Targeting the chromatin-modifying activities of the SUV4-20H enzyme family offers a promising epigenetic strategy to enhance the potency of the topoisomerase-2 poison etoposide in prostate cancer ther...

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Abstract. Commonly used in cancer therapy, topoisomerase II (TOP2) poisons are designed to stabilize the normally transient DNA TOP2 cleavage complexes in chromatin, leading to deleterious DNA double-...

DNA double-strand breaks induce local genome maintenance and inhibition of replication initiation at nearby topologically associating domains without affecting global DNA synthesis.