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Charles de Bock

@charles-debock.bsky.social
473 followers 164 following 26 posts

Cancer Researcher #bloodcancer #leukemia #functionalgenomics #TCellLeukemia. Group Leader at Children's Cancer Institute, Sydney. bit.ly/3zxhpW6

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Reposted by Charles de Bock
HemaSphere Journal @hemasphere-journal.bsky.social · 17/07/2026
Ever wonder why some cancer models don’t quite match real patients? Here's the truth. 🧬Knock-in mouse models show that natural mutation levels matter—and that biallelic TP53 loss is what truly drives leukemia #CancerResearch hsphere.pub/d3z
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Charles de Bock @charles-debock.bsky.social · 17/07/2026
Happy to share my new commentary in @bloodjournal.bsky.social highlighting two papers by Di Giacomo et al. & Mimura et al. that define a novel, high-risk leukemia subtype driven by BCL11B enhancer hijacking and FOXF1 activation. www.sciencedirect.com/science/arti...
sciencedirect.com
OutFOXing a FENDRR bender in T-ALL
All content on this site: Copyright © 2026 Elsevier B.V., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
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Mick Milsom @milsommick.bsky.social · 06/02/2026
Abstract submission just opened for #ISEH2026 in Frankfurt. Outstanding scientific program; welcoming community; and more than double the number of short talk slots for abstract to be presented in. Looking forward to seeing you there. @isehsociety.bsky.social
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Charles de Bock @charles-debock.bsky.social · 01/11/2025
A wonderful discussion with Anika Sijs-Szabó from Erasmus MC and Leiden University Medical Center and Roger Mulet Lazaro from Erasmus MC on their work improving the classification of #ALAL cases published in @hemasphere-journal.bsky.social . Tune in to find out how collaboration fuels discovery!
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Charles de Bock @charles-debock.bsky.social · 05/09/2025
Another great conversation on NUP98-rearranged #AML and the use of #Menin inhibitors. Plus some hot tips on how to measure cytotoxicity in co-culture systems and finally, how to pronounce #MEIS1. Listen below and subscribe where ever you get your podcasts from @hemasphere-journal.bsky.social
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HemaSphere Journal @hemasphere-journal.bsky.social · 22/08/2025
🎧REPLAY! In this episode host Dr Charles de Bock discusses the role of mouse models in understanding leukemogenesis & hematopoiesis w/ Prof Richard Lock: bit.ly/40Ch3NP Listen & enjoy casual, insightful discussions about #hematology research.
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NDLR_conference @ndlrconference.bsky.social · 20/08/2025
We are honoured to welcome Professor John D. Crispino, from @stjude.bsky.social as speaker to #NDLR2026. John’s research focuses on mechanisms of #Leukemia development in children with Down syndrome and the malignant progression of #MyelodysplasticSyndrome and #MyeloproliferativeNeoplasms.
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Reposted by Charles de Bock
ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · 31/07/2025
The NIC welcomes speakers Hanna Mikkola and Elizabeth Ng who will present their latest research on stem cell development and regeneration at the 20 August webinar on Human HSC Ontogeny. Register now www.iseh.org/ISEHWebinars
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Charles de Bock @charles-debock.bsky.social · 01/08/2025
So the latest @hemasphere-journal.bsky.social Podcast is out! This time all about Metabolism. You can subscribe podcasts.apple.com/au/podcast/h... to get all the podcasts direct into your feed. Each is around 30 min, perfect for that commute to work.
podcasts.apple.com
HemaSphere Podcast
Medicine Podcast · Updated Monthly · HemaSphere is the official online, open access journal of the European Hematology Association (EHA). HemaSphere publishes exciting basic, translational, and clinic...
