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Kyojiro N Ikeda

@beingkyo.bsky.social
1K followers 1.6K following 11 posts

Submicron morphogenesis Senior postdoc at University of Vienna @univie.ac.at

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Reposted by Kyojiro N Ikeda
mareikejordan.bsky.social @mareikejordan.bsky.social · 04/09/2026
Check out our preprint on the structural mechanisms of how LEM2 and ESCRTs seal the nuclear envelope. Awesome collaboration with @karenpalacior.bsky.social who brought my structures to life 💃🔬❄️🌀 @hummerlab.bsky.social www.biorxiv.org/content/10.6...
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PLOS Biology @plosbiology.org · 26/08/2026
What are the genetic mechanisms for the #evolution of novel traits? This study by @brhopkins92.bsky.social &co links #Drosophila sex comb teeth to expression changes within ancestral cells, leading to diverged metabolic/developmental rates, and a novel structure. 🧪 #AcademicSky plos.io/4gQOnZK
Graphical abstract on the gain of a novel trait in Drosophila. The teeth of the recently evolved, male-specific Drosophila sex comb evolved from a more ancient organ, the mechanosensory bristle. We show that changes in the expression of genes that are shared between mechanosensory bristle and sex comb teeth cells lead to changes in a variety of fundamental cellular processes that together enable the morphological transformation.

The photo, phylogeny, general design are those of the corresponding author(s). They made the bristle schematics in biorender and the fly silhouette is their modified drawing of D. melanogaster from SciDraw (https://doi.org/10.5281/zenodo.3925939).
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Journal of Cell Biology @jcb.org · 21/08/2026
Localized active transport shapes the nanoscopic features at the tip of mechanosensory #cilia. From Shan Wang, Rui Ma, Xin Liang @tsinghuauniversity.bsky.social and colleagues: rupress.org/jcb/article/... 📕 Part of #Centrosomes and #Cilia 2026: rupress.org/jcb/collecti...
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Kirsty Wan @micromotility.bsky.social · 17/08/2026
What does a single-celled organism tell us about the origins of complex behaviour? Delighted to see the final version of our paper: Embodied behavioural complexity in a ciliated microorganism out in@natcomms.nature.com (Funded by @erc.europa.eu ERC) doi.org/10.1038/s414... #cilia #protistsonsky
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Journal of Cell Biology @jcb.org · 06/08/2026
Ana1/Cep295 regulates #centriole elongation via Cep135 and #microtubules. New stutdy from Zhenjie Wang, Zhe Feng and colleagues (Fudan University): rupress.org/jcb/article/... #Biochemistry #CellCycle #CellDivision #Genetics #Cilia #Drosophila #Spermatogenesis
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Kyojiro N Ikeda @beingkyo.bsky.social · 04/08/2026
My interview on Japanese national TV is on air at the NHK platform from the 9th of August. Talking about morphogenesis and how bristles can save lives. Huge thanks to @tessmar-Raible Labs. www.web.nhk/tv/an/zero/p...
