Reposted by Amy C Fan (she/her)Balyn Zaro @balynzaro.bsky.social · 09/09/2026Proud to see this paper lead by my amazing student Regan finally out in the world! Using chemical biology approaches, we reveal a transcriptionally silent process by which macrophages acquire new functional proteins from the surface of interacting cells. 02110
Reposted by Amy C Fan (she/her)Emily Goldberg @dremilygoldberg.bsky.social · 09/09/2026Really excited to see this paper from @balynzaro.bsky.social finally out!!! Membrane proteins from phagocytosed cells get redeployed to the macrophage cell surface. And they're functional!!! www.nature.com/articles/s41...nature.comMacrophages transfer functional proteins to their surface during live-cell uptake - Nature Chemical BiologyMacrophages acquire intact surface proteins from cancer cells during live-cell uptake, with these proteins remaining active, revealing a transcriptionally silent process where macrophages can reengine... 094
Reposted by Amy C Fan (she/her)Colette Delawalla, PhD @cdelawalla.bsky.social · 01/09/2026BREAKING: OMB PROPOSED RULE IS PAUSED UNTIL DEC 11th. This is a direct result of OUR ACTIVISM! It's a critical step in the right direction AND the fight continues. NOW, it's time to revoke the rule. Email here: fight2win.standupforscience.net/campaign/rev... www.theguardian.com/us-news/2026...theguardian.comHouse passes funding bill to avoid shutdown before midtermsContinuing resolution to approve government spending until 11 December passes 370-48 and will now go to Trump 422885
Amy C Fan (she/her) @amycfanphd.bsky.social · 21/08/2026Big congrats to Caleb & co for this huge effort to systematically identify & characterize viral ubiquitin ligases. Caleb finds these ligases converge on 3 mechanistically distinct categories to modulate antiviral responses. Read more below ⬇️ 000
Reposted by Amy C Fan (she/her)Global Immunotalks @globalimmuno.bsky.social · 18/08/2026Coming up! 023
Reposted by Amy C Fan (she/her)Fred Hutch @fredhutch.org · 15/08/2026🔬 Fred Hutch Cancer Center is hiring an Assistant or Associate Professor in the Basic Sciences Division @basicsci.fredhutch.org. Join a world-class research community in Seattle and help advance discoveries in fundamental biology. Apply: apply.interfolio.com/190640 02322
Reposted by Amy C Fan (she/her)Ran Blekhman @blekhman.bsky.social · 09/08/2026Huge faculty recruitment effort at the University of Chicago -- a division-wide, open-rank search looking to hire about 20 faculty across 5 research areas in biology. Come be our colleague! Full announcement: uchicago.app.box.com/s/ckih9zv3rj... 3222232
Reposted by Amy C Fan (she/her)zunigalab.bsky.social @zunigalab.bsky.social · 04/08/2026Hi there #DC2026—late-breaking abstracts just OPEN TODAY! Join us at the international #dendriticcell community premier conference in beautiful #SanDiego for cutting-edge #immunology, collaboration, and networking! 📍 Oct 11–14, 2026. Register today! dc2026sandiego.com 143
Reposted by Amy C Fan (she/her)ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · 30/07/2026Congratulations to the 2026 ISEH Leadership Award recipients! 🎉 These awards recognize outstanding leadership, service, and mentorship in experimental hematology. Join us in celebrating this year's honorees: iseh.org/Publications... @goodell-lab.bsky.social 021
Reposted by Amy C Fan (she/her)George Davey Smith @mendelrandom.bsky.social · 22/07/2026Does the (live) shingles vaccine protect against dementia? Fergus Hamilton and colleagues provide important evidence in a new preprint using hospital data from the whole of England in a regression discontinuity design from which we *don't* show evidence of a meaningful protective effect /cont 38144
Reposted by Amy C Fan (she/her)Brynn Paulsen, PhD @brynnpaulsen.bsky.social · 22/07/2026📣 Researchers in the Boulder/Denver area: I'm building a photo library of real researchers at work and looking for volunteers! If you're a grad student, postdoc, faculty member, or research scientist, I'll take professional-quality photos of you - for free. Interested? DM me! 22922
Reposted by Amy C Fan (she/her)Science Magazine @science.org · 15/07/2026The White House has received more than 340,000 comments on rules many researchers fear would politicize science. scim.ag/4fiHIWiscim.agU.S. researchers outraged at proposed changes to federal grantsWhite House receives 340,000 comments on rules many fear would politicize science 28031
