iiinova — where your digital self keeps evolving

Reposted by Daniele Mattei, PhD

Daniele Mattei, PhD @denjo3.bsky.social · 12/07/2025

Microglia don’t act the same around the clock! Their transcriptional/proteomic/functional programs shift across sleep/wake phases - yet most studies ignore time-of-day. This perspective calls for a circadian rethink in neuroimmunology! pubmed.ncbi.nlm.nih.gov/40618264/

pubmed.ncbi.nlm.nih.gov

Rethinking microglia from a circadian perspective in neuroimmunology: New insights - PubMed

Rethinking microglia from a circadian perspective in neuroimmunology: New insights

063

Daniele Mattei, PhD @denjo3.bsky.social · 12/07/2025

pubmed.ncbi.nlm.nih.gov

Rethinking microglia from a circadian perspective in neuroimmunology: New insights - PubMed

Rethinking microglia from a circadian perspective in neuroimmunology: New insights

063

Daniele Mattei, PhD @denjo3.bsky.social · 15/04/2025

April is #Parkinson's awareness month! PD is the second most common #neurodegenerative disease. Below you see two sections of human midbrain processed in our lab, where you can see the hallmark of PD: #Dopaminergic neuronal death in the SNpc, from where I sort intact #microglia for MultiOmics.

150

Reposted by Daniele Mattei, PhD

Daniele Mattei, PhD @denjo3.bsky.social · 29/03/2025

Maternal immune activation may compromise offspring #neurodevelopment via #glia activation. In this chapter, we discuss the most up-to-date evidence and mechanisms gathered via #COVID_19 and other pandemics, preclinical models and brain-organoid models with integrated #microglia. shorturl.at/0B8Bw

shorturl.at

From womb to world: The interplay between maternal immune activation, neuroglia, and neurodevelopment

This chapter introduces and discusses maternal immune activation (MIA) as a contributing factor in increasing the risk of neurodevelopmental disorders…

041

Reposted by Daniele Mattei, PhD

Daniele Mattei, PhD @denjo3.bsky.social · 20/11/2024

What time do you collect Microglia from preclinical models for downstream analyses? Microglia undergo transcriptional, proteomic and functional adaptations to the wake and sleep phases🧵 shorturl.at/LpEQk

3104

Daniele Mattei, PhD @denjo3.bsky.social · 29/03/2025

shorturl.at

From womb to world: The interplay between maternal immune activation, neuroglia, and neurodevelopment

This chapter introduces and discusses maternal immune activation (MIA) as a contributing factor in increasing the risk of neurodevelopmental disorders…

041

Daniele Mattei, PhD @denjo3.bsky.social · 05/12/2024

Very interesting study showing how Astrocytes in the cerebellum can regulate aggressive behavior! "Neuron-glial interactions in the cerebellar vermis may play a role in adjusting Purkinje cell excitability and setting the tone of aggression."

080

Reposted by Daniele Mattei, PhD

Anna Molofsky Lab @annamolofskylab.bsky.social · 17/11/2024

go.bsky.app/Eaua5Jk my starter for neuroimmunology

417840

Reposted by Daniele Mattei, PhD

Bowles Lab @bowleslab.bsky.social · 28/11/2024

Finally got this across the finish line! We made an isogenic panel of MAPT splicing mutation iPSCs that express high levels of endogenous 4R tau... ...and saw some cool stuff! 👇👇👇 tinyurl.com/38e5d6d2 Big thanks to supporters RCFneuro, Brightfocus, AFTD & UKDRI!

0136

Reposted by Daniele Mattei, PhD

Bowles Lab @bowleslab.bsky.social · 25/11/2024

Abstract submission for Stem Cell Models of Neurodegeneration 2025 is open until January 31st 2025! Come register and share your work with us! scmnd.com We look forward to hosting you in Edinburgh next year :-) #neuroscience #iPSC #neurodegeneration #stemcells #dementia #organoids

0208

Daniele Mattei, PhD @denjo3.bsky.social · 25/11/2024

Microglia are key players in neurodevelopment. It is thus essential to include them in brain organoids to study neurodevelopment, especially to study prenatal immune activation and how it impacts such a delicate process. Thrilled to have participated to this beautiful study. shorturl.at/7M9DU

shorturl.at

Microglia undergo molecular and functional adaptations to dark and light phases in male laboratory mice

Microglia are increasingly recognized to contribute to brain health and disease. Preclinical studies using laboratory rodents are essential to advance…

082

Reposted by Daniele Mattei, PhD

Seth Abramson @sethabramson.bsky.social · 24/11/2024

I feel seen

574628478284

Reposted by Daniele Mattei, PhD

Daniele Mattei, PhD @denjo3.bsky.social · 21/11/2024

Any researcher here also looking into glia circadian differences in disease models? Eager to connect amd discuss! We study glia in disease and physiology, but mostly during rodent's sleep phase, as they're often hosted in a light:dark cycle. Hence, are we looking at only half of the picture?

152

Reposted by Daniele Mattei, PhD

Silvia De Rubeis @derubeislab.bsky.social · 23/11/2024

We are recruiting a postdoc! Have expertise in RNA biology and want to apply it to neuro and neurodev disorders? Then apply 👇🏼 📌 $73,588 💰 📌 access to postdoc housing 🏠 📌 Support for internationals 🌍 📌 Awesome view 😅 🙏 RT labs.icahn.mssm.edu/derubeislab/...

12016

Reposted by Daniele Mattei, PhD

Nicola Fattorelli @nicola-fattorelli.bsky.social · 16/11/2024

Hi Bluesky 🦋 I’m Nico, a microglia enthusiast based in VIB, Belgium 🧠 if you are curious about the science we do, take a look at our latest work! Here we use xenotransplantation models to map the spectrum of human microglia responses to Alzheimer’s disease pathology www.nature.com/articles/s41...

nature.com

Xenografted human microglia display diverse transcriptomic states in response to Alzheimer’s disease-related amyloid-β pathology - Nature Neuroscience

Human microglia transplanted in the mouse brain mount a multipronged response to amyloid-β pathology, displaying unique transcriptional states. Alzheimer’s disease risk genes are differentially regula...

25610

Daniele Mattei, PhD @denjo3.bsky.social · 21/11/2024

152

Daniele Mattei, PhD @denjo3.bsky.social · 20/11/2024

3104

Reposted by Daniele Mattei, PhD

Saint Hoax @sainthoax.bsky.social · 17/11/2024

arriving to bluesky after shedding all the bots and naz*s

1252450191