web.nhk
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Tessmar-Raible Labs @tessmarraiblelabs.bsky.social · 15/07/2026
…Our "bio-metals" work builds on a fantastic collaboration between @tuwien.at @univie.ac.at @viennabiocenter.bsky.social, support by @oeaw.bsky.social and matching funds. Original @biophysicalsoc.bsky.social article: doi.org/10.1063/5.03...; coverage by @newscientist.com: bit.ly/4yniP4w [5/5]
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Tessmar-Raible Labs @tessmarraiblelabs.bsky.social · 15/07/2026
…Matching the experimental breakthrough, Christian Hellmich’s team @tuwien.at developed a conceptual framework of “manifold micromechanics” linking atomistically-grounded force singularities and strain incompatibilities with gradient-dependent stress and strain quantities… [4/5]
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Tessmar-Raible Labs @tessmarraiblelabs.bsky.social · 15/07/2026
… To put this hypothesis to test, we now probed individual specimens of Perinereis cultrifera jaws with thousands of indentations of different depths. Final proof: #bristleworm #jaws are the first #biomaterial shown to exhibit metal-like Nix&Gao indentation size effects! …[3/5]
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Tessmar-Raible Labs @tessmarraiblelabs.bsky.social · 15/07/2026
...5 years back, we had first hypothesised that bristleworm jaws might have “bio-metallic” properties, still based on cross-species comparisons, supported by an @oeaw.bsky.social Innovation Fund programme grant. See doi.org/10.1007/s118... rdcu.be/ftIkf ... [2/5]
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Tessmar-Raible Labs @tessmarraiblelabs.bsky.social · 15/07/2026
Hot off the press: our joint @univie.ac.at @tuwien.at @viennabiocenter.bsky.social proof for the “bio-metallic” properties of worm jaws, and pioneering work in conceptualising them using manifold micromechanics. Check out @biophysicalsoc.bsky.social Biophys. Rev. doi.org/10.1063/5.03... ... [1/5]
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epithelial mechanics fan club @epimechfc.bsky.social · 03/07/2026
Herawati, E., Taniguchi, D., Kanoh, H., Tateishi, K., Ishihara, S., & Tsukita, S. (2016). Multiciliated cell basal bodies align in stereotypical patterns coordinated by the apical cytoskeleton. The Journal of cell biology, 214(5), 571–586. #EpithelialMechanics doi.org/10.1083/jcb....
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Journal of Cell Biology @jcb.org · 01/07/2026
Rajan, Yoon, Terman, Reisler et al. identify mechanisms for assembling & disassembling complex networks of multi-protein–bundled F-actin, including a synergism between different bundlers and disassemblers in these processes. rupress.org/jcb/article/... #Migration #Development #Cytoskeleton #Actin
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epithelial mechanics fan club @epimechfc.bsky.social · 29/06/2026
Werner, M. E., Hwang, P., Huisman, F., Taborek, P., Yu, C. C., & Mitchell, B. J. (2011). Actin and microtubules drive differential aspects of planar cell polarity in multiciliated cells. The Journal of cell biology, 195(1), 19–26. #EpithelialMechanics doi.org/10.1083/jcb....
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Michael Sars Centre @msarscentre.bsky.social · 16/06/2026
New preprint from the Burkhardt lab 🚨The work explores the origins of sensory system components by looking at the closest relatives to animals, choanoflagellates ⤵️ Congratulations @smannsaker.bsky.social, @jeffcolgren.bsky.social & @pawelburkhardt.bsky.social!
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Anubhav Dhar @anubhavdhar.bsky.social · 27/05/2025
🚨 New preprint alert! We used IntAct + Ultrastructure Expansion microscopy to map actin isoforms in 3D🤯 Check out this gorgeous 3D volume of U2OS cells - revealing diverse filament networks including the elusive nuclear actin filaments! #cytoskeleton #microscopy #actin
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Annika Barber @annikabarber.bsky.social · 02/06/2026
Is it pronounced ORCID 🌸 like the flower or Orc ID 👹 like an identity card for a Middle Earth monster? Smart people disagree. Personally, I pronounce it Orc ID because I like the idea that I am a science goblin with a fixed numerical identifier. @orcid.org
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Tessmar-Raible Labs @tessmarraiblelabs.bsky.social · 27/05/2026
Massive protests now in @wien.gv.at now against planned budged cuts of the #University sector. #unisretten. Speeches now in front of @univie.ac.at main building.
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Wallace Marshall @wallaceucsf.bsky.social · 09/05/2026
so maybe this protein is acting as a calcium sensor to let the cell keep track of its current stimulation state or past stimulus history. right now, almost any hypothesis can be on the table. in case you missed the paper you can read it here: www.cell.com/current-biol...
cell.com
Molecular pathways for learning in the single-cell Stentor coeruleus
Rajan et al. explore the molecular basis of habituation in the unicellular organism Stentor coeruleus using a combination of pharmacological methods, proteomics, transcriptomics, and RNAi. These exper...
