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Peter Carlton

@carltonlab.org
802 followers 577 following 304 posts

From Seattle USA, now in Hieidaira, Japan. Researching meiosis @ Kyoto University. he/him. シアトル生まれ、比叡平(滋賀県大津市)に住む。京都大学・生命科学研究科の准教授。研究テーマは線虫の減数分裂 Orcid: 0000-0002-5320-6024 HP: www.carltonlab.org

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Peter Carlton @carltonlab.org · 3h
I've long had a hunch that "able to do nondestructive photochemistry" is at least as big an influence as transmission through water; <300 does better than >600 but might destroy rather than isomerize a photoreceptor molecule. (data from Segelstein, D., 1981: "The Complex Refractive Index of Water")
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Peter Carlton @carltonlab.org · 4h
yes, but not that far into either the UV or IR. Too blue and you start destroying bonds; too red and you can't excite them.
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Peter Carlton @carltonlab.org · 17h
Bingo! This is the primary reason, I think. Only that range can trigger nondestructive chemical changes in protein-coupled molecules. Same reason fluorescence microscopy uses a similar wavelength range for fluorophores.
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Peter Carlton @carltonlab.org · 02/10/2026
If we ever do get to see the original NSWiM grayscale video, I expect it will look more or less like this.
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Peter Carlton @carltonlab.org · 28/09/2026
"jiggery-pokery" still has some life too, I reckon
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Reposted by Peter Carlton
Marie Held @makaefer.bsky.social · 28/09/2026
Want to enhance your image analysis skills with napari? We’re running a two-day training event on how to use napari to effectively analyse your bioimaging data. 🕒 Applications close on 15 September. Learn more and apply 👇 www.crick.ac.uk/whats-on/cbi...
crick.ac.uk
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Peter Carlton @carltonlab.org · 28/09/2026
Not real data here in this example but I am really enjoying interactive #terminal plotting… 2 tmux panes with ssh replicating ~90% of what I usually do with jupyter.
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Peter Carlton @carltonlab.org · 27/09/2026
Interesting! It was 193 frames, 1288x720 px when I obtained it; shasum-1 : 1bccd…. I scanned the other 30 hosted entries and found no SynthID watermarks.
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Christophe 🔬 Leterrier @christlet.bsky.social · 25/09/2026
Here's a balanced account of where the microscopy community stands on AI use by this year's Small World in Motion winner. My main issue is that no one seems to have seen the original data despite requests (no mention of it being reviewed by the organizers) www.the-scientist.com/allegations-...
the-scientist.com
Allegations of AI Use in Nikon Competition Spark Controversy | The Scientist
Microscopists raise concerns about inappropriate AI usage in Nikon's microscopy contest-winning video. Nikon stands their ground, citing no policy breach.
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Peter Carlton @carltonlab.org · 25/09/2026
Here is an amazing 1960's video from a company that once cared deeply about quality, starting with making their own glass www.youtube.com/watch?v=qwej...
youtube.com
科学の眼-ニコン-
YouTube video by NPO法人科学映像館
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Peter Carlton @carltonlab.org · 25/09/2026
I know, and they also swing down into what should be intracellular space?! Here's another one using Grid/Collection stitching (thanks @preibischs.bsky.social !) showing the whole movie.
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Peter Carlton @carltonlab.org · 25/09/2026
"Made the cilia wave around, boss"
Maximum-intensity projection of images showing hallucinated green cilia reaching into the cell they're projecting from - that is supposed to be intracellular space
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Peter Carlton @carltonlab.org · 24/09/2026
Adventureland and the rest that came after: en.wikipedia.org/wiki/Adventu... My ideal and favorite game is Nethack - but these games flipped, as you say, the switch.
en.wikipedia.org
Adventureland (video game) - Wikipedia
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Peter Carlton @carltonlab.org · 24/09/2026
Yes! I thought it might be because stage movement induced cilia bending, but if this is all in a sealed chamber it's unlikely that such an "inertial" effect would manifest (Life at Low Reynolds Number) -- but then again I don't know the relevant biomechanics of airway cilia well enough to judge.
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Peter Carlton @carltonlab.org · 24/09/2026
re:hallucination/fabrication: insofar as there's a difference, I think since they seem to have used one video as a basis and used AI to "enhance" it that it might be the better term? But I'm not really clear on the distinction myself.
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Peter Carlton @carltonlab.org · 24/09/2026
Diffraction ≠ refraction The authors' hallucinated contest entry and apparent misuse of AI in figure generation do not automatically imply their optical techniques are invalid; that has to be assessed separately.
