Sign in

Cadwell Lab

@cadwelllab.bsky.social
888 followers 270 following 28 posts

We investigate the interface between the immune system and diverse infectious agents ranging from friendly gut microbes and viruses to disease-causing parasites Our Lab: www.med.upenn.edu/cadwell-lab

PostsRepliesMedia
Cadwell Lab @cadwelllab.bsky.social · 08/10/2026
Curious how viruses 🦠 impact your personal ecosystem or that of the entire 🌍? We have a fantastic speaker lineup for the Keystone on Global Virome in Health & Disease in Geneva, Feb 1–4, 2027 hubs.la/Q04xTpPb0We. Abstract deadline extended to Oct 21!
hubs.la
021
Reposted by Cadwell Lab
Michael Glickman @michaelglickman.bsky.social · 23/07/2026
Please repost! #microsky🦠 The Glickman Lab at MSK is recruiting! Projects in Mtb pathogenesis, basic biology of mycobacteria, and mycobacterial cancer therapies. See our publications here: tinyurl.com/3f386f4x Send CV and cover letter to: glickmanmycolab@gmail.com
scholar.google.com
02433
Cadwell Lab @cadwelllab.bsky.social · 27/05/2026
Many 🙏 to all the collaborators who contributed their unique technical expertise and access to valuable specimens
001
Cadwell Lab @cadwelllab.bsky.social · 27/05/2026
Congratulations Hairu Yang for publishing in Gut and leading this amazing ✨collaboration with Bryson Katona to identify cellular changes including MAIT cell enrichment associated with colorectal cancer in Lynch syndrome 🎉 gut.bmj.com/content/earl...
gut.bmj.com
MAIT cell enrichment in Lynch syndrome is associated with immune surveillance and colorectal cancer risk
Background Lynch syndrome (LS) is the most common hereditary cause of colorectal cancer (CRC) and results from pathogenic germline variants affecting mismatch repair. The tissue microenvironment that ...
151
Reposted by Cadwell Lab
Burroughs Wellcome Fund @bwfund.bsky.social · 03/04/2026
📣📣 BWF is hiring! www.linkedin.com/jobs/view/43... #ProjectManagement #ScienceEducation #DiversityInScience #GrantsManagement #NonprofitJobs #STEMCareers #BWFJobs #DurhamNC #HybridWork
0106
Reposted by Cadwell Lab
Dr. Sunny Shin @sunnyshinlab.bsky.social · 28/02/2026
Please join us for the Cold Spring Harbor Asia @cshlnews.bsky.social meeting on Bacterial Infection & Host Defense this May 11-15 in Suzhou, China! We have a fantastic lineup of speakers. Abstract deadline is March 6. Hope to see you there!
Poster of the 2026 CSHA meeting on Bacterial Infection & Host Defense.
12825
Reposted by Cadwell Lab
American Society for Virology @amersocvirology.bsky.social · 18/02/2026
Congrats to the 2026 Ann Palmenberg Junior Investigator Awardees Arinjay Banerjee (left) and Louise Moncla (right). Check out their accolades in your member email. Read more about Ann Palmenberg's impact on virology and ASV here: news.wisc.edu/remembering-... journals.asm.org/doi/10.1128/...
Picture of Arinjay BanerjeePicture of Louise Moncla
2226
Reposted by Cadwell Lab
Golnaz Vahedi @vahedilab.bsky.social · 26/11/2025
I am very excited to share our collaborative work on multiome profiling of gene expression and chromatin accessibility of more than 1 million immune cells in pancreatic lymph nodes and spleens in human type 1 diabetes in @sciimmunology.bsky.social scim.ag/4o12TOZ
scim.ag
Joint profiling of gene expression and chromatin accessibility in pancreatic lymph nodes and spleens in human type 1 diabetes
Joint chromatin accessibility and transcriptomic profiling of human and mouse pancreatic lymph nodes uncovers distinct features of CD4 T cells in T1D.
5227
Reposted by Cadwell Lab
Julie Pfeiffer @jkpfeiff.bsky.social · 18/08/2025
Faculty search announcement 2025: Tenure-Track Assistant Professor in Microbiology at UT Southwestern. We seek candidates working in microbial pathogenesis (some preference may be given to bacterial pathogens). Come join our community! (1/5) www.utsouthwestern.edu/departments/...
Department members sit at a very long table in the hallway eating a pre-Thanksgiving potluck feast.
