Tissue-resident memory (TRM) CD8+ T cells in the tumor microenvironment are relevant for anti-tumor immunity and immune checkpoint blockade response. Here, the authors conditionally ablate type 1 and ...

Transcription factors are known to guide dendritic cell identity, but how they cooperate to drive lineage diversification remains unclear. Henriques-Oliveira, Altman, Kurochkin, et al. identify two tr...

Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the process regu...

Deciphering the role of intra-tumoral dendritic cells in the dynamic controlof CD4+ and CD8+ lymphocytes in lung cancer. A 3-year, post-doctoral position is available in the Guermonprez lab at Institu...

Cyclooxygenase-driven prostaglandin E2, produced by a variety of tumors, drives malignant growth through successful evasion of type I interferon and/or T-cell-dependent tumor elimination. A remarkable synergy between cyclooxygenase inhibitors and checkpoint blockade immunotherapy results in tumor eradication.