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Heather Lee @heatherjlee.bsky.social · 28/07/2025
I'm pleased to share that Leukemia have published our analysis of heterogeneous responses to hypomethylating agents #HMAs in Acute Myeloid Leukaemia #AML www.nature.com/articles/s41...
nature.com
Hypomethylating agents induce epigenetic and transcriptional heterogeneity with implications for acute myeloid leukemia cell self-renewal - Leukemia
Leukemia - Hypomethylating agents induce epigenetic and transcriptional heterogeneity with implications for acute myeloid leukemia cell self-renewal
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HemaSphere Journal @hemasphere-journal.bsky.social · 18/06/2025
This was very happy news to arrive to today! Thank you to our authors, reviewers, and readership for your continued support. We are glad to know that everyone's hard work is well-appreciated.
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HemaSphere Journal @hemasphere-journal.bsky.social · 14/06/2025
🚨Today! @ 15:45, MiCo room CORAL 6  We warmly invite you to the HemaSphere Scientific Session where we will dive into 3 of our exciting + cutting-edge biology publications. Hope to see you there! 🕰️: 15:45 - 16:45 📍: Room CORAL 6, #EHA2025 🎤: bit.ly/4koLwXk
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Reposted by Charles de Bock
Franziska Auer @franziskaauer.bsky.social · 14/06/2025
Don’t miss the second YERM Session on „New insights into clonal hematopoiesis“ at 10 o‘clock in Brown Hall 2! #EHA2025 #YoungEHA #Hematology
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Charles de Bock @charles-debock.bsky.social · 12/06/2025
The team representing @kidscancerinst.bsky.social at #EHA2025 @hansenjk.bsky.social Faezeh Khalili, Jackie Huang, Yashna Walia
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HemaSphere Journal @hemasphere-journal.bsky.social · 12/06/2025
We are HemaSphere proud at #EHA2025, where 2 of our editors received special EHA awards! Congrats to Jan Cools, Ed in Chief, for the education & mentoring award; and to Mandy Lauw, Scientific Ed, for the YoungEHA award. Well deserved 👏 @jancools.bsky.social @mandylauw.bsky.social
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Charles de Bock @charles-debock.bsky.social · 12/06/2025
Honoured to have been a mentee of @jancools.bsky.social who is this years #EHA2025 Education and Mentoring award winner. Amazing and recognising his unwavering support for so many researchers!
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HemaSphere Journal @hemasphere-journal.bsky.social · 12/06/2025
Dr C de Bock hosts co-authors Dr F Fioredda & Dr E Papadaki to discuss Guidelines for treating neutropenias. Delve into the importance of international guidelines, challenges  ➕ more. 🎧 bit.ly/42O9l4v. Part 1: 2023 neutropenia Guidelines, diagnosis &management #2025HemaSphereAward winner 🏆
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Charles de Bock @charles-debock.bsky.social · 12/06/2025
Next up is Dr Hansen Kosasih @hansenjk.bsky.social looking at cis-regulome of AKR1C3 which activates super prodrug ACHM-025 and can eradicate T-ALL. He is speaking today at #EHA2025 molecular Hematopoiesis workshop. Plus poster PS1332 @kidscancerinst.bsky.social
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Charles de Bock @charles-debock.bsky.social · 12/06/2025
For #EHA2025 our group has Phd Candidate Yashna Walia doing in vivo PDX dual gRNA screen of epigenetic regions looking into GR resistance. Check out Poster PS1334 @kidscancerinst.bsky.social
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Charles de Bock @charles-debock.bsky.social · 12/06/2025
Hello #EHA2025. Happy to be here with my group this week. Connecting with old friends and colleagues and making new friends this week. Let me know if you are around!
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Charles de Bock @charles-debock.bsky.social · 12/06/2025
Hello #EHA2025. Happy to be here with my group this week. Connecting with old friends and colleagues and making new friends this week. Let me know if you are around!
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Charles de Bock @charles-debock.bsky.social · 08/06/2025
Looking forward to attend the #EHA2025 @hemasphere-journal.bsky.social sessions next week!
