmflash lab
Heemskerk Lab @heemskerklab.bsky.social · 18/05/2026
New preprint! We show that cell fate can be predicted from a snapshot of combinatorial signaling — and the underlying map is a single angle in signaling space. Work by first authors Bassit Fijabi and Seth Teague and collaboration with @davidbrueckner.bsky.social. www.biorxiv.org/content/10.6...
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Warmflash lab @warmflashlab.bsky.social · 18/05/2026
My lab is hiring! We have an open postdoc position to study the endometrial-embryo interface using organoids, embryo models, and live imaging. Reach out or apply: bit.ly/4duGA0P
bit.ly
Postdoctoral Research Fellow (Warmflash) Stem Cell Biology
We are seeking a postdoctoral researcher to join an interdisciplinary project focused on the biology of embryo implantation. The position centers on understanding how the endometrium and early embryo ...
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Reposted by Warmflash lab
Development @dev-journal.bsky.social · 24/04/2026
Read the Research Article 'Dependence of cell fate potential and cadherin switching on the coordinate within the primitive streak during differentiation of human pluripotent stem cells' here. journals.biologists.com/dev/article/...
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Reposted by Warmflash lab
Development @dev-journal.bsky.social · 24/04/2026
Primitive streak cells retain broad fate potential uncoupled from cadherin switching This Research Highlight showcases work by Ye Zhu and Aryeh Warmflash. journals.biologists.com/dev/article/...
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Warmflash lab @warmflashlab.bsky.social · 20/02/2026
Send us your stem cell manuscripts! Very easy to transfer from biorxiv and we can also quickly consider a manuscript based on reviews received elsewhere. JCS does a tremendous job of supporting the scientific community (see the link below). Reach out if you have questions!
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Adrienne Roeder Lab @roederlab.bsky.social · 13/01/2026
Feb 1 deadline approaching for our @kitp-ucsb.bsky.social QBio summer course on Physical Principles of Morphogenesis in Plants and Animals. @streichan.bsky.social @maurazimmermann.bsky.social @maizel-lab.org @yusuke-mori.bsky.social @akankshi.bsky.social @nicolettapetridou.bsky.social
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Melissa Kane PhD @cornymel.bsky.social · 31/07/2025
As stressful as it is to run a laboratory in the US right now, my thoughts are often with the NIH staff living in the awful chaos trying to preserve the whole enterprise. I’m grateful for every moment they choose not to give up. These people are the only thing keeping it from entirely collapsing.
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Warmflash lab @warmflashlab.bsky.social · 14/07/2025
Happy to share our latest preprint. We show that juxtaposing amnion cells with human pluripotent cells is enough to trigger gastrulation-like events. Great work by former student Xiangyu Kong now a postdoc in the Theunissen lab @washumedicine.bsky.social www.biorxiv.org/content/10.1...
biorxiv.org
Juxtaposition of human pluripotent stem cells with amnion-like cells is sufficient to trigger primitive streak formation
Studies in the mouse have established that communication between the trophectoderm and the epiblast is crucial for initiating gastrulation. In the primate embryo, the amnion rather than the trophectod...
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American Society for Cell Biology @ascbiology.bsky.social · 01/07/2025
The "Big Beautiful Bill" isn’t the federal budget—it’s a reconciliation bill focused on tax cuts. The real FY26 funding decisions for NIH, NSF, and more are happening now in Congress. www.ascb.org/science-poli...
ascb.org
The "Big Beautiful Bill" is Not the Budget - ASCB
If you’ve read recent news about Congress trying to pass “the budget,” you may have noticed that even Washington, D.C. reporters don’t always have a firm grasp on the details of what they’re covering....
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Hillary Rodham Clinton @hillaryclinton.bsky.social · 30/06/2025
If one of these people is your senator, it is incredibly important that you call them today. Urge them to vote NO on the Senate budget bill that would make most Americans poorer to give billionaires a tax cut they don't even need.

Iowa: Sen. Ernst
Maine: Sen. Collins
Missouri: Sen. Hawley
North Carolina: Sen. Tillis
Ohio: Sen. Husted
Utah: Sen. Curtis
West Virginia: Sen. Capito
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Jenna Norton @jenna-m-norton.bsky.social · 10/06/2025
Today, my NIH colleagues and I did something scary but really important. We spoke up about egregious harms we are seeing happen to research participants and public health through thoughtless and politicized policies at NIH. 🧵1/3 apnews.com/article/nih-...
