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Bethan Lloyd-Lewis

@bethlloydlewis.bsky.social
1.4K followers 1.2K following 9 posts

Wellcome Trust Research Fellow, University of Bristol. Epithelial cell fate dynamics during tissue development and cancer. #stemcells #devbio #mammarygland #morphogenesis #microscopy #breastcancer. She/her.

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Reposted by Bethan Lloyd-Lewis
Yanlan Mao @yanlanmao.bsky.social · 30/07/2026
This epic paper, which has been a heroic 10 year journey for the lead author, Ricardo Barrientos, is finally out in Cell today! Many thanks to all co-authors, especially Billie Meadowcroft and Andela Saric for their beautiful MD simulations www.cell.com/cell/fulltex...
cell.com
Basement membrane turnover controls cell shape
Basement membranes are scaffolds of proteins, like collagen, that give organs shape. During development, basement membranes must adapt to the growing organ. We infer how fast the basement membrane ada...
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Reposted by Bethan Lloyd-Lewis
Silvia Fre lab @frelab.bsky.social · 26/06/2026
Week-end reading? Check out our new review on development and regeneration of glandular epithelia! With two fantastic co-authors: @robinjournot.bsky.social and @candice-merle.bsky.social ! 🤗 authors.elsevier.com/sd/article/S...
authors.elsevier.com
Shared molecular and cellular programs during regeneration of glandular epithelia
An emerging concept across multiple adult tissues implies that regeneration involves the transient reactivation of developmental programs, rather than…
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Reposted by Bethan Lloyd-Lewis
Yanlan Mao @yanlanmao.bsky.social · 06/05/2026
This exciting paper is now out in PNAS: www.pnas.org/doi/10.1073/...
pnas.org
3D epithelial cell topology tunes signaling range to promote precise patterning | PNAS
Cell behaviors in multicellular organisms are coordinated via both diffusible molecules and by signals based on direct cell–cell contacts. The mode...
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Floris BOSVELD @florisbosveld.bsky.social · 17/02/2026
How resilient are tissues to cell mispositioning and loss, and how do they restore their cell numbers? Check our latest work, from @ybellaichelab.bsky.social Congratulations to all authors. Artwork from the artist @lale-alpar.bsky.social (lalealpar.com) www.cell.com/developmenta...
cell.com
Tissue mechanics and systemic signaling safeguard epithelial tissue against spindle misorientation
Bosveld et al. identified a multilayered system of safeguards that reuses homeostatic mechanisms to maintain epithelial integrity and cell number in the face of spindle misorientation. This work delin...
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Reposted by Bethan Lloyd-Lewis
Cathy Abbott @cathyabbott.bsky.social · 06/02/2026
So now we have it- not only the reduction from 12-13 to 3 grants from each board recommended for funding but the budget for applicant-led research to be reduced from £200 million to £113 million per year. This is appalling, Especially given all that is happening with medical research in the US.
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Reposted by Bethan Lloyd-Lewis
Matthew Freeman @mjafreeman.bsky.social · 05/02/2026
Helpful update into UKRI and research council funding changes from Zoe Kleinman @zsk.bsky.social But please more focus on 2 things... 1) Immediate effects (eg funding decisions expected in March) 2) Likely disproportionate effects on early career scientists www.bbc.co.uk/news/article...
bbc.co.uk
UK’s £8bn research fund faces “hard decisions” as it pauses new grants
UKRI boss Ian Chapman said it had been told by the government to
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Robert Insall @robinsall.bsky.social · 03/02/2026
I think Ian Chapman's focus throughout this process has been excessively PI-centred and ignores early career researchers and training. A big funding pause doesn't cause them to worry about their jobs. It causes them to lose their jobs. And to be unable to get new ones. Their careers will be ended.
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Robin Journot 🔬| 🎾 @robinjournot.bsky.social · 17/11/2025
🚨 New preprint! We built a single-cell atlas of 14 multilayered epithelia and revealed a conserved transcriptomic program guiding tissue architecture and fate composition. Our work brings decades of tissue-specific studies together into a unified evo-devo framework. www.biorxiv.org/content/10.1...