361100
Cadwell Lab @cadwelllab.bsky.social · 27/06/2025
Overall, we discovered that an intervention as simple as changing cages can control duration of viral infection in mice. Huge shoutout 🙏 to Christin and coauthors, the Gnotobiotics core at both Penn and NYU, and PennCHOP microbiome program for making this study possible 5/5
010
Cadwell Lab @cadwelllab.bsky.social · 27/06/2025
Cage change is a stress-inducing event for 🐭! We found that the fluctuation of glucocorticoids (hormones released under stress) contributes to viral clearance, and interference with this hormonal stress response actually inhibits MuAstV clearance after cage change! 4/5
110
Cadwell Lab @cadwelllab.bsky.social · 27/06/2025
Although continuous exposure to the viral reservoir does contribute to this persistent infection, we found that there is more at play here 🤔 In fact, cage change induces the activation of CD8 T cells and an interferon response in intestinal epithelial cells, driving the clearance of MuAstV. 3/5
110
Cadwell Lab @cadwelllab.bsky.social · 27/06/2025
We found in this study that Murine Astrovirus (MuAstV), an enteric RNA virus that is prevalent in wild, lab, and pet store mice, persists indefinitely in mice when they remain unperturbed in their cage. However, MuAstV is rapidly cleared after we change a mouse’s cage 🤯 2/5
110
Cadwell Lab @cadwelllab.bsky.social · 27/06/2025
Congratulations @christinviral.bsky.social and team for publishing this super cool discovery 😎 www.nature.com/articles/s41.... Here’s a quick summary of our cool findings about how stress due to simple mouse husbandry drives clearance of persistent enteric viral infection 🦠🐭 1/5
nature.com
Environmental stress drives clearance of a persistent enteric virus in mice - Nature Microbiology
Cage change of mice with persistent murine astrovirus infection triggers stress responses marked by corticosterone fluctuation, which is followed by CD8 T cell activation and induction of epithelial a...
1223
Reposted by Cadwell Lab
Waggoner Lab @labwaggoner.bsky.social · 17/06/2025
Review @natimmunol.nature.com @cadwelllab.bsky.social Gene–environment interactions shape the host–microbial interface in inflammatory bowel disease www.nature.com/articles/s41...
142
Cadwell Lab @cadwelllab.bsky.social · 26/06/2025
Congratulations @christinviral.bsky.social !!! Amazing job starting from an intriguing observation and drilling down to an exciting immune mechanism!
010
Cadwell Lab @cadwelllab.bsky.social · 26/06/2025
Thanks for highlighting our paper @lozanzi.bsky.social 🙏
140
Reposted by Cadwell Lab
Carlyn Zwarenstein @carlynzwaren.bsky.social · 01/06/2025
www.salon.com/2025/06/01/i... Featuring @cadwelllab.bsky.social and @angierasmussen.bsky.social
salon.com
It's time to make friends with your viruses
Viruses are in us. They're even part of us. Now researchers want to map the human virome
011
Reposted by Cadwell Lab
Mucosal Immunology @mucosalimmunol.bsky.social · 28/05/2025
Chris Hunter @kingofpathogens.bsky.social and colleagues review parasite and host immune factors that impact the development of a mucosal vaccine for #Cryptosporidium : www.mucosalimmunology.org/article/S193...
0136
Cadwell Lab @cadwelllab.bsky.social · 17/05/2025
Once again, thank you NIH for making this possible and our amazing coauthors. Special shoutout to coauthors Patty Martin and @torreslab.bsky.social for launching this project 🚀 5/n
051
Cadwell Lab @cadwelllab.bsky.social · 17/05/2025
Maybe ATG16L1 T300A is under balancing selection, like hemoglobin and APOL1 variants that are protective if you have 1 copy but 2 copies are bad (sickle cell/kidney disease)🤷‍♀️? Lots of questions surrounding mechanism that we’re continuing to examine 4/n
120
Cadwell Lab @cadwelllab.bsky.social · 17/05/2025
Turns out mice heterozygous for the variant, but not homozygotes, are highly protected from Salmonella and Listeria due to enhanced inflammasome🔥 activity! Macrophages from T300A heterozygous humans displayed similar enhanced inflammasome 🔥 3/n
130
Cadwell Lab @cadwelllab.bsky.social · 17/05/2025
Most people have at least 1 copy of the ATG16L1 T300A variant even though it’s associated with increased susceptibility to Crohn’s disease. What gives? 2/n
media.tenor.com
a rabbit from the secret life of pets is making a funny face and saying heh .
