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Bryan Lenneman

@brlenneman.bsky.social
240 followers 442 following 2 posts

Instructor @ Massachusetts General Brigham & Harvard Medical School | Phage & microbiome engineering | He/him | Views my own

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The Phage @thephage.bsky.social · 13/10/2026
We have finalised another course on Phage Genome Assembly, Annotation, and Visualisation. This free, self-paced training guides you from raw sequencing data to a finished genome map using real, published phage sequencing runs. Start the training here: www.thephage.xyz/training/pha... #phage
Phage genome assembly and annotation course flyer
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Vivek Mutalik @vivekmutalik.bsky.social · 13/10/2026
A new preprint 🎉 from phagefoundry.org Mycobacteriophages are candidate therapies for drug-resistant mycobacterial infections, but we still don't know how most of them get into their hosts. Our new preprint tackles this challenge 👉🏽 www.biorxiv.org/content/10.6...
Artistic view of Bacteriophages as a solution to treating antibiotic resistant bacterial infections
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The Phage @thephage.bsky.social · 03/10/2026
We designed a free, self-paced introduction to command line course for those who are ready to embark on building their bioinformatics skills. Our new course, The Command Line for #Phage Biologists, assumes you do not know anything about the terminal. www.thephage.xyz/training/int...
thephage.xyz
The Command Line for Phage Biologists | The Phage
A ground-up introduction to the terminal and Bash for bench scientists. No coding experience needed. Learn to easily navigate and manipulate data files.
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Vivek Mutalik @vivekmutalik.bsky.social · 29/09/2026
In our brand new 🥳 review, @hemaa-selvakumar.bsky.social & team pull a scattered literature in phage biology into a coherent framework for scaling up to engineering complex communities. We poured our hearts into this to share challenges & future opportunities for the nextGen!
Next generation application space with systematic characterization of phage-host interaction landscapes.
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Vivek Mutalik @vivekmutalik.bsky.social · 29/09/2026
Happy to share that @averynoonan.bsky.social paper “Phylogeny-agnostic strain-level prediction of phage–host interactions from genomes using machine learning” is now published in @natmicrobiol.nature.com 🎉🎊 👉🏽 rdcu.be/nR2NizD7H5va
Machine learning workflow for GenoPHI platform
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Vivek Mutalik @vivekmutalik.bsky.social · 14/08/2026
Newest preprint 🎉 from phagefoundry.org Here we built one of the most comprehensive K. pneumoniae phage–host interaction datasets to date, an atlas of 8,484 interactions testing 84 taxonomically diverse phages vs 101 globally sourced clinical strains, including some of the most resistant kinds.
Phage art
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Vivek Mutalik @vivekmutalik.bsky.social · 25/07/2026
New Preprint 🥳 Here we wondered how phages that have been extensively studied in laboratory E. coli strains actually behave when they encounter a real pathogen such as O157:H7 strain...one with a far more complex cell surface & one of the most consequential foodborne pathogens in the United States.
static.klipy.com
Animated E. coli Bacteria Drawing
Alt: Animated E. coli Bacteria Drawing
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Kate Baker @ksbakes.bsky.social · 09/07/2026
👀👇 New work on sexually transmitting Shigella (press-friendly: bit.ly/4bBarEL) From continued collaboration with @clairejenkins2.bsky.social @ukhsa.bsky.social, @pducambridge.bsky.social co-lead @hsalje.bsky.social, a talented student Julia Marshall www.linkedin.com/in/julia--ma..., and others! 🧫🧬💊
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The Verge @theverge.com · 29/06/2026
"Everyone will be affected, not just scientists. Every community in the country.“ A sneaky rule change has the potential to blow up scientific research in the United States. But there’s still time to fight it. Read more from @beebrookshire.bsky.social: www.theverge.com/science/9576...
Verge headline: The war against ‘woke’ could end US science as we know it
by Bethany Brookshire

