Grant Rowe @bloodandtime.bsky.social · 12/09/2025There are two types of people in academic medicine - those who are there because it is their lifetime calling, others who are there to take home a paycheck. The fundamental problem is that those there for the paycheck hold all of the power. 000
Reposted by Grant RoweShannon McKinney-Freeman @smckinneyfreeman.bsky.social · 10/09/2025The ISEH just launched a brand new website! Check it out and join our society today to network with your colleagues and keep abreast of the latest advances in basic and translational experimental hematology research! iseh.orgiseh.org Home 053
Grant Rowe @bloodandtime.bsky.social · 12/08/2025I really enjoyed reading this paper. Use of basic culture-based and in vivo differentiation models with targeted application of -omics. 020
Grant Rowe @bloodandtime.bsky.social · 30/06/2025Excellent obituary summarizing the contributions of Dr Till's foundational work in defining the hematopoietic hierarchy in Experimental Hematology @isehsociety.bsky.social www.exphem.org/article/S030...exphem.orgRemembering James Till, 1931-2025It has been 64 years since the publication of the classic 1961 Till & McCulloch paper that described spleen colonies in lethally irradiated mice following a bone marrow transplant [1]. On May 18, 2024... 032
Grant Rowe @bloodandtime.bsky.social · 27/05/2025Here is the first in a planned series of article commentaries in Experimental Hematology @isehsociety.bsky.social - thanks to @challenlab.bsky.social and @lindemileslab.bsky.social! www.exphem.org/article/S030...exphem.orgCell-extrinsic factors contribute toward myeloid-biased expansion in Tet2-mutant clonal hematopoiesisHematopoietic stem cells (HSCs) acquire somatic mutations throughout life, with the frequency of mutational incidence increasing with age [1]. Occasionally, certain mutations confer a fitness advantag... 093
Reposted by Grant RoweShannon McKinney-Freeman @smckinneyfreeman.bsky.social · 28/02/2025What an interesting read...did you know that Developmental Hematopoiesis pioneer Elaine Dzierzak was also an artist? Read on to learn more in a recent issue of Experimental Hematology! The developmental clock: where art and science meet - Experimental Hematology www.exphem.org/article/S030...exphem.orgThe developmental clock: where art and science meetElaine DzierzakDrs. Elaine Dzierzak and Anna Bigas recently edited a special collection for Experimental Hematology entitled “Making blood: mechanisms of early hematopoietic development” [1]. This is ... 0116
Reposted by Grant RoweAlessandro Donada @alessandrodonada.bsky.social · 27/02/2025Absolute pleasure to chat with those two brilliant scientists! Do yourself a favour and have a look at their preprints! #hemesky 083
Grant Rowe @bloodandtime.bsky.social · 21/02/2025I failed a billing audit this week and it was like I had left the new coversheets off of my TPS reports #medicaladministrativestate 010
Grant Rowe @bloodandtime.bsky.social · 19/02/2025We are very proud of this new content spearheaded by @alessandrodonada.bsky.social! Our lab is very grateful to Alessandro for highlighting our two recent preprints. 172
Reposted by Grant RoweMick Milsom @milsommick.bsky.social · 06/02/2025@isehsociety.bsky.social community: if you’re interested in HSC research in humans then this is a must read from leaders in the field. www.exphem.org/article/S030...exphem.orgMethodological Considerations on How to Identify Human Hematopoietic Stem CellsThe hematopoietic system is highly regenerative and is organized hierarchically with hematopoietic stem cells (HSCs) sitting at the apex. Despite being some of the most widely studied stem cells, ques... 0269
Reposted by Grant RowebioRxivpreprint @biorxivpreprint.bsky.social · 30/01/2025Uridine Metabolism as a Targetable Metabolic Achilles' Heel for chemo-resistant B-ALL www.biorxiv.org/content/10.1101/202… 011
Grant Rowe @bloodandtime.bsky.social · 25/01/2025Second preprint of the day: www.biorxiv.org/content/10.1...biorxiv.orgPath of differentiation defines human macrophage identityMacrophages play central roles in immunity, wound healing, and homeostasis - a functional diversity that is underpinned by varying developmental origins. The impact of ontogeny on properties of human ... 010
Reposted by Grant Roweernstlaboratory.bsky.social @ernstlaboratory.bsky.social · 24/01/2025Look at that, a trifecta of ISEH member preprints @bloodandtime.bsky.social @dorrancelab.bsky.social @kentlab.bsky.social biorxiv.org/content/earl... biorxiv.org/content/earl... biorxiv.org/content/earl... 042
Grant Rowe @bloodandtime.bsky.social · 24/01/2025Here's a new preprint from our group. This manuscript continues our efforts to understand the mechanisms that distinguish fetal/juvenile versus adult hematopoiesis to better understand pediatric blood diseases. www.biorxiv.org/content/10.1...biorxiv.orgDynamic activity of Erg promotes aging of the hematopoietic systemHematopoiesis changes to adapt to the physiology of development and aging. Temporal changes in hematopoiesis parallel age-dependent incidences of blood diseases. Several heterochronic regulators of he... 2124
