Sign in

Stephen Graham's Lab

@atomicvirology.bsky.social
2.3K followers 800 following 154 posts

Lab in the University of Cambridge 🇬🇧 studying the cell biology, biophysics and structural biology of virus infection. Blame Stephen 🇦🇺 for the content.

PostsRepliesMedia
Stephen Graham's Lab @atomicvirology.bsky.social · 4h
Now published in Science Advances @science.org Herpes simplex virus has a single protein that completely silences neuronal activity by removing ion channels from the cell surface 🧠🤫⚡ www.science.org/doi/10.1126/... Bluetorial of the preprint 👇
science.org
Herpes simplex virus pUL56 abolishes neuronal activity by removing voltage-gated ion channels from the plasma membrane
Herpes simplex virus 1 (HSV-1) infections of the central nervous system cause encephalitis and are associated with increased risk of neurodegeneration, yet the molecular consequences of lytic infectio...
1177
Stephen Graham's Lab @atomicvirology.bsky.social · 26/09/2026
Where in the world is @atomicvirology.bsky.social ?
040
Stephen Graham's Lab @atomicvirology.bsky.social · 23/09/2026
Excited to be on my way to the mini herpesvirus workshop in Hannover tomorrow. Almost there... 🚅 4/4...no ✈️!
060
Reposted by Stephen Graham's Lab
Jordan P. Skittrall @skittrallj.bsky.social · 10/09/2026
Funded PhD in Cambridge: "Mathematical and computational methods to discover and characterise critical genetic features in RNA viruses, with application to Rift Valley Fever Virus" Group: skittrallgroup.org Ad: bbsrcdtp.lifesci.cam.ac.uk/project-refe... Info: bbsrcdtp.lifesci.cam.ac.uk/how-apply
Goats in the shade of a thatched hut during an investigation into a Rift Valley fever outbreak in Saudi Arabia, 2000. Courtesy CDC/Abbigail Tumpey
153
Stephen Graham's Lab @atomicvirology.bsky.social · 09/09/2026
Their expression conduct included the signal peptide so furin will have been cotranslationally secreted into the ER, unlikely to be any furin activity in the cytoplasm
060
Reposted by Stephen Graham's Lab
Chris H. Hill @chillzaa.bsky.social · 24/08/2026
Thrilled to share that our paper describing protein-dependent frameshifting is now out in Molecular Cell @cellpress.bsky.social. Huge congratulations to @jemmabetts.bsky.social for publishing the first research paper from her PhD 🧬🧪🥳 www.sciencedirect.com/science/arti... 1/8
sciencedirect.com
A protein-dependent riboswitch activates ribosomal frameshifting in cardioviruses
Programmed −1 ribosomal frameshifting (PRF) is a translational control mechanism used by RNA viruses to regulate the relative abundance of proteins en…
46719
Reposted by Stephen Graham's Lab
Aakash Mukhopadhyay @aakash89.bsky.social · 27/07/2026
Come join us in beautiful Cambridge to uncover the fascinating biology of eukaryotic parasites! #Postdoc #Cambridge #cryoEM #parasitology #cilia #Trypanosoma #Leishmania
042
Reposted by Stephen Graham's Lab
Yo Akiyama @yoakiyama.bsky.social · 21/07/2026
Excited to share our now published paper @cp-cell.bsky.social highlighting advances in modeling the evolution of protein-protein interactions with MSA Pairformer. Big thanks to Zhidian Zhang, Olivia Tang, @eunbelivable.bsky.social @milot.bsky.social @martinsteinegger.bsky.social and @sokrypton.org!
cell.com
Expanding the scope of protein language modeling to protein-protein interactions with MSA Pairformer
Protein language models have excelled at modeling individual proteins, but extending these capabilities to protein complexes remains a major challenge. MSA Pairformer, a parameter-efficient protein la...
26027
Stephen Graham's Lab @atomicvirology.bsky.social · 17/07/2026
💯 - up until now making MD data accessible has been a real pain, kudos to @wheelerlab.org and colleagues.
020
Reposted by Stephen Graham's Lab
Christophe 🔬 Leterrier @christlet.bsky.social · 16/07/2026
"Our findings likewise suggest that scientific impact does not translate into happiness. This gap reflects a deeper misalignment: the external recognition conferred by citations may not satisfy researchers’ intrinsic psychological needs" doi.org/10.1093/rese...
doi.org
Scientific impact at the expense of happiness? Work/life balance in performance-driven research careers
Abstract. Research evaluation systems place increasing emphasis on scientific impact, yet their consequences for researchers themselves remain underexplore
2227
Stephen Graham's Lab @atomicvirology.bsky.social · 08/07/2026
Well done to Shrestha, who had a tough slot as second talk of #bunya2026 (straight after the keynote) but did a great job presenting her work on computational affinity maturation of nanobodies against emerging #Oropouche virus variants 💪
040
Stephen Graham's Lab @atomicvirology.bsky.social · 08/07/2026
The Cambridge crew after a good dinner in a local bar last night, ready for #bunya2026 to kick off!
