Sign in

Bowles Lab

@bowleslab.bsky.social
608 followers 354 following 45 posts

UK DRI Group leader at the University of Edinburgh. Neuroscientist using iPSC, organoids & genetics to understand Tauopathy and other dementias. Instagram: @bowleslab She/Her

PostsRepliesMedia
Bowles Lab @bowleslab.bsky.social · 30/09/2026
Announcing our plenary speakers for SCMND2027! View all of our confirmed speakers, Register, and Submit your abstract on SCMND.com SCMND2027: 19th-21st May 2027, Edinburgh, UK @ukdri.ac.uk #iPSC #neurodegeneration #organoids
010
Bowles Lab @bowleslab.bsky.social · 09/09/2026
Labby 4th Birthday to us! 🎂🎉🎂
020
Bowles Lab @bowleslab.bsky.social · 31/08/2026
We're BACK! 🥳 SCMND returns for 2027! 🎉🎉 Agenda, Speakers, Registration & Abstract submission now available on scmnd.com #iPSC #Organoids #Neurodegeneration #StemCell
022
Bowles Lab @bowleslab.bsky.social · 29/07/2026
The next Stem Cell Models of Neurodegeneration meeting is now loading... 🚨SAVE THE DATE!🚨 19th - 21st May 2027 Edinburgh, UK Registration & Abstract submission opening soon!
022
Bowles Lab @bowleslab.bsky.social · 05/07/2026
New pre-print from us! We compare two iPSC-microglia protocols, and take a look at the cell autonomous and non-cell autonomous effects of MAPT mutation: www.biorxiv.org/content/10.6...
biorxiv.org
Cross-protocol comparison of iPSC-microglia reveals hypofunction contributes to neuronal vulnerability and synaptic alterations in the MAPT-S305N model of frontotemporal dementia.
Progressive and chronic neuroinflammation is associated with numerous neurodegenerative diseases, including primary tauopathies such as frontotemporal dementia and progressive supranuclear palsy. Unli...
0123
Bowles Lab @bowleslab.bsky.social · 02/05/2026
Bowles lab Spring Thing 2026! We all went pottery painting - finished articles coming in a few weeks!
010
Bowles Lab @bowleslab.bsky.social · 15/12/2025
We had a super time at Curl Edinburgh for our lab Christmas party! So much fun - definitely recommend! See photo 4 for this year's lab gifts 🤩
010
Bowles Lab @bowleslab.bsky.social · 01/12/2025
We are looking for a bioinformatics postdoc to join our group! Apply here 👇👇👇 www.jobs.ac.uk/job/DPQ109/p...
023
Bowles Lab @bowleslab.bsky.social · 20/11/2025
New PhD position with us and @eastbio.bsky.social is now open, focused on developing novel iPSC- organoid models 👇👇👇 www.findaphd.com/phds/project...
010
Bowles Lab @bowleslab.bsky.social · 25/10/2025
Huge congratulations to lab postdocs Dr. Sousa & Dr. Lopez for each winning grants from @pspassociation.bsky.social! Such cool projects!!
020
Bowles Lab @bowleslab.bsky.social · 18/09/2025
🚨We're hiring!🚨 We're looking for a new postdoc to join our team, to lead a project focused on ELAVL4 subcellular localisation in iPSC organoids - check it out! 👇👇 elxw.fa.em3.oraclecloud.com/hcmUI/Candid...