Reposted by Amy C Fan (she/her)Journal of Experimental Medicine @jem.org · 10/07/2026CSF1R-dependent CD169-positive #macrophages locally constrain #melanoma growth in the skin. From Yuki Honda Keith, Tri Giang Phan @labphan.bsky.social and colleagues: rupress.org/jem/article/... 📘 Part of our #Mucosal #Immunology collection: 👉 rupress.org/jem/collecti... #ICMI2026 041
Reposted by Amy C Fan (she/her)Idoyaga Lab @idoyagalab.bsky.social · 02/07/2026You love #DendriticCells... how could you not? 😊 ⏰ Tomorrow is your last chance to register at the Early Bird rate! #DC2026 Join us this October in San Diego! dc2026sandiego.com 🙏 Please repost! 🔁 @maxkrummel.bsky.social @zunigalab.bsky.social 034
Reposted by Amy C Fan (she/her)Tina Termini @cterminiphd.bsky.social · 23/06/2026Congratulations to the 8th cohort of @fredhutch.org Dr. Eddie Méndez scholars! Co-directing this program is one of my favorite part of the job. We are excited to welcome you to Fred Hutch later this summer to share your research with our scientific community. www.fredhutch.org/en/news/rele...fredhutch.orgFred Hutch names 8 recipients of the Dr. Eddie Méndez AwardFred Hutch names eight recipients of the Dr. Eddie Méndez Award, which celebrates early-career scientists' research in cancer, infectious disease and basic sciences. 0225
Reposted by Amy C Fan (she/her)Julie Pfeiffer @jkpfeiff.bsky.social · 26/06/2026Faculty search announcement 2026: Tenure-Track Assistant Professor in Microbiology at UT Southwestern in Dallas. We seek candidates working in microbial pathogenesis (broadly defined). Come join our community! (1/5) www.utsouthwestern.edu/departments/... 34553
Reposted by Amy C Fan (she/her)Journal of Experimental Medicine @jem.org · 05/06/2026Kuhn, @maxkrummel.bsky.social et al. demonstrate how local gene editing of cancer-associated fibroblasts alters their cell state and, subsequently, the cellular tumor microenvironment. rupress.org/jem/article/... 📘 Part of JEM #Cancer Collection: rupress.org/jem/collecti... #EACR2026 062
Reposted by Amy C Fan (she/her)Di Jiang @dijiang319.bsky.social · 03/06/2026Check out this Associate or Senior Editor opportunity @science.org recruiting.ultipro.com/AME1123ASEM/...recruiting.ultipro.com 085
Reposted by Amy C Fan (she/her)ISEH - International Society for Experimental Hematology @isehsociety.bsky.social · 28/05/2026We're kicking off our 2026 Interview Series with the 2026 Donald Metcalf Award Winner Ellen Rothenberg, PhD. She dives into her current work, reflects on her most notable discoveries, and offers helpful guidance to early career scientists. Watch now on iseh.org/Publications... 011
Amy C Fan (she/her) @amycfanphd.bsky.social · 26/05/2026Interesting paper on mitochondrial control of cross-presentation in cDC1s: loss of Complex I impairs cross-presentation of cell-associated antigen and alters NAD+/NADH balance. Restoring NAD+/NADH rescues the phenotype, while correcting lipid peroxidation does not. 030
Reposted by Amy C Fan (she/her)Patrick S. Mitchell @psmitchej.bsky.social · 25/05/2026Thrilled to announce that the Department of Microbiology at the University of Washington, School of Medicine is hiring at the Assistant Professor level (tenure-track)! The Pacific Northwest is an awesome place to live and do science 🧪🦠. Join us! apply.interfolio.com/185622 Applications due 8/1.apply.interfolio.com Apply - Interfolio {{$ctrl.$state.data.pageTitle}} - Apply - Interfolio 2138126
Reposted by Amy C Fan (she/her)Nature Reviews Immunology @natrevimmunol.nature.com · 11/05/2026Macrophages sample the living selfdlvr.itMacrophages sample the living selfNature Reviews Immunology, Published online: 11 May 2026; doi:10.1038/s41577-026-01311-4Macrophages continuously ‘nibble’ healthy neighbouring cells, capturing minute amounts of cytosolic material that are preserved in specialized vesicles and preferentially routed for cross-presentation to CD8+ T cells. 063
Amy C Fan (she/her) @amycfanphd.bsky.social · 21/05/2026Congrats to Tristan & @maxkrummel.bsky.social for this herculean effort to immunoprofile 15 murine tumor models to identify conserved immune networks. An important resource for mapping what we can understand about human cancers from mouse systems. www.nature.com/articles/s41... #immunology #cancernature.comDifferential assembly of mouse and human tumor microenvironments - Nature ImmunologyIn this Resource paper, Krummel and colleagues provide analysis of 15 commonly used syngeneic mouse tumor models and compare these to the diversity of human tumor microenvironments. 040