0190
Stephen Graham's Lab @atomicvirology.bsky.social · 08/07/2026
Yes, I saw her name on the programme, looking forward to her presentation. We'll think of you when enjoying pinchos and cañas 🍤🍢🍻
100
Stephen Graham's Lab @atomicvirology.bsky.social · 08/07/2026
Where in the world is @atomicvirology.bsky.social ...
130
Stephen Graham's Lab @atomicvirology.bsky.social · 24/06/2026
Tell a tragic tale in two images...
3100
Reposted by Stephen Graham's Lab
Kate Baker @ksbakes.bsky.social · 11/06/2026
I know a lot of people on the fence about frontiers… hopefully this is all you need to come down
0102
Stephen Graham's Lab @atomicvirology.bsky.social · 09/06/2026
What do you think, should I go and try to reclaim some of my gold from abcam?
1121
Reposted by Stephen Graham's Lab
Reese Richardson @reeserichardson.bsky.social · 05/06/2026
The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)
18590367
Reposted by Stephen Graham's Lab
James Briscoe @jamesbriscoe.bsky.social · 03/06/2026
Is this the future of peer review? New from @biologyopen.bsky.social: expanded Fast & Fair trial paying reviewers £220 per paper The result: rapid peer review with no drop in quality or change in acceptance rate Paying referees makes peer review faster & fairer www.biorxiv.org/content/10.6...
biorxiv.org
06220
Reposted by Stephen Graham's Lab
Frank Noe @franknoe.bsky.social · 03/06/2026
Postdoc openings on experimental data integration integration into BioEmu-next, focusing on cryo-EM and binding affinities. Join us at @msftresearch.bsky.social Cambridge or Berlin. #AI #MachineLearning #Protein #Biology apply.careers.microsoft.com/careers/job/...
apply.careers.microsoft.com
AI for Science Postdoctoral Researcher - Biomolecular AI & Experimental Data Integration | Microsoft Careers
Design and scale experimental datasets for ML Develop workflows that connect noisy experimental signals to actionable model insights 1. Bridging Models with Real-World Experimental Signals Develop met...
0218
Reposted by Stephen Graham's Lab
Department of Pharmacology | University of Cambridge @phar.cam.ac.uk · 02/06/2026
The Cambridge Protein Screening Facility has launched their new website! This facility, aims to enable the development of novel antibody binders for research, diagnostics and therapeutics using phage and yeast display. See our news post here: www.phar.cam.ac.uk/news/announc...
122
Reposted by Stephen Graham's Lab
Brett Collins @brettcollins.bsky.social · 30/05/2026
This is an interesting analysis of AlphaFold3. I don't claim to understand all of the technicalities, but the conclusion matches our own anecdotal experience that evolutionary depth is important for the most confident AlphaFold predictions. www.biorxiv.org/content/10.6...
biorxiv.org
11711
Reposted by Stephen Graham's Lab
Laurel Oldach @laureloldach.bsky.social · 28/05/2026
Thermo Fisher has responded to research integrity activists who spotted apparent manipulation in its antibody catalog: "In ... preparing antibody images for publication on our website, some images may have been adjusted to clarify for presentation purposes." More: cen.acs.org/research-int...
Headline "Sleuths say Thermo Fisher doctored data to sell antibodies," subhead "Apparent manipulation of validation images in reagent catalog concern researchers," byline Laurel Oldach, image of a pipette loading an SDS-PAGE gel for a western blot
97938
Stephen Graham's Lab @atomicvirology.bsky.social · 29/05/2026
This is shocking (but also not terribly surprising)! Blatant manipulation of antibody validation data on the Thermo website... As Mulder said, trust no-one 👽
031
Reposted by Stephen Graham's Lab
Reese Richardson @reeserichardson.bsky.social · 28/05/2026
TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data. @sholtodavid.bsky.social @johanduchene.bsky.social reeserichardson.blog/2026/05/28/h...
reeserichardson.blog
How much of Thermo Fisher’s antibody data has been manipulated?
We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog
23591312
Reposted by Stephen Graham's Lab
Shivkumar Lab @shivkumarlab.bsky.social · 22/05/2026
📢 Funded #PhD studentship (UK Home students) for a multidisciplinary project on the disinfection of wastewater using novel technologies. Collaboration with environmental engineering firm Hazen & Sawyer, covering microbiology, virology, chemistry. Apply here: tinyurl.com/28he6ztp @dmu.ac.uk
144
Stephen Graham's Lab @atomicvirology.bsky.social · 22/05/2026
Where in the world is @atomicvirology.bsky.social? (And what in the world is going on 👨‍🚒🚒?!)