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myosinactncrazy.bsky.social @myosinactncrazy.bsky.social · 12/05/2026
elifesciences.org/reviewed-pre...
elifesciences.org
Actin-membrane interface stress regulates Arp2/3-branched actin density during lamellipodial protrusion
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Maureen Barr @barrlab.bsky.social · 06/04/2026
Another #cilia kinesin motor: kinesin-8 KIF19A localizes to ciliary tips of Drosophila mechanosensory neurons In 2012, Hirokawa lab showed KIF19A regulated ciliary length & localized to ciliary tips in mice; knockouts had hydrocephalus and female infertility phenotypes (PMID 23168168). #ciliopathy
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Journal of Cell Biology @jcb.org · 03/04/2026
Park, Liu, Sun, Roll-Mecak et al. present the crystal structure of an RPGR–TTLL5 co-complex, which reveals TTLL recognition paradigms for non-tubulin substrates and sheds light on disease mechanism for retinal dystrophies caused by TTLL5 and RPGR mutations. rupress.org/jcb/article/... #Cilia
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Cell - a Cell Press journal @cp-cell.bsky.social · 20/03/2026
Now online! Deciphering mechanical determinants of morphological evolution
dlvr.it
Deciphering mechanical determinants of morphological evolution
A comparative analysis of cnidarian larval morphogenesis combined with active surface theory identifies a set of mesoscale mechanical modules that predict species-specific shapes. Manipulating these modules reprograms morphology, revealing how variation in tissue-scale mechanics underlies morphological diversity.
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Journal of Cell Biology @jcb.org · 06/01/2026
🎦 See a short video summary by Sachi Inagaki: youtu.be/50JRPysrTNU
youtu.be
Endoplasmic reticulum patterns insect cuticle nanostructure
Original paper: [LINK] Video Summary by Sachi Inagaki (RIKEN Center for Biosystems Dynamics Research, Kobe, Japan) Description: In this work, Inagaki and coworkers report the intracellular mechanism…
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Reposted by Kyojiro N Ikeda
Journal of Cell Biology @jcb.org · 06/01/2026
How do cells fabricate nanoscale extracellular matrix structures? Inagaki, Hayashi et al. @riken-bdr.bsky.social show that the ER network stimulates complex remodeling of the plasma membrane, thereby patterning nanoscale cuticular pore formation in insect sensilla. rupress.org/jcb/article/...
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Journal of Cell Biology @jcb.org · 05/01/2026
Medina, Chang et al. of the @nanigrotjahn.bsky.social lab introduce a new method based on the Surface Morphometrics pipeline to measure global and local thicknesses of organellar #membranes from cellular cryo-electron tomography data. rupress.org/jcb/article/... #CryoET
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Nature @nature.com · 25/12/2025
Demogorgons, Shadow Monsters and psychokinetically gifted 12-year-olds are strictly fictional creations - but what about the parallel universe at the core of Stranger Things? go.nature.com/48Mo2br
go.nature.com
Are we living in a parallel universe? The strange physics of Stranger Things
Nature - Nature speaks to theoretical physicists to explore the real theories that inspired the hit series. Warning: contains spoilers.
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Kyojiro N Ikeda @beingkyo.bsky.social · 04/11/2025
www.cell.com/biophysj/abs...
cell.com
Membrane morphologies arising from multiconformational protein states
Dynamic compartmentalization by lipid membranes is a hallmark of living cells. The shapes of membrane surfaces are tightly coupled to their various functions, resulting in the myriad of complex membra...
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Reposted by Kyojiro N Ikeda
Pilhofer Lab 🦠❄️🔬 @pilhoferlab.bsky.social · 08/10/2025
Congrats🥳 to @mike-wieczorek.bsky.social, Bin Cai, and our former lab member Jingwei Xu @xujwet.bsky.social to their multiscale imaging 🔬 story of the centriolar AC linker #teamtomo www.science.org/doi/10.1126/...
science.org
Structure and assembly of the A-C linker connecting microtubule triplets in centrioles
Multiscale cryo-EM of centrioles reveals the structure and polymorphism of the A-C linker connecting microtubule triplets.