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ProPublica @propublica.org · 12/06/2025
NEW: The Trump administration cut research funding that sought cures for future pandemics, examined the causes of dementia and tried to prevent HIV transmission. ProPublica heard from more than 150 researchers to understand the work that’s been lost.
projects.propublica.org
Shattered Science: The Research Lost as Trump Targets NIH Funding
The Trump administration cut research funding that sought cures for future pandemics, examined the causes of dementia and tried to prevent HIV transmission. More than 150 researchers shared with…
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Warmflash lab @warmflashlab.bsky.social · 11/06/2025
Happy to share our latest on a system to study anterior-posterior patterning of the nervous system. We show Wnt signaling pattern is not a simple low to high gradient and timing of activation is crucial to setting the pattern. From outstanding grad student Siqi Du. www.biorxiv.org/content/10.1...
biorxiv.org
A novel self-organizing embryonic stem cell system reveals the role of Wnt signaling parameters in anterior-posterior patterning of the nervous system
A Wnt activity gradient is essential for the formation of the anterior-posterior (AP) axis in all vertebrates. The relationship between the dynamics of Wnt signaling and specification of AP coordinate...
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Reposted by Warmflash lab
Josh Marshall @joshtpm.bsky.social · 16/05/2025
A Path Forward to Save American Bio-Medical Research talkingpointsmemo.com/edblog/a-pat...
talkingpointsmemo.com
A Path Forward to Save American Bio-Medical Research
Over the past four months I’ve spoken to dozens of biomedical researchers...
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Heemskerk Lab @heemskerklab.bsky.social · 08/05/2025
Our work on mesoderm development in 2D gastruloids is now published in nature methods www.nature.com/articles/s41...
nature.com
Extended culture of 2D gastruloids to model human mesoderm development - Nature Methods
This study reports an extended 2D gastruloid system for spatially modeling human mesoderm development.
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Warmflash lab @warmflashlab.bsky.social · 07/05/2025
Many people are asking - what on earth is the point of killing biomedical research? Read this from @joshtpm.bsky.social who has covered this very well. Admin is using funding to exert control over universities, they don't care about resulting damage to science. talkingpointsmemo.com/edblog/why-d...
talkingpointsmemo.com
Why Do They Have It In For Biomedical Research?
Here is a brief follow-up on the question TPM Reader MA addresses...
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Jeremy Berg @jeremymberg.bsky.social · 23/04/2025
ACTION ITEM-----ACTION ITEM Implementation of Schedule F This is what a lot of us have been worried about. This allows for many civil service positions to replaced with political appointees. This could include NIH institute directors and even POs. BUT THERE IS A COMMENT PERIOD... 1/n
media.tenor.com
the word alert is in a purple circle
ALT: the word alert is in a purple circle
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Jeremy Berg @jeremymberg.bsky.social · 22/04/2025
I received this letter, sent to 11 Republican members of Congress this weekend from anonymous NIHers. 1/n .
A letter to Republican Senators from concerned federal workers at NIH.
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Scott Delaney @scott-delaney.bsky.social · 15/04/2025
As someone directly affected by this, let me be clear: I'd rather lose my job because Harvard chose to fight than keep my job and see a generation of white supremacists parade its corpse around like a war trophy.
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Josh Marshall @joshtpm.bsky.social · 07/04/2025
This is a big deal. Spread the word. But it’s tiny compared to the totality of what’s happening at NIH. Cure Research for all cancers, Alzheimer’s, everything is being gutted. Intentionally. It’s all getting burned to the ground but the news isn’t getting out. The new cures won’t be there for you.
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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 04/04/2025
From a source at NIH: “Right now NIH’s ability to buy things is dead. Nearly all people with the power to make an order — purchasing people — have been removed. The NIH hospital can’t buy medicines, the labs can’t buy petri dishes. X-Ray machine breaks? Too bad. Everything is stopped”
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David Corn @davidcorn.bsky.social · 02/04/2025
It’s stunning to me that the New York Times did not put the story on the bloodbath at the NIH, CDC, and FDA on its front page this morning.
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Pam Herd @pamherd.bsky.social · 30/03/2025
Trump has cut the NIH budget by more than half in defiance of Congressionally mandated appropriations for the agency. No comparison historically, not even the Great Recession. This is clearly not legal and Congress needs to address it.