Illustration of an American flag draped into a measuring glass, where it dissolves
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Vivek Mutalik @vivekmutalik.bsky.social · 21/06/2026
www.nature.com/articles/s41... How N4 pushes its vRNAP into the target cell 🥹 #phage #phagesky
nature.com
Structural choreography of bacteriophage N4 ejection proteins and the giant virion-associated RNA polymerase - Nature Communications
Schitoviruses inject a giant RNA polymerase into bacteria to initiate infection. Here, Bellis et al. reveal the architecture of the coliphage N4 vRNAP and its crosstalk with phage ejection proteins th...
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MSU MGI @msumgi.bsky.social · 16/06/2026
Former MSU president Teresa Woodruff has launched a new website and podcast focused on reproductive science and human health. We love to see members of the MSU community continuing to make science accessible and engaging for broader audiences. Check it out at repro101.com.
A copy of a linkedin post by Teresa Woodruff saying, " I am delighted to share the launch of Repro101.com, a new home for accessible, science-based conversations about reproductive health, featuring learning tools from my lab. 
 
I am also excited to announce something I never expected to do - I've started a podcast!  
 
The podcast covers much of the work that has been done in my lab, and we’re starting with a season of episodes covering puberty. This first season, Parenting Through the Change, is for anyone looking to learn more about the biology of puberty and better communicate with kids between ages 5 and 15 on the topic. 
 
The podcast is hosted on all major streaming platforms and at Repro101.com.
 
I hope you will give a listen and share it with anyone who might find it useful. If you find it valuable, please leave a comment, like/reaction, subscribe and share it with your networks. You can also find me and the podcast on Instagram and Substack (both @teresakwoodruff) and on Facebook at Teresa K Woodruff and Repro101."
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RCSB Protein Data Bank @rcsbpdb.bsky.social · 12/06/2026
Scientists are actively researching ways to make phage therapies more effective. This includes efforts to engineer phages to expand their host range and aid in bacterial defense system evasion. More at Molecule of the Month: pdb101.rcsb.org/motm...
Left: JBD30 is a siphophage that infects Pseudomonas aeruginosa by attaching to hair-like pili on the bacterial surface. This illustration was created by combining pdb_00008rkc, pdb_00008rkb, pdb_00008rk9, pdb_00008rk8, pdb_00008rk7, pdb_00008rk6,pdb_00008rk5, and pdb_00008rk4. Right: Andhra is a podophage that infects Staphylococcus epidermidis. This illustration was created by combining pdb_00008egt, pdb_00008egs, pdb_00008egr, and pdb_00008ej5.
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Biosciences Area at Berkeley Lab @biosci.lbl.gov · 11/06/2026
Phage Foundry lead @vivekmutalik.bsky.social was mentioned in a Q&A by Aeron Hammack of the @molecularfoundry.lbl.gov. Phages are bacterial antagonists useful in medicine; Phage Foundry is making a database of them. Mutalik’s team saves researchers resources by bypassing a demanding research phase.
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Jessica Sacher @jessicasacher.bsky.social · 05/06/2026
NIAID (@niaidnews.bsky.social) has awarded $6M to launch a coordinated US phage therapy research network — 3 new centers! Excited our Stanford Center for Phage Pharmaceuticals (@stanfordmedicine.bsky.social) is one, & to work w/ @gladstoneinst.bsky.social & @pghphageprogram.bsky.social! 🧵 1/
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Vivek Mutalik @vivekmutalik.bsky.social · 04/06/2026
Any phage ppl at #ASMMicrobe2026 ? I’ll be a panelist at the Science & Society Lecture on phage therapy & AMR, Sunday June 7, 2026, 4:30 PM, Ballroom AB, Washington D.C. Will be sharing experience - phagefoundry.org on platform techs needed fo translation #PhageTherapy #AMR #phagesky #microsky
ASM Microbe 2026 science and society lecture on phage therapy
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Pittsburgh Phage Program @pghphageprogram.bsky.social · 03/06/2026
Big news for phage therapy! NIAID has funded the first coordinated U.S. research network dedicated to advancing phage therapeutics against antibiotic-resistant infections. We're proud to be part of this national effort. Read more: dom.pitt.edu/nih-funds-fi... #PhageTherapy #PittsburghPhageProgram
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CIDRAP @cidrap.bsky.social · 17/04/2026
The CDC warns that extensively drug-resistant (XDR) Shigella is on the rise in US. The prevalence of XDR Shigella isolates in US surveillance data rose from 0% during 2011-2015 to 8.5% in 2023. Read more: ow.ly/VXee50YLphl 📷: CDC, Stephanie Rossow
Rendering of Shigella bacteria under the microscope.