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Manuel Thery @manuelthery.bsky.social · 07/10/2025
What would happen if cells would express more molecular motors ? They would break all microtubules 😱 As shown by recent great work from @kjverhey1.bsky.social rupress.org/jcb/article-...
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Thibaut Brunet @thibautbrunet.bsky.social · 05/10/2025
Latest from ours: www.cell.com/cell-reports... This is two stories in one: a case study/cautionary tale on developing genetic tools in new organisms, and the first hint at a gene regulatory network for choanoflagellate multicellular development (which turn out to involve a Hippo/YAP/ECM loop!) A 🧵
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Ben Engel @cellarchlab.com · 20/09/2025
A molecular-resolution look into the near-native architecture of the spinach chloroplast🌱. This one was a long time in the oven, but we're happy to finally share our "version of record". What long-standing debates did we settle? Check back for a short thread🧵 on Monday. #TeamTomo #PlantScience 🧪🧶🧬🔬🌾
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Laura Boulan @lboulan.bsky.social · 10/08/2025
Our new paper is out in @currentbiology.bsky.social! Using 3D reconstructions and volume measurements in Drosophila wing primordia, we show that growth can be uncoupled from cell proliferation and uncover a new time window for growth arrest. With @leopoldlab.bsky.social www.cell.com/current-biol...
cell.com
A switch to non-proliferative growth sustains Drosophila wing development during the early pupal stage
Using precise tissue volume quantification, El Marzkioui, Gaugué, et al. show that wing primordia continue to grow during the early pupal stage, a phase of increased cell volume driven by insulin/IGF ...
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Kyojiro N Ikeda @beingkyo.bsky.social · 06/08/2025
Out stody Is now on National Geographic!!! www.nationalgeographic.com/animals/arti...
nationalgeographic.com
This creature can 3D-print its own body parts
Bristle worms have protrusions that act like a 3D printer, helping us to understand how cells regenerate.
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José Dinneny @josedinneny.bsky.social · 03/08/2025
Very proud to share our latest preprint: postdoc/LRSF fellow Yue Rui studies the mechanisms regulating attachment of the cell wall to the plasma membrane. The Cellulose Synthase Complex and REMORINs determine the extent of attachment and root osmotic stress tolerance. www.biorxiv.org/content/10.1...
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Bruce Taylor @brucedstaylor.bsky.social · 31/05/2025
An amoeba with teeth. When building its shell, Netzelia corona selects sharp grains of quartz and positions them around its aperture with the tips pointing inward. I took a few closeups, yesterday. #ProtistsonSky #amoebae #peatlands #MEvoSky
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eLife @elife.bsky.social · 15/07/2025
One protein, two opposing roles: This ‘compelling’ study shows how the same signalling molecule can drive either protrusion or retraction in migrating cells depending on its concentration and activation dynamics. elifesciences.org/articles/931...
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Journal of Cell Biology @jcb.org · 05/06/2025
Belyantseva and Liu et al. report that taperin encircles and stabilizes F-#actin at auditory hair cell #stereocilia bases and bundles F-actin. Taperin deficiency causes stereocilia disassembly, rootlet breakage at pivots, and other abnormalities culminating in deafness. rupress.org/jcb/article/...
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Kyojiro N Ikeda @beingkyo.bsky.social · 05/05/2025
I can say that I lived in the times of CRISPR. - @jenniferdoudna.bsky.social 's talk at @gmivienna.bsky.social 25th year anniversary jubilee at ÖAW.
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Alex Eve @amjeve.uk · 23/04/2025
#DevBio job opportunity! Development (@dev-journal.bsky.social) is looking for a new Community Manager to run our community site, the Node (@the-node.bsky.social) – a great opportunity if you love devbio, #stemcells, #scicom and community engagement. Happy to chat informally about the role. ⬇️
biologists.com
Work for us
Working for us We’re always looking for talented and motivated people to work as part of our close-knit team. Roles range from editorial to production, marketing to event co-ordination, HR to accounts...