Graph from the Washington Post showing declines in spending at NIH. New grants cut from 1 billion to around 400 million. Overall grants down from 4.5 billion to 2.4 billion.
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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 28/03/2025
"The consolidation/RIF plan pulls power away from scientists and puts it in the hands of political employees. It sets up Trump and Musk to kill NIH as an evidence-based science funder. We must stop this plan." New contributed post on our blog: Please read. It describes Orban and authoritarianism. 🧪
open.substack.com
The NIH firing plan is really a radical institute merger and an authoritarian takeover
this is an Orbanization of US science: a move to exert political control over discovery, which will kill the US medical research industry and end cancer cures. The plan must be stopped. We can act.
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Jeremy Berg @jeremymberg.bsky.social · 28/03/2025
Just before bedtime last night I got a message from inside NIH which read: “It’s so, so bad and no one cares (who has any influence)” I asked “What, in particular?” My friend responded “Everything”
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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 07/03/2025
The @standupforscience.bsky.social DC rally is on. What we are hearing from around the country: "this is big!" "biggest rally I have seen around here in years and years" The public cares about medical research--and students, GenZ, and other people too are ready to stand up.
Crowd at Lincoln memorial
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Warmflash lab @warmflashlab.bsky.social · 07/03/2025
Good crowd to #StandUpForScience on Rice campus. Some powerful speeches from trainees about having opportunities suddenly taken from them and the personal impacts of the administration's targeting of minorities. Very real damage has already been done.
Image of crowd at Rice Stand up for Science event
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Molly Jong-Fast @mollyjongfast.bsky.social · 02/03/2025
Richest guy in the world telling us we can’t afford to have our government fund cancer research.
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Expedition Works @expeditionworks.bsky.social · 01/03/2025
A story from one of the fired 18F employees: www.linkedin.com/posts/zachar...
linkedin.com
Zachary Cohn on LinkedIn: In 2015, I became a federal employee at 18F, an office inside of the…
In 2015, I became a federal employee at 18F, an office inside of the General Services Administration. It was the hardest, and best, job of my life. While…
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Josh Marshall @joshtpm.bsky.social · 28/02/2025
We talk about Bezos, or Citi, or Big Tech, but cancer's brand is seriously in the toilet. Everyone hates it. And yet, day one hit from Trump/Musk was to shut down all federal funding for cancer cure research. And it's still mostly shut down. Have you ever known anyone with cancer?
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Katherine J. Wu @katherinejwu.com · 27/02/2025
I talked to NIH officials, current and former, about what's been happening inside the agency since the Trump administration shut down their grantmaking pipeline in January. Their stories showed just how willing our new leaders are to break the law: www.theatlantic.com/health/archi...
theatlantic.com
Inside the Collapse at NIH
Administration officials pressured NIH to avoid clear advice from the agency’s own lawyers to restart grant funding now.
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Warmflash lab @warmflashlab.bsky.social · 27/02/2025
This is horrifying and should be read by anyone who thinks we can just wait and things at NIH will go back to normal. NIH leadership currently breaking the law in defiance of judges orders and their own lawyers' advice. Cranks like Memoli and Bhattacharya are only going to make the situation worse.
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Elizabeth Kolbert @elizkolbert.bsky.social · 22/02/2025
This is what you call robbing the future.
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Stand Up for Science! @standupforscience.net · 22/02/2025
🚨 WANT TO HELP US STAND UP FOR SCIENCE? 🚨 Here's a little update on where we're currently at with the planning process! Is your state red or grey & you want to see an event happen? Fill out our volunteer form or share with a friend! airtable.com/app4h5wUssMG... #standupforscience2025
Photo of the United States with a color code for states that have rallies confirmed, in progress, needing a leader, or no leader.
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Jeremy Berg @jeremymberg.bsky.social · 21/02/2025
New York Times article now up on Federal Register stuff. www.nytimes.com/2025/02/21/s... 1/n
nytimes.com
Trump Administration Stalls Scientific Research Despite Court Ruling (Gift Article)
Using an arcane law, officials have effectively delayed funding from the National Institutes of Health, leaving medical studies in jeopardy.
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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 21/02/2025
As you see NIH restrictions and bans lifted now, it’s not a coincidence that happened after a big rally that got coverage all over TikTok and on Maddow. Trump is susceptible to public pressure! They want to do their coup in the dark. As we’ve been saying, science must speak to the public now. 🧪
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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 21/02/2025
Dear scientists at US universities: Trump/Musk continue to freeze your grants. NIH is not reviewing grants nor funding them in council. This is a backhanded, legal method to effectively stop NIH grants. See thread and linked article. Are we going to “keep our heads down” about this?