📷: CDC, Stephanie Rossow
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Microbes.Info @microbesinfo.bsky.social · 16/04/2026
#Diarrhea-causing #infection increasing in United States ... | #shigella | #MicroSky | #bacteria | #pathogen | #publichealth | Via @usatoday.com
usatoday.com
Diarrhea-causing infection increasing in US, CDC says
Officials called the increase "a public health threat," especially since shigella is spread easily from person to person.
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Christina Faherty @christinafaher1.bsky.social · 15/04/2026
#Shigella in the #news. We've known about #MDR, now we're seeing a rise in #XDR isolates @shigellameeting.bsky.social #Microsky #AMR #IDsky thehill.com/homenews/nex...
thehill.com
Cases of drug-resistant infection that causes diarrhea are rising: What to know
Cases of drug-resistant Shigella infections are increasing in the United States in a trend that the Centers for Disease Control and Prevention (CDC) are calling a “public health threat.&#8221…
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Boston Bacterial Meeting @bostonbacteria.bsky.social · 14/04/2026
‼️There are a FEW DAYS LEFT to submit an abstract to present a poster or be considered for a talk at BBM! ‼️ ⭐️Regsiter and submit abstracts through our website: bostonbacterial.org ⭐️ Abstract submission deadline/early registration: April 17th Registration deadline: June 5th SEE YOU AT #BBM2026!
bostonbacterial.org
Boston Bacterial Meeting
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MSU MGI @msumgi.bsky.social · 13/04/2026
MGI's Rudolph Hugh Endowed Professor Sean Crosson gave a talk at this weekend's "Classes Without Quizzes" event entitled "Many Microbes, One Health: Bacteria at the interface of animal, plant, and human health." Read more about the event here: natsci.msu.edu/alumni-frien...
Professor Sean Crosson stands at a lectern behind bouquets of flowers to deliver a talk at this year's Classes without quizzes event. On the screen behind him is the quote "Between animal and human medicine there are no dividing lines - nor should there be." attributed to Rudolf Virchow (ca. 1858).
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George O'Toole (he/him/his) @geiselbiofilm.bsky.social · 08/04/2026
McLaughlin, Fiebig, Crosson et al. discover/characterize two variants of Circe, a freshwater N4-like podophage that requires smooth LPS as a receptor. journals.asm.org/doi/10.1128/... @asm.org #JBacteriology
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Nature @nature.com · 02/04/2026
Bacteria have been fighting off viruses using a huge arsenal of molecular weaponry that scientists did not know about — until now. Researchers have identified proteins that could lead to virus-fighting drugs and technologies. go.nature.com/4dqQnXI
go.nature.com
‘Treasure trove’ of antiviral proteins could inspire powerful molecular tools
Two research teams mined genomic data from bacteria to create databases containing thousands of antiviral defence proteins that could inspire powerful biotechnologies.
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Vivek Mutalik @vivekmutalik.bsky.social · 03/04/2026
📣Huge preprint 🔔 Today we share something our group has been working toward for a long time, led by @lucasmoriniere.bsky.social We asked can we predict which receptor a phage targets from its genome sequence alone? For most phages, we couldn’t. So Lucas set out to do something I had only dreamed of.
Phage receptor prediction from genome sequencing alone. Bacterial receptor (blue) interacting with phage proteins (purple) is shown here
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ASM @asm.org · 31/03/2026
Tackling antimicrobial resistance requires treating coordinated phage therapy as a strategic priority. Read the new op-ed from ASM Health Director Dev Mittar: asm.social/2Sc
More patients will face bacterial infections that no antibiotic can treat, and the pipeline for new drugs cannot keep up. One of the most promising options for treating resistant infections already exists in nature: bacteriophages, the viruses that infect and kill bacteria.
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Dave Baltrus 🦦 @surtlab.bsky.social · 27/02/2026
Bringing in @simrouxvirus.bsky.social because it feels like we as a community are going to begin having vigorous discussion about ground truthing phage-bacteria interactions and what data prove and don’t prove
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ASM @asm.org · 28/01/2026