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Reposted by Charles de Bock
HemaSphere Journal @hemasphere-journal.bsky.social · 29/05/2025
Heading to #EHA2025 in Milan in 1.5(ish) weeks? HemaSphere has 2 exciting sessions on the program! 📌Peer Review Workshop: Fri 13 June, 13:30 - 15:00 💡Learn + master the peer review role/process 📌HemaSphere Scientific Session: Sat 14 June, 15:45 - 16:45 💡Dive into 3 of our cutting-edge biology papers
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HemaSphere Journal @hemasphere-journal.bsky.social · 16/05/2025
This HemaTopic by Sci Ed C de Bock discusses using PDXs for testing leukemia therapies, focusing on PDX model maintenance, immunodeficient mice & standardized reporting for preclinical drug testing. It also ties in a recent HemaSphere podcast with Prof Richard Lock.  See both👉
bit.ly
Patient‐derived xenografts: Practical considerations for preclinical drug testing
Click on the article title to read more.
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HemaSphere Journal @hemasphere-journal.bsky.social · 07/05/2025
New Episode! Dr. Charles De Bock hosts Prof Jan Cools, Prof Heidi Segers & Dr Margo Aertgeerts to discuss advancements in ALL treatment, challenges of relapse & innovative use of SCS to uncover genetic mutations & clonal composition. Listen to their insightful discussion 🎧 bit.ly/42N3cWx
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Beth Psaila @bethpsaila.bsky.social · 27/03/2025
We are recruiting!! Ads now live for a Data Coordinator and 2 Research Assistants/biobankers to join a new @ludwigcancer.bsky.social - @imm.ox.ac.uk joint initiative to prevent progression from early- to advanced blood cancer. Joint posts with Adam Mead+others in Oxford Ludwig. Links below
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Nick van Gastel @nickvangastel.bsky.social · 20/03/2025
We have put together an amazing line-up of invited speakers and talks selected from abstracts for the 2nd Annual ISEH Mini-Symposium!!! Join us online on March 26th (free for ISEH members) to learn what’s new and exciting in Experimental Hematology!!! @isehsociety.bsky.social
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Vijay G. Sankaran @bloodgenes.bsky.social · 12/03/2025
Huge congratulations to this incredible group!!! 👏👏👏
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Nick van Gastel @nickvangastel.bsky.social · 19/02/2025
One week left for abstract submission!
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Grant Rowe @bloodandtime.bsky.social · 19/02/2025
We are very proud of this new content spearheaded by @alessandrodonada.bsky.social! Our lab is very grateful to Alessandro for highlighting our two recent preprints.
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Charles de Bock @charles-debock.bsky.social · 17/02/2025
If you are interested in learning about #PDX models in in vivo drug testing, take the time to listen to the following @hemasphere-journal.bsky.social podcast featuring Prof Richard Lock. 👇
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Nick van Gastel @nickvangastel.bsky.social · 12/02/2025
There’s still time to submit an abstract! Join us for what promises to be a great online symposium for all interested in hematology research! And you might win a travel grant for the 2025 Annual ISEH meeting in Japan… what more do you need 🤷‍♂️
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Mick Milsom @milsommick.bsky.social · 06/02/2025
@isehsociety.bsky.social community: if you’re interested in HSC research in humans then this is a must read from leaders in the field. www.exphem.org/article/S030...
exphem.org
Methodological Considerations on How to Identify Human Hematopoietic Stem Cells
The hematopoietic system is highly regenerative and is organized hierarchically with hematopoietic stem cells (HSCs) sitting at the apex. Despite being some of the most widely studied stem cells, ques...
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Charles de Bock @charles-debock.bsky.social · 10/02/2025
I recently had the pleasure of discussing the utility of PDX models in preclinical testing with Prof Richard Lock @kidscancerinst.bsky.social as part of the @hemasphere-journal.bsky.social podcast series. If you are about to use PDX models for your next project, then check out shorturl.at/2W0Al
hemasphere-podcast.captivate.fm
Revolutionizing Pediatric Cancer Research with PDXs - HemaSphere Podcast
In this episode of the HemaSphere podcast, host Dr Charles de Bock discusses the critical role of mouse models in understanding leukemogenesis and hemat...
