Abstract. Mendelian randomization (MR) is increasingly used in epidemiological studies to investigate causal relationships. MR depends on 3 fundamental ins

Careers 5 Prime Sciences uses insights from human genetics to accelerate drug development and increase return on investment in the life sciences. Using unique datasets and advanced human genetics anal...

FIMM-EMBL Group Leaders in Molecular Medicine

Kári Stefánsson, founder and long-time CEO of DeCode Genetics, has officially stepped down from his leadership role at the company he established nearly three decades ago. The announcement marks the e...

A genome-wide study by the Long COVID Host Genetics Initiative identifies an association between the FOXP4 locus and long COVID, implicating altered lung function in its pathophysiology.

Mendelian randomization (MR) enables the estimation of causal effects while controlling for unmeasured confounding factors, but MR estimators often rely on strong parametric assumptions. We propose an...

The polygenic risk score genetic quantitative ultrasound speed of sound (gSOS) was developed using machine learning algorithms in adults of European ancestry and associates with reduced odds of fractu...

Senior investigator at Mount Sinai Hospital was one of five researchers jointly awarded US$3-million in world’s largest science prize

This randomized clinical trial examines the efficacy of high-dose cholecalciferol (vitamin D) as monotherapy in reducing disease activity in patients with clinically isolated syndrome typical of multi...

He says the 25% levies on Mexico and Canada will begin Tuesday. Stocks fall.

Research Associate Postdoc opportunity Research Associate Principle Duties and Responsibilities Management and execution of multiple computational genomics research studies, including but not l...

-- JOURNAVX is the first and only approved non-opioid oral pain signal inhibitor and the first new class of pain medicine approved in more than 20 years -- -- JOURNAVX is an effective and well-tolerat...

Two-step Mendelian randomization, combined with multiple layers of omics evidence, implicates COL6A3-derived endotrophin as a mediator of coronary artery disease risk in the context of obesity.

Apolipoprotein C-III (apoC-III) inhibits triglyceride hydrolysis and has been implicated in coronary artery disease. Through a genome-wide association study, we have found that about 5% of the Lancast...

Large-scale experimental analysis of Human Domainome 1, a library containing more than 500,000 missense mutation variants across more than 500 human protein domains, reveals that 60% of pathogenic mis...