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adam grieve @adamgrieve.bsky.social · 25/11/2025
Add our first pre-print to your reading list? Using AF2 and MD, we've characterised structures and conformational ensembles of human rhomboid proteases - and revealed some surprises along the way. Feel v.lucky to work alongside Bryony & @robincorey.bsky.social! Please share: tinyurl.com/3h8r7f5y
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Reposted by Bethan Lloyd-Lewis
Rob Clarke @robclarkelab.bsky.social · 05/11/2025
Really happy to share a link to our work showing that anti-progestin therapy could help prevent breast cancer before menopause. Published today in Nature, the study suggests this could be a new way to stop breast cancer before it starts: urldefense.com/v3/__https:/... Brilliant team science
urldefense.com
Anti-progestin therapy targets hallmarks of breast cancer risk
Nature - Results of an early-phase breast cancer prevention trial demonstrate the potential for breast cancer prevention in premenopausal women with anti-progestin therapy by inducing...
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Reposted by Bethan Lloyd-Lewis
(GIRISH)MALI LAB @dyneinassembly.bsky.social · 31/10/2025
This was a fun chat. Thanks @jcellsci.bsky.social for featuring me and spotlighting our work. Check out the special issue on Cilia and Flagella journals.biologists.com/jcs/issue/13.... We have an article on Axonemal Dynein Assembly Factors (DNAAFs) which may be useful for the field.
journals.biologists.com
Volume 138 Issue 20 | Journal of Cell Science | The Company of Biologists
Journal of Cell Science publishes cutting-edge science encompassing all aspects of cell biology. It is published by The Company of Biologists, a not-for-profit organisation.
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Reposted by Bethan Lloyd-Lewis
Denis Krndija @deniskrndija.bsky.social · 08/10/2025
Ever wondered how adult organs preserve epithelial barrier integrity while continuously exposed to mechanical stress? We tackled this question in our new preprint – led by our brilliant PhD student Vishnu Krishnakumar! (1/11) 🔗 www.biorxiv.org/content/10.1...
biorxiv.org
Robust pan-junctional reinforcement preserves the gut epithelial barrier under mechanical stress
Epithelia are specialized tissue barriers that safeguard the organism's internal milieu from the hostile external environment, a function critically dependent on intercellular junctions. In the colon,...
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The Company of Biologists @biologists.bsky.social · 17/10/2025
This week has been special for us, marking 100 years of supporting biologists and inspiring biology. We celebrated our achievements at @zoologymuseum.bsky.social last night. We want to thank all our staff, whose continual inspiration and daily support for one another make our work possible.
Photo of whale at Museum of Zoology and photo of 100 cake
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James Briscoe @jamesbriscoe.bsky.social · 07/10/2025
Very sad news, John Gurdon has died. A developmental biologist's developmental biologist, Nobel prize winner His work is the foundation of much of today's dev & stem cell bio. An inspiration to many, including me. Always asking questions & wanting the answers www.magd.cam.ac.uk/news/profess...
magd.cam.ac.uk
Professor Sir John Gurdon FRS (1933-2025) | Magdalene College
Magdalene College is deeply saddened to announce the death of Professor Sir John Gurdon FRS, who served as Master of the College from 1995 to 2002.
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Giulia Paci @giuliapaci.bsky.social · 11/08/2025
Thrilled to share the first story from my postdoc! 🎉 A wonderful experiment + simulations collaboration. In the Drosophila wing, we find that 3D cell shapes affect signalling range and fine-tune developmental patterning www.biorxiv.org/content/10.1... Thread below ⬇️
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Geula Hanin @geula.bsky.social · 14/07/2025
I’m looking for a Postdoc to join my new lab @pdncambridge.bsky.social on an MRC-funded project and explore maternal inter-organ communication with a focus on the mammary gland, using a novel mouse model. 📍 Tenure: 3 years ⏳ Deadline: 15 August 2025 Please RT 🙏 👉 www.jobs.cam.ac.uk/job/51984/
jobs.cam.ac.uk
Research Associate (Fixed Term) - Job Opportunities - University of Cambridge
Research Associate (Fixed Term) in the Department of Physiology, Development and Neuroscience at the University of Cambridge.
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Tung Le @tunglejic.bsky.social · 10/07/2025
Fantastic opportunity to start your independent career at the JIC here. Great startup package. Repost = nice. Thank you!!!
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Juliane Glaser @julianeg.bsky.social · 09/07/2025
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁 Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
nature.com
Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics
Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...
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Bethan Lloyd-Lewis @bethlloydlewis.bsky.social · 07/07/2025
Get in touch if you are interested in applying for an MSCA fellowship to come work with us on the mechanisms regulating epithelial cell fate decisions during mammary gland morphogenesis and cancer. Great environment in a vibrant city!
marie-sklodowska-curie-actions.ec.europa.eu
MSCA opens €404.3 million call for Postdoctoral Fellowships
Postdoctoral Fellowships offer researchers holding a PhD the opportunity to acquire new skills through advanced training and international, interdisciplinary, and inter-sectoral mobility.