010
Bowles Lab @bowleslab.bsky.social · 10/05/2025
Bowles lab Spring Thing 2025
080
Bowles Lab @bowleslab.bsky.social · 02/05/2025
From Tau2025 to #BNA2025 @britishneuro.bsky.social in Liverpool! We had the opportunity to host a session on Glial Mechanisms in Primary Tauopathy, sponsored by ARUK. Our PhD student Lois Keavey gave a super talk, followed by Dr. Aitana Sogorb-Esteve and Prof. Delphine Boche 🧠🧠🧠
070
Bowles Lab @bowleslab.bsky.social · 27/04/2025
We all had a super time at #Tau2025 this week! Learned a thing or two, made some new collabs and caught up with good friends! Thank you so much Rainwater Foundation, CurePSP, Alzheimer's Association & @pspassociation.bsky.social 😊
031
Bowles Lab @bowleslab.bsky.social · 26/03/2025
Day 1 of #SCMND2025 today! The Edinburgh weather was glorious and the science was incredible 😍😍 Looking forward to Day 2! @ukdri.ac.uk
071
Bowles Lab @bowleslab.bsky.social · 03/03/2025
Still thinking about #SCMND2025? Only 6 tickets left! 👇👇👇 scmnd.com #ipsc #organoids #dementia #neurodegeneration #neurons #microglia #astrocytes #oligodendrocytes
022
Bowles Lab @bowleslab.bsky.social · 25/02/2025
A reminder of the incredible line-up of speakers and panel discussants we have for the inaugural #SCMND2025 meeting next month. Registration CLOSES 7th March Find out more at scmnd.com @UKDRI #iPSC #neurodegeneration #organoids #stemcells #neuroscience
010
Bowles Lab @bowleslab.bsky.social · 19/02/2025
Meet our 5 ECR speakers, selected from >160 abstract submissions! You still have just over 2 weeks left to register for #SCMND2025! Head to 👉 scmnd.com for more info! @julien-klimmt.bsky.social @ukdri.ac.uk @cbdresearch.bsky.social @sheffielduni.bsky.social @ub.edu @lmumuenchen.bsky.social
051
Bowles Lab @bowleslab.bsky.social · 12/02/2025
A nice spotlight from us in @cp-trendsneuro.bsky.social, summarizing recent work in @natureneuro.bsky.social from the Zoghbi lab, showing tau phosphorylation & aggregation by TYK2 Original article👉https://tinyurl.com/wd4n2ewf Spotlight 👉https://tinyurl.com/3dwpw75m
000
Bowles Lab @bowleslab.bsky.social · 11/02/2025
Did you know, the venue for #SCMND2025 sits at the bottom of Arthur's Seat - an ancient extinct volcano? Come see some cool science AND take a stroll up a volcano, all in the same week - registration is still open! 👉https://scmnd.com/ #organoids #iPSC #stemcells #dementia
000
Bowles Lab @bowleslab.bsky.social · 03/02/2025
Wow! We have had such a fantastic response to our call for abstracts for #SCMND2025, we've been able to DOUBLE our poster capacity!!! Abstracts are closed, but Registration is still open! Come join us 🤗🤗🤗 👇👇👇 scmnd.com #ipsc #dementia #organoids
030
Bowles Lab @bowleslab.bsky.social · 30/01/2025
Not only are we bringing together the best #dementia #iPSC researchers, but we also want to platform the best resources and repositories at #SCMND2025. Interested in joining us @coriellinstitute.bsky.social @ncrad.bsky.social @isscr.org? 👇👇👇 scmnd.com
010
Bowles Lab @bowleslab.bsky.social · 28/01/2025
Haven't decided whether you're coming to #SCMND2025 yet? Perhaps Edinburgh in Springtime can convince you! Come join us for #iPSC, castles, and maybe a wee dram! Find everything you need to know at scmnd.com! #organoids #stemcells #neuroscience
010
Bowles Lab @bowleslab.bsky.social · 27/01/2025
Here's our incredible FULL LINEUP of speakers for #SCMND2025! Abstract submission closes Friday! scmnd.com @rikvanderkant.bsky.social @selinawray.bsky.social @carlescalatayud.bsky.social @rcasterton.bsky.social @annawilliamslab.bsky.social @sergiuppasca.bsky.social @neuralstemcells.bsky.social
0168
Bowles Lab @bowleslab.bsky.social · 24/01/2025
🚨ONLY ONE MORE WEEK LEFT TO SUBMIT AN ABSTRACT!🚨 👇👇👇 scmnd.com #iPSC #stemcells #organoids #neurodegeneration #Alzheimers #FTD #ALS #Parkinsons #neuroscience #cureND #DZNE #UKDRI #ParisBrainInstitute @cbdresearch.bsky.social @edinunineuro.bsky.social
041
Bowles Lab @bowleslab.bsky.social · 21/01/2025
We need to improve the diversity of our iPSC models - we'll be discussing how we can do that and hearing from some fabulous speakers from around the world at #SCMND2025! @asapresearch.bsky.social Come and join the discussion - submit your abstract & register 👉 scmnd.com
043
Bowles Lab @bowleslab.bsky.social · 20/01/2025
We are so fortunate that #SCMND2025 is not only supported by UKDRI, but also by ARUK, Brain and Company of Biologists, as well as a host of other sponsors! Go to scmnd.com to find out more, submit your abstract & register! #ipsc #neuroscience #neurodegeneration #stemcell