ALT: a rabbit from the secret life of pets is making a funny face and saying heh .
110
Cadwell Lab @cadwelllab.bsky.social · 17/05/2025
Congratulations Xiaomin Yao and Eugene Rudensky for publishing this story @cp-immunity.bsky.social! Big thank you to NIH for making this work possible. Here’s a brief summary of this 🤯 finding about a gene variant that YOU 🫵 most likely have 1/n
kwnsfk27.r.eu-west-1.awstrack.me
4216
Cadwell Lab @cadwelllab.bsky.social · 30/04/2025
Fantastic. Congrats!!!
030
Reposted by Cadwell Lab
Rita Strack @ritastrack.bsky.social · 10/04/2025
Your yearly reminder to acknowledge the core facilities you use and their staff scientists in your papers. These scientists are a crucial part of the scientific ecosystem and to continue to exist they need tangible credit for their work. Plus their associated expertise adds credibility to your work.
7484164
Reposted by Cadwell Lab
Carl Zimmer @carlzimmer.com · 05/04/2025
In other airborne news, here's a fabulous visual explanation of what measles does once it floats into your body. Gift link: www.nytimes.com/interactive/...
nytimes.com
How Measles Attacks an Unvaccinated Child (Gift Article)
With falling vaccination rates and outbreaks that have caused more than 580 U.S. cases and at least one death, health experts expect hundreds or even thousands more to be infected in the coming months...
18757
Reposted by Cadwell Lab
@KingOfPathogens @kingofpathogens.bsky.social · 27/03/2025
For those still interested in infection and the brain - here is a nice mix of math and pathogens - that tests the function of latency and how the immune system deals with a neuronal infection. Lots going on here to dissect - but turns out latency benefits host and parasite. rdcu.be/efknc
rdcu.be
Immune targeting and host-protective effects of the latent stage of Toxoplasma gondii
Nature Microbiology - In vivo and in silico analyses suggest that bradyzoite-directed immunity contributes to control of cyst numbers, tissue damage and mortality in mice.
2104
Reposted by Cadwell Lab
Mel Vazquez Hernandez @melvazquezh.bsky.social · 24/03/2025
What is up Bluesky! I'm an Associate Editor working at #PLOSBiology with everything related with #Microbiology and #Immunology Looking forward to all #science posts! Also, if you wanna book a meet-the-editor zoom meeting with me and talk about your work, just click scheduler.zoom.us/melissa-vazq...!
scheduler.zoom.us
Zoom Scheduler
Zoom external booking management
15610
Cadwell Lab @cadwelllab.bsky.social · 22/03/2025
Beautiful work @edelblumlab.bsky.social !
020
Reposted by Cadwell Lab
Alec Downie @aedownie.bsky.social · 16/03/2025
@cadwelllab.bsky.social has already posted about it, but we do have a new paper out about rewilding the immune system! This one is led by Ying-Han Chen (then NYU, now Academia Sinica) and Kimberly Zaldana (NYU), and it dives into the world of B cells. www.science.org/doi/full/10....
science.org
Rewilding catalyzes maturation of the humoral immune system
Releasing laboratory mice into the natural environment enhanced maturation and activation of the humoral immune system.
152
Reposted by Cadwell Lab
Alec Downie @aedownie.bsky.social · 16/03/2025
There's more exciting work to come from the rewilding experiments, so please do stay tuned for work from @grahammunology.bsky.social @cadwelllab.bsky.social et al.
021
Reposted by Cadwell Lab
Bella Rauch @rauchlab.bsky.social · 13/03/2025
Let's not forget that apart from science advocacy the Rauch lab also does kick-ass science! Together with the @psmitchej.bsky.social and Tait Wojno labs, we show that #tuftcells can induce specific protective signaling after recognition of intracellular bacterial infection via the #inflammasome!