Reposted by Grant RoweAlessandro Donada @alessandrodonada.bsky.social · 10/01/2025I really enjoy putting those together, please if you see your preprint in this list do not hesitate to get in touch! #hemesky 🔬🩸 0113
Grant Rowe @bloodandtime.bsky.social · 03/01/2025answers.childrenshospital.org/blood-atlas/answers.childrenshospital.orgBlood across our lifetimes: A dynamic story - Boston Children's AnswersA new atlas reveals how blood stem cells ramp up and pivot their activities to match our needs across our lifespan. 040
Reposted by Grant RoweKate MacNamara @macnamaralab.bsky.social · 27/12/2024Winter break is good for catching up on some reading 😉! #ISEH #SimplyBlood @isehsociety.bsky.social 084
Grant Rowe @bloodandtime.bsky.social · 27/12/2024Interesting mechanistic work on reticular dysgenesis from my former colleague Dr Weinacht @bloodjournal.bsky.social ashpublications.org/blood/articl...ashpublications.orgFailure of metabolic checkpoint control during late-stage granulopoiesis drives neutropenia in reticular dysgenesisKey PointsActive metabolic checkpoints respond to AK2 deficiency by decreasing anabolic pathways to maintain nutrient homeostasis and proliferation.When me 030
Reposted by Grant RowePeter van Galen @vangalenlab.bsky.social · 23/12/2024Our latest work is now available to read on bioRxiv! Very proud of this and its potential implications for patients with acute myeloid leukemia 🩸 🧪 🔬💊 **eIF4A-mediated translation initiation as an AML cell vulnerability that can be co-targeted with BCL-2 inhibition** www.biorxiv.org/content/10.1... 34214
Grant Rowe @bloodandtime.bsky.social · 18/12/2024We are very proud of this new resource for the community. Thanks @alessandrodonada.bsky.social for leading this initiative! 160
Grant Rowe @bloodandtime.bsky.social · 18/12/2024I am very proud to direct the Bone Marrow Failure Clinic at Dana-Farber/Boston Children's. answers.childrenshospital.org/sadie-aplast...answers.childrenshospital.orgA small act of kindness: Blood donations get Sadie off the sidelines after her aplastic anemia diagnosis - Boston Children's Answers Sadie thrives with aplastic anemiaSadie was sidelined by aplastic anemia. Now she's back in the game, thanks to life-saving blood transfusions and expert care. 0130
Grant Rowe @bloodandtime.bsky.social · 14/12/2024This paper still irritates me - harvesting marrow from one-day-old neonates (human!) www.cell.com/developmenta...cell.comTemporal molecular program of human hematopoietic stem and progenitor cells after birthZhang et al. provided an integral transcriptomic analysis of HSPCs, defined their dynamics in post-natal steady-state hematopoiesis, and refined the heterogeneity of MPPs by CD52 expression. Neonate bone-marrow-derived HSCs exhibited higher reconstruction capability than cord blood HSCs. This resource will help understand hematopoiesis in development and disease. 180
Reposted by Grant RoweJohn Prensner @johnprensner.bsky.social · 08/12/2024Hey all you #ASH24 people. You need to look at this new paper in @naturemethods.bsky.social by Heme extraordinaires Grant Rowe and the Bluesky-less #HojunLi. A paper that looks at Blood & Time from @bloodandtime.bsky.social himself! #scRNAseq #bioinformatics 🧬 💻 www.nature.com/articles/s41...nature.comThe dynamics of hematopoiesis over the human lifespan - Nature MethodsThis Resource presents an atlas classifying the age-related changes in human hematopoietic stem and progenitor cells from gestation through aging. 1477
Grant Rowe @bloodandtime.bsky.social · 07/12/2024The nice thing about the jet lag is that I can watch Dr Ambros's Nobel lecture #ASH24 060
Grant Rowe @bloodandtime.bsky.social · 07/12/2024My #ASH24 is getting shorter by the minute. Sitting on the tarmac in Boston for the past two hours... 540
Reposted by Grant RoweAlessandro Donada @alessandrodonada.bsky.social · 06/12/2024On your way to #ASH24🩸? Here is something to read for the road ;) 052
Grant Rowe @bloodandtime.bsky.social · 06/12/2024The other side of what I do - one of my favorite patients: answers.childrenshospital.org/diamond-blac...answers.childrenshospital.orgKit handles Diamond-Blackfan anemia - Boston Children's AnswersKit is a happy and active 2-year-old who relies on blood transfusions to manage the rare genetic blood disorder Diamond-Blackfan anemia. 020
Grant Rowe @bloodandtime.bsky.social · 05/12/2024Just in time for #ASH24, our latest paper is out. We performed scRNA-seq on HSPCs over human development, maturation, and postnatal aging. We looked at dynamics of HSPC subsets, lineage biases, HSC level priming, and identified a developmentally restricted human HSC. www.nature.com/articles/s41...nature.comThe dynamics of hematopoiesis over the human lifespan - Nature MethodsThis Resource presents an atlas classifying the age-related changes in human hematopoietic stem and progenitor cells from gestation through aging. 25314
Grant Rowe @bloodandtime.bsky.social · 04/12/2024This is a great review. We hope to present our own contribution to this field very soon. 072
Grant Rowe @bloodandtime.bsky.social · 04/12/2024Don't miss our lab's big story at #ASH24. We are hoping to rewrite some major paradigms with this one. 030