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Grant Rowe

@bloodandtime.bsky.social
498 followers 135 following 30 posts

Physician-Scientist at Boston Children's/Dana-Farber. Pediatric bone marrow failure, hematopoietic stem cell transplantation, developmental hematopoiesis, disease modeling, pluripotent stem cells.

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Grant Rowe @bloodandtime.bsky.social · 12/09/2025
There are two types of people in academic medicine - those who are there because it is their lifetime calling, others who are there to take home a paycheck. The fundamental problem is that those there for the paycheck hold all of the power.
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Shannon McKinney-Freeman @smckinneyfreeman.bsky.social · 10/09/2025
The ISEH just launched a brand new website! Check it out and join our society today to network with your colleagues and keep abreast of the latest advances in basic and translational experimental hematology research! iseh.org
iseh.org
Home
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Grant Rowe @bloodandtime.bsky.social · 12/08/2025
I really enjoyed reading this paper. Use of basic culture-based and in vivo differentiation models with targeted application of -omics.
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Grant Rowe @bloodandtime.bsky.social · 30/06/2025
Excellent obituary summarizing the contributions of Dr Till's foundational work in defining the hematopoietic hierarchy in Experimental Hematology @isehsociety.bsky.social www.exphem.org/article/S030...
exphem.org
Remembering James Till, 1931-2025
It has been 64 years since the publication of the classic 1961 Till & McCulloch paper that described spleen colonies in lethally irradiated mice following a bone marrow transplant [1]. On May 18, 2024...
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Grant Rowe @bloodandtime.bsky.social · 27/05/2025
Here is the first in a planned series of article commentaries in Experimental Hematology @isehsociety.bsky.social - thanks to @challenlab.bsky.social and @lindemileslab.bsky.social! www.exphem.org/article/S030...
exphem.org
Cell-extrinsic factors contribute toward myeloid-biased expansion in Tet2-mutant clonal hematopoiesis
Hematopoietic stem cells (HSCs) acquire somatic mutations throughout life, with the frequency of mutational incidence increasing with age [1]. Occasionally, certain mutations confer a fitness advantag...
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Shannon McKinney-Freeman @smckinneyfreeman.bsky.social · 28/02/2025
What an interesting read...did you know that Developmental Hematopoiesis pioneer Elaine Dzierzak was also an artist? Read on to learn more in a recent issue of Experimental Hematology! The developmental clock: where art and science meet - Experimental Hematology www.exphem.org/article/S030...
exphem.org
The developmental clock: where art and science meet
Elaine DzierzakDrs. Elaine Dzierzak and Anna Bigas recently edited a special collection for Experimental Hematology entitled “Making blood: mechanisms of early hematopoietic development” [1]. This is ...
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Alessandro Donada @alessandrodonada.bsky.social · 27/02/2025
Absolute pleasure to chat with those two brilliant scientists! Do yourself a favour and have a look at their preprints! #hemesky
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Grant Rowe @bloodandtime.bsky.social · 21/02/2025
I failed a billing audit this week and it was like I had left the new coversheets off of my TPS reports #medicaladministrativestate
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Grant Rowe @bloodandtime.bsky.social · 19/02/2025
We are very proud of this new content spearheaded by @alessandrodonada.bsky.social! Our lab is very grateful to Alessandro for highlighting our two recent preprints.
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Mick Milsom @milsommick.bsky.social · 06/02/2025
@isehsociety.bsky.social community: if you’re interested in HSC research in humans then this is a must read from leaders in the field. www.exphem.org/article/S030...
exphem.org
Methodological Considerations on How to Identify Human Hematopoietic Stem Cells
The hematopoietic system is highly regenerative and is organized hierarchically with hematopoietic stem cells (HSCs) sitting at the apex. Despite being some of the most widely studied stem cells, ques...
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bioRxivpreprint @biorxivpreprint.bsky.social · 30/01/2025
Uridine Metabolism as a Targetable Metabolic Achilles' Heel for chemo-resistant B-ALL www.biorxiv.org/content/10.1101/202…
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Grant Rowe @bloodandtime.bsky.social · 25/01/2025
Second preprint of the day: www.biorxiv.org/content/10.1...
biorxiv.org
Path of differentiation defines human macrophage identity
Macrophages play central roles in immunity, wound healing, and homeostasis - a functional diversity that is underpinned by varying developmental origins. The impact of ontogeny on properties of human ...
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ernstlaboratory.bsky.social @ernstlaboratory.bsky.social · 24/01/2025
Look at that, a trifecta of ISEH member preprints @bloodandtime.bsky.social @dorrancelab.bsky.social @kentlab.bsky.social biorxiv.org/content/earl... biorxiv.org/content/earl... biorxiv.org/content/earl...
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Grant Rowe @bloodandtime.bsky.social · 24/01/2025
Here's a new preprint from our group. This manuscript continues our efforts to understand the mechanisms that distinguish fetal/juvenile versus adult hematopoiesis to better understand pediatric blood diseases. www.biorxiv.org/content/10.1...
biorxiv.org
Dynamic activity of Erg promotes aging of the hematopoietic system
Hematopoiesis changes to adapt to the physiology of development and aging. Temporal changes in hematopoiesis parallel age-dependent incidences of blood diseases. Several heterochronic regulators of he...