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Peter Carlton @carltonlab.org · 23/09/2026
You may still need a microscope for raw images, may I suggest this model
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Simon Cleary @simoncleary.bsky.social · 22/09/2026
The response from Nikon makes me wonder whether tools marketed by Nikon were used: www.microscope.healthcare.nikon.com/en_EU/produc...
microscope.healthcare.nikon.com
NIS-Elements | NIS.ai
The optional NIS.ai module allows users to utilize pretrained AI networks for image processing, as well as create, annotate, and train custom AI networks for segmentation and analysis. Advanced image ...
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Peter Carlton @carltonlab.org · 23/09/2026
Yeah, they're firing all the lasers directly into the CCD! Or would be, if the beam splitter orientations were correct. Their earlier Nat.Comms paper had a more reasonable, less AI-flavored diagram.
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Peter Carlton @carltonlab.org · 23/09/2026
It wouldn’t even necessarily have to be their own tool; they all work more or less the same way and to disqualify the whole class might be politically bad within Nikon
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Peter Carlton @carltonlab.org · 23/09/2026
They state the video technically satisfies “AI generated videos are not permitted”, but unless they want a deluge of increasingly bizarre “merely AI-enhanced” videos in the future, they’d better provide clarity.
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Christophe 🔬 Leterrier @christlet.bsky.social · 22/09/2026
From the new info my bet is fluo labeling inference pushed to 11. Hallucinating nonsensical DAPI nuclei, mitochondria stain, membrane labeling from a kind of phase contrast image: wrong localization, wrong scale, wrong movement. Keeping this movie as SWiM winner is a disgrace to the competition
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Christophe 🔬 Leterrier @christlet.bsky.social · 20/09/2026
Human cilia disease specialist on the Small World in Motion winning movie
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Peter Carlton @carltonlab.org · 18/09/2026
I have no idea about it, not being my area of expertise at all, but I am very curious about the methods used here.
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Peter Carlton @carltonlab.org · 18/09/2026
just finished! laptop is slow…
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Peter Carlton @carltonlab.org · 18/09/2026
Registered from the beginning, caveats about compression etc apply of course
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Peter Carlton @carltonlab.org · 18/09/2026
let's have a look
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André Marques @amarques.bsky.social · 16/09/2026
Out today in Nature: sex without crossovers. Rhynchospora tenuis makes pollen, fertilises and sets seed, yet 0 crossovers in 10,997 pollen nuclei. Chromosome drive and ~87% seed abortion rebuild the mother's genotype, so the offspring are clones. doi.org/10.1038/s415...
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Peter Carlton @carltonlab.org · 14/09/2026
At long last, we have immanentized the…
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Peter Carlton @carltonlab.org · 13/09/2026
definitely not for murdering!
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Shiori Iida @shiori-iida.bsky.social · 08/09/2026
Happy to share that this paper is now published in Nature Genetics! Grateful to everyone who supported this work throughout this long journey. I’m proud to see it out! www.nature.com/articles/s41...
nature.com
Cohesin prevents local mixing of condensed euchromatic domains in living human cells - Nature Genetics
Single-nucleosome imaging/tracking and super-resolution three-dimensional structured illumination microscopy within euchromatic regions show that cohesin-mediated loops constrain condensed euchromatic...
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Kazuhiro Maeshima @kazu-maeshima.bsky.social · 08/09/2026
Is euchromatin really “open”? 🧬 Using super-resolution imaging🔬 our new study @natgenet.nature.com reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing for proper transcriptional insulation🚧 🔗 www.nature.com/articles/s41... (1/2)
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Masa A. Shimazoe @masaashimazoe.bsky.social · 09/09/2026
Our paper on euchromatin and cohesin is now published!!🙌 Euchromatin forms condensed domains, and cohesin constrains their local mixing. This organization maintains transcriptional insulation. This work was truly a team effort, and I’m grateful to everyone who contributed to it.
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Peter Carlton @carltonlab.org · 11/09/2026
Pear Jam
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Peter Carlton @carltonlab.org · 09/09/2026
Back from an unforgettable trip to Indonesia! First, a weekend of discussing study opportunities with highly motivated students. Then, a few days waiting for a volcano to let us fly home. Glad to have spent 5 days in Jakarta, but have really just scratched the surface of an amazing city and country.