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Pablo Arantes @pabloarantes.bsky.social · 20/03/2025
I’ve just updated the BioEmu notebook to include the powerful LogMD. Now, you can generate equilibrium ensembles and explore the full ensemble directly in the notebook. A huge thanks to Alexander Mathiasen for the support! 🙌 🔗 Try it on Google Colab: lnkd.in/gcuqd-fT
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Tessmar-Raible Labs @tessmarraiblelabs.bsky.social · 04/04/2025
Kyojiro Ikeda @beingkyo.bsky.social @univie.ac.at presenting now at #DevStem2025 @viennabiocenter.bsky.social on first mechanistic & molecular regulators of #bristle biogenesis in the #Platynereis model. Also check Kyojiro's recent @naturecomms.bsky.social publication www.nature.com/articles/s41...
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Tessmar-Raible Labs @tessmarraiblelabs.bsky.social · 01/04/2025
Are you in for a PhD project on neural #regeneration? Only 2 more weeks to apply to the @vbcscitraining.bsky.social @univie.ac.at VBC PhD programme: vbcphd.at ! Pls. see tiny.cc/RaibleLab and our recent @naturecomms.bsky.social study www.nature.com/articles/s41... for information and contact!
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Universität Wien / University of Vienna @univie.ac.at · 01/04/2025
Take the next step in your academic career and become part of a thriving international research community! The Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences (VDS-PhaNuSpo) are offering 13 fully four-year funded PhD positions at the moment!
vds-phanuspo.univie.ac.at
Open positions
Open positions
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Zach Marin @zacsimile.bsky.social · 29/03/2025
Incredible 4Pi and pan-expansion imaging of the Golgi 👇
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Ben Engel @cellarchlab.com · 20/03/2025
We're on the cover of @science.org this week. Awesome work by @florentwaltz.bsky.social. #CryoET is reaching crazy resolutions inside cells, and this is just the beginning. Fantastic interpretation of the proton motive force by @verenaresch.bsky.social. Always a pleasure making #SciArt with you!🧪🧶🧬🌾
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Nature @nature.com · 20/03/2025
Nature research paper: Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium go.nature.com/4hrHX0v
go.nature.com
Dynamic cytoskeletal regulation of cell shape supports resilience of lymphatic endothelium - Nature
Dynamic cytoskeletal regulation of lymphatic endothelial cell shape, induced by isotropic stretch and crucial for dermal lymphatic capillary function, is identified and found to result from continuous remodelling of cellular overlaps that maintain vessel integrity.
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Hao Yin @haoyin.bsky.social · 02/03/2025
My continued biological education #Mechanobiology #RigiditySensing Stiffness Sensing by Cells "Substrate Stiffness Can Lead to Heritable Epigenetic Changes" "Cell Motility Is Faster on Soft Elastic Substrates" #PhysiolRev 2020 journals.physiology.org/doi/full/10....
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Matthias Soller @matthiassoller.bsky.social · 12/02/2025
Cool story on nanopatters! We had picked Osiris genes as erect wing regulated, but no clue what this was about. genomebiology.biomedcentral.com/articles/10....
genomebiology.biomedcentral.com
Erect wing regulates synaptic growth in Drosophilaby integration of multiple signaling pathways - Genome Biology
Background Formation of synaptic connections is a dynamic and highly regulated process. Little is known about the gene networks that regulate synaptic growth and how they balance stimulatory and restr...
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Julian Kompa @juliankompa.bsky.social · 07/02/2025
Can you spot the difference? 🔬 SiR-actin labeling can be cytotoxic and affects actin dynamics - while the new XActin probes do not! Developed by @veselin-nasufovic.bsky.social and perfect for time-resolved and STED imaging without the need for genetic manipulation. www.biorxiv.org/content/10.1...
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