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Grant Rowe @bloodandtime.bsky.social · 17/01/2025
Early morning swimming in the cold at Stanford.
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Alessandro Donada @alessandrodonada.bsky.social · 10/01/2025
I really enjoy putting those together, please if you see your preprint in this list do not hesitate to get in touch! #hemesky 🔬🩸
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Grant Rowe @bloodandtime.bsky.social · 03/01/2025
answers.childrenshospital.org/blood-atlas/
answers.childrenshospital.org
Blood across our lifetimes: A dynamic story - Boston Children's Answers
A new atlas reveals how blood stem cells ramp up and pivot their activities to match our needs across our lifespan.
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Kate MacNamara @macnamaralab.bsky.social · 27/12/2024
Winter break is good for catching up on some reading 😉! #ISEH #SimplyBlood @isehsociety.bsky.social
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Grant Rowe @bloodandtime.bsky.social · 27/12/2024
Interesting mechanistic work on reticular dysgenesis from my former colleague Dr Weinacht @bloodjournal.bsky.social ashpublications.org/blood/articl...
ashpublications.org
Failure of metabolic checkpoint control during late-stage granulopoiesis drives neutropenia in reticular dysgenesis
Key PointsActive metabolic checkpoints respond to AK2 deficiency by decreasing anabolic pathways to maintain nutrient homeostasis and proliferation.When me
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Peter van Galen @vangalenlab.bsky.social · 23/12/2024
Our latest work is now available to read on bioRxiv! Very proud of this and its potential implications for patients with acute myeloid leukemia 🩸 🧪 🔬💊 **eIF4A-mediated translation initiation as an AML cell vulnerability that can be co-targeted with BCL-2 inhibition** www.biorxiv.org/content/10.1...
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Grant Rowe @bloodandtime.bsky.social · 18/12/2024
We are very proud of this new resource for the community. Thanks @alessandrodonada.bsky.social for leading this initiative!
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Grant Rowe @bloodandtime.bsky.social · 18/12/2024
I am very proud to direct the Bone Marrow Failure Clinic at Dana-Farber/Boston Children's. answers.childrenshospital.org/sadie-aplast...
answers.childrenshospital.org
A small act of kindness: Blood donations get Sadie off the sidelines after her aplastic anemia diagnosis - Boston Children's Answers Sadie thrives with aplastic anemia
Sadie was sidelined by aplastic anemia. Now she's back in the game, thanks to life-saving blood transfusions and expert care.
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Grant Rowe @bloodandtime.bsky.social · 14/12/2024
This paper still irritates me - harvesting marrow from one-day-old neonates (human!) www.cell.com/developmenta...
cell.com
Temporal molecular program of human hematopoietic stem and progenitor cells after birth
Zhang et al. provided an integral transcriptomic analysis of HSPCs, defined their dynamics in post-natal steady-state hematopoiesis, and refined the heterogeneity of MPPs by CD52 expression. Neonate bone-marrow-derived HSCs exhibited higher reconstruction capability than cord blood HSCs. This resource will help understand hematopoiesis in development and disease.
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John Prensner @johnprensner.bsky.social · 08/12/2024
Hey all you #ASH24 people. You need to look at this new paper in @naturemethods.bsky.social by Heme extraordinaires Grant Rowe and the Bluesky-less #HojunLi. A paper that looks at Blood & Time from @bloodandtime.bsky.social himself! #scRNAseq #bioinformatics 🧬 💻 www.nature.com/articles/s41...
nature.com
The dynamics of hematopoiesis over the human lifespan - Nature Methods
This Resource presents an atlas classifying the age-related changes in human hematopoietic stem and progenitor cells from gestation through aging.
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Grant Rowe @bloodandtime.bsky.social · 07/12/2024
The nice thing about the jet lag is that I can watch Dr Ambros's Nobel lecture #ASH24
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Grant Rowe @bloodandtime.bsky.social · 07/12/2024
My #ASH24 is getting shorter by the minute. Sitting on the tarmac in Boston for the past two hours...
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Alessandro Donada @alessandrodonada.bsky.social · 06/12/2024
On your way to #ASH24🩸? Here is something to read for the road ;)
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Grant Rowe @bloodandtime.bsky.social · 06/12/2024
The other side of what I do - one of my favorite patients: answers.childrenshospital.org/diamond-blac...
answers.childrenshospital.org
Kit handles Diamond-Blackfan anemia - Boston Children's Answers
Kit is a happy and active 2-year-old who relies on blood transfusions to manage the rare genetic blood disorder Diamond-Blackfan anemia.
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Grant Rowe @bloodandtime.bsky.social · 05/12/2024
Just in time for #ASH24, our latest paper is out. We performed scRNA-seq on HSPCs over human development, maturation, and postnatal aging. We looked at dynamics of HSPC subsets, lineage biases, HSC level priming, and identified a developmentally restricted human HSC. www.nature.com/articles/s41...
nature.com
The dynamics of hematopoiesis over the human lifespan - Nature Methods
This Resource presents an atlas classifying the age-related changes in human hematopoietic stem and progenitor cells from gestation through aging.
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Grant Rowe @bloodandtime.bsky.social · 04/12/2024
This is a great review. We hope to present our own contribution to this field very soon.
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Grant Rowe @bloodandtime.bsky.social · 04/12/2024
Don't miss our lab's big story at #ASH24. We are hoping to rewrite some major paradigms with this one.
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