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Peter Carlton @carltonlab.org · 08/09/2026
Anak Krakatau has calmed down enough to let us slip out of Jakarta tonight; hopefully it will stay that way for a long time.
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Anton Goloborodko @golobor.bsky.social · 03/09/2026
1/ out in @science.org! We found a new asymmetry in large-scale chromosome structure: sister chromatids are shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! A close collaboration w/ @gerlichlab.bsky.social , led by @flaviacorsi.bsky.social www.science.org/doi/10.1126/...
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Peter Carlton @carltonlab.org · 03/09/2026
He comes around here too, I hate that guy! But you just reminded me to put my 98% DEET in my travel bag since I'm headed to Indonesia for the weekend.
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Peter Carlton @carltonlab.org · 03/09/2026
Me too, but as a Crickian Orthodox Central Dogmatist I take issue with some phrasing here.
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Peter Carlton @carltonlab.org · 03/09/2026
modern terminals are amazing, it hasn't been this good since Tektronix emulation in xterm.
a screenshot of a terminal window running teemux (tmux) showing an interactive ipython session in the left pane and a semi-interactive plot in the right pane.
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Peter Carlton @carltonlab.org · 29/08/2026
I spent 16 years in the SF Bay Area, and have lived 16 more in Kansai, Japan where I'll most likely stay for the rest of my life, but this picture depicts one uniquely representative frame from my permanently imprinted birthplace (Seattle/Salish Sea)
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Peter Carlton @carltonlab.org · 29/08/2026
いつもありがとうございます!
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Peter Carlton @carltonlab.org · 29/08/2026
Make your favorite film sound as boring as possible without giving away the title: A family man from the country visits the big city, but when he is urged to participate in a religious ceremony, he goes back home.
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Peter Carlton @carltonlab.org · 28/08/2026
🇦🇺↔🇯🇵 for undergrad/masters students studying in Australia and interested in short-term research opportunities this summer (Jan 7 – Feb 18 2027) - please check out Kyoto University's KU-STAR program: www.kugd.k.kyoto-u.ac.jp/en/ku-star-p... ! Application deadline is Sep. 25, happy to take questions.
kugd.k.kyoto-u.ac.jp
KU-STAR Program AUS
What’s the KU-STAR Program? KU-STAR Program, Kyoto University Short-Term Academic Research Pro
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Peter Carlton @carltonlab.org · 26/08/2026
guitar and flute is a great combination!
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Peter Carlton @carltonlab.org · 26/08/2026
My brain entertaining me this morning
Screenshot of a text passage describing my dream:

5am this morning after returning to sleep:
I was walking along a sidewalk in daytime, and crossed paths with… a guy who was just a head riding on a skateboard?! with a mounted computer keyboard, and the context was that in this dream world a person could detach their head and use it to control things; there was nothing distressing the guy, an early tech-adopter; the keyboard keys were clacking up and down, controlling the skateboard while controlled by his head. 
After I walked along a bit more, I heard a sound that made me look back, and his skateboard had gotten stuck on a broken slab of pavement, and I felt disappointed and angry about how bad the sidewalk infrastructure had gotten despite the amazing head-dislocation tech we had… my last dream thought just upon waking was “Heads should roll for this!” -- 
was the whole dream a setup for that punchline??
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Peter Carlton @carltonlab.org · 16/08/2026
I can never resist running full speed across them when there’s no one around.
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Peter Carlton @carltonlab.org · 16/08/2026
No, he could be Keith instead, or maybe Fox. Season 1: M&C Season 2: Post Captain/HMS Surprise Season 3: The Mauritius Command Season 4: Desolation Island Season 5: FoW/SM Season 6: Treason's Harbor,FSotW,RotM Season 7: LoM,13GS,NoC, bits of the rest
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Joumana Medlej @majnouna.com · 13/08/2026
Is Claude, let alone his pal Jimmy "Trust me bro" the Feckless, out there deciphering hundreds of pages of unconventionally-spelled scrawl and vanished words across a dozen text variants that require chemistry experiments to fully settle?
Passage from an Arabic manuscript with unconventional spelling and  several letters written with the same shape, requiring previous understanding o teh subject matter before reading is possible
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Mariko Sasaki @marikosasakiatnig.bsky.social · 06/08/2026
The Sasaki lab at the National Institute of Genetics in Japan are seeking for highly motivated PhD students to work on extrachromosomal circular DNA, gene amplification, genome stability, and cancer genome dynamics, starting in October 2027. Please see below and apply by August 31.
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