Very excited to share another new study from our lab - led by Lyn Yong. Unexpectedly, CD4 T cells have no major role in promoting primary or recall CD8 T cell immunity induced by mRNA vaccines. The mRNA vaccines seem to stand apart from most other vaccine or infection models.
doi.org/10.1002/eji....
doi.org
Distinct Requirements for CD4+ T Cell Help for Immune Responses Induced by mRNA and Adenovirus‐Vector SARS‐CoV‐2 Vaccines
The role of CD4+ T cells in promoting cellular and humoral immunity induced by novel mRNA–LNP and adenovirus vector vaccine technologies is incompletely understood. Surprisingly, we identified a disc...