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Julien Klimmt

@julien-klimmt.bsky.social

Postdoc @PaquetLab using novel stem-cell-derived 3D brain tissue models to study Alzheimer's disease

Julien Klimmt @julien-klimmt.bsky.social · 05/08/2026

I am very excited and proud to share our new paper that I worked on for the past years, out now in #NatureNeuroscience Full thread on what we found below. Huge thanks to all colleagues, especially @carolinacgoncalves.bsky.social for the great teamwork, @paquetlab.bsky.social for all the support 1/2

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Reposted by Julien Klimmt

PaquetLab @paquetlab.bsky.social · 10/04/2026

🧵New paper from the lab @isd-research.bsky.social @lmu-klinikum.bsky.social @lmu.de in STM @science.org! A human #iPSC-derived #Tauopathy model that endogenously develops late-stage Tau pathology. Free personal PDF: www.science.org/eprint/5H5YD.... Here's what we found👇 1/10

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PaquetLab @paquetlab.bsky.social · 29/03/2025

Great talks and discussions at the 🧠 #SCMND meeting in Edinburgh this week, where @julien-klimmt.bsky.social from our lab presented our #ipsc 3D brain tissue model for #Alzheimer’s diseases to a full audience

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Reposted by Julien Klimmt

PaquetLab @paquetlab.bsky.social · 12/03/2025

Open #Postdoc position @isd-research.bsky.social @lmumuenchen.bsky.social to develop an #iPSC-derived #BBB model. Fully funded and embedded in our international Foundation Leducq Network of Excellence www.brenda-leducq.de Experience in vascular biology or related field required. Please RP and apply

The research group of Prof. Dr. Dominik Paquet (https://www.isd-research.de/paquetlab) is looking for a Postdoc. Our research involves the development of human brain tissue models to study the molecular mechanisms of Alzheimer's disease, Frontotemporal dementia, stroke and other related brain diseases and to develop therapeutic approaches. We use state-of-the-art molecular and cell biological methods, such as induced pluripotent stem cells (iPSCs), advanced molecular biology techniques, CRISPR/Cas9 genome editing, brain tissue engineering, scRNAseq, proteomics etc. We offer a highly international, versatile, extremely well equipped and productive work environment.

We have received funding by an international research organization for a very interdisciplinary and collaborative project to develop a human iPSC model of the blood brain barrier and apply it to study neurovascular diseases, with a focus on Small vessel disease (SVD). The project will focus on CRISPR genome engineering of SVD-relevant mutations, differentiation of iPSCs into neurovascular cells, microfluidic 3D vascular tissue engineering, and identifying disease-relevant alterations by microscopy and omics techniques. It will be embedded in the highly collaborative and stimulating environment of the PaquetLab, ISD, SyNergy Cluster of Excellence, and our international collaboration network.

We are looking for a highly motivated individual with the following skills:

-extensive international scientific working experience in vascular
biology or a closely related research field (required)
-experience in molecular biology, biochemistry and/or omics
techniques; cell culture experience is a plus
-excellent English skills in speaking, writing about and
presenting scientific data
-interest in working in collaborative network of
friendly scientists around the world

A start date soon in 2025 is desired.

Join us!
dominik.paquet@med.uni-muenchen.de
www.isd-research.de/paquetlab
www.brenda-leducq.de

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Julien Klimmt @julien-klimmt.bsky.social · 19/02/2025

Very happy to be selected as a speaker and present our 3D brain tissue model for AD research, I'm looking forward to seeing you in Edinburgh!

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