46322
Cadwell Lab @cadwelllab.bsky.social · 08/03/2025
We are eternally 🙏 that the NIH officers and reviewers have expressed enthusiasm for these types of studies. Return in investment for the growing dirty mouse field is huge and will help industry, and gov’t 💰is essential to support the next phase 10/n
020
Cadwell Lab @cadwelllab.bsky.social · 08/03/2025
We previously received a great score on an NIH grant and hope we can get it funded by incorporating helpful suggestions from reviewers who spent lots of time reviewing these grants together with NIH staff 9/n
120
Cadwell Lab @cadwelllab.bsky.social · 08/03/2025
Investigators and equipment are NSF and NIH, both direct + indirect funds. Ying-Han and Kim are supported by Charles Revson and @hhmi.org fellowships. @hhmi.org contributed seed funding (through faculty scholars award) for initial studies and 3 universities 🎓chipped in infrastructure 8/n
110
Cadwell Lab @cadwelllab.bsky.social · 08/03/2025
In addition to our amazing coauthors, we thank the funding sources for making this possible. This is a fantastic example of how gov’t 💰 is maximized by private and university 🎓 funding 7/n
110
Cadwell Lab @cadwelllab.bsky.social · 08/03/2025
Therefore, dirty 🐀 approaches like rewilding can be used to better model and understand B cell and antibody responses in infectious and chronic inflammatory diseases to improve 🧑 health 🩺 6/n
110
Cadwell Lab @cadwelllab.bsky.social · 08/03/2025
This includes heightened germinal center responses leading to more antibodies that recognize the microbiota. Intriguingly, some B cell subsets become more🧑-like. Other groups like @langloislab.bsky.social and @tiffanyreeselab.bsky.social showed that vaccination is altered in dirty 🐀 5/n
120
Cadwell Lab @cadwelllab.bsky.social · 08/03/2025
These findings build on growing literature showing that Dirty Mice 🐀 (not in a squeaky clean lab) develop a more mature 🧑-like immune system thanks to microbes 🦠. In this new study, we teamed up with Sergei Koralov to show that development of B cells is jacked up💪 4/n
130
Cadwell Lab @cadwelllab.bsky.social · 08/03/2025
www.science.org/doi/10.1126/... 3/n
science.org
Rewilding of laboratory mice enhances granulopoiesis and immunity through intestinal fungal colonization
Fungal colonization of lab mice, through release into the wild or inoculation with Candida albicans, enhances granulopoiesis.
130
Cadwell Lab @cadwelllab.bsky.social · 08/03/2025
@grahammunology.bsky.social brought together multiple labs over the yrs to release 🐭 outdoor, called “rewilding”, to study how environment impacts immunity. Previously, we showed that neutrophils (white blood cells that eat microbes) are increased due to fungi upon rewilding 2/n
150
Cadwell Lab @cadwelllab.bsky.social · 08/03/2025
Congratulations Ying-Han Chen and Kim Zaldana for showing how B cells are altered when lab mice 🐭 are released outdoors! www.science.org/doi/10.1126/... Here’s some context for the paper followed by how gov’t 💰 + other sources combine to make these types of studies possible 1/n
science.org
Rewilding catalyzes maturation of the humoral immune system
Releasing laboratory mice into the natural environment enhanced maturation and activation of the humoral immune system.
47720
Reposted by Cadwell Lab
Victor J. Torres @torreslab.bsky.social · 22/02/2025
1/2 New publication from the lab from the talented postdoc Dr. Andy Perrault in collaboration with Dr. Alejandro Pironti! pubmed.ncbi.nlm.nih.gov/39977318/
pubmed.ncbi.nlm.nih.gov
Enterobacter hormaechei replaces virulence with carbapenem resistance via porin loss - PubMed
Pathogenic <i>Enterobacter</i> species are of increasing clinical concern due to the multidrug-resistant nature of these bacteria, including resistance to carbapenem antibiotics. Our understanding of ...
33112
Reposted by Cadwell Lab
Igor Brodsky @brodskyigorlab.bsky.social · 14/02/2025
Congratulations Yasmine!! Fantastic news and well deserved!
0153
Reposted by Cadwell Lab
Ardem Patapoutian @ardemp.bskyverified.social · 10/02/2025
Petition to Reverse the NIH Indirect Cost Cap initiated by Tom Maniatis. Please amplify Sign the Petition: chng.it/kK2HMP5pGk "Share with Leadership & Faculty. Reach out to professional societies, biotech and pharma leaders, and philanthropic organizations to raise awareness and mobilize support."
chng.it
Sign the Petition
Petition to Reverse the NIH Indirect Cost Cap (NOT-OD-25-068)
9157139
Reposted by Cadwell Lab
Daniel Mucida @danmucida.bsky.social · 02/02/2025
@solvingforsci.bsky.social (@maxkrummel.bsky.social and others)came up with an alternative (I think, transformative) peer-review system (still in its pilot phase). Contribute by submitting (or reviewing) @biorxiv-immuno.bsky.social studies to solvingfor.org/discovery-st...
solvingfor.org
1134
Cadwell Lab @cadwelllab.bsky.social · 25/01/2025
Congratulations Katie!!!
010