Breakthrough science needs coordination to deliver impact. ASM Health is launching 4 initiatives to turn microbial discovery into real-world solutions—starting with the Phage Therapy Coordination Network to address AMR at scale. Apply to collaborate: asm.social/2MU
ASM Health: Advancing Microbial Science for a Healthier World
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Yonker Lab @laelyonker.bsky.social · 28/01/2026
Our first lab publication from UT Southwestern! Phage-Based Approaches to Chronic Pseudomonas aeruginosa Lung Infection in #CysticFibrosis www.mdpi.com/2079-6382/15...
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Alexander Harms @aharms485.bsky.social · 20/11/2025
🚨Preprint alert - this is a big one! We transfer the revolutionary power of TnSeq to bacteriophages. Our HIDEN-SEQ links the "dark matter" genes of your favorite phage to any selectable phenotype, guiding the path from fun observations to molecular mechanisms. A thread 1/8
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Christina Faherty @christinafaher1.bsky.social · 21/10/2025
Why attend the @shigellameeting.bsky.social in 6 months you ask? (🧵) 🦠 🧫 🔬 #Microsky #IDsky What a question and a grand request, To muse on why scientists should travel for a pest! Forget lonely lab benches and the pipette's cold song, There are better pursuits for which researchers long.
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Christina Faherty @christinafaher1.bsky.social · 25/09/2025
Exciting to see the Standardized #Organoid Modeling Center is opening to help standardize protocols, provide tools and resources, and connect the research community at the national level after being in development for a few years www.nih.gov/som
nih.gov
NIH Standardized Organoid Modeling (SOM) Center
The Standardized Organoid Modeling (SOM) Center will be the nation’s first fully integrated platform dedicated to developing standardized organoid-based New Approach Methodologies (NAMs).
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Christina Faherty @christinafaher1.bsky.social · 19/09/2025
Registration & abstract submissions are open for the #Shigella meeting! Travel grants available too! All are welcomed, whether you are active in #Shigella research or interested in the 21st century perspective on this formidable pathogen! 🦠 🧫 #Microsky www.shigella2026.conferences-pasteur.org/home
shigella2026.conferences-pasteur.org
Home - EMBO Workshop Shigella: from biology to prevention
EMBO Workshop Shigella: from biology to prevention
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The Shigella Meeting @shigellameeting.bsky.social · 18/09/2025
Come and join us in Paris 2026 to talk all about Shigella!
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Bryan Lenneman @brlenneman.bsky.social · 08/08/2025
Had a wonderful time at #phages2025. Cool venue, exciting science, and inspiring people!
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George Bouras @gbouras13.bsky.social · 08/08/2025
I also put together an extra ColabFold formatted database of nearly 130M phage proteins that can be used to make better viral protein structure predictions github.com/gbouras13/co...
github.com
GitHub - gbouras13/colabfoldv: Augmented Local MSA Generation for Phage and Viral Proteins using the ColabFold Framework
Augmented Local MSA Generation for Phage and Viral Proteins using the ColabFold Framework - gbouras13/colabfoldv
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Yonker Lab @laelyonker.bsky.social · 30/07/2025
Our MISC clinical trial results, just published! “Clinical Trial Finds Safe, Effective Treatment for Children with Severe Post-COVID Syndrome” massgeneralbrigham.org/en/about/newsr… #COVID @ScienceTM @biotium.bsky.social
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Christina Faherty @christinafaher1.bsky.social · 25/07/2025
Really looking forward to the First #Shigella International Meeting to be held in Paris, France, April 2026! The meeting website is almost ready. Please follow @shigellameeting.bsky.social for more information and updates! #Microsky 🦠 🧫 🔬
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Mo lab @molabuw.bsky.social · 22/07/2025
Delighted to be part of this collaboration with the Raman Lab at @uwmadison.bsky.social: www.sciencedirect.com/science/arti...
sciencedirect.com
Systematic, high-throughput characterization of bacteriophage gene essentiality on diverse hosts
Understanding core and conditional gene essentiality is crucial for decoding genotype-phenotype relationships in organisms. We present phage high-thro…
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Anthony William Maresso Ph.D. @tailor-labs.bsky.social · 06/06/2025