040
Bowles Lab @bowleslab.bsky.social · 17/01/2025
Oooh look at that little green oligodendrocyte making its way through an organoid! #FluorescenceFriday #iPSC #organoids (Want to see more cool iPSC stuff? Come join us at #SCMND2025 in Edinburgh! Register at scmnd.com)
0151
Bowles Lab @bowleslab.bsky.social · 16/01/2025
Neurons, astrocytes, microglia, oligodendrocytes, blood brain barrier, organoids, chips... we've got it all covered! 🧠 Check out our full list of speakers (and register to come see them) at scmnd.com! #iPSC #neuroscience #neurodegeneration #organoid #stemcells
030
Bowles Lab @bowleslab.bsky.social · 15/01/2025
ANOTHER exceptional 3D organoid models session at #SCMND2025? What a treat! Come join us in Edinburgh this March for some incredible science! Submit your abstract and register here 👉👉https://scmnd.com/ #iPSC #organoids #neuroscience #dementia #neurodegeneration #Edinburgh #UKDRI
041
Bowles Lab @bowleslab.bsky.social · 14/01/2025
More incredible speakers lined up for SCMND2025 - in the first of two sessions focused on 3D models of neurodegeneration! Submit your abstract before 31/01/2025 and register now! scmnd.com @cbdresearch.bsky.social @selinawray.bsky.social @annawilliamslab.bsky.social @edinunineuro.bsky.social
054
Bowles Lab @bowleslab.bsky.social · 13/01/2025
Come see our amazing plenary speakers at SCMND2025, March 26th-28th! Full agenda & registration are available at scmnd.com And hurry - abstract submissions are only open until the end of January!! 🏃‍♂️🏃‍♂️🏃‍♂️ #stemcell #iPSC #Neuroscience #Edinburgh #organoids
072
Bowles Lab @bowleslab.bsky.social · 10/01/2025
My son asked for a space cake, and a space cake he got!! 🚀 I'm very proud of it - it took a few evenings, and I made all of those chocolates myself from scratch! It's strawberry & vanilla with strawberry cream cheese frosting 😋 The kitchen is covered in glitter!
050
Bowles Lab @bowleslab.bsky.social · 09/01/2025
Really cool PhD opportunity with a colleague at the University of Strathclyde, developing an iPSC model of stroke on a chip: 👇👇👇 www.findaphd.com/phds/project... #PhD #iPSC #stroke #neuroscience
findaphd.com
Development of 'human stroke-on-a-chip' model to replace rodent stroke models at University of Strathclyde on FindAPhD.com
PhD Project - Development of 'human stroke-on-a-chip' model to replace rodent stroke models at University of Strathclyde, listed on FindAPhD.com
010
Bowles Lab @bowleslab.bsky.social · 07/01/2025
New toy for the lab arrived today! 🤗🤗🤗
020
Reposted by Bowles Lab
Dr Soraya M @sorayam.bsky.social · 06/01/2025
Cool new paper from Edinburgh (@edinunineuro.bsky.social) using the FIRE mice to assess synaptic and neuronal properties in development in the absence of microglia. Maybe microglia aren’t as important as we thought? (lol jk don’t @ me glia people). 🧠🧪 rdcu.be/d5ru3
rdcu.be
Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus
Nature Neuroscience - Microglia are proposed to have a role in brain development through synaptic engulfment and paracrine signaling. O’Keeffe et al. show that certain neurodevelopmental...
2162
Bowles Lab @bowleslab.bsky.social · 31/12/2024
A great 2024 for the lab! So grateful to have such a wonderful team, doing such fun and interesting work! Really looking forward to what we will all accomplish together in 2025! 🤗🧠
020
Bowles Lab @bowleslab.bsky.social · 20/12/2024
I hope I'm not too late for #FluorescenceFriday! Here's one of our organoids from a recent pilot protocol we're testing out! (whole mount, cleared & imaged by light sheet)
0121
Bowles Lab @bowleslab.bsky.social · 18/12/2024
Don't forget, the abstract deadline for SCMND 2025 is next month! Check out scmnd.com for more information! #ipsc #stemcells #neuroscience #Edinburgh #neurodegeneration #organoids
041
Bowles Lab @bowleslab.bsky.social · 17/12/2024
We had our lab Christmas party at The Anatomist escape room last night (highly recommend!) Super fun, we all escaped, then celebrated with a quiz and dinner 🤗🤗🤗
020
Bowles Lab @bowleslab.bsky.social · 04/12/2024
10 years after completing my PhD @cardiffuni.bsky.social, I'm on my way back for the first time to examine a viva and give a seminar in my old department! So honoured to have the opportunity for this full circle moment, and excited to visit both old friends and new!