010
Reposted by Stephen Graham's Lab
Sholto David @sholtodavid.bsky.social · 17/05/2026
Surprised to discover that Thermo Fisher appears to show a fake western blot for the validation of one of their p53 antibodies. I've added a diagram to show the very similar bands. This does not appear to be one of the "published figures" but their own internal data.
22272114
Stephen Graham's Lab @atomicvirology.bsky.social · 17/05/2026
Congrats
010
Stephen Graham's Lab @atomicvirology.bsky.social · 16/05/2026
I stand corrected
000
Stephen Graham's Lab @atomicvirology.bsky.social · 16/05/2026
And here I was thinking we wouldn't get any metal animal heads... Thank you Austria
110
Stephen Graham's Lab @atomicvirology.bsky.social · 16/05/2026
Not holding my breath, sadly
000
Stephen Graham's Lab @atomicvirology.bsky.social · 16/05/2026
Italy's Scarface tribute act had some intense dancing
110
Stephen Graham's Lab @atomicvirology.bsky.social · 16/05/2026
Intense COVID vibes from Sweden...
110
Stephen Graham's Lab @atomicvirology.bsky.social · 16/05/2026
The silver surfer's long awaited Eurovision debut
110
Stephen Graham's Lab @atomicvirology.bsky.social · 16/05/2026
The backdrop image looks rather unhappy with Moldova's entry
110
Stephen Graham's Lab @atomicvirology.bsky.social · 16/05/2026
Oh dear... Another year of nil points for the UK
410
Stephen Graham's Lab @atomicvirology.bsky.social · 16/05/2026
And we have this year's cha cha cha...
110
Stephen Graham's Lab @atomicvirology.bsky.social · 16/05/2026
The Maltese cowboy...
110
Stephen Graham's Lab @atomicvirology.bsky.social · 16/05/2026
110
Stephen Graham's Lab @atomicvirology.bsky.social · 16/05/2026
110
Stephen Graham's Lab @atomicvirology.bsky.social · 16/05/2026
Oh my...
110
Stephen Graham's Lab @atomicvirology.bsky.social · 16/05/2026
And so it begins...
130
Reposted by Stephen Graham's Lab
Chris H. Hill @chillzaa.bsky.social · 16/05/2026
We just had our second -80 freezer failure in four years... On a Friday evening of course. All samples transferred safely, thanks to the amazing dedication of my team. Eppendorf CryoCube is disappointing in every possible way - it's neither a cube, nor does it stay cold.
3163
Reposted by Stephen Graham's Lab
Bosse lab at CSSB Hamburg @bosse-lab.bsky.social · 12/05/2026
Want to do a PhD combining cryo-EM, AI-driven binder design, and deep virology in a cutting-edge environment and in an international team? We're hiring @CSSB_Hamburg 🔬 You: curious, rigorous, MSc in biochem, biophysics, virology, related Interested? DM me. Please RT 🙏 #PhDposition #cryoEM #virology
01516
Reposted by Stephen Graham's Lab
The Conversation AUNZ @aunz.theconversation.com · 12/05/2026
A virus doesn’t become a pandemic simply because it’s deadly.
theconversation.com
Hantavirus is very different to COVID. Here’s why the ‘Andes virus’ won’t cause the next pandemic
052
Reposted by Stephen Graham's Lab
Ed Hutchinson @socialinfluenza.bsky.social · 05/05/2026
Still time to apply for one of three joint virology PhDs @cvrinfo.bsky.social and @pirbrightinst.bsky.social, including one with myself and the fantastic @peacockflu.bsky.social! Informal enquiries welcome by e-mail (including re the primary location of ours, which is negotiable), deadline 8th May
01214
Stephen Graham's Lab @atomicvirology.bsky.social · 30/04/2026
Congratulations to @danielacl.bsky.social for winning a poster prize at the @isaricar.bsky.social international conference on antiviral research #ICAR2026 🎉🥳🏅👩‍🔬
052
Stephen Graham's Lab @atomicvirology.bsky.social · 29/04/2026
Where in the world is @atomicvirology.bsky.social? #ICAR2026
130
Stephen Graham's Lab @atomicvirology.bsky.social · 28/04/2026
My colleague @socialinfluenza.bsky.social has written an absolutely excellent explainer for @theconversation.com about our recent paper with @dalan-bailey.bsky.social identifying a new human surface receptor for alphacoronaviruses: theconversation.com/scientists-h...
theconversation.com
Scientists have found a safer way to hunt for the next pandemic virus
Scientists are learning to spot pandemic threats without touching dangerous pathogens.
02010