TAILΦR Milestone! Dosed our first patient with @bwtrautner.bsky.social in an academic-led clinical trial (NCT06559618). The phages were discovered, manufactured, tested, FDA approved and now administered in one location by one team, an end-to-end miracle we hope will counter the AMR crisis. Dream!
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SellinLab @sellinlab.bsky.social · 12/06/2025
Our latest work combines human gut epithelial #organoid culture with experimental #Shigella #infections, transposon mutagenesis, and statistical modeling. This has led to the mapping of the comprehensive geneset that drives Shigella epithelial colonization. Out @natgenet.nature.com: rdcu.be/eqGgf
rdcu.be
A scalable gut epithelial organoid model reveals the genome-wide colonization landscape of a human-adapted pathogen
Nature Genetics - A genome-wide screen using human gut epithelial organoids combined with transposon-directed insertion sequencing identifies over 100 Shigella flexneri genes required for...
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Bryan Lenneman @brlenneman.bsky.social · 11/06/2025
Had a wonderful time learning from the amazing scientists presenting at #bbm2025. Huge congrats to Morgan Devlin for recognition of her poster presentation! Very well deserved! #phagesky #proudPI
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ASM @asm.org · 10/06/2025
The human body is chock full of phages, from the skin to the gut. What role does the phageome have in health and disease? Watch Microbial Minutes for the story! www.youtube.com/watch?v=5PyM...
youtube.com
The Phageome’s Role in Health and Disease
YouTube video by American Society for Microbiology
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Paul Adamson MD MPH @padamsonmd.bsky.social · 06/06/2025
🚨 Extensively drug-resistant #Shigella is increasing in #LosAngeles. PLWH and GBMSM are disproportionately affected. We have seen several of these, very difficult to treat. Antibiogram shows 📈 resistance, susceptibility testing is 🔑. #IDsky #Medsky #EMSky #AMR #XDR 🔗: t.e2ma.net/webview/3apx...
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Emmanuele Severi @emmseveri.bsky.social · 29/05/2025
#phagesky www.science.org/doi/10.1126/...
science.org
Engineering bacteriophages through deep mining of metagenomic motifs
We unlock the potential encoded in phage metagenomes to engineer phages to change host range and kill pathogenic bacteria.
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INCATE @incate.bsky.social · 27/05/2025
📢 Attention all phage-interested: the WHO has just release its first report on phages! This report highlights key insights from expert consultations, webinars, and a dedicated workshop in Tbilisi, Georgia. Read report here ➡️ www.who.int/europe/publi...
who.int
Building the evidence for the use of bacteriophage therapy
Publicaciones de la Organización Mundial de la Salud
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Sherry Pagoto, PhD @drsherrypagoto.bsky.social · 12/03/2025
New report shows that NIH grants fueled $95 billion in economic activity and 407,782 jobs in 2024. That's not to mention the countless lives that biomedical research has saved. Show me a better investment than that. www.forbes.com/sites/michae...
forbes.com
NIH Grants Fueled $95 Billion In FY 2024 Economic Activity, Finds New Report
National Institutes of Health grants generated almost $95 billion in economic activity nationwide in FY 2024 according to a new report by United for Medical Research.
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John Hatchard @johnhatchard.bsky.social · 22/12/2024
#SuperBug #Shigella #Diarrhea #LA #LosAngeles #California #StomachFlu #XDR #Bacteria #Sonnei Researchers have tracked down a worrying new strain of Shigella bacteria in the area—one that can resist almost every antibiotic thrown at it. Abridged (shortened) article thread ⬇️ 4 min
gizmodo.com
'Alarming': A Dangerous Diarrhea-Causing Superbug Is Spreading in Los Angeles
An novel and extensively drug-resistant strain of Shigella sonnei has emerged and is likely still actively spreading in the U.S., scientists warn.
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Christina Faherty @christinafaher1.bsky.social · 22/11/2024
#USUHS Summer Scholars Program is accepting applications for #high-schoolers and #undergrads to gain #research experience. #Paid internship for 8-10 weeks, options for #mentors across campus, including my lab 😀 Other #career development activities included, links below! 🧫🦠🧪🧬🔬
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