050
Bowles Lab @bowleslab.bsky.social · 02/12/2024
Don't forget to register for Stem Cell Models of Neurodegeneration 2025 at scmnd.com !! Abstract submissions are open until the end of January 2025. We look forward to hosting you in Edinburgh 🤗 #iPSC #stemcells #neuroscience #neurodegeneration #dementia
051
Bowles Lab @bowleslab.bsky.social · 28/11/2024
Finally got this across the finish line! We made an isogenic panel of MAPT splicing mutation iPSCs that express high levels of endogenous 4R tau... ...and saw some cool stuff! 👇👇👇 tinyurl.com/38e5d6d2 Big thanks to supporters RCFneuro, Brightfocus, AFTD & UKDRI!
0136
Reposted by Bowles Lab
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 26/11/2024
Exciting new discovery from colleagues @stanfordmedicine.bsky.social, astrocyte metabolism compromised by amyloid and tau oligomers leading to insufficient support for neurons. Possible new target for treating AD. www.science.org/doi/10.1126/...
science.org
Restoring hippocampal glucose metabolism rescues cognition across Alzheimer’s disease pathologies
Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer’s disease (AD), with recent proteomic studies highlighting disrupted glial metabolism in AD. We report that inhibition of indo...
420947
Bowles Lab @bowleslab.bsky.social · 26/11/2024
On my way to UCL to give a seminar on all things #tau and #iPSC! Looking forward to hanging out with the @marcaurelbusche.bsky.social and @selinawray.bsky.social labs 😊 Struggling with my enormous Edinburgh-weather-appropriate but London-inappropriate coat on the Piccadilly line though 🫣
1103
Reposted by Bowles Lab
Dementia Researcher @dementiaresearcher.bsky.social · 26/11/2024
The new @alzheimerssoc.bsky.social funded 🔬 VIDA DTC focuses on vascular & immune contributors to dementia. Join a collaborative PhD programme to advance understanding & treatments. 8 funded positions, and 14 projects to choose from. Apply by 20 Dec www.dementiaresearcher.nihr.ac.uk/phd-students...
dementiaresearcher.nihr.ac.uk
PhD Studentships at the VIDA Doctoral Training Centre - DEMENTIA RESEARCHER
Join the Alzheimer's Society VIDA-DTC for a funded PhD in Vascular and Immune Contributions to Dementia! Work with top UK institution. Applications open now!
183
Reposted by Bowles Lab
Patrick Martin @pcnmartin.bsky.social · 20/11/2024
An organoid Atlas? I'm listening... www.nature.com/articles/s41...
nature.com
An integrated transcriptomic cell atlas of human neural organoids - Nature
A human neural organoid cell atlas integrating 36 single-cell transcriptomic datasets shows cell types and states and estimates transcriptomic similarity between primary and organoid counterparts, sho...
0167
Reposted by Bowles Lab
Axel Montagne @axelmontagne.bsky.social · 25/11/2024
Interested in pursuing a PhD with Dr Ben Dickie, Dr Harry Pritchard, and me to explore the role of mural cells in Alzheimer’s disease? Feel free to apply or share this opportunity widely! www.findaphd.com/phds/project...
findaphd.com
(VIDA DTC) Role of arterial smooth muscle and pericyte dysfunction towards brain waste clearance in Alzheimer’s Disease at The University of Manchester on FindAPhD.com
PhD Project - (VIDA DTC) Role of arterial smooth muscle and pericyte dysfunction towards brain waste clearance in Alzheimer’s Disease at The University of Manchester, listed on FindAPhD.com
069
Reposted by Bowles Lab
Philip Hasel @philiphasel.bsky.social · 25/11/2024
PhD opportunity: If you're interested in how astrocytes and the meninges talk to each other and how this is affected in dementia come do your PhD with us in Edinburgh (cc: Karen Horsburgh and Ingo Schiessl)! www.findaphd.com/phds/project...
findaphd.com
(VIDA DTC) Exploring the role of the astrocyte-leptomeningeal vessel interface in dementia at University of Edinburgh on FindAPhD.com
PhD Project - (VIDA DTC) Exploring the role of the astrocyte-leptomeningeal vessel interface in dementia at University of Edinburgh, listed on FindAPhD.com
02324
Reposted by Bowles Lab
Daniele Mattei, PhD @denjo3.bsky.social · 25/11/2024
Microglia are key players in neurodevelopment. It is thus essential to include them in brain organoids to study neurodevelopment, especially to study prenatal immune activation and how it impacts such a delicate process. Thrilled to have participated to this beautiful study. shorturl.at/7M9DU
shorturl.at
Microglia undergo molecular and functional adaptations to dark and light phases in male laboratory mice
Microglia are increasingly recognized to contribute to brain health and disease. Preclinical studies using laboratory rodents are essential to advance…
082