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European Research Council (ERC) @erc.europa.eu · 17/06/2025
Could this be the future of cancer prevention? Walid Khaled‬, a new ERC Advanced Grant recipient @cam.ac.uk‬, will work on a preventive vaccine for breast cancer. Learn more 👉 buff.ly/s6cBCwL #ERCAdG #CancerResearch #FrontierResearch @wtklab.bsky.social‬
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Walid Khaled @wtklab.bsky.social · 06/05/2025
Our latest paper from is out! Congratulations to all members the lab that contributed over the years! No UMAPs in this one! @phar.cam.ac.uk @scicambridge.bsky.social Thanks to our funders @cancerresearchuk.org @breastcancernow.bsky.social
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Denis Krndija @deniskrndija.bsky.social · 06/04/2025
🥳 Thrilled to share our lab's first preprint, led by our talented postdoc Justine Creff! 👩🏻‍🔬 We tackled a fundamental question: how the epithelium withstands mechanical stress at the interface of cells with distinct geometries and mechanics, such as enterocytes (E) and goblet cells (G) (1/9)
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Rage Against the Miocene @organiccarbon.bsky.social · 31/05/2025
"Welsh is not a “minority language.” It is an indigenous language of Britain. It’s a language that grew here, shaped by the deep time of these islands – by the millennia it has spent in, and of, this land, shaping it and being shaped by it." nation.cymru/opinion/wels...
nation.cymru
Welsh: the language that shaped Britain
Owen Williams Listen carefully, and you’ll hear it: a language older than the hills, older than the state. The names of rivers and mountains still whisper it – Pen-y-Fan, Penicuik, Aberystwyth, Aberde...
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adam grieve @adamgrieve.bsky.social · 09/04/2025
Pls re-skeet! There's a postdoc job available to join us in Bristol! We're looking for a molecular cell biologist to help us investigate plasma membrane proteostasis in neurons. Apply here by 23 April: www.jobs.ac.uk/job/DMO097/r.... If interested, do contact me and check out grieve-lab.com! Thanks!
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Assoc. Professor Tim J Sargeant @timsargeant.bsky.social · 08/04/2025
Check out our latest Comment in Nature Cell Biology on #autophagy (the mechanism that cells of your body use to recycle damaged material and slow ageing). While declining autophagy is often seen as a hallmark of #ageing, we explore emerging exceptions to this idea. www.nature.com/articles/s41...
nature.com
Autophagy does not always decline with ageing - Nature Cell Biology
Autophagy has long been presumed to decline with age, underpinning its designation as a hallmark of ageing. However, emerging evidence challenges this notion, showing tissue-specific variability and, ...
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MRC-LMB Cell Biology Division @cellbiol-mrclmb.bsky.social · 07/04/2025
A great tribute to David Stevens, a terrific cell biologist and missed by so many of his friends and colleagues. As they say 'one of the good guys'. journals.biologists.com/jcs/article/...
journals.biologists.com
Remembering David Stephens (1971–2024)
In the autumn of 2024, David Stephens, a prominent member of the UK cell biology community and a brilliant scientist, leader and mentor, passed away. With his pragmatism and natural authority, combine...
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Reposted by Bethan Lloyd-Lewis
Development @dev-journal.bsky.social · 25/03/2025
Are you enjoying all the exciting science at #biologists100? Want to spread the love of developmental biology to your friends and family? Together with @bsdb.bsky.social, we've produced a documentary video to showcase the fascinating world of #DevBio: 🎥
youtu.be
BSDB - The Fascinating World of Developmental Biology (full length)
In this half-hour long documentary we showcase some of the beauty, as well as the translatability, of developmental biology research being undertaken current...