Reposted by Amy C Fan (she/her)Waggoner Lab @labwaggoner.bsky.social · 20/05/2026Differential assembly of mouse and human tumor microenvironments @natimmunol.nature.com @maxkrummel.bsky.social www.nature.com/articles/s41... 0104
Reposted by Amy C Fan (she/her)Tami Gjorgjieva @tamigj.bsky.social · 18/05/2026Hi Genetics/Comp-Bio community 👋 Interested in mentoring a comp-bio research student in East Africa over the summer? Do you have any experience in bioinformatics, biostats, genome/RNA-seq analyses, ML, or metagenomics? We'd love to have you as a mentor in our new program! 🧵 (1/n) 12323
Reposted by Amy C Fan (she/her)Molly Schumer @mollyschumer.bsky.social · 12/05/2026Do you know any students who are planning to apply to graduate school this cycle? Encourage them to apply to the Biology Preview Program! We provide intensive workshops to help students w/ their applications + 1:1 mentorship. 14759
Reposted by Amy C Fan (she/her)Chris Hsiung @chrishsiung.bsky.social · 08/05/2026Faculty search at the Institute for Human Genetics at UCSF. Come be my colleague! aprecruit.ucsf.edu/JPF06052aprecruit.ucsf.eduFaculty Positions - Institute for Human GeneticsUniversity of California, San Francisco is hiring. Apply now! 074
Reposted by Amy C Fan (she/her)Christian Mosimann @chrmosimann.bsky.social · 08/05/2026Open-rank search: 2 (!) PI positions in Pulmonary Biology at @cuanschutz.bsky.social 🌄 We are looking for new colleagues @cupediatrics.bsky.social, working in lung fibrosis, focusing on #devbio, stem cell, & regen.biology of the lung 🫁🫀. Please help spread the word! cu.taleo.net/careersectio...cu.taleo.netOpen Rank- Assistant Professor, Associate Professor, or ProfessorClick the link provided to see the complete job description. 02222
Reposted by Amy C Fan (she/her)Nature @nature.com · 04/05/2026Nature research paper: Submicrometre sampling of living cells by macrophages go.nature.com/428tTUmgo.nature.comSubmicrometre sampling of living cells by macrophages - NatureMacrophages can sample antigens from living cells through a trogocytosis-like mechanism that routes ingested material away from degradation, a finding that delineates a previously unknown pathway for antigen presentation to CD8 T cells. 0183
Amy C Fan (she/her) @amycfanphd.bsky.social · 29/04/2026We think this creates a stable depot of antigens. Macrophages may not only present this material to T cells, but also potentially share with other immune cells, with implications for self-tolerance and tumor immunity. Questions? Drop them below! #immunology #cellbiology #macrophages #trogocytosis 141
Amy C Fan (she/her) @amycfanphd.bsky.social · 29/04/2026What regulates this alternative trafficking and what happens when we disrupt it? We found that SNX27-retromer complex diverts live-sampled material away from lysosomes AND Deleting SNX27 in macrophages decreased T cell priming after live-sampling. 131
Amy C Fan (she/her) @amycfanphd.bsky.social · 29/04/2026If the antigens are not getting degraded, does this affect macrophages’ ability to activate T cells? Yes. Surprisingly, macrophages that sample live-cells efficiently cross-present that material to prime CD8 T cell activation and proliferation 121
Amy C Fan (she/her) @amycfanphd.bsky.social · 29/04/2026Phagocytosis of dead cells and endocytosis of soluble material led to accumulation of this antigen in the degradative lysosome. In contrast, we found live-sampled materials avoids lysosomes and is diverted to an alternative compartment negative for canonical endolysomal markers. 111
Amy C Fan (she/her) @amycfanphd.bsky.social · 29/04/2026What happens once this sampled material enters macrophage? To answer this question, we developed a 10-parameter flow-based vesicle profiling method to track vesicles. In effect, we can now do flow cytometry with the contents of a cell and analyze this entire vesicle pool all at once. 110
Amy C Fan (she/her) @amycfanphd.bsky.social · 29/04/2026Macrophage-target cell interactions spontaneously result in a tiny protrusion from the target cell that separates into a submicron vesicle containing cytoplasm. This is a fast process, taking just minutes. 121