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Warmflash lab @warmflashlab.bsky.social · 20/02/2025
My senator's voice mailbox is full, so I wrote a letter about the administration's underhanded use of the Federal Register to block NIH funding. Putting it here in case it useful to anyone else contacting their representatives about this outrageous abuse of power.
Don't allow the Trump administration to use the Federal Register to block NIH funding

Dear Senator Cruz,

I am a professor at Rice University in Houston where I run a research lab which focuses on stem cell biology. Our research provides the basis for new ways to prevent birth defects and infertility and for designing new treatments in regenerative medicine. My lab has nine full time employees who work hard every day pushing this important research forward. Like many labs in biomedical science, my lab is dependent on NIH funding. All over the country, funding from NIH creates jobs and drives progress towards cures that benefit all Americans.

Recently, federal courts have blocked the Trump administration's freeze on federal spending. However, the administration is now using a technicality to prevent any new grants from being funded. Funding relies on rigorous peer review meetings with a roster that must be published in the Federal Register before the meeting. The Trump administration is currently blocking posting to the register, effectively preventing any new grants from being funded. This circumvents both Congress's power of the purse and a court order stating that the federal spending freeze must end.

If this is allowed to continue, the impacts on scientific progress towards cures as well as on our economy will be severe. Research will stop and people will lose their jobs. I urge you to do everything in your power to call attention to this issue and to put an end to this abuse of procedural rules to implement policies which the courts have blocked. 

Sincerely,
Aryeh Warmflash
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Elizabeth Jacobs, PhD @elizabethjacobs.bsky.social · 20/02/2025
The court ordered that NIH grant funding be unfrozen, so The Regime found a way around it. For NIH grants to be funded, a review panel must rank them. In order for a review panel to meet, they must post it on the Federal Register. Submissions to the Federal Register are now on hold “indefinitely”.
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Jeremy Koster @jeremykoster.bsky.social · 19/02/2025
Upon learning that yesterday would be my last day as a program officer at the National Science Foundation, I shared this parting message with my colleagues. The next few months will be frenetic and stressful for them. Here are some things that you can do to help them with the mission ahead. (1)
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Angie Voyles Askham @avaskham.bsky.social · 18/02/2025
I just covered this for @thetransmitter.bsky.social — will keep following! www.thetransmitter.org/funding/fede...
thetransmitter.org
Federal Register hold makes ‘end run’ around court pause on NIH funding freeze
NIH-related updates to the Federal Register, which are required for the scheduling of study sections and advisory councils, are on hold indefinitely, according to an email reviewed by <i>The Transmitt...
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Katie Hinde @mammalssuck.bsky.social · 18/02/2025
I escaped poverty because I am a scientist. And I am a scientist because of the National Science Foundation. A 🧵:
A Lady Professor with brown hair and glasses, wearing a scarf in red, green, yellow, & black, a gift from an incredible lactation  consultant, sitting in in front of cactus.
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Josh Marshall @joshtpm.bsky.social · 18/02/2025
I think anyone who's been paying attention knows this. But it's worth stating clearly. The idea that any of Elon's wilding spree is being done in the name of efficiency is absurd on its face because the terminations are virtually all being done based on duration of service because that creates ...
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Stacey Ogden 🦔 @labogden.bsky.social · 17/02/2025
Special shout out this AM to NIH 🧪 grant mgmt specialists, POs, and SROs during this chaotic time - THANK YOU for caring for our grants and uploading scores/summary statements despite the unprecedented challenges you may be facing. You are science warriors and we APPRECIATE & SUPPORT YOU 🫶
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Robert Reich @rbreich.bsky.social · 14/02/2025
The federal civilian worker payroll totaled $271 billion in 2022. The annual cost of permanently extending Trump's tax cuts that primarily benefited rich individuals? $400 billion. Keep this in mind as Trump and DOGE lay off thousands of federal workers.
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Alt NIH Bluesky 🧪 @altnih4science.bsky.social · 12/02/2025
Yes. Important for all NIH people and scientists: The executive orders are not law. The President *cannot* make laws. And in fact, executive orders may violate the law. As a federal employee, you are obligated not to follow illegal orders. That includes illegal EOs.
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