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Katherine Brown @katherine-brown.bsky.social · 25/03/2025
If you’re a PhD or postdoc developmental biologist in the UK who cares about the field and the community, please nominate yourself to join the BSDB committee. Great opportunity to get involved, have real input and give back to the community @bsdb.bsky.social #biologists100
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Emilia Peuhu @epeuhu.bsky.social · 20/03/2025
We are looking for a doctoral candidate to join the lab! If you are interested in working with human breast tissue samples straight from the clinic and do not fear large data sets, this might just be your dream project ☺️ Apply now ⬇️ ats.talentadore.com/apply/vaitos... 📸 @oonapaavolainen.bsky.social
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Maxim Greenberg @maxvcg.bsky.social · 04/03/2025
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Walid Khaled @wtklab.bsky.social · 15/01/2025
JOB ALERT We are seeking a Computational Research Assistant or Research Associate to help drive an ambitious multiomics ageing project part of the NMGN Mouse Ageing Cluster. www.jobs.cam.ac.uk/job/49939/ @scicambridge.bsky.social @phar.cam.ac.uk @cambridgebiosci.bsky.social
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the Node @the-node.bsky.social · 22/01/2025
What do we mean by ‘mechanism’ anyway? @dev-journal.bsky.social Executive Editor @katherine-brown.bsky.social gives her perspective on the recent article "A case for broadening our view of mechanism in developmental biology" by @biyolokum.bsky.social @swathiarur.bsky.social and Mansi Srivastava:
thenode.biologists.com
What do we mean by 'mechanism' anyway? - the Node
The latest issue of Development (vol 152 issue 2) features a Perspective article by Duygu Özpolat, Swathi Arur (one of Development's Academic Editors),
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TanentzapfLab @tanentzapflab.bsky.social · 27/11/2024
My 3 favourite things about being a scientist: my full time job is to solve mysteries (how cool is that!), constantly being amazed by how beautiful & surprising the natural world is, getting to work w/ people who are smarter than me & have skills I can only dream of having on problems I care about.
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Duncan Sproul @sproullab.bsky.social · 12/12/2024
We've been awarded a UKRI MRC grant to examine the causes and consequences of #heterochromatin hypomethylation in cancer 🥳. #postdoc opportunity coming in the near future. #epigenetics. Please share with anyone who might be interested.
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John Wallingford @jbwallingford.bsky.social · 27/11/2024
Looking for something fun to read? Here’s a #popsci piece I did on the crazy history of cilia and left/right patterning in embryos. Remember #devbiolwriteclub Bluesky Boot Camp starts Monday Dec. 2! Please RS (re-skeet?) nautil.us/the-anatomic...
nautil.us
The Anatomical Quirk That Saved Dr. No
A wild tale of how scientists unraveled embryology's most fascinating mystery.
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Jessica Cross @jessicacross.bsky.social · 28/11/2024
Please share this PhD opportunity in my new lab in Bristol, using protein design/ engineering to understand and build molecular motors to control intracellular transport. Working with @markdodding.bsky.social and Prof Dek Woolfson. www.findaphd.com/phds/project... www.swbio.ac.uk/biomolecular...
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Sara Pensa @drsarapensa.bsky.social · 26/11/2024
We are forming a patient advisory group to help shape our research on BRCA breast cancer prevention! Follow the link/scan the barcode for more info and to express interest. Please share! @wtklab.bsky.social www.stemcells.cam.ac.uk/about-us/eng...
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The Company of Biologists @biologists.bsky.social · 25/11/2024
We are happy to report that our journals and community sites now have Bluesky accounts. Follow them at: @dev-journal.bsky.social @jcellsci.bsky.social @jexpbiol.bsky.social @dmmjournal.bsky.social @biologyopen.bsky.social @the-node.bsky.social @prelights.bsky.social @focalplane.bsky.social
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Maik Bischoff @maikbischoff.bsky.social · 19/11/2024
Even though there are great #devbio and #biophysics starter packs, I felt #morphogenesis & #organogenesis was missing as a subfield :D Far from complete or full. Tell me if you want to be added! go.bsky.app/PB6s8PQ
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Joyce Yu @joyceyu.bsky.social · 09/11/2024
Do you work in #DevBio and want to introduce the fascinating world of developmental biology to your family and friends? You can show them this science documentary, produced by the British Society for Developmental Biology, The Company of Biologists and Cambridge Filmworks! 📽️ youtu.be/avrmIs3vPUQ?...
youtu.be
BSDB - The Fascinating World of Developmental Biology (full length)
YouTube video by The Company of Biologists
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James Briscoe @jamesbriscoe.bsky.social · 15/11/2024
Upcoming Development Special Issue 'Lifelong Development' Beyond the embryo: tissue maintenance, regeneration & plasticity Guest eds: Meri Huch & Mansi Srivastava Deadline: 15 May 2025 All article types welcome #DevBio #Regeneration #StemCells journals.biologists.com/dev/pages/li...
journals.biologists.com
CFP | Lifelong Development | Development | The Company of Biologists
CFP | Lifelong Development | Development | The Company of Biologists Special Issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues Development invites yo...
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adam grieve @adamgrieve.bsky.social · 15/11/2024
Can I ask you to share a PhD advert at Bristol Uni please? Rhomboid proteases play a role in neurons that is essential for life- but it is not characterised. Got a student interested in cell biology, electrophysiology and neurobiology? Send them our way! tinyurl.com/56f24f7c
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