Amy C Fan (she/her) @amycfanphd.bsky.social · 29/04/2026How does this happen? The antigen-containing vesicles were SO small that conventional microscopy could not capture this process. So we turned to Nikon NSPARC and lattice light-sheet microscopy. This revealed… 111
Amy C Fan (she/her) @amycfanphd.bsky.social · 29/04/2026Instead, we found that: ✅ Sampling is contact-dependent ✅ Sampling is caspase-independent ✅ Target cell remains alive 110
Amy C Fan (she/her) @amycfanphd.bsky.social · 29/04/2026When we put macrophages and highly viable cells together, we saw that macrophages could continuously sample cytoplasmic material from living, healthy cells. This is not: ❌ Endocytosis of soluble particles ❌ Traditional phagocytosis of dying cells. 110
Amy C Fan (she/her) @amycfanphd.bsky.social · 29/04/2026We know that the immune system can sample dead/dying cells to determine what is “you” vs “not you.” But -- how does the immune system gather information without destroying cells? 110
Amy C Fan (she/her) @amycfanphd.bsky.social · 29/04/2026Excited to announce our new study (w/ @maxkrummel.bsky.social) published today @nature.com: Macrophages “hold our living identities” by taking tiny bites from living cells and presenting this information to CD8 T cells. www.nature.com/articles/s41... #immunology #cellbiology @immunox.bsky.socialnature.comSubmicrometre sampling of living cells by macrophages - NatureMacrophages can sample antigens from living cells through a trogocytosis-like mechanism that routes ingested material away from degradation, a finding that delineates a previously unknown pathway... 16022
Reposted by Amy C Fan (she/her)Ludwig Cancer Research @ludwigcancer.bsky.social · 22/04/2026Ludwig @stanford.edu Siddhartha Jaiswal spoke at #AACR2026 about his lab’s exploration of the drivers of clonal hematopoiesis—in which the descendants of certain mutated stem cells come to dominate the blood cell population—and the implications of the pre-malignant process for cancer. 022
Reposted by Amy C Fan (she/her)blackinimmuno.bsky.social @blackinimmuno.bsky.social · 21/04/2026Next Monday!!! Spread the word! 012
Reposted by Amy C Fan (she/her)Eric Pietras @ericpietras.bsky.social · 16/04/2026📢📢📢 There's still time to submit your abstract!!!! Showcase your science and enjoy the company of your colleagues at this year's @isehsociety.bsky.social meeting! iseh.org/Annual-Meeting 011
Reposted by Amy C Fan (she/her)Idoyaga Lab @idoyagalab.bsky.social · 15/04/2026⏳ 2 days left! Abstract submission for #DC2026 closes April 17 🌍 Join the global DC community in San Diego Submit your work now — don’t miss it! www.dc2026sandiego.com @maxkrummel.bsky.social @zunigalab.bsky.social 🔁 031
Reposted by Amy C Fan (she/her)Idoyaga Lab @idoyagalab.bsky.social · 25/03/2026If dendritic cells are part of your science, #DC2026 should be part of your year! 🌍Global DC community in San Diego ✳️New biology & discoveries Abstracts & registration are OPEN www.dc2026sandiego.com ⭐️ Come for the science. Stay for the community. @maxkrummel.bsky.social @zunigalab.bsky.social 🔁 185
Reposted by Amy C Fan (she/her)Eachan Johnson @eachan.scbir.org · 07/04/2026We're hiring a Postdoctoral Fellow! How does Mycobacterium tuberculosis survive drug treatment? You'll use molecular genetics and single-cell approaches to investigate how gene expression variability drives drug-tolerant subpopulations. Full details and application instructions below. 156
Reposted by Amy C Fan (she/her)Science Magazine @science.org · 03/04/2026If at first you don’t succeed, try, try again. That appears to be the thinking behind the 2027 budget request to Congress that President Donald Trump unveiled today. scim.ag/4sRnw3x scim.agSlasher sequel: Trump again proposes major cuts to U.S. science spendingScience advocates urge Congress to reject 2027 budget plan 46329
Reposted by Amy C Fan (she/her)Mick Milsom @milsommick.bsky.social · 30/03/2026First (to my knowledge) manuscript describing a correlation between number of infections and incidence of clonal hematopoiesis (CHIP). Really important from the perspective of highlighting a possible modifiable driver of CHIP during aging. @isehsociety.bsky.social www.exphem.org/article/S030...exphem.orgAssociation of Infection Frequency and Incident Clonal Hematopoiesis of Indeterminant PotentialClonal hematopoiesis of Indeterminant Potential (CHIP) is an age-related phenomenon characterized by clonal expansion of hematopoietic stem cells (HSCs)1. CHIP results from a fitness advantage conferr... 1166