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Shannon McKinney-Freeman @smckinneyfreeman.bsky.social · 28/01/2025
Really enjoyed talking about the value of joining our community of scientists, working to solve the most difficult problems in hematopoiesis, HSPCs, leukemia and more. The International Society for Experimental Hematology welcomes burgeoning scientists and group leaders. Join! #ISEH #HSC #leukemia
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ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · 28/01/2025
You can now submit an abstract to the second virtual Mini Symposium taking place 26 March. Submit an abstract by 26 February and register today❗Learn more: www.iseh.org/2025MiniSymposium
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ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · 22/01/2025
The first issue of #ExpHem for 2025 is here, marking the beginning of what promises to be a great year of new science! Don't miss articles in this issue from @charles-debock.bsky.social, Lev Kats, Hitoshi Takizawa, and more! www.exphem.org/issue/S0301-...
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Mick Milsom @milsommick.bsky.social · 22/01/2025
In the Jan issue of @isehsociety.bsky.social journal, the very first “Society Voices article: Advice for effective leadership and hitting the ground running as a new group leader - Experimental Hematology www.exphem.org/article/S030...
exphem.org
Advice for effective leadership and hitting the ground running as a new group leader
Congratulations—you have just been appointed a new group leader! That position that you coveted from the time you first set foot in a laboratory as an undergraduate student. You have a great hypothesi...
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Alba R Meira @albarmeira.bsky.social · 13/12/2024
There's no better way to start the new year than by hearing the exciting science of organoids! 🤩 Join us for the first 2025 New Investigator Committee webinar on January 8th.
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Katherine Bridge @bridgekatherine.bsky.social · 12/12/2024
Announcing the launch of the European Hematology Association (EHA) Mentorship Program - call for Mentors is now open - apply today!
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Marlies Vanden Bempt @marliesvandenbempt.bsky.social · 11/12/2024
For all experienced hematology researchers in Europe: we welcome you to join the EHA mentorship program (a new youngEHA initiative 🤩) As a mentor, you can really have a positive impact on the careers of young researchers! ⏱️ Deadline to sign up is 13 January 2025
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ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · 05/12/2024
This week on #SimplyBlood🩸 learn more about the ISEH New Investigators Committee that organizes year-round education and networking opportunities to support early career researchers➡️ www.simplyblood.org
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Mick Milsom @milsommick.bsky.social · 27/11/2024
First post on BSky and I'm going to use it to promote the outstanding line up of faculty that we've managed to put together for #ISEH2025 in Kumamoto, Japan (with more to come). Save the date: lots of space reserved in the program for you to present your exciting science! Link below.
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ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · 26/11/2024
Check out the November Preprint Watch on #SimplyBlood🩸 featuring 14 preprints covering clonal dynamics, AML biology and tumor-immune dynamics - plus, a community submission! Read more and submit your own preprint today simplyblood.org
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Charles de Bock @charles-debock.bsky.social · 26/11/2024
As my group rounds off 2024, honours student Kristy Yeats won best student oral presentation @kidscancerinst.bsky.social annual research symposium. Followed by a Functional Genomics of Leukemia lab Korean BBQ dinner to celebrate and obligatory photo booth moment. Lets see what 2025 holds.
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Charles de Bock @charles-debock.bsky.social · 24/11/2024
The transition from bench top scientist to junior faculty or group leader brings numerous challenges. In a new article shorturl.at/u8HnJ from @isehsociety.bsky.social published in a new section called #SocietyVoices, we ask Prof Margaret (Peggy) Goodell and @rickyjohnstone.bsky.social for advice🧵1/4
sciencedirect.com
Advice for effective leadership and hitting the ground running as a new group leader.
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ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · 22/11/2024
Have you had a chance to check out Experimental Hematology's special issue on the Recent Advance in MDS Research? Edited by Dr. Goro Sashida, additional authors include Drs. Aaron Viny, Jörg Cammenga, @daichi-inoue.bsky.social and more! 📖➡️www.exphem.org/content/special_issues
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